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Distraction osteogenesis
Presenter : Dr.G V Shetty
• CONTENTS
 INTRODUCTION
 HISTORY OF D O
 BIOLOGICAL FOUNDATION .
 DISTRACTION DEVICE
CLASSIFICATION
 INDICATIONS AND CONTRAINDICATIONS
 ADVANTAGES AND DISADVANTAGES
 ORTHODONTIC CONSIDERATIONS
 FUTURE OF DISTRACTION OSTEOGENESIS
 CASES OF DO
 CONCLUSION
 REFERENCES
INTRODUCTION
 Facial asymmetry, mandibular hypoplasia, and congenital
malformation of jaws are common abnormalities of the craniofacial
complex.
 Traditionally, skeletal deformities have been corrected via functional
orthopedics in growing patients or orthognathic surgery with
skeleton fixation in non-growing patients
 Many congenial deformities require large amount of skeletal
movements which is perhaps not possible with orthognathic
surgery may lead to compromise in function and esthetics.
INTRODUCTION
DISTRACTION OSTEOGENESIS (Transosseous synthesis)
(Osteodistraction)
• DEFINITION: Is a biological process of new bone
formation between the vascularised margins of
bone segments when they are gradually seperated
by incremental traction - COPE (1999)
History
Earlier attempts at D.O. of long bones by Alessandro Codivilla
(1905)
History
First mandibular osteodistaction by Wassmund&Rosenthal
(1927) (intraoral tooth borne appliance)
G.A. Ilizarov (1950’s)
– Lengthening limbs through gradual distraction of
fracture callus
– Rhythm and rate of distraction
– Minimal complications
• In 1948 ,crawford followed gradual
incremental traction to the callus of mandible
• In 1957 traucher and obwegesser introduced
the concept of sagittal split osteotomy .
• HISTORICAL PERSPECTIVE
 Mc’Carthy– (1989) conducted the first reported human
trial of craniofacial distraction using external fixators.
 4 children with craniofacial anomalies were
subjected to a distraction protocol of upto three weeks
followed by a 8-10 week consolidation.
 Long-term studies of the same patients indicate a
successful result.
McCarthy (1992)
• – DO to lengthen congenitally hypoplastic
mandible
Rachmiel et al (1993) and Blocks et al (1995)
– Maxillary distraction
• Polley et al (1995)
– Midface distraction with externally fixed cranial halo frame
Chin and Toth (1996)
• Mandibular alveolar distraction osteogenesis to increase the
height of the alveolus
Chin M, Toth BA. Distraction osteogenesis in maxillofacial surgery using internal devices:
review of five cases. J Oral Maxillofac Surg. 1996 Jan;54(1):45-53.
DISTRACTION OSTEOGENESIS
A BIRD EYE-VIEW THE ORIGINS AND EVOLUTION OF
DO IN THE CRANIOFACIAL REGION
 Progression from extra-oral to intraoral devices
 Progression from manual devices to motorized
devices
 Progression from the removable fixators to
biodegradable fixators
• PHASES OF DISTRACTION OSTEOGENESIS
• Steps involved :
a) Corticotomy/Osteotomy
b) Latency period
c) Distraction phase
d) Consolidation phase
e) Remodelling
• Osteotomy Phase
Divides the bone into two segments
Triggers process of bone repair
• – Angiogenesis
• – Fibrogenesis
• – Osteogenesis
Latency Phase
• Period from bone division to onset of distraction
• Inflammation and soft callus formation of the
fractured bone
• Soft callus formation begins 3-7 days and lasts 2-3
weeks
• Latency period = 5-7 days
Distraction Phase
• Characterized by the application of traction forces to
osteotomized segments
• Rate : 1 mm/day
• Rhythm : 0.25 mm every 6 hours
0.5 mm twice a day
• Duration : 1-3 weeks
Consolidation Phase
Cessation of traction forces to removal of distractor
• Newly formed bone mineralizes and increases in
bone density
and strength
Duration: 3- 4 months
Remodeling Phase
• Removal of distractor to application of
functional loading
• Formation of lamellar bone
HISTOLOGY OF DISTRACTION OSETOGENESIS
LATENCY PERIOD DISTRACTION PHASE
Latency
Histological sequence in latency period in distraction
osteogenesis is similar to that of fracture bone healing
and in this phase soft callus formation takes place. Initial
latency period is recommended is between 5 to 10 days.
