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ark-invest.com
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WELCOME TO INNOVATION!
Rooted in almost 40 years of experience, ARK Invest aims to
identify large-scale investment opportunities resulting from
technological change. We believe innovation is key to growth.
From a broad spectrum of disruptive innovations, “Big Ideas”
represents our annual breakout of technologies that we believe
will accelerate significantly in the months ahead.
Each section provides you with a brief introduction before
illustrating the opportunity. At the end of each section we list
sources for additional research and insights.
1.  Deep Learning
2.  Mobility-as-a-Service
3.  3D Printing
4.  CRISPR Genome-Editing
5.  Mobile Payments
6.  Robotics
7.  Cryptoassets
ark-invest.com
ARK INVEST | BIG IDEAS 2017
3
ARK INVEST | BIG IDEAS 2017ARK’s ANALYST TEAM PRESENTS BIG IDEAS 2017
Join the Conversation. Get in Touch with ARK’s Analysts. More Information: ark-invest.com/ark-team
Brett Winton, Director of Research
bwinton@ark-invest.com
@wintonARK
James Wang, Analyst
jwang@ark-invest.com
@jwangARK
Chris Burniske, Blockchain Products Lead
cburniske@ark-invest.com
@ARKblockchain
Bhavana Yarasuri, Analyst
byarasuri@ark-invest.com
@bhavanaARK
Tasha Keeney, Analyst
akeeney@ark-invest.com
@tashaARK
Manisha Samy, Analyst
msamy@ark-invest.com
@msamyARK
Julia Hemmendinger, Analyst
jhemmendinger@ark-invest.com
@juliahARK
Sam Korus, Analyst
skorus@ark-invest.com
@skorusARK
4
“A breakthrough in machine learning*
would be worth ten Microsofts.”
– Bill Gates (2004)
*Deep Learning is a sub-category of Machine Learning
1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017
5
1. DEEP LEARNING
Artificial Intelligence (AI) vs. Machine Learning vs. Deep Learning
Classic AI is based on deductive logic.
Rules are based on human ingenuity.
Machine Learning is based on statistical
inference. Rules are inferred from data.
Deep Learning is a type of Machine Learning
modeled after the biological brain.
Artificial Intelligence
Machine Learning
Deep Learning
ARK INVEST | BIG IDEAS 2017
6
Mapping Products to AI
Artificial Intelligence
Machine Learning
Deep Learning
Source: ARK Investment Management LLC
1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017
Cyc
IBM Deep Blue
Wolfram Alpha
Video Game AI
Pandora Radio
Google PageRank
IBM Watson
Email Spam Filter
Netflix
Recommendation
Engine
Facebook Newsfeed
Spotify Discover Weekly
AlphaGo
Google Photos
Gmail Smart Reply
Baidu Voice Search
Tesla Auto Pilot
Facebook Photo Tagging
Google RankBrain
Skype Translator
7 Source: Google Search Trends
TRENDING:
Deep Learning
dominates
machine learning.
1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017
Five Tribes of AI – One Breakout Winner
RelativeSearchFrequency
0
25
50
75
100
Jan 2013 Jan 2014 Jan 2015 Jan 2016 Jan 2017
Deep Learning
Genetic Algorithm
Support Vector Machine
Expert System
Bayesian inference
Different Machine Learning Algorithms: Google Search Trends
8 Source: ARK Investment Management LLC
Speech Recognition
Question Answering Accuracy
Disease Prediction Accuracy
AI Game Performance
Image Classification
1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017
Recent Deep Learning Breakthroughs
9
Lung Legions Breast Cancer Skin Cancer
Diabetic
Retinopathy
Alzheimer's
Disease
Global Cases
Per Year
1.8M 1.7M 2.5M 93M 44M
Diagnostic Accuracy
with Deep Learning
97% 97% 72% 95% 99%
Source: WHO, Medical Journals
1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017
Example: Deep Learning Is Transforming Medical Imaging
10 Source: ARK Investment Management LLC
Relative to the internet,
Deep Learning could
impact more sectors,
causing more profound
disruptive innovations.
Agriculture
Manufacturing
Pharmaceuticals
Health CareAutomotive
New Industries
AdvertisingTelevision
Information Technology
Retail
News Financial Services
Deep Learning
Internet
1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
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How impactful was the internet?
1996 Internet companies made up 0% of the S&P 500
2016 Internet companies made up 9% of the S&P 500
This Foundational Technology Took 9% Share In 20 Years
1. DEEP LEARNING
SIZING THE OPPORTUNITY
Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
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US Internet
Companies 9%
Others 91%
Pure Internet Companies As A Percent of S&P 500
Source: ARK investment Management LLC, as of December 2016
1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
S&P 500 Market Cap Created by The Internet
13
Source: ARK Investment Management LLC,
Deep learning penetration adjusted for global market cap, assuming 6.9% historical growth rate of global equities, 6.6% deep learning share in 20 years.
Globally, Deep Learning Could Approach A $17 Trillion Market Cap in 20 Years
…creating the equivalent
of 35x Amazon’s.
1. DEEP LEARNING
SIZING THE OPPORTUNITY
ARK INVEST | BIG IDEAS 2017
$Trillions
14
1. DEEP LEARNING
Additional Research:
Join the Conversation. Get in Touch with ARK’s Analysts.
James Wang
Analyst
WHITE PAPER
Deep Learning—A Revolution in Artificial Intelligence
ARK INVEST | BIG IDEAS 2017
jwang@ark-invest.com
@jwangARK
DOWNLOAD
15
“The removal of the driver is arguably the most significant and
transformative innovation ever faced by the automotive industry.”
— "The Future of Autonomous Cars", Berg Insights (2016)
2. MOBILITY-AS-A-SERVICE ARK INVEST | BIG IDEAS 2017
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2. MOBILITY-AS-A-SERVICE
Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
ARK expects that before 2020 fully autonomous vehicles will become
commercially available, enabling the rapid rise and growth of autonomous
taxi networks.
These networks should decrease the cost and inconvenience of
point-to-point mobility dramatically, spurring a transformative
boost in economic productivity.
As a result, the traditional automotive industry may be
subsumed by Mobility-as-a-Service (MaaS) platforms that
could become one of the most valuable investment
opportunities in public equity markets.
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2. MOBILITY-AS-A-SERVICE
Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
•  These compelling economics will drive consumer adoption
•  Autonomous taxis should become the dominant form of vehicle transportation in urban areas
$3.50
$2.86
$0.70
$0.35
Average US Taxi Uber San Francisco Personal Car Autonomous Taxi 2020
All-in Cost Per Mile of Vehicle Services
ARK’s research shows that the price of autonomous travel will be roughly
half the cost of driving a personal car today.
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2. MOBILITY-AS-A-SERVICE
Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
Because battery costs have declined faster than most analysts anticipated,
ARK foresees a wholesale shift to electric vehicles (EVs). By 2022 EVs
should be cheaper than comparable gas-powered cars.
$49,900
$41,800
$31,000
$22,400$22,700 $23,100 $23,900
$24,700
2013 2016 2019 2022
MSRP
Projected Price Parity for 200-Mile Range EV 200 Mile Range EV Toyota Camry MSRP
ARK’s expectation for EV MSRP (manufacturer's suggested retail price) parity is largely based on decreasing lithium-ion
battery costs. Other factors could influence MSRP. The MSRP prices shown do not include any government subsidies.
