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Music and the brain
1. Tone deafness: a disorder of the mind’s ear Tim Griffiths Auditory Group, Newcastle University Cognitive Neurology Clinic, Newcastle General Hospital http://www.staff.ncl.ac.uk/t.d.griffiths/tdg.html Supported by the Wellcome Trust (UK)
2. My work: Ordered and disordered acoustic worlds The Ear The person 2. NEUROLOGY Disordered sound pattern analysis Speech Music Environmental Sound The mind’s ear 1. NEUROSCIENCE Ordering of sound pattern
3. How do we explain this? Click picture for sound
5. Tone deafness: some basic questions His brain? His DNA? His neurons? His deficit?
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9. Construction of the pitch percept 400Hz sine 400Hz fundamental Harmonic 1 - 6 400Hz fundamental Harmonic 4 - 6 frequency (kHz) time (s) frequency (kHz) frequency (kHz) time (s) time (s) 5 5 5 0.1 0.1 0.1 Common pitch explained better by time structure than frequency structure of stimulus
15. noise - silence fixed pitch – matched noise ‘ lively’ pitch – fixed pitch NB NO TASK Individual fMRI data: Pitch sequence Griffiths et al Nature Neurosci 1998, 2001 Patterson et al Neuron 2002
16. PET group data: Pitch sequence NB TASK Griffiths et al Neuroreport 1999
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18. Pitch: studies of stroke patients Summary data Stewart et al Brain 2006
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20. Tone deafness: what is the pitch deficit? Pitch change and pitch direction analysis Foxton et al Brain 2004 Pitch Change 1 Pitch Change 2 Pitch DIRECTION
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22. Tone deafness: Brain structure 1 White matter density: Montreal and Newcastle structural MRI data Hyde, Zatorre, Griffiths, Lerch and Peretz Brain 2006
23. Tone deafness: Brain structure 2 Cortical thickness: Montreal and Newcastle structural MRI data Hyde, Lerch, Zatorre, Griffiths, Evans, Peretz (Human Brain Mapping Meeting 2006)
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25. Tone deafness: genes? Family undergoing genetic analysis in Newcastle Stewart , McDonald, Kumar, Chinnery, Griffiths (Music and Genetics Meeting Bologna 2007 ) Proband Family