alzheimers disease

1. ROLE OF ANTI CHOLINE ESTERASES IN
ALZHEIMERS DISEASE
SIRISHA. A
POST GRADUATE
DEPT OF PHARMACOLOGY

2. OVER VIEW
• INTRODUCTION
• DEFINING ALZHEIMERS DISEASE
• PATHOGENESIS
• NEUROCHEMISTRY
• DRUGS USED FOR COGNITIVE SYMPTOMS
• ANTI CHOLINE ESTERASES
• CONCLUSION

3. PATHOPHYSIOLOGY

4. NEUROCHEMISTRY

5. FEATURES TACRINE DONEPEZIL RIVASTIGMINE GALANTAMINE
ENZYMES
INHIBITED
ACHE, BuCHE ACHE ACHE, BuCHE ACHE
MECHANISM NON
COMPETITIVE
NON
COMPETITIVE
NON
COMPETITIVE
COMPETITIVE
MAINTENECE
DOSE
20 mg QID 10 mg OD 6 mg BD 12 mg BD
T1/2 70 Hrs 2Hrs
METABOLISM CYP1A2 CYP2D6,
CYP3A4
ESTERASES CYP2D6,
CYP3A4
FDA APPROVED
USES
MILD-MOD AD MILD-SEVERE
AD
MILD-MOD AD,
MILD-MOD PD
MILD-MOD AD
ADVERSE
EFFECTS
HEPATOCELLUL
AR NECROSIS
SPECIAL
DELIVERY
SYSTEMS
9.5 mg/24h
(transdermal
16-24 mg/day
(extended-
release)
ANOREXIA, ABNORMAL DREAMS, DIARRHEA,
VOMITING, TREMORS, AND MUSCLE CRAMPS

6. THANK U