Distraction
In this phase normal process of fracture healing interrupted by the
application of gradual traction to the soft callus.
As a result of the tension created by this traction force a dynamic
microenvironment created which encourages new tissue formation in the
direction parallel to the vector
of traction.
During distraction, four zones[4] appear: a fibrous, less vascular center with
collagen fibers parallel to the distraction vector, a transition zone of early
bone formation, a bone remodeling zone, and mature bone at
the ends. Distraction process is generally carried out at
the rate of 0.5 to 1 mm per day.
CONSOLIDATION REMODELLING
Consolidation and remodeling
Bone maturation occurs and continues over a period of
a year or more before the structure of the newly formed
bony tissue is comparable to that of preexisting bone
and in which soft tissue adaptation also occurs. After
distraction ceases, this soft callus ossifies and a distinct
zone of woven bone completely bridge the gap mainly
by intramembranous ossification.
• Indications of Maxillo Mandibular Distraction
Osteogenesis
1. Severe mandibular retrognathia/micrognathia
2. Craniofacial syndromes: hemifacial microsomia, Treacher Collins syndrome,
Nager syndrome, Pierre Robin sequence
3. Severe mandibular asymmetry
4. Post-traumatic deficient mandibular growth and temporomandibular joint
ankylosis
5. Revision mandibular orthognathic surgery
6. Mandibular retrognathia with temporomandibular joint disease or juvenile
rheumatoid arthritis
7. Mandibular retrognathia with obstructive sleep apnea
8. Mandibular defects from tumor resection
9.Midfacial hypoplasia .
10.Expansion of mandibular symphysis
Indications of D O
Single calibrated rod with two clamps
• Each clamp holds two 2-mm half-pins
• 20-24mm of bone posterior to last tooth bud
• Limitations:
– Difficulty in predicting direction
– Inability to change direction
– Scarring
External Unidirectional Distractors
External Bidirectional Distractors
Molina and Ortiz Monasterio
• Two geared arms 5 cm in length
• Middle screw - change angulation
• Double osteotomy (horizontal in ramus and vertical in corpus)
• Two 2-mm pins in each segment of bone
Advantages:
– Additional degree of freedom
– Deficiencies in more than one plane
– Two osteotomies - flexible distraction
– Easy and optimal device placement
Potential problems
– Risk for avascular necrosis of intervening segment
– Damage to tooth buds during pin placement
External Multiplanar Distractors
• Two distraction rods with sliding clamps
connected
in by multiplanar hinge in the middle
• Two arms extend with pin clamps at either end
• Each quarter turn results in 0.25 mm of expansion
• Advantages of Distraction Osteogensis
1. Allows greater mandibular lengthening of 10–30 mm
2. Can be applied to unusual bony and soft tissue anatomy
3. Allows slow gradual soft tissue adaptation to extreme mandibular
lengthening
4. Minimal to no skeletal relapse after extreme mandibular lengthening
5. Can be applied to neonates, infants, and pediatric patients with obstructive
sleep apnea
6. Less invasive surgery compared with bone-grafting procedures
7. Avoids intermaxillary fixation
8. Avoids bone grafting and potential donor-site morbidity
9. Can be used for mandibular widening
10. Fewer adverse temporomandibular joint effects in response to
asymmetric lengthening
11. Decreased hospitalization time and cost compared with bone grafting
12. Less need for blood transfusion
• Drawbacks of Distraction Osteogenesis
1. Skin scars
2. Technique sensitive surgery, equipment sensitive surgery
