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4TH MERIAL FORUM
 HAVE WE GOT PCVD &
SWINE INFLUENZA UNDER
       CONTROL?
PCVD

      Moderator: Dr Stéphane Imbert

• Viral reproductive disorders in sows, an
  update 2012. Pr. H. Nauwynck
• Benefits of CIRCOVAC® piglet vaccination
  in Hngary. Dr T. Kecskés
• Additional benefits of sow and piglet
  CIRCOVAC vaccination: Bulgarian field
  experience. Dr M. Grozeva
4TH MERIAL FORUM
 HAVE WE GOT PCVD &
SWINE INFLUENZA UNDER
       CONTROL?
ADDITIONAL BENEFITS
OF SOW AND PIGLET CIRCOVAC
       VACCINATION


 Bulgarian field experience
CIRCOVAC : a dual approach for the
        total herd performance benefits
               Different                       Different
               targets                        approaches


    Piglet performance      Reproductive   Total herd performance
                            performance

                     x
Piglet vaccination       Sow vaccination        Sow & Piglet
                                                vaccination
BULGARIA
ROMANIA
SERBIA




                110,993,6 km2
MACEDONIA




                          Bulgaria


                                     TURKEY

            GREECE
BULGARIA
            7 628 103

                              2007

      Moderate and transitional-continental


      Huge temperature variation
       in swine producing regions
           + 40˚ C     - 30˚ C
BULGARIA
   36 890 accessible sows in 37 farms
   Traditional pork consuming people
Distribution of industrial (accessible)
   pigs in different types of farms
               1%
         10%
                                       Large Farrow-to-Finish Farms
                                       (>400 pigs)


                                       Small Farrow-to Finish Farms
                                       (<400 pigs)


                 89%                   Fatteners Farms




          23 farms ≈ 90% of industrial sows
Distribution of genetics
One site, farrow-to-finish farm
(>30 000 pigs at any moment)
Swine farm “Brashlen”

   Number of sows – 2700
   250 hectares
   Genetic -           farm № 41
   Number of batches – 8
   Batch management – 4 days
    Type of flow – all in, all out
Health status of the farm

    PRRS (-)
    App (+)
    M. hyo (+)
    Aujezsky (-)
Vaccination against PCV2 - Why?
Vaccination against PCV2 - Why?

 Farm performance before vaccination

    No visible reproductive disorders
    Farrowing Rate >90%
    ADWG in growers – 0.566 kg
    ADWG in fatteners – 0.983 kg
 Stoykov et al. (2011), APVS, Pattaya, Thailand
Vaccination against PCV2 - Why?
Farm performance before
vaccination

  Increased %
  ”lightweight” pigs,
  especially in fattening
  period
  Mortality rate - slight
  increase in fatteners
  (2%)
  Single cases of PDNS
Vaccination against PCV2 - Why?

 Farm performance before vaccination

   Necropsy – stomach ulcers
   Performance lower than top DanBred farms
   Positive PCV2 serology

         SUB CLINICAL PCVD
No changes meantime
    Same genetic
    Same feed
    Same vaccination program
    (except CIRCOVAC)
    Same biosecurity

    … but the farm is live organism…
CIRCOVAC - Piglet MASS
vaccination - PROTOCOL
        All pigs at age 29-100 days




          Single injection - 0,5 ml, IM
CIRCOVAC - Piglet REGULAR
vaccination - PROTOCOL
       All pigs at weaning (28-29 days)




        Single injection - 0,5 ml, IM
Benefits of CIRCOVAC - piglet
vaccination
     First (visible)
    observations :

Disappeared stomach
       ulcers
  Very well uniform
       piglets
Significant improvement of ADWG
               Growing                           Fattening
610                                1080

                                   1060                      1052*
600
                         590       1040
590
                                   1020

580                                1000
                                             983
570      566                        980

                                    960
560
                                    940
550
                                    920

540                                 900
        Before           Piglets             Before           Piglets



      + 24 g ADWG in growers              + 69 g ADWG in fatteners
Days from birth to 100 kg


                            - 4 days
After good piglet results – sow
vaccination – WHY?

A lot of confirmations of
  influence of PCV2 on
       reproduction
After good piglet results – sow
vaccination – WHY?