19
2. MOBILITY-AS-A-SERVICE
Source: ARK Investment Management
ARK INVEST | BIG IDEAS 2017
Based on ARK’s Research, The Demand For EVs Will Be Orders Of Magnitude
Higher Than Current Consensus Forecasts.
500,000
2,000,000 2,000,000
17,000,000
-
5,000,000
10,000,000
15,000,000
20,000,000
2015 Global EV Sales 2022 OPEC Annual EV Sales
Estimate
2022 EIA Annual EV Sales
Estimate
2022 ARK EV Sales Estimate
Annual EV Sales Estimates
2016
20
2. MOBILITY-AS-A-SERVICE
Source: ARK Investment Management LLC, BP Energy Outlook 2016
ARK INVEST | BIG IDEAS 2017
What will happen to oil prices?
EVs and autonomous technology could cause oil demand to peak before the end of the decade.
*Mb/d = Millions of barrels per day.
80
90
100
110
120
2016 2018 2020 2022 2024 2026 2028 2030 2032 2034
Mb/d
Oil Demand Forecast
BP Oil Demand Forecast (Mb/d) ARK Oil Demand Forecast with EV Adoption (Mb/d)
ARK Oil Demand with Autonomous and EV Adoption (Mb/d)
*
21
2. MOBILITY-AS-A-SERVICE
Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
What will happen to auto sales?
ARK expects auto sales to be much lower than anticipated, thanks to autonomous taxis.
45
55
65
75
85
95
105
115
125
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030
Global Annual Auto Sales
IHS ARK
Millions of units
Autonomous vehicles will have higher utilization rates than personally driven cars, lowering the number of
required vehicles on the road despite an expanded total passenger base and increased per-person miles.
~24 million units lower
22 Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Source: ARK Investment Management LLC
Based on ARK’s research, mobility-as-a-service (MaaS) should be valued
at $1-3 trillion today.
$114
$2,000
$1,020
0
500
1,000
1,500
2,000
2,500
MaaS (Actual) MaaS (Should Be) Automakers
Global Market Capitalization Today
$Billions
midpoint
2. MOBILITY-AS-A-SERVICE
23 Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Source: ARK Investment Management LLC
ARK estimates autonomous MaaS will reach $10 trillion in gross sales by the
early 2030s, 20% of which could accrue to service operators.
0
2
4
6
8
10
12
2020 2025 2030 2035
Global Revenue for Autonomous Cars and Services
Autonomous Mobility-as-a-Service Revenue
Autonomous Vehicle Sales Revenue
$Trillions
2. MOBILITY-AS-A-SERVICE
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2. MOBILITY-AS-A-SERVICE ARK INVEST | BIG IDEAS 2017
WHITE PAPER
Mobility-as-a-Service: Why Self-Driving Cars Could Change Everything
Additional Research:
Join the Conversation. Get in Touch with ARK’s Analysts.
DOWNLOAD
Sam Korus, Analyst
skorus@ark-invest.com
@skorusARK
Tasha Keeney, Analyst
akeeney@ark-invest.com
@tashaARK
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“3D printing is already shaking our age-old notions of
what can and can’t be made.”
– Hod Lipson, Director of Columbia University's Creative Machines Lab (2013)
Source: McKinsey Global, “Institute Disruptive technologies: Advances that will transform life, business, and the global economy”
3. 3D PRINTING ARK INVEST | BIG IDEAS 2017
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3. 3D PRINTING
Source: ARK Investment Management LLC
3D printing has the potential to revolutionize traditional manufacturing.
By building objects layer-by-layer, instead of removing material from a
larger block or using a mold, 3D printing offers a range of benefits:
• Shortens design-to-production time
• Shifts power to the designers
• Creates products with less waste
• Enables radically new architectures
• Reduces the cost of manufacturing significantly
ARK INVEST | BIG IDEAS 2017
27 Source: ARK Investment Management LLC
3D printing and machine learning create better designed parts that
humans never would have imagined.
3. 3D PRINTING
Traditional
Manufacturing
3D Printing &
Machine Learning
ARK INVEST | BIG IDEAS 2017
For example, these structural nodes
all support the same weight, but
the part on the right weighs 75%
less and is 50% smaller than the
original part on the left.
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*Sources: http://www.geglobalresearch.com/innovation/3d-printing-creates-new-parts-aircraft-engines
https://www.ge.com/investor-relations/sites/default/files/GE%20Additive_Oppenheimer%20Annual%20Industrial%20Growth%20Conference.pdf
GE expects additive
manufacturing to
generate $1 billion in
revenues by 2020,
and it expects to save
$3 – 5 billion in costs.
3. 3D PRINTING
Use Case: Aerospace & Aviation
ARK INVEST | BIG IDEAS 2017
29 Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Source: ARK Investment Management LLC
0
10
20
30
40
50
60
70
80
90
100
2016 Lux Credit Morgan Stanley AT Kearney Wohlers ARK McKinsey
Estimates For Global 3D Printing Market
in 2020 to 2025
$6B
$12B
By 2025
$12B
By 2020
$13-21B
By 2020
$17B
By 2020
$180 - 490B
By 2025
50+% Annual Growth Rate
$27B
By 2020
$41B
By 2020
2x 2x 2-4x 3x 4x
7x
31-82x
3. 3D PRINTING
$ Billions
500
.
.
.
30
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Source: ARK Investment Management LLC, Data from McKinsey, Fredonia Group, US Congressional Research Service
*Source: ARK Investment Management LLC; http://www.avplastics.co.uk/3d-printing-history
3D Printing Global Market Penetration:
The final frontier for 3D printing will be the finished product market.
3. 3D PRINTING
31
ARK INVEST | BIG IDEAS 20173. 3D PRINTING
Additional Research:
Join the Conversation. Get in Touch with ARK’s Analysts.
WHITE PAPER
3D Printing: A Disruptive Innovation In Its Infancy
DOWNLOAD
Tasha Keeney
Analyst
akeeney@ark-invest.com
@tashaARK
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“The idea of gene correction is not new at all, but before CRISPR
it never worked well enough so that people could do it routinely.”
– Carl June, Biologist University of Pennsylvania (2016)
4. CRISPR GENOME-EDITING ARK INVEST | BIG IDEAS 2017
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4. CRISPR GENOME-EDITING
Source: ARK Investment Management LLC; Image Source: http://dharmacon.gelifesciences.com/gene-editing/crispr-cas9/crispr-guide-rna/
CRISPR is one of the breakthrough technologies of the century
and will increase the pace of innovation in biotechnology.
Derived from bacteria,
Clustered Regularly
Interspaced Short
Palindromic Repeats
(CRISPR for short)
is a new genome-editing
platform technology that
can correct mistakes in
the genome.
Previously
ARK INVEST | BIG IDEAS 2017
1980’s Gene expression
manipulated
2001 First whole human
genome sequenced
2013  Next generation
sequencing platform
enabled $1,000 per
genome
2020 Improved sequencing
platforms enables
$100 per genome
Cheap, Easy, and Rapid DNA “Write” Capabilities:
34
4. CRISPR GENOME-EDITING
Source: Time Magazine, MIT Technology Review, Wired Magazine
CRISPR technology has emerged as a winner in genome-editing.
ARK INVEST | BIG IDEAS 2017
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4. CRISPR GENOME-EDITING
Source: ARK Investment Management LLC
Genome-Editing Technologies
ZFNs1 TALENs2 CRISPR
Year of First Human
Cell Modification
2003 2009 2012
Time to Manufacture
(days) 22 10 5
Cost
(per pair of
nucleases)
~$5,500 ~$360 ~$30
Efficient Editing? Yes Yes Yes
Newer Genome-Editing Technique
CRISPR TECHNOLOGY IS:
ü  Easier to use thanks to simple
manufacturing process and
faster learning curve.
