1. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Lucine Health Sciences
Real World Data for Real Life
Decisions

2. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Data Matter
One cannot practice
medicine, make personal
healthcare or business
decisions without accurate
data.

3. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
50%
OF MEDICAL
INTERVENTIONS
UNPROVEN
ONLY 35% KNOWN TO BE BENEFICIAL
Source: Greenhalgh, Trisha. How to read a paper: The basics of evidence-based medicine. John Wiley & Sons, 2014.2

4. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
70% OF OB/GYN CLINCAL
PRACTICE GUIDELINES
NOT BASED ON EVIDENCE
Source: Obstetrics & Gynecology: September 2011 - Volume 118 - Issue 3 - p 505–512

5. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Lucine Health Sciences
Health data for the real world
LucineHealthSciences.com

6. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Fundamental Assumptions
• The way we investigate medication risks is flawed
• Not gender specific: clinical testing before 1998 did not
include women; drug development before 2014 only
included male animals
• Too narrow in assessment of what constitutes side effects
• Too static: only experts can recognize/report a side effect
• Too broad in the analysis of population based risks, when
what we need are methods to assess each patient’s
individual risks

7. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Resulting in
• Underestimate of real risk for any given
individual, but especially, for women
• Inability to assess medication, health, and
lifestyle interactions
• A lack of recognition of important side effects
by all involved
• Lives lost to predictable side effects, had
anyone looked.

8. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
We Need
• A more open conversation about side effects
and risks
• A more comprehensive approach to
understanding drug effects
• A better, more personal math to describe the
risks
I need to know that given my health
characteristics and my lifestyle what my risks
are

9. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Risks have numbers (weights)
• Identify the side effects and the patterns
• Patient characteristics
• Symptom expression
• Event occurrence
• Predictors of impending event
• Find the math
• Set the algorithms
• Understand individual risk
• Given XXY characteristics, what is my risk for blood clot?

10. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Research Philosophy
• Listen to patients
• Self-reported case histories have tremendous value
• Discovery comes from unfiltered interaction
• Patients, researchers, and medical professionals
• No silver bullets just tipping points
• Health and disease are complex, dynamic algorithms
• Nothing happens in a vacuum
• Everything is connected

11. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Dialogue
Knowledge
Insight
The Process
• Open the
dialogue on
side effects
• Build the
knowledgebase
• Inspire more
research
Save
lives

12. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Hormonesmatter.com

13. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Hormones Matter
• ~1000 articles published to
date
• 3-4 articles per week
• Patient histories and research
analysis
• 70,000-100,000 views per
month
• 150 guest contributors/writers
• 18 PhDs, 5 MDs, 2 DPTs

14. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Patient
stories
Research
More stories
and research
Patient stories
present research
questions and
patterns
Leads to mechanism
research, then to
online survey
research
Online studies inspire
more stories,
publications, and
collaborations
Integrated

15. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Insight Accrued
•Medication reactions
• Attack the thyroid (Hashimoto’s)
• Systemic, not limited to intended target
• Derail mitochondrial function
• Induce/exacerbate nutrient deficiencies (which
further derail mitochondrial functioning)
• Thiamine, Magnesium, CoQ10, Vitamin D, B12,
others
• Rare mutations are not so rare (just unmeasured)

16. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Current Project
• Birth Control and Blood Clot Study
• Privately funded, multiphase project
to develop risk calculator
• Phase 1 completed; 3 reports
published online, more coming
Major finding: among women who develop
birth control induced blood clots, in
younger, more active women the clots are
more likely to be fatal than in older less
active women
• Phase 2 data collection in progress

17. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
In Review
• Lupron Side Effect Study
• ~1000 respondents
• 1st report published online; additional reports
forthcoming
Major finding: moderate to severe global side effects
affecting 15-90% women depending on symptom,
with only non-clinically significant, temporary
reduction of the symptoms for which it is prescribed.
Some side effects appear to be chronic.

18. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Ongoing Projects
• Gardasil Study
• 1900 respondents, open
• Fluoroquinolone Study
• 1600 respondents, open
• Hysterectomy Outcomes
• 1500 respondents, open
• Oral Contraceptive Use
• 900, closed, analyzed, unpublished

19. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Chandler Marrs, PhD
• Specialties
• Big messy data sets and complex systems
• Medication adverse events
• Mechanisms of action and pathway mapping
• Medication induced mitochondrial
dysfunction (and repair)
• Hormones
• Neuroendocrinology, neuropsychiatry

20. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Chandler Marrs, PhD
• Writing
• Hundreds of articles on diverse topics
• Medical Textbook Chapter
• Micronutrient Deficiencies and Mitochondrial
Dysfunction. In Integrative Therapies for Depression.
J Greenblatt and K Brogan, Eds. Taylor and Francis
Group, LLC. FL. (2015)
• Medical Textbook Co-Author
• Thiamine Deficiency Disease, Dysautonomia and
High Calorie Malnutrition. Elsevier. (Spring 2017)

21. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
How may I help with
your projects?

22. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Thank you.