Multiplexity occurs in entrepreneurial networks when flows interact within and across relationships. It defines how these networks function and evolve and cannot be examined by studying network structure or flows separately. Despite the growing recognition of the importance of multiplexity, related research has remained limited and lacks an integrated approach to simultaneously examine structure and flows, thus restricting our understanding of entrepreneurial networks. We propose an integrated approach for conducting inductive studies into multiplexity, involving an adaptation of the “business networks” conceptual model, the configuration theory perspective, and the Q-analysis method.