1. Pig Production in Asia and Experiences with Circovac ® 3 rd Merial Forum April 13 th to 15 th 2011 Malta Henry Too Merial Asia Pte Ltd

2. Introduction Name: Henry Too Veterinarian, BVSc (University of Melbourne), MVSc (University of Sydney) Joined Merial end 2001 Last held position prior to joining Merial: associate professor in Faculty of Veterinary Medicine in Malaysia Current position: Technical Services (Swine) in Asia Cluster Region

4. Pig Production in Asia Domesticated wild boars

5. Pig Production in Asia Village pigs

7. Sucklers Weaners Growers/Finishers Majority are farrow-to-finish herds, all stages in one farm Gestation Breeding

8. Pigs in commercial piggeries are housed indoors. Farm housing in tropical Asia is usually open-sided. Some trends towards closed housing system.

9. Pigs in commercial piggeries are housed indoors. Farm housing is usually open-sided. Sows are usually kept in individual stalls.

10. Mating is usually by artificial insemination. In most cases, this is due to labour constraints rather than a desire for better reproductive efficiency.

11. Mating is usually by artificial insemination although in some of the smaller farms, natural mating is still the norm. Supervised mating in East Malaysia

12. Quality of farrowing house facilities and management is highly variable.

13. Quality of farrowing house facilities and management is highly variable.

14. Quality of farrowing house facilities and management is highly variable.

15. Closed housing system is common in Korea. Nursery house in Korea.

16. Closed housing system is common in Korea. Nursery house in Korea.

17. Swine demographics in Asia cluster region: sow population (in 000) 1% 1,134 1,052 1,101 1,104 CWD -5% 988 988 1,330 1,148 THL -2% 608 615 621 650 TWN 2% 658 642 626 615 PHL -4% 875 816 913 1,004 KOR COMMERCIAL POPULATION -3% 8,518 7,920 9,073 9,204 CWD -5% 988 988 1,330 1,148 THL -2% 676 684 690 722 TWN 2% 2,454 2,393 2,333 2,291 PHL -4% 875 896 913 1,004 KOR TOTAL POPULATION CAGR ’ 07-‘10 2010 2009 2008 2007 ENTITY

18. Swine demographics in Asia cluster region: Commercial versus backyard sow population (in 000)

23. Mystery Pig Disease in China in 2006

25. Outbreak of “blue ear disease” in Vietnam

26. Outbreak of “blue ear disease” in Vietnam

27. Outbreak of “blue ear disease” in Vietnam

29. Circovac ® Registration Country Registration Date (Sow claim only) Actual Launch Thailand 14 Sep 2007 Feb-2008 Malaysia 07 Dec 2007 Dec -2007 Philippines 10 Sep 2008 Oct-2008 Vietnam 22 Sep 2007 Nov-2008 South Korea 09 Feb 2009 May-2009 Indonesia 21 Sep 2010 Nov-2010 Cambodia 28 Apr 2010 Taiwan 2 nd Qtr 2012

31. Piglet vaccination trial in Malaysia: Post-weaning mortality Farm A and B = piglet vaccination at 3 weeks of age

32. Piglet vaccination trial in Malaysia: grower mortality Farm A and B = vaccination at 3 weeks of age

36. Piglet vaccination in Thailand Table 1 PCV2 load confirmed in NV and V3w (15-16 week-old). Data are represented as mean log 10 (PCV2 copies/ml) ± SD NV = non vaccinated V3w = vaccinated at 3 weeks PCV2 RT-PCR at 15-16 weeks of age 0.00 ± 0.00 7.34 ± 0.81 Mean ±SD V3w (n=5) NV (n=4) Group

45. Results Viraemia and fecal shedding results - *p<0.05 2/49 12/52 0/60 13/60* 14/60 1/60 NVG 0/60 7/60 0/60 3/60* 7/60 3/60 VG 18w 12w 3w 18w 12w 3w age PCV2 antigen in feces PCV2 antigen in serum