1. International Conference on Nutrigenomics - INCON 2012
“Gene-Diet Interaction for Personalized Health and Disease Prevention"
San José, Costa Rica. October, 1 fst to 4 th , 2012.
Conference Center -Ramada Plaza Herradura Hotel
El INCON cuenta con Traducción Simultánea
PRELIMINARY PROGRAM *
MONDAY , OCTOBER 1 fst, 2012.
14:00 - 17:30 Registration
Participants Registration. Counter - Conference Center.
11:30 - 16:30 Pre-Conference Meeting (1) - Delegates Invited and Project Members of:.
Micronutrient Genomics Project (MGP).
Coordinator : Michael Fenech , CSIRO, Australia.
Biomarkers of Nutrition for Development (BOND).
Coordinator: Dan J. Raiten, NICHD Global Nutrition Program, United States of
America).
Microgennet.
Coordinador: Chris Evelo, Maastricht University, The Netherlands.
(1) Attendance by invitation only.
17:30 - 18:15 Opening Ceremony
Rebeca Vindas Smith - Conference General Coordinator. Instituto de Investigaciones
en Salud, INISA, Universidad de Costa Rica (Institute for Health Research, University
of Costa Rica).
Lúcia Regina Ribeiro , Coordinator, Conference International Advisory Board. Red
Latinoamericana de Nutrigenómica (Latin-American Network on Nutrigenomics;
State University of São Paulo, Brazil).
Henning Jensen Pennington, Rector, Universidad de Costa Rica (President,
University of Costa Rica).
Daisy Corrales Díaz , Ministra de Salud, República de Costa Rica (Minister of Health,
Republic of Costa Rica).
18:25- 19:25 Opening Plenary Lecture
Lecture 01
Dr. Ben van Ommen, TNO (The Netherlands).
"The nutritional systems biology solution in Type 2 Diabetes and Cardiovascular
Desease prevention and therapy".
Chair: Rebeca Vindas, INISA-Universidad de Costa Rica

2. 19: 30 - 21:00 Opening Reception
TUESDAY, OCTOBER 2 nd, 2012.
07:30 - 12:00 Registration
Registration. Counter - Conference Center.
08:30 - 09:30 Symposium 01: Biomarkers of Nutrition for Development (BOND)
Chair: Dan J. Raiten, NICHD Global Nutrition Program, Bethesda, USA.
Co-Chair: Lynn Bailey, University of Georgia, USA.
1. BOND Project Overview. Dan J. Raiten, Director, NICHD Global Nutrition
Program, Bethesda, USA.
2. Folate biomarkers. Lynn Bailey, Leader of BOND Folate expert Panel,
University of Georgia, USA.
09:30 - 09:50 Coffee Break and poster viewing
09:55 - 10:55 Symposium 01: Continuation
3. Zinc biomarkers. Janet King, Leader of BOND Zinc expert panel, Children’s
Hospital Oakland Research Institute, USA.
4. Iron biomarkers. Sean Lynch, Leader of BOND Iron expert panel, Eastern
Virginia Medical School, USA.
10:55-11:10 Discussion
Plenary Session: Oral Papers Presentations: TOPIC 1: N utrigenomics and
11:15- 11:55 chronic diseases such as obesity, diabetes, cancer, cardiovascular disease,
metabolic syndrome, and Alzheimer.
1.- Combined effect of genetic polymorphisms related to lipid metabolism and
lifestyle on the risk factors for chronic diseases in adolescents . Emilia Alonso
Balthazar, Fcfar Araraquara, Food and Nutrition Department, Universidad Estatal de
Sao Paulo, Brazil.
2.- Role of Low Salt-based Personalized Nutrition in Moving “Gate” for Prevention of
Cardiovascular Diseases Backward. Lin He , Shanghai Genome Pilot Institutes for
Genomics and Human Health. Bio-X Institutes. Shanghai Jiao Tong University, China.
(Acceptance to be confirmed)
11:55-12:05 Discussion

3. 12:10 - 12:40 Plenary Lecture 02
Programa de tamizaje neonatal en Costa Rica (National Newborn Screening
Program) y la dieta de niños con Fenilcetonuria. Carlos de Céspedes, Consultor en
Genética y Metabolismo del Hospital Nacional de Niños, Costa Rica (Consultant
Genetics and Metabolism).
12:45– 14:15 Lunch and poster viewing
14:20 - 15:05 Plenary Lecture 03
Merging personalized nutrition, medicine and health. Ben van Ommen, TNO,
The Netherlands.
Chair: Patricia Cuenca, Directora INISA - Universidad de Costa Rica
15:05-15:15 Questions
15:20 - 16:05 Plenary Lecture 04
The impact of the genomic views on cholesterol and vitamin D sensors on
personalized nutrition. Carsten Carlberg, School of Medicine and Institute of
Biomedicine, University of Eastern Finland (Finland).
Chair: Georgina Gómez, Escuela de Medicina - Universidad de Costa Rica
16:05- 16:15 Questions
16:20-16:40 Coffee Break and poster viewing
Symposium 02 - Micronutrients Genomics Project
16:45-18:45 Chair: Michael Fenech
Co - Chair: Carolina Santamaría, INISA - Universidad de Costa Rica
1. Overview of the Micronutrients Genomics Project.
Michael Fenech, CSIRO, Australia.
2. Zinc as an exemplar of micronutrient-gene interactions.
Giuditta Perozzi, National Research Institute on Food and Nutrition
(I.N.R.A.N.). Rome, Italy.
3. Vitamin D as an exemplar of micronutrient-gene interactions.
Lucia Regina Ribeiro, State University of São Paulo, SP, Brazil.
4. Using biological network approaches for dynamic extension of
micronutrient related pathways with regulatory information.
Chris Evelo, Maastricht University,The Netherlands.
18:45 -18:55 Discussion