3. Possible need for second surgery to remove distraction device and patient
compliance
4. Transient changes in temporomandibular joint
5. An adequate bone stock is necessary to accept the distraction appliances
and to provide suitable
6. opposing surface capable of generating a healing callus
7. Damage to tooth germ
8. Premature consolidation
9. Damage to inferior alveolar nerve
10. Bilateral Coronoid Ankylosis
11. Tendency towards clockwise rotation
Classifications of distraction osteogenesis
techniques
Orthodontics considerations
DIAGNOSIS
• Extraoral Examination
– Forehead, orbit, zygoma, external ear
– Oral commissure, chin, mandibular angles
• Intraoral Examination
– Occlusion
– Occlusal plane
• Function
– Maximum interincisal opening
– Mandibular deviation or deflection
– TMJ evaluation
– Sensory nerve function
Diagnostic Records
– Standard extraoral and intraoral photographs
– Dental models articulated on a semi-adjustable
articulator
– Lateral and PA cephalograms
– OPG
– CBCT
– CT Scan
– Stereolithographic models
Factors affecting DO
ORTHODONTIC TREATMENT PROTOCOL
• PRE DISTRACTION ORTHODONTICS
• ORTHODONTICS DURING DISTRACTION AND
CONSOLIDATION PHASE
• POST DISTRACTION PHASE
• RETENTION.
• The Orthodontist’s role
a. Decompensation of the dentition
b. Planning the distraction vector
c. Bone Moulding using intermaxillary elastics
d. Post-distraction Orthodontics
DISTRACTION OSTEOGENESIS
PLANNING THE DISTRACTION VECTOR
VERTICAL HORIZONTAL OBLIQUE
Biomechanical Considerations
• Factors related to distractor device
• Factors related to bone and surrounding
tissues
• Factors related to device orientation
Properties of Distractor
• Mechanical integrity of device
• Number, length and diameter of fixation pins
• Material properties
Transverse plane (Model I)
– Distractors oriented parallel to the lateral surface of
mandible
Transverse plane (Model II)
– Distractors oriented parallel to each other and to
midsagittal axis
Transverse plane (Model III & IV)
– Distractors placed parallel to lateral surface of
mandible (III), parallel to each other (IV)
• • Sagittal plane (Model V)
• Sagittal plane (Model VI)
Use of Intermaxillary Elastics
• Modification of distraction vectors
• Intermaxillary elastics can have skeletal effects
during distraction
– Secondary to molding of the regenerate
• “Fine tuning” of the occlusal outcome
• Elastics may be worn in Class II, III, vertical, or
transverse pattern
• Helpful in the retention of results
MANIBULAR
DISTRACTION
OSTEOGENESIS
MAXILLARY
DISTRACTION
For V shape mandible
• Severe mandibular crowding
• Brodie’s syndrome
• To avoid inderdental stripping or
extractions
Symphyseal Distraction
Symphyseal Distraction
DENTAL DISTRACTION
DISTRACTION OSTEOGENESIS
CURRENT SCOPE OF DO
 Correction of Maxillo-Mandibular deformities
a) Maxillary lengthening
b) Mandibular lengthening
c) Maxillary and Mandibular widening
d) Lengthening of the Hard palate
e) Distraction in other cranio-facial areas.
DISTRACTION OSTEOGENESIS
CURRENT SCOPE OF DO
 Alveolar ridge augmentation
 Transport disc and Transformation
osteogenesis.
 Dental Distraction.
DISTRACTION OSTEOGENESIS
Directions for the future
a. Refinements in the distraction protocol
b. Improvement in distraction devices
c. Enhancement of regenerate maturation
Conclusion
• Distraction osteogenesis has revolutionised the management
of maxillomandibular deformities .
• Patients with severe deformities can be better managed by
distraction osteogenesis at much lower risk and complications
than with orthognathic surgery
• Distraction osteogenesis has indeed redefined the envelope
of discrepancy .