ü  More cost effective as
research capacity expands.
ü  Comparable to legacy
genome-editing technologies
in editing efficiencies.
ARK INVEST | BIG IDEAS 2017
[1] ZFNs: Zinc Finger Nucleases [2] TALENs: Transcription activator-like effector nuclease
36
4. CRISPR GENOME-EDITING
* Subject to pre-made versus custom-made editing reagents
The cost of genome-editing has declined by 28x-52x* in the last 4 years.
$-
$2,000.00
$4,000.00
$6,000.00
$8,000.00
$10,000.00
2011 2012 2013 2014 2015 2016 2017
Cost,USD
TALENs Gene Editing Cost Decline ~50-60%
Compounded Yearly
Premade TALENS
Custom TALENS
•  Cost of TALENs genome-
editing has fallen 50-60%
per year since 2012
•  CRISPR is four times
cheaper than TALENs
based genome-editing
• CRISPR costs should
continue to decline
ARK INVEST | BIG IDEAS 2017
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ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Source: ARK Investment Management LLC
CRISPR could address 10,000 monogenic diseases*,
only 5% of which are treatable today.
4. CRISPR GENOME-EDITING
*A disease acquired by a single gene mutation
0
20
40
60
80
Est. Annual US Revenue from Treatment Est. Annual Global Revenue from Treatment
$Billions
CRISPR Opportunity: Addressing all Monogenic Diseases Could Yield
$70 billion in Global Annual Treatment Revenue
Therapeutic Pricing Curative Pricing
$70 Billion
$30 Billion
38 Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Today, ~18% of publications focused on stem cells involve genome-editing,
up from 1% in 2012 when CRISPR was discovered.
4. CRISPR GENOME-EDITING
201720162015201420132012201120102009200820072006200520042003
0
500
1000
1500
2000
2500
3000
Publication
Volume
Share of Genome-Editing Based Stem Cell Research Is Accelerating
iPSc OR Stem Cells Gene-Editing AND Stem Cells
2012: CRISPR for genome-
editing first described
2006: Technique to derive
induced pluripotent stem
cells first described in Japan
Pre-CRISPR Post-CRISPR
51% of new CRISPR users
are focused on stem cell
therapy research
39 Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
CRISPR Applications Extend Beyond The Therapeutics Space
4. CRISPR GENOME-EDITING
Drug Development
Animal Models
Gene-Silencing
Agriculture
Biodefense
Biofuels
Personalized Medicine
Materials
Diagnostics
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0
1
2
3
4
5
6
1980 1981 1982 1983 1984 1985 1986
Market Cap
$ Millions Genentech Market Capitalization
Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Genentech’s market capitalization increased 11-fold in 6 years
largely due to its strong IP position for recombinant DNA.
4. CRISPR GENOME-EDITING
The scope and scalability of CRISPR
technology should continue to expand
rapidly across different applications,
with several companies vying for
CRISPR intellectual property rights.
1980: Genentech IPO
1982: Patent Granted for human
insulin using recombinant DNA
CAGR: 47%
41
4. CRISPR GENOME-EDITING ARK INVEST | BIG IDEAS 2017
Additional Research:
Join the Conversation. Get in Touch with ARK’s Analysts.
RESEARCH BLOGS:
The CRISPR Gene Editing Approach to Treating and Curing Diseases
Spell-Checking the Language of Life: CRISPR Gene Editing In Living Animals
Manisha Samy
Analyst
msamy@ark-invest.com
@msamyARK
42
“Future of Payments is Mobile.”
– Dan Schulman, CEO PayPal (2016)
5. MOBILE PAYMENTS ARK INVEST | BIG IDEAS 2017
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5. MOBILE PAYMENTS
Source: ARK Investment Management LLC
Smart phone penetration and technological innovations
are supporting the growth of mobile payments.
Smart phone penetration
should reach 75% of the
world population by 2020
In Millions
2015
500
2065
5600
2010 2020
• Demonetization in India and
the introduction of a unified
digital payments interface.
• China Regulatory Authority
encouraging development of
digital payment platforms.
New regulations are
supporting the shift to mobile
payments
New technologies such as
Biometrics, NFC* & POS** will
boost security and usage
Biometric enabled smartphones
2020
2015 .2 Billion
2 Billion
ARK INVEST | BIG IDEAS 2017
≈ 02010
*NFC: Near Field Communications, **POS: Point of Sale
44
5. MOBILE PAYMENTS
Source: ARK Investment Management LLC
Mobile
Payments
Digital
Transaction
Data
Financial
Inclusion
Credit
Investing
Insurance
Economic
Development
Mobile payments are key
to financial inclusion
in developed and
emerging markets.
ARK INVEST | BIG IDEAS 2017
45
5. MOBILE PAYMENTS
Source: ARK Investment Management LLC
SHARING ECONOMY
Mobile payments will enable frictionless payments in the sharing economy.
Frictionless
Mobile
Payment
Platforms
Improved
Asset
Utilization
Better
Customer
Experience
+
ARK INVEST | BIG IDEAS 2017
46
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Source: ARK Investment Management LLC
Mobile Payments Are Reaching An Inflection Point
The transaction value that flows through mobile should grow
by 15X from 2015 to 2020.
$15 Trillion
2010 2015 2020
$0.04 Trillion $1.1 Trillion
5. MOBILE PAYMENTS
47 Source: ARK Investment Management LLC
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Mobile Transaction Data Is A Hidden Asset
ARK estimates a $125 billion opportunity from transaction data:
• 20% of global transactions are already digital, providing a
roughly $25 billion monetization opportunity.
• The remaining 80% of cash transactions are moving
increasingly into mobile, adding $100 billion to the
transaction data opportunity.
Gr$100 B
From cash transactions
that are yet to be
digitized
$125 B
Total Opportunity
5. MOBILE PAYMENTS
48
ARK INVEST | BIG IDEAS 20175. MOBILE PAYMENTS
RESEARCH BLOGS
Data from Cash Disruption: A Clear Advantage for Fintech Firms
Fintech Explained—The Financial Revolution Has Just Begun
Additional Research:
Join the Conversation. Get in Touch with ARK’s Analysts.
Julia Hemmendinger, Analyst
jhemmendinger@ark-invest.com
@juliahARK
Bhavana Yarasuri, Analyst
byarasuri@ark-invest.com
@bhavanaARK
49
“Closely coupled machine-human manufacturing
capabilities will drive accelerating productivity
throughout the physical economy.”
– Brett Winton (2017)
6. ROBOTICS ARK INVEST | BIG IDEAS 2017
50
6. ROBOTICS ARK INVEST | BIG IDEAS 2017
$10,800
$24,309
$131,433
$119,677
$67,656
$45,476
$31,312
$0
$20,000
$40,000
$60,000
$80,000
$100,000
$120,000
$140,000
Unit Cost
Industrial Robot Cost Decline (2015 Dollars)
ARK Cost Decline BCG Cost Decline Historic Prices
Industrial robots are continuing to decline in cost
and are thereby expanding the addressable market.
