Chronic Venous Insufficiency (CVI) is a common progressive disorder affecting the legs that is caused by chronic venous hypertension. It is estimated to affect 5-15% of the adult population. CVI has major health and economic impacts, consuming 1-2% of European healthcare budgets and costing over 1 billion Euros annually in some countries. The hallmark of CVI is distal venous hypertension leading to valvular incompetence, reflux, and venous obstruction over time.