4. 19:00 - 21:30 Activity to be defined
WEDNESDAY, OCTOBER 3rd, 2012
08:30- 09:15 Plenary Lecture 05
Nutrigenomics of the two hits: non-resolving metabolic and pro-inflammatory
stress. Michael Müller, Netherlands Nutrigenomics Centre, Wageningen
Universityn The Netherlands.
Chair: Silvia Quesada, Escuela de Medicina, Universidad de Costa Rica
9:15-9:25 Questions
9:30 - 10:15 Plenary Lecture 06
Profiles of Health-Related Lipid Derivatives in Persea Cultivars. Rocío Díaz de la
Garza, Escuela de Biotecnología y Alimentos,Tecnológico de Monterrey, México.
Chair: Raquel Arriola, Escuela de Nutrición, Universidad de Costa Rica.
10:15-10:25 Questions
10:30- 10:50 Coffee Break and poster viewing
Plenary Session: Oral Papers Presentations: Continuation : TOPIC 1:
09:50 - 10:50 Nutrigenomics and chronic diseases such as obesity, diabetes, cancer,
cardiovascular disease, metabolic syndrome, and Alzheimer.
3.- Coffee consumption, polymorphisms in GSTM1, GSTT1 and cutaneous melanoma
risk. Cristina Fortes, Istituto Dermopatico Dell’ Immacolata, IDI-IRCSS, Italia.
4.- Effects of environmental factors risk and genetic risk in the excess weight in
young . Claudia María Velásquez, Universidad de Antioquia, Medellín, Colombia.
5.- Gut microbiota of healthy human adults according to body mass index: a pilot
study , Gloria María Agudelo Ochoa, Centro de Investigación Vidarium, Colombia.
10:50 -11:05 Discussion
11:10 - 11:55 Plenary Lecture 07
Nutrients and epigenetics. Thomas Prates Ong, São Paulo University, Brazil.
Chair: Ernesto Vargas, Escuela de Medicina, Universidad de Costa Rica

5. 11:55-12:05 Questions
12:05– 13:35 Lunch and poster viewing
13:40 - 14:20 Plenary Session: Oral Papers Presentations: Continuation , TOPIC 1:
Nutrigenomics and chronic diseases such as obesity, diabetes, cancer,
cardiovascular disease, metabolic syndrome, and Alzheimer.
6.- Resveratrol inhibits functional expression of voltage-gated sodium channels Nav
1.5 in human breast cancer cell line MDA-MB 231: activity-dependent negative
feedback and cellular migration. Eduardo Monjaraz , Instituto de Fisiología,
Benemérita Universidad Autónoma de Puebla, México.
7- Association of genetic factors and their relationship with the overweight.
Angélica Muñoz , Universidad de Antioquia Colombia.
14:20-14:30 Discussion
14:35 - 15:20 Plenary Lecture 08
“From maize to tortilla: Example of nutraceutical complexity in functional foods.”
Janet Gutiérrez-Uribe .
Escuela de Biotecnología y Alimentos, Tecnológico de Monterrey, México.
Chair: Melissa Vásquez, INISA - Universidad de Costa Rica.
15:20-15:30 Questions
15:35 - 15:55 Coffee Break and poster viewing
16:00- 16:40 Plenary Session: Oral Papers Presentations: TOPIC 6: Functional Foods
1.- Colonic microflora and the bioconversion of ellagitannins from tropical highland
blackberries into bioactive molecules. Cristina García, Corporación Colombiana de
Investigación Agropecuaria, CORPOICA, Colombia.
2.- Antioxidant and anti-inflammatory activities of a blackberry (Rubus adenotrichos)
phenolic extract. Gabriela Azofeifa , Universidad de Costa Rica, Costa Rica.
16:40-16:50 Questions