Source: ARK Investment Management LLC, Data from: Sources: United Nations Economic Commission for Europe, International Federation of Robotics, Boston Consulting Group,
51
6. ROBOTICS
Source: Amazon | Preferred Networks
ARK INVEST | BIG IDEAS 2017
Collaborative robots and deep learning are shrinking programming costs
and increasing use cases for robotics.
52
6. ROBOTICS
Sources: Bureau of Labor Statistics, International Federation of Robotics
ARK INVEST | BIG IDEAS 2017
Employment in the auto industry has continued to grow even as
the number of robots has increased.
0
20,000
40,000
60,000
80,000
100,000
120,000
0
200,000
400,000
600,000
800,000
1,000,000
1,200,000
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
StockofRobots
EmploymentinAutoManufacturing
Employment and Operational Stock of Robots in Auto Manufacturing
Operational Stock of Robots in Auto Manufacturing Annual Avg. of Seasonally Adjusted Auto Manufacturing Employment
53
111,264
(44%)
143,033
(56%)
2015 Stock of Industrial Robot Distribution
Robots in Auto
Manufacturing
Robots in Other
(Assumed Mostly
Manufacturing)
6. ROBOTICS
Sources: Bureau of Labor Statistics, International Federation of Robotics
Industrial robot sales have been driven by the auto industry, but as upfront capital costs and programming costs
decline, all manufacturing firms should be increasing adoption.
ARK INVEST | BIG IDEAS 2017
913,500
(7%)
11,421,750
(93%)
2015 Manufacturing Employment Breakdown
Auto Manufacturing
All Manufacturing Less
Auto Manufacturing
SIZING THE OPPORTUNITY
ARK anticipates increased adoption of automation in many industries.
54
6. ROBOTICS
Sources: ARK Investment Management LLC, Boston Consulting Group, International Federation of Robotics
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
Robot sales growth should accelerate, thanks to decreasing capital costs,
lower programming costs, and many more use cases.
-
200,000
400,000
600,000
800,000
1,000,000
1,200,000
1,400,000
2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025
AnnualUnitSales
Annual Industrial Robot Sales Forecast
BCG Low BCG High ARK Model
55
ARK INVEST | BIG IDEAS 2017
WHITE PAPER
The Future of Automation
Additional Research:
Join the Conversation. Get in Touch with ARK’s Analysts.
Sam Korus
Analyst
skorus@ark-invest.com
Twitter: @skorusARK
6. ROBOTICS
DOWNLOAD
56
“Blockchain could slash the cost of transactions
and reshape the economy.”
– Harvard Business Review (2017)
7. CRYPTOASSETS ARK INVEST | BIG IDEAS 2017
57
7. CRYPTOASSETS
For more information Read ARK’s whitepaper “Bitcoin: Ringing The Bell For A New Asset Class”, http://research.ark-invest.com/bitcoin-asset-class
Cryptoassets
Uses: means of exchange, store of value, unit of account
Examples: bitcoin, litecoin, monero, zcash
Uses: cloud storage, compute cycles, bandwidth
Examples: ether, golem, storj, sia
Uses: consumer facing distributed applications
Examples: augur, gnosis, swarm city, steemit
Cryptocurrencies
Cryptocommodities
Cryptotokens
We believe that bitcoin and other cryptocurrencies are not just “currencies”. Traditional asset classes differ in three
ways: politico-economic features, correlation of price movements, and risk-reward profiles. “Cryptoassets” can be
considered a new assert class entirely.1 Verticals within cryptoassets include:
ARK INVEST | BIG IDEAS 2017
58
7. CRYPTOASSETS
Source: blockchain.info, as of 05/31/2017
Bitcoin: From a $3B to a ~$38B Market Capitalization in Two Years
ARK INVEST | BIG IDEAS 2017
Shown below is the total USD value of bitcoin supply in circulation, as calculated by the daily average
market price across major exchanges.
$0
$5
$10
$15
$20
$25
$30
$35
$40
$45
$Billions Bitcoin Market Capitalization
59
7. CRYPTOASSETS
Source: https://coinmarketcap.com/charts/, as of 05/31/2017
At ~$43B, Other Cryptoassets Now Rival Bitcoin’s Market Capitalization
ARK INVEST | BIG IDEAS 2017
60
7. CRYPTOASSETS
Source: https://coinmarketcap.com/, as of 05/31/2017
The ‘Crypto World’ includes 700 Assets, and Counting
ARK INVEST | BIG IDEAS 2017
Top 20 Cryptoassets in May 2017
61
7. CRYPTOASSETS
Source: http://www.usv.com/blog/fat-protocols
How does blockchain technology compare to the web?
Unlike the web, blockchain based systems incorporate native units, like bitcoin, within a protocol. In order for the
protocol to function, those units must have value. As more applications are built on top of the protocol, the value of
the native unit appreciates, and the value accrues to the protocol layer more than the application layer.
ARK INVEST | BIG IDEAS 2017
62 Source: Survey via Twitter by ARK Investment Management LLC
Blockchain technology is still in its
infancy, so cryptoasset markets are
characterized by enthusiasm,
uncertainty, and speculation.
The nascent community expects the
aggregate cryptoasset market cap to
grow at a compound annual rate of
35%, from $50 billion to $1 trillion,
during the next 10 years.
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
7. CRYPTOASSETS
63 Source: Survey by ARK Investment Management LLC
51% of the people who participated in our
survey think that the aggregate cryptoasset
market cap will scale 100X to $5+ Trillion
in the next 10 years.
If they are correct, the value of cryptoassets
would compound at a 50-60% annual rate
for the next 10 years.
While exciting, we point out that rarely has
an asset class seen that rate of growth in such
a short period of time.
ARK INVEST | BIG IDEAS 2017
SIZING THE OPPORTUNITY
7. CRYPTOASSETS
64
ARK INVEST | BIG IDEAS 20177. CRYPTOASSETS
Additional Research:
Join the Conversation. Get in Touch with ARK’s Analysts.
WHITE PAPER:
Bitcoin: Ringing The Bell For A New Asset Class
Chris Burniske
Blockchain Products Lead
cburniske@ark-invest.com
@ARKblockchain
DOWNLOAD
65
ARK INVEST | BIG IDEAS 2017
The content of this presentation is for informational purposes only and is subject to change without notice. This presentation does not constitute,
either explicitly or implicitly, any provision of services or products by ARK Investment Management LLC (“ARK”) and investors should determine for
themselves whether a particular investment management service is suitable for their investment needs. All statements made regarding companies or
securities are strictly beliefs and points of view held by ARK and are not endorsements by ARK of any company or security or recommendations by
ARK to buy, sell or hold any security. Historical results are not indications of future results. Certain of the statements contained in this presentation
may be statements of future expectations and other forward-looking statements that are based on ARK's current views and assumptions and involve
known and unknown risks and uncertainties that could cause actual results, performance or events to differ materially from those expressed or
implied in such statements. The matters discussed in this presentation may also involve risks and uncertainties described from time to time in ARK's
filings with the U.S. Securities and Exchange Commission. ARK assumes no obligation to update any forward-looking information contained in this
presentation. Certain information was obtained from sources that ARK believes to be reliable; however, ARK does not guarantee the accuracy or
completeness of any information obtained from any third party. ARK and its clients as well as its related persons may (but do not necessarily) have
financial interests in securities or issuers that are discussed.
ARK's statements are not an endorsement of any company or a recommendation to buy, sell or hold any security. For a list of all purchases and
sales made by ARK for client accounts during the past year that could be considered by the SEC as recommendations go to http://ark-invest.com/
wp-content/trades/ARK_Trades.pdf.
