Diese Präsentation wurde erfolgreich gemeldet.
Wir verwenden Ihre LinkedIn Profilangaben und Informationen zu Ihren Aktivitäten, um Anzeigen zu personalisieren und Ihnen relevantere Inhalte anzuzeigen. Sie können Ihre Anzeigeneinstellungen jederzeit ändern.

Parameters in Preformulation Studies

1.725 Aufrufe

Veröffentlicht am

What are the Parameters of Research in Preformulation Studies?

Veröffentlicht in: Bildung
  • DOWNLOAD THIS BOOKS INTO AVAILABLE FORMAT (Unlimited) ......................................................................................................................... ......................................................................................................................... Download Full PDF EBOOK here { https://tinyurl.com/yyxo9sk7 } ......................................................................................................................... Download Full EPUB Ebook here { https://tinyurl.com/yyxo9sk7 } ......................................................................................................................... ACCESS WEBSITE for All Ebooks ......................................................................................................................... Download Full PDF EBOOK here { https://tinyurl.com/yyxo9sk7 } ......................................................................................................................... Download EPUB Ebook here { https://tinyurl.com/yyxo9sk7 } ......................................................................................................................... Download doc Ebook here { https://tinyurl.com/yyxo9sk7 } ......................................................................................................................... ......................................................................................................................... ......................................................................................................................... .............. Browse by Genre Available eBooks ......................................................................................................................... Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, Cookbooks, Crime, Ebooks, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult,
       Antworten 
    Sind Sie sicher, dass Sie …  Ja  Nein
    Ihre Nachricht erscheint hier
  • How can I improve my memory book? How can I improve my memory recall? visit to learn...➤➤ https://bit.ly/2GEWG9T
       Antworten 
    Sind Sie sicher, dass Sie …  Ja  Nein
    Ihre Nachricht erscheint hier

Parameters in Preformulation Studies

  1. 1. What are the Parameters of Research in Preformulation Studies?
  2. 2. Preformulation Study  Preformulation study; the term is frequently hear d in a pharmaceutical industry. But, what is it exa ctly?  A Preformulation study is an investigation of the physical, chemical, and mechanical properties of a drug substance to develop a safe, effective, and stable dosage form. Thus, it forms an integral part of the drug development process.
  3. 3.  To establish the physicochemical properties of the new drug substance  To determine its kinetic profile and stability  To determine its compatibility with inactive ingred ients or excipients  To know the methods of drug processing and stora ge Just like any research study is carried out to accomplish a particular goal, the main objective of Preformulation studies is to accomplish the following:
  4. 4. In order to accomplish these goals, certain Preformulation parameters of the drug substance a re investigated. Let’s see what these parameters are:
  5. 5. 1.Organoleptic properties of the drug Organoleptic properties are the aspects that can be experienced through one’s senses like taste, smell, sight, and touch. Thus, it includes a recording of the colour, odour, and taste of the drug.
  6. 6. 2.Bulk characters of the drug • This includes:  Crystallinity and Polymorphism  Hygroscopicity  Fine particle characterization  Powder flow properties
  7. 7. Crystallinity and Polymorphism Crystallinity refers to the outer appearance and internal structure of the drug molecule and can affect its physicochemical properties. Polymorphism is the ability of a compound to crystallise in different shapes with different internal structure.
  8. 8. Hygroscopicity Hygroscopicity is the measure of the tendency to adsorb atmospheric moisture by the drug substance. It characterizes the drug stability with respect to the environmental humidity.
  9. 9. Fine particle characterization The size of the drug particle can influence its dissolution rate, suspendability and other properties. Thus, it becomes important to classify the drug substances as coarse, moderately coarse, very coarse, fine, and very fine.
  10. 10. Powder flow properties Since the majority of active pharmaceutical in gredients are delivered as powders, either as a pill or for dissolution, understanding and controlling the powder behaviour of drugs are extremely important. Powder flow properties help you understand the ease with which the drug powder will flow under a set of specific conditions like humidity, pressure etc.
  11. 11. 3.Solubility analysis  Ionization constant- pKa is the measurement of the acidity of the compound. Its determination helps in un derstanding the solubility, protein binding, and permea bility of the drug substance to characterize its propertie s like absorption, distribution, metabolism and excretio n from the body.  pH solubility profile helps to understand the influ ence of pH on drug solubility, stability, and absorption.  Common ion effect (Ksp) determines the solubili ty of the drug substance when a soluble compound hav ing a common ion with the drug is added to the test sol ution.
  12. 12.  Thermal effects help to evaluate the drug solubility with respect to the changes in the temperature of the solve nt.  Solubilization is the method of increasing the solubili ty of sparingly soluble drug substance by various techniqu es like adding a co-solvent, changing the pH and temperat ure, adding a surfactant, reducing the particle size etc.  Partition co-efficient is the measurement of the dru g lipophilicity or ability to cross a cell membrane.  Dissolution is the process of resolving the drug substa nce into its individual components and characterizing thei r properties.
  13. 13. 4.Stability analysis  Stability in toxicology formulations  Solution stability  pH-rate profile  Solid state stability  Bulk stability  Compatibility The stability of the drug is studied with respect to various factors like:
  14. 14. Thus, by investigating the above parameters of a new drug molecule , scientists can formulate the drug substance into a stable, safe, and effective dosage form that can be easily taken by the patient to cure his illness.
  15. 15. E-mail: project@cognibrain.com Phone: 044-49595223 URL: https://www.cognibrain.com/

×