 • Very good
   farrowing rate…
   …but opportunity to
   reach better results in
   number of
   born/weaned piglets
CIRCOVAC – Reproduction herd
 MASS vaccination - PROTOCOL
                     Sows, gilts, boars

         Start – end of July 2009

         Dose – 2 ml, IM, 2 injections, 3 weeks apart

         One further injection at least 2 weeks before
         farrowing
*in mass vaccination some animals received 1 injection, another - 2
 and other -3
CIRCOVAC – Sow REGULAR
vaccination - PROTOCOL


      One injection at each gestation at least
      2 weeks before farrowing

      Dose – 2 ml, IM
CIRCOVAC – Gilts REGULAR
vaccination - PROTOCOL
             Primary vaccination:

      Dose – 2 ml, IM, 2 injections, 3 weeks apart,
      second injection at least 2 weeks before
      mating
                    Booster:

      One injection at least 2 weeks before
      farrowing
Benefits of CIRCOVAC - sow
vaccination
                            Total born/litter

 18                                               16*           16,7*
                                     15,5*
 16
 14
           13            13,3
 12
 10
       controls          piglets      2010S1      2010S2         2011T1

                    + 3,7 born piglets / litter
                                                    Control
  P<0.05 (Dunett test)                              Sows vaccinated
Benefits of CIRCOVAC - sow
vaccination
                           Live born/litter

  16                                           14,9*
                                   13,9* 14,2*
  14
             11,8         12
  12

  10
           controls      piglets    2010S1      2010S2       2011T1
             + 3,1 live born piglets / litter
                                                   Control
  P<0.05 (Dunett test)                             Sows vaccinated
Benefits of CIRCOVAC - sow
vaccination
                               Weaned /litter

  12,5
                                                                   12,2*
   12
               11,2                     11,4* 11,5*
  11,5                      11,1
   11
  10,5
   10
              controls      piglets     2010S1   2010S2             2011

                   + 1 weaned piglet / litter
                                                 Control
  P<0.05 (Dunett test)                           Sows vaccinated
CIRCOVAC - Sow & piglets – REGULAR
            vaccination

               PROTOCOL

  Sow – one injection at least 2 weeks before
  each farrowing
  Gilts – Primary vaccination – 2 injection, 3
  weeks apart, booster – 1 injection, 2 weeks
  before farowing
  Piglets – one injection at 7 weeks of age
IMPORTANT !!!
           After mass sow vaccination –
       piglets vaccination was postponed to
                   7 weeks of age


Farrowing    Weaning       Begin.
                           of Finishing              Slaughter

                                      Weeks of age
            28 days    7 weeks
CIRCOVAC – Boar – REGULAR
                            vaccination
      6 months apart

Transmission of porcine circovirus
         2 (PCV2) by semen
 and viral distribution in different
            piglet tissues1
Danielle Gava2, Eraldo L. Zanella3,
Nelson Morés4 and Janice R.
Ciacci-Zanella5*
CIRCOVAC - Sow + Piglets
The best improvement of ADWG
                     Growing                                                     Fattening
                                                          607*
 610                                     602*                    1080
                                                                                             1060*          1060*
 600                                                             1060            1052*
                     590
 590                                                             1040
 580
                                                                 1020
 570
            566
                                                                 1000
 560                                                                    983
                                                                  980
 550
 540                                                              960

                                                                  940
                                                            1
                                         09
                     s
            re




                    et




                                                          01
         fo




                                       20
                    gl




                                                        /2
       Be




                  Pi




                                   ts




                                                      10




                                                                  920
                                  le




                                                    20
                                   g
                                pi




                                                   s
                                                et
                           s+




                                              igl




                                                                  900
                            w
                         so




                                            p
                                         s+




                                                                        Before    Piglets   sows+ piglets   sows+piglets
                                          w




                                                                                               2009          2010/2011
                                       so




            + 41 g ADWG in growers                                      + 77 g ADWG in fatteners
Days from birth to 100 kg

          150,7
                                - 5,3 days




                            145,3
Summary of vaccination protocol

 2009          Feb      Mar   Apr    May June July   Aug   Sept Oct    Nov     Dec

 2010 Jan         Feb   Mar   Apr    May June July   Aug   Sept Oct    Nov     Dec

 2011    Jan      Feb   Mar    Apr   May June July   Aug   Sept Oct     Nov    Dec

 2012    Jan      Feb   Mar    Apr   May




        Piglets                      Sow + Piglets               Regular
                                                               Sow + Piglets
CONCLUSION
In farm “Brashlen” CIRCOVAC:

  increases the reproductive
  performances – number of
  live born piglets + 3.1 and +
  1 weaned pig/litter

  increases the kg produced
  by sow
CONCLUSION
In farm “Brashlen” CIRCOVAC :
 improves the pig growth from birth to slaughter
 + 41 g ; + 77 g
 reduces the duration to 100 kg – 5,3 days
 helps for homogenous pig batches
 restore mortality rate
 prevent from appearance of stomach ulcers
CONCLUSION

 CIRCOVAC helps the farm “Brashlen” to have a
 good profit at the difficult time with a lots of
 crisis…and welfare requirements…

 CIRCOVAC regular sow + piglet vaccination is
 an investment in that farm with 2700 sows
 and a lots of piglets…
CONCLUSION

             …but ROI are justified already
             more than 3 years and prove
             definitely that the sow +
             piglet vaccination gives the
             best performance in farrow-
             to-finish farm.
THANK YOU !