It should not be assumed that recommendations made in the future will be profitable or will equal the performance of the securities in this list. For
full disclosures http://ark-invest.com/terms-of-use.
DISCLOSURE

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Disruptive Innovation: Big Ideas 2017

  • 2. 2 WELCOME TO INNOVATION! Rooted in almost 40 years of experience, ARK Invest aims to identify large-scale investment opportunities resulting from technological change. We believe innovation is key to growth. From a broad spectrum of disruptive innovations, “Big Ideas” represents our annual breakout of technologies that we believe will accelerate significantly in the months ahead. Each section provides you with a brief introduction before illustrating the opportunity. At the end of each section we list sources for additional research and insights. 1.  Deep Learning 2.  Mobility-as-a-Service 3.  3D Printing 4.  CRISPR Genome-Editing 5.  Mobile Payments 6.  Robotics 7.  Cryptoassets ark-invest.com ARK INVEST | BIG IDEAS 2017
  • 3. 3 ARK INVEST | BIG IDEAS 2017ARK’s ANALYST TEAM PRESENTS BIG IDEAS 2017 Join the Conversation. Get in Touch with ARK’s Analysts. More Information: ark-invest.com/ark-team Brett Winton, Director of Research bwinton@ark-invest.com @wintonARK James Wang, Analyst jwang@ark-invest.com @jwangARK Chris Burniske, Blockchain Products Lead cburniske@ark-invest.com @ARKblockchain Bhavana Yarasuri, Analyst byarasuri@ark-invest.com @bhavanaARK Tasha Keeney, Analyst akeeney@ark-invest.com @tashaARK Manisha Samy, Analyst msamy@ark-invest.com @msamyARK Julia Hemmendinger, Analyst jhemmendinger@ark-invest.com @juliahARK Sam Korus, Analyst skorus@ark-invest.com @skorusARK
  • 4. 4 “A breakthrough in machine learning* would be worth ten Microsofts.” – Bill Gates (2004) *Deep Learning is a sub-category of Machine Learning 1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017
  • 5. 5 1. DEEP LEARNING Artificial Intelligence (AI) vs. Machine Learning vs. Deep Learning Classic AI is based on deductive logic. Rules are based on human ingenuity. Machine Learning is based on statistical inference. Rules are inferred from data. Deep Learning is a type of Machine Learning modeled after the biological brain. Artificial Intelligence Machine Learning Deep Learning ARK INVEST | BIG IDEAS 2017
  • 6. 6 Mapping Products to AI Artificial Intelligence Machine Learning Deep Learning Source: ARK Investment Management LLC 1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017 Cyc IBM Deep Blue Wolfram Alpha Video Game AI Pandora Radio Google PageRank IBM Watson Email Spam Filter Netflix Recommendation Engine Facebook Newsfeed Spotify Discover Weekly AlphaGo Google Photos Gmail Smart Reply Baidu Voice Search Tesla Auto Pilot Facebook Photo Tagging Google RankBrain Skype Translator
  • 7. 7 Source: Google Search Trends TRENDING: Deep Learning dominates machine learning. 1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017 Five Tribes of AI – One Breakout Winner RelativeSearchFrequency 0 25 50 75 100 Jan 2013 Jan 2014 Jan 2015 Jan 2016 Jan 2017 Deep Learning Genetic Algorithm Support Vector Machine Expert System Bayesian inference Different Machine Learning Algorithms: Google Search Trends
  • 8. 8 Source: ARK Investment Management LLC Speech Recognition Question Answering Accuracy Disease Prediction Accuracy AI Game Performance Image Classification 1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017 Recent Deep Learning Breakthroughs
  • 9. 9 Lung Legions Breast Cancer Skin Cancer Diabetic Retinopathy Alzheimer's Disease Global Cases Per Year 1.8M 1.7M 2.5M 93M 44M Diagnostic Accuracy with Deep Learning 97% 97% 72% 95% 99% Source: WHO, Medical Journals 1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017 Example: Deep Learning Is Transforming Medical Imaging
  • 10. 10 Source: ARK Investment Management LLC Relative to the internet, Deep Learning could impact more sectors, causing more profound disruptive innovations. Agriculture Manufacturing Pharmaceuticals Health CareAutomotive New Industries AdvertisingTelevision Information Technology Retail News Financial Services Deep Learning Internet 1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY
  • 11. 11 How impactful was the internet? 1996 Internet companies made up 0% of the S&P 500 2016 Internet companies made up 9% of the S&P 500 This Foundational Technology Took 9% Share In 20 Years 1. DEEP LEARNING SIZING THE OPPORTUNITY Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017
  • 12. 12 US Internet Companies 9% Others 91% Pure Internet Companies As A Percent of S&P 500 Source: ARK investment Management LLC, as of December 2016 1. DEEP LEARNING ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY S&P 500 Market Cap Created by The Internet
  • 13. 13 Source: ARK Investment Management LLC, Deep learning penetration adjusted for global market cap, assuming 6.9% historical growth rate of global equities, 6.6% deep learning share in 20 years. Globally, Deep Learning Could Approach A $17 Trillion Market Cap in 20 Years …creating the equivalent of 35x Amazon’s. 1. DEEP LEARNING SIZING THE OPPORTUNITY ARK INVEST | BIG IDEAS 2017 $Trillions
  • 14. 14 1. DEEP LEARNING Additional Research: Join the Conversation. Get in Touch with ARK’s Analysts. James Wang Analyst WHITE PAPER Deep Learning—A Revolution in Artificial Intelligence ARK INVEST | BIG IDEAS 2017 jwang@ark-invest.com @jwangARK DOWNLOAD
  • 15. 15 “The removal of the driver is arguably the most significant and transformative innovation ever faced by the automotive industry.” — "The Future of Autonomous Cars", Berg Insights (2016) 2. MOBILITY-AS-A-SERVICE ARK INVEST | BIG IDEAS 2017
  • 16. 16 2. MOBILITY-AS-A-SERVICE Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 ARK expects that before 2020 fully autonomous vehicles will become commercially available, enabling the rapid rise and growth of autonomous taxi networks. These networks should decrease the cost and inconvenience of point-to-point mobility dramatically, spurring a transformative boost in economic productivity. As a result, the traditional automotive industry may be subsumed by Mobility-as-a-Service (MaaS) platforms that could become one of the most valuable investment opportunities in public equity markets.
  • 17. 17 2. MOBILITY-AS-A-SERVICE Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 •  These compelling economics will drive consumer adoption •  Autonomous taxis should become the dominant form of vehicle transportation in urban areas $3.50 $2.86 $0.70 $0.35 Average US Taxi Uber San Francisco Personal Car Autonomous Taxi 2020 All-in Cost Per Mile of Vehicle Services ARK’s research shows that the price of autonomous travel will be roughly half the cost of driving a personal car today.
  • 18. 18 2. MOBILITY-AS-A-SERVICE Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 Because battery costs have declined faster than most analysts anticipated, ARK foresees a wholesale shift to electric vehicles (EVs). By 2022 EVs should be cheaper than comparable gas-powered cars. $49,900 $41,800 $31,000 $22,400$22,700 $23,100 $23,900 $24,700 2013 2016 2019 2022 MSRP Projected Price Parity for 200-Mile Range EV 200 Mile Range EV Toyota Camry MSRP ARK’s expectation for EV MSRP (manufacturer's suggested retail price) parity is largely based on decreasing lithium-ion battery costs. Other factors could influence MSRP. The MSRP prices shown do not include any government subsidies.