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Distraction osteogenesis in orthodontics -Dr.G V SHETTY

  • 2. • CONTENTS  INTRODUCTION  HISTORY OF D O  BIOLOGICAL FOUNDATION .  DISTRACTION DEVICE CLASSIFICATION  INDICATIONS AND CONTRAINDICATIONS  ADVANTAGES AND DISADVANTAGES  ORTHODONTIC CONSIDERATIONS  FUTURE OF DISTRACTION OSTEOGENESIS  CASES OF DO  CONCLUSION  REFERENCES
  • 3. INTRODUCTION  Facial asymmetry, mandibular hypoplasia, and congenital malformation of jaws are common abnormalities of the craniofacial complex.
  • 4.  Traditionally, skeletal deformities have been corrected via functional orthopedics in growing patients or orthognathic surgery with skeleton fixation in non-growing patients
  • 5.  Many congenial deformities require large amount of skeletal movements which is perhaps not possible with orthognathic surgery may lead to compromise in function and esthetics.
  • 6. INTRODUCTION DISTRACTION OSTEOGENESIS (Transosseous synthesis) (Osteodistraction) • DEFINITION: Is a biological process of new bone formation between the vascularised margins of bone segments when they are gradually seperated by incremental traction - COPE (1999)
  • 7.
  • 8. History Earlier attempts at D.O. of long bones by Alessandro Codivilla (1905)
  • 9. History First mandibular osteodistaction by Wassmund&Rosenthal (1927) (intraoral tooth borne appliance)
  • 10. G.A. Ilizarov (1950’s) – Lengthening limbs through gradual distraction of fracture callus – Rhythm and rate of distraction – Minimal complications
  • 11. • In 1948 ,crawford followed gradual incremental traction to the callus of mandible • In 1957 traucher and obwegesser introduced the concept of sagittal split osteotomy .
  • 12. • HISTORICAL PERSPECTIVE  Mc’Carthy– (1989) conducted the first reported human trial of craniofacial distraction using external fixators.  4 children with craniofacial anomalies were subjected to a distraction protocol of upto three weeks followed by a 8-10 week consolidation.  Long-term studies of the same patients indicate a successful result.
  • 13. McCarthy (1992) • – DO to lengthen congenitally hypoplastic mandible
  • 14. Rachmiel et al (1993) and Blocks et al (1995) – Maxillary distraction • Polley et al (1995) – Midface distraction with externally fixed cranial halo frame
  • 15. Chin and Toth (1996) • Mandibular alveolar distraction osteogenesis to increase the height of the alveolus Chin M, Toth BA. Distraction osteogenesis in maxillofacial surgery using internal devices: review of five cases. J Oral Maxillofac Surg. 1996 Jan;54(1):45-53.
  • 16. DISTRACTION OSTEOGENESIS A BIRD EYE-VIEW THE ORIGINS AND EVOLUTION OF DO IN THE CRANIOFACIAL REGION  Progression from extra-oral to intraoral devices  Progression from manual devices to motorized devices  Progression from the removable fixators to biodegradable fixators
  • 17. • PHASES OF DISTRACTION OSTEOGENESIS • Steps involved : a) Corticotomy/Osteotomy b) Latency period c) Distraction phase d) Consolidation phase e) Remodelling
  • 18.
  • 19. • Osteotomy Phase Divides the bone into two segments Triggers process of bone repair • – Angiogenesis • – Fibrogenesis • – Osteogenesis
  • 20. Latency Phase • Period from bone division to onset of distraction • Inflammation and soft callus formation of the fractured bone • Soft callus formation begins 3-7 days and lasts 2-3 weeks • Latency period = 5-7 days
  • 21. Distraction Phase • Characterized by the application of traction forces to osteotomized segments • Rate : 1 mm/day • Rhythm : 0.25 mm every 6 hours 0.5 mm twice a day • Duration : 1-3 weeks
  • 22. Consolidation Phase Cessation of traction forces to removal of distractor • Newly formed bone mineralizes and increases in bone density and strength Duration: 3- 4 months
  • 23. Remodeling Phase • Removal of distractor to application of functional loading • Formation of lamellar bone
  • 24. HISTOLOGY OF DISTRACTION OSETOGENESIS LATENCY PERIOD DISTRACTION PHASE
  • 25. Latency Histological sequence in latency period in distraction osteogenesis is similar to that of fracture bone healing and in this phase soft callus formation takes place. Initial latency period is recommended is between 5 to 10 days.