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06 m grozeva

  • 1. 4TH MERIAL FORUM HAVE WE GOT PCVD & SWINE INFLUENZA UNDER CONTROL?
  • 2. PCVD Moderator: Dr Stéphane Imbert • Viral reproductive disorders in sows, an update 2012. Pr. H. Nauwynck • Benefits of CIRCOVAC® piglet vaccination in Hngary. Dr T. Kecskés • Additional benefits of sow and piglet CIRCOVAC vaccination: Bulgarian field experience. Dr M. Grozeva
  • 3. 4TH MERIAL FORUM HAVE WE GOT PCVD & SWINE INFLUENZA UNDER CONTROL?
  • 4. ADDITIONAL BENEFITS OF SOW AND PIGLET CIRCOVAC VACCINATION Bulgarian field experience
  • 5. CIRCOVAC : a dual approach for the total herd performance benefits Different Different targets approaches Piglet performance Reproductive Total herd performance performance x Piglet vaccination Sow vaccination Sow & Piglet vaccination
  • 7. ROMANIA SERBIA 110,993,6 km2 MACEDONIA Bulgaria TURKEY GREECE
  • 8. BULGARIA 7 628 103 2007 Moderate and transitional-continental Huge temperature variation in swine producing regions + 40˚ C - 30˚ C
  • 9. BULGARIA  36 890 accessible sows in 37 farms  Traditional pork consuming people
  • 10. Distribution of industrial (accessible) pigs in different types of farms 1% 10% Large Farrow-to-Finish Farms (>400 pigs) Small Farrow-to Finish Farms (<400 pigs) 89% Fatteners Farms 23 farms ≈ 90% of industrial sows
  • 12. One site, farrow-to-finish farm (>30 000 pigs at any moment)
  • 13. Swine farm “Brashlen” Number of sows – 2700 250 hectares Genetic - farm № 41 Number of batches – 8 Batch management – 4 days Type of flow – all in, all out
  • 14. Health status of the farm PRRS (-) App (+) M. hyo (+) Aujezsky (-)
  • 16. Vaccination against PCV2 - Why? Farm performance before vaccination No visible reproductive disorders Farrowing Rate >90% ADWG in growers – 0.566 kg ADWG in fatteners – 0.983 kg Stoykov et al. (2011), APVS, Pattaya, Thailand
  • 17. Vaccination against PCV2 - Why? Farm performance before vaccination Increased % ”lightweight” pigs, especially in fattening period Mortality rate - slight increase in fatteners (2%) Single cases of PDNS
  • 18. Vaccination against PCV2 - Why? Farm performance before vaccination Necropsy – stomach ulcers Performance lower than top DanBred farms Positive PCV2 serology SUB CLINICAL PCVD
  • 19. No changes meantime Same genetic Same feed Same vaccination program (except CIRCOVAC) Same biosecurity … but the farm is live organism…
  • 20. CIRCOVAC - Piglet MASS vaccination - PROTOCOL All pigs at age 29-100 days Single injection - 0,5 ml, IM
  • 21. CIRCOVAC - Piglet REGULAR vaccination - PROTOCOL All pigs at weaning (28-29 days) Single injection - 0,5 ml, IM
  • 22. Benefits of CIRCOVAC - piglet vaccination First (visible) observations : Disappeared stomach ulcers  Very well uniform piglets
  • 23. Significant improvement of ADWG Growing Fattening 610 1080 1060 1052* 600 590 1040 590 1020 580 1000 983 570 566 980 960 560 940 550 920 540 900 Before Piglets Before Piglets + 24 g ADWG in growers + 69 g ADWG in fatteners
  • 24. Days from birth to 100 kg - 4 days
  • 25. After good piglet results – sow vaccination – WHY? A lot of confirmations of influence of PCV2 on reproduction
  • 26. After good piglet results – sow vaccination – WHY? • Very good farrowing rate… …but opportunity to reach better results in number of born/weaned piglets