  • 19. 19 2. MOBILITY-AS-A-SERVICE Source: ARK Investment Management ARK INVEST | BIG IDEAS 2017 Based on ARK’s Research, The Demand For EVs Will Be Orders Of Magnitude Higher Than Current Consensus Forecasts. 500,000 2,000,000 2,000,000 17,000,000 - 5,000,000 10,000,000 15,000,000 20,000,000 2015 Global EV Sales 2022 OPEC Annual EV Sales Estimate 2022 EIA Annual EV Sales Estimate 2022 ARK EV Sales Estimate Annual EV Sales Estimates 2016
  • 20. 20 2. MOBILITY-AS-A-SERVICE Source: ARK Investment Management LLC, BP Energy Outlook 2016 ARK INVEST | BIG IDEAS 2017 What will happen to oil prices? EVs and autonomous technology could cause oil demand to peak before the end of the decade. *Mb/d = Millions of barrels per day. 80 90 100 110 120 2016 2018 2020 2022 2024 2026 2028 2030 2032 2034 Mb/d Oil Demand Forecast BP Oil Demand Forecast (Mb/d) ARK Oil Demand Forecast with EV Adoption (Mb/d) ARK Oil Demand with Autonomous and EV Adoption (Mb/d) *
  • 21. 21 2. MOBILITY-AS-A-SERVICE Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 What will happen to auto sales? ARK expects auto sales to be much lower than anticipated, thanks to autonomous taxis. 45 55 65 75 85 95 105 115 125 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 Global Annual Auto Sales IHS ARK Millions of units Autonomous vehicles will have higher utilization rates than personally driven cars, lowering the number of required vehicles on the road despite an expanded total passenger base and increased per-person miles. ~24 million units lower
  • 22. 22 Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Source: ARK Investment Management LLC Based on ARK’s research, mobility-as-a-service (MaaS) should be valued at $1-3 trillion today. $114 $2,000 $1,020 0 500 1,000 1,500 2,000 2,500 MaaS (Actual) MaaS (Should Be) Automakers Global Market Capitalization Today $Billions midpoint 2. MOBILITY-AS-A-SERVICE
  • 23. 23 Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Source: ARK Investment Management LLC ARK estimates autonomous MaaS will reach $10 trillion in gross sales by the early 2030s, 20% of which could accrue to service operators. 0 2 4 6 8 10 12 2020 2025 2030 2035 Global Revenue for Autonomous Cars and Services Autonomous Mobility-as-a-Service Revenue Autonomous Vehicle Sales Revenue $Trillions 2. MOBILITY-AS-A-SERVICE
  • 24. 24 2. MOBILITY-AS-A-SERVICE ARK INVEST | BIG IDEAS 2017 WHITE PAPER Mobility-as-a-Service: Why Self-Driving Cars Could Change Everything Additional Research: Join the Conversation. Get in Touch with ARK’s Analysts. DOWNLOAD Sam Korus, Analyst skorus@ark-invest.com @skorusARK Tasha Keeney, Analyst akeeney@ark-invest.com @tashaARK
  • 25. 25 “3D printing is already shaking our age-old notions of what can and can’t be made.” – Hod Lipson, Director of Columbia University's Creative Machines Lab (2013) Source: McKinsey Global, “Institute Disruptive technologies: Advances that will transform life, business, and the global economy” 3. 3D PRINTING ARK INVEST | BIG IDEAS 2017
  • 26. 26 3. 3D PRINTING Source: ARK Investment Management LLC 3D printing has the potential to revolutionize traditional manufacturing. By building objects layer-by-layer, instead of removing material from a larger block or using a mold, 3D printing offers a range of benefits: • Shortens design-to-production time • Shifts power to the designers • Creates products with less waste • Enables radically new architectures • Reduces the cost of manufacturing significantly ARK INVEST | BIG IDEAS 2017
  • 27. 27 Source: ARK Investment Management LLC 3D printing and machine learning create better designed parts that humans never would have imagined. 3. 3D PRINTING Traditional Manufacturing 3D Printing & Machine Learning ARK INVEST | BIG IDEAS 2017 For example, these structural nodes all support the same weight, but the part on the right weighs 75% less and is 50% smaller than the original part on the left.
  • 28. 28 *Sources: http://www.geglobalresearch.com/innovation/3d-printing-creates-new-parts-aircraft-engines https://www.ge.com/investor-relations/sites/default/files/GE%20Additive_Oppenheimer%20Annual%20Industrial%20Growth%20Conference.pdf GE expects additive manufacturing to generate $1 billion in revenues by 2020, and it expects to save $3 – 5 billion in costs. 3. 3D PRINTING Use Case: Aerospace & Aviation ARK INVEST | BIG IDEAS 2017
  • 29. 29 Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Source: ARK Investment Management LLC 0 10 20 30 40 50 60 70 80 90 100 2016 Lux Credit Morgan Stanley AT Kearney Wohlers ARK McKinsey Estimates For Global 3D Printing Market in 2020 to 2025 $6B $12B By 2025 $12B By 2020 $13-21B By 2020 $17B By 2020 $180 - 490B By 2025 50+% Annual Growth Rate $27B By 2020 $41B By 2020 2x 2x 2-4x 3x 4x 7x 31-82x 3. 3D PRINTING $ Billions 500 . . .
