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- 1. Jorge L. Posada, MD University of Puerto Rico School of Medicine Assistant Professor of Internal Medicine Nephrology Fellow 4/17/08
- 23. Calcineurin Inhibitors: Mechanism of Action CsA: Cyclosporine FK506: Tacrolimus FKBP: FK Binding Protein CpN: Cyclophilin NF-AT: Nuclear Factor of Activated T-cells (c- cytosolic component; n- nuclear component). Stepkowski, Expert Rev Mol Med , 2000;2(4):1
- 30. Calcineurin Inhibitors: Adverse Effects Adapted from Danovitch, Handbook of Kidney Transplantation , Lippincott Williams & Wilkins, 2005 Cyclosporine Tacrolimus Hypertension ++ + Pancreatic islet toxicity + ++ Neurotoxicity + ++ Hirsutism + - Hair loss - + Gum hypertrophy + - GI side effects - + Gastric motility - + Dyslipidemia + - Hyperuricemia ++ + ↑ K + /↓Mg 2+ + +
- 32. Sirolimus: Mechanism of Action SRL: Sirolimus FKBP: FK Binding Protein mTOR: Mammalian target of rapamycin Cdk: cyclin-dependent kinase Stepkowski, Expert Rev Mol Med , 2000;2(4):1