  • 26. Distraction In this phase normal process of fracture healing interrupted by the application of gradual traction to the soft callus. As a result of the tension created by this traction force a dynamic microenvironment created which encourages new tissue formation in the direction parallel to the vector of traction. During distraction, four zones[4] appear: a fibrous, less vascular center with collagen fibers parallel to the distraction vector, a transition zone of early bone formation, a bone remodeling zone, and mature bone at the ends. Distraction process is generally carried out at the rate of 0.5 to 1 mm per day.
  • 28. Consolidation and remodeling Bone maturation occurs and continues over a period of a year or more before the structure of the newly formed bony tissue is comparable to that of preexisting bone and in which soft tissue adaptation also occurs. After distraction ceases, this soft callus ossifies and a distinct zone of woven bone completely bridge the gap mainly by intramembranous ossification.
  • 29. • Indications of Maxillo Mandibular Distraction Osteogenesis 1. Severe mandibular retrognathia/micrognathia 2. Craniofacial syndromes: hemifacial microsomia, Treacher Collins syndrome, Nager syndrome, Pierre Robin sequence 3. Severe mandibular asymmetry 4. Post-traumatic deficient mandibular growth and temporomandibular joint ankylosis 5. Revision mandibular orthognathic surgery 6. Mandibular retrognathia with temporomandibular joint disease or juvenile rheumatoid arthritis 7. Mandibular retrognathia with obstructive sleep apnea 8. Mandibular defects from tumor resection 9.Midfacial hypoplasia . 10.Expansion of mandibular symphysis
  • 31.
  • 32.
  • 33.
  • 34. Single calibrated rod with two clamps • Each clamp holds two 2-mm half-pins • 20-24mm of bone posterior to last tooth bud • Limitations: – Difficulty in predicting direction – Inability to change direction – Scarring External Unidirectional Distractors
  • 35. External Bidirectional Distractors Molina and Ortiz Monasterio • Two geared arms 5 cm in length • Middle screw - change angulation • Double osteotomy (horizontal in ramus and vertical in corpus) • Two 2-mm pins in each segment of bone
  • 36. Advantages: – Additional degree of freedom – Deficiencies in more than one plane – Two osteotomies - flexible distraction – Easy and optimal device placement Potential problems – Risk for avascular necrosis of intervening segment – Damage to tooth buds during pin placement
  • 37. External Multiplanar Distractors • Two distraction rods with sliding clamps connected in by multiplanar hinge in the middle • Two arms extend with pin clamps at either end • Each quarter turn results in 0.25 mm of expansion
  • 38. • Advantages of Distraction Osteogensis 1. Allows greater mandibular lengthening of 10–30 mm 2. Can be applied to unusual bony and soft tissue anatomy 3. Allows slow gradual soft tissue adaptation to extreme mandibular lengthening 4. Minimal to no skeletal relapse after extreme mandibular lengthening 5. Can be applied to neonates, infants, and pediatric patients with obstructive sleep apnea 6. Less invasive surgery compared with bone-grafting procedures 7. Avoids intermaxillary fixation 8. Avoids bone grafting and potential donor-site morbidity 9. Can be used for mandibular widening 10. Fewer adverse temporomandibular joint effects in response to asymmetric lengthening 11. Decreased hospitalization time and cost compared with bone grafting 12. Less need for blood transfusion
  • 39. • Drawbacks of Distraction Osteogenesis 1. Skin scars 2. Technique sensitive surgery, equipment sensitive surgery 3. Possible need for second surgery to remove distraction device and patient compliance 4. Transient changes in temporomandibular joint 5. An adequate bone stock is necessary to accept the distraction appliances and to provide suitable 6. opposing surface capable of generating a healing callus 7. Damage to tooth germ 8. Premature consolidation 9. Damage to inferior alveolar nerve 10. Bilateral Coronoid Ankylosis 11. Tendency towards clockwise rotation
  • 40. Classifications of distraction osteogenesis techniques
  • 41.
