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1 7 O c t . 2 0 1 7
Review of photon interaction
cross section data in the
medical and biological context
Jimin Lee
Radiological Physics Laboratory,
Seoul National University
Contents
2
1. Introduction
2. History
3. The individual photon interaction processes
4. The mass energy-absorption coefficient
5. Current status and future tasks, particularly for medical and biological applications
1. Introduction
1. Introduction
4
• The discovery of x-rays by R ሷ𝑜ntgen (1895)
• The transmission of a narrow (parallel) beam of x-rays was measured and quantified.
- Barkla (1907), Sadler (1909)
• Mass attenuation coefficient
 𝑡 : Mass thickness (𝑔 𝑐𝑚−2
)
 𝐼0 : Intensity of the incident beam
 𝐼(𝑡) : Intensity of the transmitted beam
1. Introduction
5
• The discovery of x-rays by R ሷ𝑜ntgen (1895)
• The transmission of a narrow (parallel) beam of x-rays was measured and quantified.
- Barkla (1907), Sadler (1909)
• Mass attenuation coefficient
(for homogeneous medium)
1. Introduction
6
• Mass attenuation coefficient
 𝜎𝑡𝑜𝑡 : Total atomic cross section
 𝑢 𝑔 : Atomic mass unit
 1.6605402 × 10−24
𝑔
 𝑢 𝑔 = 1/𝑁𝐴 (𝑁𝐴 : Avogadro’s number, 6.0221367 × 1023
𝑎𝑡𝑜𝑚𝑠/𝑚𝑜𝑙 )
 1/12 of the mass of an atom of the nuclide 12 𝐶
 A : Relative atomic mass of the target element
 1 𝑏𝑎𝑟𝑛 = 10−24
𝑐𝑚2
1. Introduction
7
• Mass attenuation coefficient
1. Introduction
8
• Mass attenuation coefficient
• Nuclear photoeffect (= Photonuclear reaction) is not readily amenable to systematic
calculation and tabulation.
• Hence, 𝜎 𝑝ℎ.𝑛. has been omitted from 𝜇/𝜌 compilations up to the present.
2. History
2. History
10
• Allen (1935) : The first major compilation of 𝜇/𝜌 data
 30 eV – 2.5 MeV, 32 elements (Z = 1 – 92)
 No theory & Only the widely scattered measurements were found in the literature.
 There were wide gaps, requiring extensive interpolation and extrapolation across Z and
photon energy.
• Victoreen (1949) : Semiempirical 𝜇/𝜌 compilation
 Klein-Nishina formula for total Compton scattering
• Davisson and Evans (1952)
 102.2 keV – 6.13 MeV (up to 25.54 MeV for Z = 13 , 82), 24 elements (Z = 1 - 83)
 They obtained pair production cross sections by graphical integration over the Bethe–
Heitler (1934) Born approximation expression.
2. History
11
︙
• Chantler(1995) : Extensive new calculations and theoretical tabulations of scattering cross
sections and quantities related to 𝜇/𝜌
 a few eV up to 1 MeV, Z = 1–92
• However, it is not yet clear how to incorporate this new source of data into 𝜇/𝜌 tables for
medical, biological and other practical applications.
3. The individual
photon interaction
process
• The atomic photoeffect cross section
• Incoherent and Coherent scattering
• Pair and Triplet production
3. The individual photon interaction process | The atomic photoeffect cross section
13
• A photon disappears and an electron is ejected from an atom.
• Absorption-edge fine structure
K edge
Ti (Z= 22)
𝐸 𝐾−𝑒𝑑𝑔𝑒 = 4.79 𝑘𝑒𝑉
3. The individual photon interaction process | Incoherent and Coherent scattering
14
• Incoherent (Compton) scattering cross section
 Berger-Hubbell (1987) XCOM PC program
 Hubbell-Seltzer (1995) tabulation
 Cullen et al (1997) LLNL data base
https://www.nist.gov/pml/xcom-photon-cross-sections-database
• Database Search Form
3. The individual photon interaction process | Incoherent and Coherent scattering
15
• Coherent (Rayleigh) scattering
 Photons are scattered by bound electrons.
 The atom is neither ionized nor excited.
• Currently, 𝜎𝑐𝑜ℎ are focused on use of the second-order relativistic S-matrix formalism.
(Kissel 1995)
3. The individual photon interaction process | Pair and Triplet production
16
• Electron-positron pair production
 A photon disappears in the field of a charged particle.
 An electron-positron pair appears.
• Biological materials except for bone are primarily low Z. → 𝜎𝑡𝑟𝑖𝑝 can be a minor but
significant contribution for high-energy photon applications (above 10 MeV).