  • 30. 30 ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Source: ARK Investment Management LLC, Data from McKinsey, Fredonia Group, US Congressional Research Service *Source: ARK Investment Management LLC; http://www.avplastics.co.uk/3d-printing-history 3D Printing Global Market Penetration: The final frontier for 3D printing will be the finished product market. 3. 3D PRINTING
  • 31. 31 ARK INVEST | BIG IDEAS 20173. 3D PRINTING Additional Research: Join the Conversation. Get in Touch with ARK’s Analysts. WHITE PAPER 3D Printing: A Disruptive Innovation In Its Infancy DOWNLOAD Tasha Keeney Analyst akeeney@ark-invest.com @tashaARK
  • 32. 32 “The idea of gene correction is not new at all, but before CRISPR it never worked well enough so that people could do it routinely.” – Carl June, Biologist University of Pennsylvania (2016) 4. CRISPR GENOME-EDITING ARK INVEST | BIG IDEAS 2017
  • 33. 33 4. CRISPR GENOME-EDITING Source: ARK Investment Management LLC; Image Source: http://dharmacon.gelifesciences.com/gene-editing/crispr-cas9/crispr-guide-rna/ CRISPR is one of the breakthrough technologies of the century and will increase the pace of innovation in biotechnology. Derived from bacteria, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR for short) is a new genome-editing platform technology that can correct mistakes in the genome. Previously ARK INVEST | BIG IDEAS 2017 1980’s Gene expression manipulated 2001 First whole human genome sequenced 2013  Next generation sequencing platform enabled $1,000 per genome 2020 Improved sequencing platforms enables $100 per genome Cheap, Easy, and Rapid DNA “Write” Capabilities:
  • 34. 34 4. CRISPR GENOME-EDITING Source: Time Magazine, MIT Technology Review, Wired Magazine CRISPR technology has emerged as a winner in genome-editing. ARK INVEST | BIG IDEAS 2017
  • 35. 35 4. CRISPR GENOME-EDITING Source: ARK Investment Management LLC Genome-Editing Technologies ZFNs1 TALENs2 CRISPR Year of First Human Cell Modification 2003 2009 2012 Time to Manufacture (days) 22 10 5 Cost (per pair of nucleases) ~$5,500 ~$360 ~$30 Efficient Editing? Yes Yes Yes Newer Genome-Editing Technique CRISPR TECHNOLOGY IS: ü  Easier to use thanks to simple manufacturing process and faster learning curve. ü  More cost effective as research capacity expands. ü  Comparable to legacy genome-editing technologies in editing efficiencies. ARK INVEST | BIG IDEAS 2017 [1] ZFNs: Zinc Finger Nucleases [2] TALENs: Transcription activator-like effector nuclease
  • 36. 36 4. CRISPR GENOME-EDITING * Subject to pre-made versus custom-made editing reagents The cost of genome-editing has declined by 28x-52x* in the last 4 years. $- $2,000.00 $4,000.00 $6,000.00 $8,000.00 $10,000.00 2011 2012 2013 2014 2015 2016 2017 Cost,USD TALENs Gene Editing Cost Decline ~50-60% Compounded Yearly Premade TALENS Custom TALENS •  Cost of TALENs genome- editing has fallen 50-60% per year since 2012 •  CRISPR is four times cheaper than TALENs based genome-editing • CRISPR costs should continue to decline ARK INVEST | BIG IDEAS 2017
  • 37. 37 ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Source: ARK Investment Management LLC CRISPR could address 10,000 monogenic diseases*, only 5% of which are treatable today. 4. CRISPR GENOME-EDITING *A disease acquired by a single gene mutation 0 20 40 60 80 Est. Annual US Revenue from Treatment Est. Annual Global Revenue from Treatment $Billions CRISPR Opportunity: Addressing all Monogenic Diseases Could Yield $70 billion in Global Annual Treatment Revenue Therapeutic Pricing Curative Pricing $70 Billion $30 Billion
  • 38. 38 Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Today, ~18% of publications focused on stem cells involve genome-editing, up from 1% in 2012 when CRISPR was discovered. 4. CRISPR GENOME-EDITING 201720162015201420132012201120102009200820072006200520042003 0 500 1000 1500 2000 2500 3000 Publication Volume Share of Genome-Editing Based Stem Cell Research Is Accelerating iPSc OR Stem Cells Gene-Editing AND Stem Cells 2012: CRISPR for genome- editing first described 2006: Technique to derive induced pluripotent stem cells first described in Japan Pre-CRISPR Post-CRISPR 51% of new CRISPR users are focused on stem cell therapy research
  • 39. 39 Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY CRISPR Applications Extend Beyond The Therapeutics Space 4. CRISPR GENOME-EDITING Drug Development Animal Models Gene-Silencing Agriculture Biodefense Biofuels Personalized Medicine Materials Diagnostics
  • 40. 40 0 1 2 3 4 5 6 1980 1981 1982 1983 1984 1985 1986 Market Cap $ Millions Genentech Market Capitalization Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Genentech’s market capitalization increased 11-fold in 6 years largely due to its strong IP position for recombinant DNA. 4. CRISPR GENOME-EDITING The scope and scalability of CRISPR technology should continue to expand rapidly across different applications, with several companies vying for CRISPR intellectual property rights. 1980: Genentech IPO 1982: Patent Granted for human insulin using recombinant DNA CAGR: 47%
  • 41. 41 4. CRISPR GENOME-EDITING ARK INVEST | BIG IDEAS 2017 Additional Research: Join the Conversation. Get in Touch with ARK’s Analysts. RESEARCH BLOGS: The CRISPR Gene Editing Approach to Treating and Curing Diseases Spell-Checking the Language of Life: CRISPR Gene Editing In Living Animals Manisha Samy Analyst msamy@ark-invest.com @msamyARK
  • 42. 42 “Future of Payments is Mobile.” – Dan Schulman, CEO PayPal (2016) 5. MOBILE PAYMENTS ARK INVEST | BIG IDEAS 2017
  • 43. 43 5. MOBILE PAYMENTS Source: ARK Investment Management LLC Smart phone penetration and technological innovations are supporting the growth of mobile payments. Smart phone penetration should reach 75% of the world population by 2020 In Millions 2015 500 2065 5600 2010 2020 • Demonetization in India and the introduction of a unified digital payments interface. • China Regulatory Authority encouraging development of digital payment platforms. New regulations are supporting the shift to mobile payments New technologies such as Biometrics, NFC* & POS** will boost security and usage Biometric enabled smartphones 2020 2015 .2 Billion 2 Billion ARK INVEST | BIG IDEAS 2017 ≈ 02010 *NFC: Near Field Communications, **POS: Point of Sale
  • 44. 44 5. MOBILE PAYMENTS Source: ARK Investment Management LLC Mobile Payments Digital Transaction Data Financial Inclusion Credit Investing Insurance Economic Development Mobile payments are key to financial inclusion in developed and emerging markets. ARK INVEST | BIG IDEAS 2017
  • 45. 45 5. MOBILE PAYMENTS Source: ARK Investment Management LLC SHARING ECONOMY Mobile payments will enable frictionless payments in the sharing economy. Frictionless Mobile Payment Platforms Improved Asset Utilization Better Customer Experience + ARK INVEST | BIG IDEAS 2017
  • 46. 46 ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Source: ARK Investment Management LLC Mobile Payments Are Reaching An Inflection Point The transaction value that flows through mobile should grow by 15X from 2015 to 2020. $15 Trillion 2010 2015 2020 $0.04 Trillion $1.1 Trillion 5. MOBILE PAYMENTS
  • 47. 47 Source: ARK Investment Management LLC ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Mobile Transaction Data Is A Hidden Asset ARK estimates a $125 billion opportunity from transaction data: • 20% of global transactions are already digital, providing a roughly $25 billion monetization opportunity. • The remaining 80% of cash transactions are moving increasingly into mobile, adding $100 billion to the transaction data opportunity. Gr$100 B From cash transactions that are yet to be digitized $125 B Total Opportunity 5. MOBILE PAYMENTS
  • 48. 48 ARK INVEST | BIG IDEAS 20175. MOBILE PAYMENTS RESEARCH BLOGS Data from Cash Disruption: A Clear Advantage for Fintech Firms Fintech Explained—The Financial Revolution Has Just Begun Additional Research: Join the Conversation. Get in Touch with ARK’s Analysts. Julia Hemmendinger, Analyst jhemmendinger@ark-invest.com @juliahARK Bhavana Yarasuri, Analyst byarasuri@ark-invest.com @bhavanaARK
  • 49. 49 “Closely coupled machine-human manufacturing capabilities will drive accelerating productivity throughout the physical economy.” – Brett Winton (2017) 6. ROBOTICS ARK INVEST | BIG IDEAS 2017
  • 50. 50 6. ROBOTICS ARK INVEST | BIG IDEAS 2017 $10,800 $24,309 $131,433 $119,677 $67,656 $45,476 $31,312 $0 $20,000 $40,000 $60,000 $80,000 $100,000 $120,000 $140,000 Unit Cost Industrial Robot Cost Decline (2015 Dollars) ARK Cost Decline BCG Cost Decline Historic Prices Industrial robots are continuing to decline in cost and are thereby expanding the addressable market. Source: ARK Investment Management LLC, Data from: Sources: United Nations Economic Commission for Europe, International Federation of Robotics, Boston Consulting Group,
  • 51. 51 6. ROBOTICS Source: Amazon | Preferred Networks ARK INVEST | BIG IDEAS 2017 Collaborative robots and deep learning are shrinking programming costs and increasing use cases for robotics.