  • 42. Orthodontics considerations DIAGNOSIS • Extraoral Examination – Forehead, orbit, zygoma, external ear – Oral commissure, chin, mandibular angles • Intraoral Examination – Occlusion – Occlusal plane • Function – Maximum interincisal opening – Mandibular deviation or deflection – TMJ evaluation – Sensory nerve function
  • 43.
  • 44. Diagnostic Records – Standard extraoral and intraoral photographs – Dental models articulated on a semi-adjustable articulator – Lateral and PA cephalograms – OPG – CBCT – CT Scan – Stereolithographic models
  • 46. ORTHODONTIC TREATMENT PROTOCOL • PRE DISTRACTION ORTHODONTICS • ORTHODONTICS DURING DISTRACTION AND CONSOLIDATION PHASE • POST DISTRACTION PHASE • RETENTION.
  • 47. • The Orthodontist’s role a. Decompensation of the dentition b. Planning the distraction vector c. Bone Moulding using intermaxillary elastics d. Post-distraction Orthodontics
  • 48. DISTRACTION OSTEOGENESIS PLANNING THE DISTRACTION VECTOR VERTICAL HORIZONTAL OBLIQUE
  • 49. Biomechanical Considerations • Factors related to distractor device • Factors related to bone and surrounding tissues • Factors related to device orientation
  • 50. Properties of Distractor • Mechanical integrity of device • Number, length and diameter of fixation pins • Material properties
  • 51. Transverse plane (Model I) – Distractors oriented parallel to the lateral surface of mandible
  • 52. Transverse plane (Model II) – Distractors oriented parallel to each other and to midsagittal axis
  • 53. Transverse plane (Model III & IV) – Distractors placed parallel to lateral surface of mandible (III), parallel to each other (IV)
  • 54. • • Sagittal plane (Model V) • Sagittal plane (Model VI)
  • 55. Use of Intermaxillary Elastics • Modification of distraction vectors • Intermaxillary elastics can have skeletal effects during distraction – Secondary to molding of the regenerate • “Fine tuning” of the occlusal outcome • Elastics may be worn in Class II, III, vertical, or transverse pattern • Helpful in the retention of results
  • 57.
  • 59.
  • 60. For V shape mandible • Severe mandibular crowding • Brodie’s syndrome • To avoid inderdental stripping or extractions Symphyseal Distraction
  • 63. DISTRACTION OSTEOGENESIS CURRENT SCOPE OF DO  Correction of Maxillo-Mandibular deformities a) Maxillary lengthening b) Mandibular lengthening c) Maxillary and Mandibular widening d) Lengthening of the Hard palate e) Distraction in other cranio-facial areas.
  • 64. DISTRACTION OSTEOGENESIS CURRENT SCOPE OF DO  Alveolar ridge augmentation  Transport disc and Transformation osteogenesis.  Dental Distraction.
  • 65. DISTRACTION OSTEOGENESIS Directions for the future a. Refinements in the distraction protocol b. Improvement in distraction devices c. Enhancement of regenerate maturation
  • 66. Conclusion • Distraction osteogenesis has revolutionised the management of maxillomandibular deformities . • Patients with severe deformities can be better managed by distraction osteogenesis at much lower risk and complications than with orthognathic surgery • Distraction osteogenesis has indeed redefined the envelope of discrepancy .