• Hubbell et al (1980) : Tabulations of 𝜎 𝑝𝑎𝑖𝑟, 𝜎𝑡𝑟𝑖𝑝 (Z = 1–100 & 1 MeV - 100 GeV)
 Still used in current 𝜇/𝜌 compilations. (i.e. XCOM)
4. The mass energy-
absorption coefficient
• The mass absorption coefficient
• The mass energy-transfer coefficient
• The mass energy-absorption coefficient
4. The mass energy-absorption coefficient
18
• Mass absorption coefficient 𝝁 𝒂/𝝆
 Only scattered photons (both coherent and
incoherent) leave the volume of interest.
• Mass energy-transfer coefficient 𝝁 𝒕𝒓/𝝆
 All secondary photons (fluorescence and
scattered photons) are lost to the volume of
interest.
Photoelectric effect
Pair productionAbsorption
Scattering
4. The mass energy-absorption coefficient
19
• Mass energy-absorption coefficient 𝝁 𝒆𝒏/𝝆
 Computing the energy deposition (ionization,
excitation, heat, etc) at a site (a ‘volume of
interest’)
Photoelectric effect
Pair productionAbsorption
Scattering
5. Current status
and future tasks
5. Current status and future tasks
21
• Uncertainty of cross section data
5. Current status and future tasks
22
• Theoretical calculations
 Atomic photoeffect absorption edge structure
 Accurate scattering results from the relativistic S-matrix theoretical model
 photonuclear data 𝜎 𝑝ℎ.𝑛.
• Experimental capabilities
 More intense and higher-energy synchrotron light sources
 New detectors with better resolution and higher efficiencies
 To provide more accurate measured values of 𝜇/𝜌
 To test and undergird the above theoretical advances
(Extra) Triplet production
23
http://slideplayer.com/slide/5246079/16/images/15/Pair+Production+in+the+Electric+Field+(Triplet+Production).jpg
𝑚 𝑒 𝑐2 + ℎ𝜈 = 𝑚 𝛽+ 𝑐2 + 𝑚 𝛽− 𝑐2 + 𝐸
𝑚 0 𝑐2
+ ℎ𝜈 = 3𝑚𝑐2
ℎ𝜈
𝑐
= 3𝑚𝜐 = 3𝑚𝛽𝑐 (𝛽 =
4
5
)
𝑚 =
𝑚0
1 − 𝛽2
=
5
3
𝑚0
ℎ𝜈 = 3𝑚𝛽𝑐2
= 3 ×
5
3
𝑚0 ×
4
5
𝑐2
= 4𝑚0 𝑐2
Thank you 

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[Paper Review] Review of photon interaction cross section data in the medical and biological context

  • 1. 1 7 O c t . 2 0 1 7 Review of photon interaction cross section data in the medical and biological context Jimin Lee Radiological Physics Laboratory, Seoul National University
  • 2. Contents 2 1. Introduction 2. History 3. The individual photon interaction processes 4. The mass energy-absorption coefficient 5. Current status and future tasks, particularly for medical and biological applications
  • 4. 1. Introduction 4 • The discovery of x-rays by R ሷ𝑜ntgen (1895) • The transmission of a narrow (parallel) beam of x-rays was measured and quantified. - Barkla (1907), Sadler (1909) • Mass attenuation coefficient  𝑡 : Mass thickness (𝑔 𝑐𝑚−2 )  𝐼0 : Intensity of the incident beam  𝐼(𝑡) : Intensity of the transmitted beam
  • 5. 1. Introduction 5 • The discovery of x-rays by R ሷ𝑜ntgen (1895) • The transmission of a narrow (parallel) beam of x-rays was measured and quantified. - Barkla (1907), Sadler (1909) • Mass attenuation coefficient (for homogeneous medium)
  • 6. 1. Introduction 6 • Mass attenuation coefficient  𝜎𝑡𝑜𝑡 : Total atomic cross section  𝑢 𝑔 : Atomic mass unit  1.6605402 × 10−24 𝑔  𝑢 𝑔 = 1/𝑁𝐴 (𝑁𝐴 : Avogadro’s number, 6.0221367 × 1023 𝑎𝑡𝑜𝑚𝑠/𝑚𝑜𝑙 )  1/12 of the mass of an atom of the nuclide 12 𝐶  A : Relative atomic mass of the target element  1 𝑏𝑎𝑟𝑛 = 10−24 𝑐𝑚2
  • 7. 1. Introduction 7 • Mass attenuation coefficient
  • 8. 1. Introduction 8 • Mass attenuation coefficient • Nuclear photoeffect (= Photonuclear reaction) is not readily amenable to systematic calculation and tabulation. • Hence, 𝜎 𝑝ℎ.𝑛. has been omitted from 𝜇/𝜌 compilations up to the present.