  • 52. 52 6. ROBOTICS Sources: Bureau of Labor Statistics, International Federation of Robotics ARK INVEST | BIG IDEAS 2017 Employment in the auto industry has continued to grow even as the number of robots has increased. 0 20,000 40,000 60,000 80,000 100,000 120,000 0 200,000 400,000 600,000 800,000 1,000,000 1,200,000 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 StockofRobots EmploymentinAutoManufacturing Employment and Operational Stock of Robots in Auto Manufacturing Operational Stock of Robots in Auto Manufacturing Annual Avg. of Seasonally Adjusted Auto Manufacturing Employment
  • 53. 53 111,264 (44%) 143,033 (56%) 2015 Stock of Industrial Robot Distribution Robots in Auto Manufacturing Robots in Other (Assumed Mostly Manufacturing) 6. ROBOTICS Sources: Bureau of Labor Statistics, International Federation of Robotics Industrial robot sales have been driven by the auto industry, but as upfront capital costs and programming costs decline, all manufacturing firms should be increasing adoption. ARK INVEST | BIG IDEAS 2017 913,500 (7%) 11,421,750 (93%) 2015 Manufacturing Employment Breakdown Auto Manufacturing All Manufacturing Less Auto Manufacturing SIZING THE OPPORTUNITY ARK anticipates increased adoption of automation in many industries.
  • 54. 54 6. ROBOTICS Sources: ARK Investment Management LLC, Boston Consulting Group, International Federation of Robotics ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY Robot sales growth should accelerate, thanks to decreasing capital costs, lower programming costs, and many more use cases. - 200,000 400,000 600,000 800,000 1,000,000 1,200,000 1,400,000 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 AnnualUnitSales Annual Industrial Robot Sales Forecast BCG Low BCG High ARK Model
  • 55. 55 ARK INVEST | BIG IDEAS 2017 WHITE PAPER The Future of Automation Additional Research: Join the Conversation. Get in Touch with ARK’s Analysts. Sam Korus Analyst skorus@ark-invest.com Twitter: @skorusARK 6. ROBOTICS DOWNLOAD
  • 56. 56 “Blockchain could slash the cost of transactions and reshape the economy.” – Harvard Business Review (2017) 7. CRYPTOASSETS ARK INVEST | BIG IDEAS 2017
  • 57. 57 7. CRYPTOASSETS For more information Read ARK’s whitepaper “Bitcoin: Ringing The Bell For A New Asset Class”, http://research.ark-invest.com/bitcoin-asset-class Cryptoassets Uses: means of exchange, store of value, unit of account Examples: bitcoin, litecoin, monero, zcash Uses: cloud storage, compute cycles, bandwidth Examples: ether, golem, storj, sia Uses: consumer facing distributed applications Examples: augur, gnosis, swarm city, steemit Cryptocurrencies Cryptocommodities Cryptotokens We believe that bitcoin and other cryptocurrencies are not just “currencies”. Traditional asset classes differ in three ways: politico-economic features, correlation of price movements, and risk-reward profiles. “Cryptoassets” can be considered a new assert class entirely.1 Verticals within cryptoassets include: ARK INVEST | BIG IDEAS 2017
  • 58. 58 7. CRYPTOASSETS Source: blockchain.info, as of 05/31/2017 Bitcoin: From a $3B to a ~$38B Market Capitalization in Two Years ARK INVEST | BIG IDEAS 2017 Shown below is the total USD value of bitcoin supply in circulation, as calculated by the daily average market price across major exchanges. $0 $5 $10 $15 $20 $25 $30 $35 $40 $45 $Billions Bitcoin Market Capitalization
  • 59. 59 7. CRYPTOASSETS Source: https://coinmarketcap.com/charts/, as of 05/31/2017 At ~$43B, Other Cryptoassets Now Rival Bitcoin’s Market Capitalization ARK INVEST | BIG IDEAS 2017
  • 60. 60 7. CRYPTOASSETS Source: https://coinmarketcap.com/, as of 05/31/2017 The ‘Crypto World’ includes 700 Assets, and Counting ARK INVEST | BIG IDEAS 2017 Top 20 Cryptoassets in May 2017
  • 61. 61 7. CRYPTOASSETS Source: http://www.usv.com/blog/fat-protocols How does blockchain technology compare to the web? Unlike the web, blockchain based systems incorporate native units, like bitcoin, within a protocol. In order for the protocol to function, those units must have value. As more applications are built on top of the protocol, the value of the native unit appreciates, and the value accrues to the protocol layer more than the application layer. ARK INVEST | BIG IDEAS 2017
  • 62. 62 Source: Survey via Twitter by ARK Investment Management LLC Blockchain technology is still in its infancy, so cryptoasset markets are characterized by enthusiasm, uncertainty, and speculation. The nascent community expects the aggregate cryptoasset market cap to grow at a compound annual rate of 35%, from $50 billion to $1 trillion, during the next 10 years. ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY 7. CRYPTOASSETS
  • 63. 63 Source: Survey by ARK Investment Management LLC 51% of the people who participated in our survey think that the aggregate cryptoasset market cap will scale 100X to $5+ Trillion in the next 10 years. If they are correct, the value of cryptoassets would compound at a 50-60% annual rate for the next 10 years. While exciting, we point out that rarely has an asset class seen that rate of growth in such a short period of time. ARK INVEST | BIG IDEAS 2017 SIZING THE OPPORTUNITY 7. CRYPTOASSETS
  • 64. 64 ARK INVEST | BIG IDEAS 20177. CRYPTOASSETS Additional Research: Join the Conversation. Get in Touch with ARK’s Analysts. WHITE PAPER: Bitcoin: Ringing The Bell For A New Asset Class Chris Burniske Blockchain Products Lead cburniske@ark-invest.com @ARKblockchain DOWNLOAD
  • 65. 65 ARK INVEST | BIG IDEAS 2017 The content of this presentation is for informational purposes only and is subject to change without notice. This presentation does not constitute, either explicitly or implicitly, any provision of services or products by ARK Investment Management LLC (“ARK”) and investors should determine for themselves whether a particular investment management service is suitable for their investment needs. All statements made regarding companies or securities are strictly beliefs and points of view held by ARK and are not endorsements by ARK of any company or security or recommendations by ARK to buy, sell or hold any security. Historical results are not indications of future results. Certain of the statements contained in this presentation may be statements of future expectations and other forward-looking statements that are based on ARK's current views and assumptions and involve known and unknown risks and uncertainties that could cause actual results, performance or events to differ materially from those expressed or implied in such statements. The matters discussed in this presentation may also involve risks and uncertainties described from time to time in ARK's filings with the U.S. Securities and Exchange Commission. ARK assumes no obligation to update any forward-looking information contained in this presentation. Certain information was obtained from sources that ARK believes to be reliable; however, ARK does not guarantee the accuracy or completeness of any information obtained from any third party. ARK and its clients as well as its related persons may (but do not necessarily) have financial interests in securities or issuers that are discussed. ARK's statements are not an endorsement of any company or a recommendation to buy, sell or hold any security. For a list of all purchases and sales made by ARK for client accounts during the past year that could be considered by the SEC as recommendations go to http://ark-invest.com/ wp-content/trades/ARK_Trades.pdf. It should not be assumed that recommendations made in the future will be profitable or will equal the performance of the securities in this list. For full disclosures http://ark-invest.com/terms-of-use. DISCLOSURE