  • 27. CIRCOVAC – Reproduction herd MASS vaccination - PROTOCOL Sows, gilts, boars Start – end of July 2009 Dose – 2 ml, IM, 2 injections, 3 weeks apart One further injection at least 2 weeks before farrowing *in mass vaccination some animals received 1 injection, another - 2 and other -3
  • 28. CIRCOVAC – Sow REGULAR vaccination - PROTOCOL One injection at each gestation at least 2 weeks before farrowing Dose – 2 ml, IM
  • 29. CIRCOVAC – Gilts REGULAR vaccination - PROTOCOL Primary vaccination: Dose – 2 ml, IM, 2 injections, 3 weeks apart, second injection at least 2 weeks before mating Booster: One injection at least 2 weeks before farrowing
  • 30. Benefits of CIRCOVAC - sow vaccination Total born/litter 18 16* 16,7* 15,5* 16 14 13 13,3 12 10 controls piglets 2010S1 2010S2 2011T1 + 3,7 born piglets / litter Control P<0.05 (Dunett test) Sows vaccinated
  • 31. Benefits of CIRCOVAC - sow vaccination Live born/litter 16 14,9* 13,9* 14,2* 14 11,8 12 12 10 controls piglets 2010S1 2010S2 2011T1 + 3,1 live born piglets / litter Control P<0.05 (Dunett test) Sows vaccinated
  • 32. Benefits of CIRCOVAC - sow vaccination Weaned /litter 12,5 12,2* 12 11,2 11,4* 11,5* 11,5 11,1 11 10,5 10 controls piglets 2010S1 2010S2 2011 + 1 weaned piglet / litter Control P<0.05 (Dunett test) Sows vaccinated
  • 33. CIRCOVAC - Sow & piglets – REGULAR vaccination PROTOCOL Sow – one injection at least 2 weeks before each farrowing Gilts – Primary vaccination – 2 injection, 3 weeks apart, booster – 1 injection, 2 weeks before farowing Piglets – one injection at 7 weeks of age
  • 34. IMPORTANT !!! After mass sow vaccination – piglets vaccination was postponed to 7 weeks of age Farrowing Weaning Begin. of Finishing Slaughter Weeks of age 28 days 7 weeks
  • 35. CIRCOVAC – Boar – REGULAR vaccination 6 months apart Transmission of porcine circovirus 2 (PCV2) by semen and viral distribution in different piglet tissues1 Danielle Gava2, Eraldo L. Zanella3, Nelson Morés4 and Janice R. Ciacci-Zanella5*
  • 36. CIRCOVAC - Sow + Piglets The best improvement of ADWG Growing Fattening 607* 610 602* 1080 1060* 1060* 600 1060 1052* 590 590 1040 580 1020 570 566 1000 560 983 980 550 540 960 940 1 09 s re et 01 fo 20 gl /2 Be Pi ts 10 920 le 20 g pi s et s+ igl 900 w so p s+ Before Piglets sows+ piglets sows+piglets w 2009 2010/2011 so + 41 g ADWG in growers + 77 g ADWG in fatteners
  • 37. Days from birth to 100 kg 150,7 - 5,3 days 145,3
  • 38. Summary of vaccination protocol 2009 Feb Mar Apr May June July Aug Sept Oct Nov Dec 2010 Jan Feb Mar Apr May June July Aug Sept Oct Nov Dec 2011 Jan Feb Mar Apr May June July Aug Sept Oct Nov Dec 2012 Jan Feb Mar Apr May Piglets Sow + Piglets Regular Sow + Piglets
  • 39. CONCLUSION In farm “Brashlen” CIRCOVAC: increases the reproductive performances – number of live born piglets + 3.1 and + 1 weaned pig/litter increases the kg produced by sow
  • 40. CONCLUSION In farm “Brashlen” CIRCOVAC : improves the pig growth from birth to slaughter + 41 g ; + 77 g reduces the duration to 100 kg – 5,3 days helps for homogenous pig batches restore mortality rate prevent from appearance of stomach ulcers
  • 41. CONCLUSION CIRCOVAC helps the farm “Brashlen” to have a good profit at the difficult time with a lots of crisis…and welfare requirements… CIRCOVAC regular sow + piglet vaccination is an investment in that farm with 2700 sows and a lots of piglets…
  • 42. CONCLUSION …but ROI are justified already more than 3 years and prove definitely that the sow + piglet vaccination gives the best performance in farrow- to-finish farm.