  • 10. 2. History 10 • Allen (1935) : The first major compilation of 𝜇/𝜌 data  30 eV – 2.5 MeV, 32 elements (Z = 1 – 92)  No theory & Only the widely scattered measurements were found in the literature.  There were wide gaps, requiring extensive interpolation and extrapolation across Z and photon energy. • Victoreen (1949) : Semiempirical 𝜇/𝜌 compilation  Klein-Nishina formula for total Compton scattering • Davisson and Evans (1952)  102.2 keV – 6.13 MeV (up to 25.54 MeV for Z = 13 , 82), 24 elements (Z = 1 - 83)  They obtained pair production cross sections by graphical integration over the Bethe– Heitler (1934) Born approximation expression.
  • 11. 2. History 11 ︙ • Chantler(1995) : Extensive new calculations and theoretical tabulations of scattering cross sections and quantities related to 𝜇/𝜌  a few eV up to 1 MeV, Z = 1–92 • However, it is not yet clear how to incorporate this new source of data into 𝜇/𝜌 tables for medical, biological and other practical applications.
  • 12. 3. The individual photon interaction process • The atomic photoeffect cross section • Incoherent and Coherent scattering • Pair and Triplet production
  • 13. 3. The individual photon interaction process | The atomic photoeffect cross section 13 • A photon disappears and an electron is ejected from an atom. • Absorption-edge fine structure K edge Ti (Z= 22) 𝐸 𝐾−𝑒𝑑𝑔𝑒 = 4.79 𝑘𝑒𝑉
  • 14. 3. The individual photon interaction process | Incoherent and Coherent scattering 14 • Incoherent (Compton) scattering cross section  Berger-Hubbell (1987) XCOM PC program  Hubbell-Seltzer (1995) tabulation  Cullen et al (1997) LLNL data base https://www.nist.gov/pml/xcom-photon-cross-sections-database • Database Search Form
  • 15. 3. The individual photon interaction process | Incoherent and Coherent scattering 15 • Coherent (Rayleigh) scattering  Photons are scattered by bound electrons.  The atom is neither ionized nor excited. • Currently, 𝜎𝑐𝑜ℎ are focused on use of the second-order relativistic S-matrix formalism. (Kissel 1995)
  • 16. 3. The individual photon interaction process | Pair and Triplet production 16 • Electron-positron pair production  A photon disappears in the field of a charged particle.  An electron-positron pair appears. • Biological materials except for bone are primarily low Z. → 𝜎𝑡𝑟𝑖𝑝 can be a minor but significant contribution for high-energy photon applications (above 10 MeV). • Hubbell et al (1980) : Tabulations of 𝜎 𝑝𝑎𝑖𝑟, 𝜎𝑡𝑟𝑖𝑝 (Z = 1–100 & 1 MeV - 100 GeV)  Still used in current 𝜇/𝜌 compilations. (i.e. XCOM)
  • 17. 4. The mass energy- absorption coefficient • The mass absorption coefficient • The mass energy-transfer coefficient • The mass energy-absorption coefficient
  • 18. 4. The mass energy-absorption coefficient 18 • Mass absorption coefficient 𝝁 𝒂/𝝆  Only scattered photons (both coherent and incoherent) leave the volume of interest. • Mass energy-transfer coefficient 𝝁 𝒕𝒓/𝝆  All secondary photons (fluorescence and scattered photons) are lost to the volume of interest. Photoelectric effect Pair productionAbsorption Scattering
  • 19. 4. The mass energy-absorption coefficient 19 • Mass energy-absorption coefficient 𝝁 𝒆𝒏/𝝆  Computing the energy deposition (ionization, excitation, heat, etc) at a site (a ‘volume of interest’) Photoelectric effect Pair productionAbsorption Scattering
  • 20. 5. Current status and future tasks
  • 21. 5. Current status and future tasks 21 • Uncertainty of cross section data
  • 22. 5. Current status and future tasks 22 • Theoretical calculations  Atomic photoeffect absorption edge structure  Accurate scattering results from the relativistic S-matrix theoretical model  photonuclear data 𝜎 𝑝ℎ.𝑛. • Experimental capabilities  More intense and higher-energy synchrotron light sources  New detectors with better resolution and higher efficiencies  To provide more accurate measured values of 𝜇/𝜌  To test and undergird the above theoretical advances
  • 23. (Extra) Triplet production 23 http://slideplayer.com/slide/5246079/16/images/15/Pair+Production+in+the+Electric+Field+(Triplet+Production).jpg 𝑚 𝑒 𝑐2 + ℎ𝜈 = 𝑚 𝛽+ 𝑐2 + 𝑚 𝛽− 𝑐2 + 𝐸 𝑚 0 𝑐2 + ℎ𝜈 = 3𝑚𝑐2 ℎ𝜈 𝑐 = 3𝑚𝜐 = 3𝑚𝛽𝑐 (𝛽 = 4 5 ) 𝑚 = 𝑚0 1 − 𝛽2 = 5 3 𝑚0 ℎ𝜈 = 3𝑚𝛽𝑐2 = 3 × 5 3 𝑚0 × 4 5 𝑐2 = 4𝑚0 𝑐2