6. Symposium 03 - Functional Foods
17:00 - 18:30 Chair: Silvia M. F. Cozzolino, São Paulo University, Brazil.
Co - Chair: Ernesto Vargas, Escuela de Medicina, U.C.R.
1. Introduction . Silvia M. F. Cozzolino, São Paulo University, Brazil.
2. Targeting the epigenome with functional foods bioactive compounds for
cancer prevention. Thomas Prates Ong, São Paulo University, Brazil.
3. Brazilian nuts as a promising selenium-containing functional food:
implications for health and disease. Silvia M. F. Cozzolino, São Paulo
University, Brazil.
18:30-18:45 Discussion
18:45-19:45 Drink and Think: Poster Viewing and Wine Tasting
Wine provided by: Gadol Gibor S.A Importations representatives of Agriverde Winery from
Abruzzo, Italy.
THURSDAY, OCTOBER 4 th , 2012.
Symposium 04 - The Gut as Gatekeeper
Chair: Michael Müller, Wageningen University, The Netherlands.
08:30 – 10:00 Co - Chair: Carolina Santamaría, INISA - Universidad de Costa Rica
1. The use of nutrigenomics to explore the impact of the intestine for
metabolic homeostasis. Michael Müller, Wageningen University, The
Netherlands.
2. Microbiota facilitates dietary heme-induced epithelial hyperproliferation
and hyperplasia by breaking the mucus barrier. Noortje Ijssennagger ,
Wageningen University, The Netherlands.
3. Assembling the mosaic of host and microbiota metabolism in health and
disease. Sunil Kochhar, Metabolomics and Biomarkers, Department of
BioAnalytial sciences, Nestlé Research Center, Lausanne, Switzerland.
10:00-10:10 Discussion
10:15 - 10:35 Coffee Break and poster viewing
Symposium 05 - Metabolomics: Biomarkers for health and disease
10:40– 11:40 Chair: Lars Ove Dragsted, University of Copenhagen, Denmark.
Co - Chair: Lúcia Ribeiro
1. Metabolomics in cohort studies – exploring biomarkers and predictions.
Lars Ove Dragsted , University of Copenhagen, Denmark

7. 2. The potential of metabolome-wide association studies and metabolic
profiling in epidemiology . Elaine Holmes, Imperial College, London, United
Kingdom.
11:40-11:50 Discussion
11:55 – 12:40 Plenary Lecture 09
You are what you eat - the impact of nutrition on health and phenotype
plasticity. Michael Müller, Netherlands Nutrigenomics Centre, Wageningen
University, The Netherlands.
Chair: Rocío Díaz de la Garza, Tecnológico de Monterrey, México.
12:40-12:50 Questions
12:55 -14:25 Lunch and poster viewing
14:30 – 15:15 Plenary Lecture 10
Tocotrienols: from antioxidants to receptor ligands. Fabio Virgili, National
Research Institute on Food and Nutrition (I.N.R.A.N.). Rome, Italy.
Chair: Janet Gutiérrez-Uribe, Tecnológico de Monterrey, México.
15:15-15:25 Questions
15:30 - 15:45 Coffee Break and poster viewing
15:50 -16:35 Closing Plenary Lecture (Lecture 11)
Combining Scientific Knowledge on Environment-Gene Interaction to Optimize
Human Health. Michel Fenech, CSIRO Food and Nutritional Sciences,
Australia.
Chair: Patricia Cuenca, INISA - Universidad de Costa Rica
16:40-17:00 Closing Ceremony
17:00 -17:30 Delivery of Participation Certificates
Poster Papers - Presentations
TOPIC 1: Nutrigenomics and chronic diseases such as obesity, diabetes,
cancer, cardiovascular disease, metabolic syndrome, and Alzheimer.

8. (043) Integrative Analysis Between Type 2 Diabetes and Obesity Microarray Data and
Probiotic Intake.
Olimpia Rodríguez León, Universidad Iberoamericana León, México.
(045) Lipidomic profiles in healthy objectives after intake of oxidized or non oxdized
fish oil.
Astrid Nilsson , Nofima Norwegian Insttute of Food, Fisheries and Aquaculture
Research, Norway.
(046) Integrative Analysis Associated with Cardiovascular Disease and Omega 3-6
Intake.
Jessica Paulina Martínez Solís , Universidad Iberoamericana León, México.
(052) DNA damage and genetic polymorphisms in brazilian morbid obese women.
Danielle Almeida , São Paulo State University, Brazil.
(054) FTO gene polymorphisms and DNA damage in obese and healthy Brazilian
women.
Bruno Luperini , São Paulo State University, Brazil.
(056) The role of nutrigenomics in gene expression microarray of breast cancer and
selenium intake.
Santiago Alférez Rayas , Universidad Iberoamericana León, México.
(057) Changes in gene expression profiles of PPARα target genes in obese individuals
during fasting.
Lucia Regina Ribeiro , Universidade Estadual Paulista “Julio de Mesquira Filho,
UNESP, SP, Brazil.
(058) Vitamin D levels associated with indicators of metabolic syndrome in Brazilian
population .
Lucia Regina Ribeiro , Universidade Estadual Paulista “Julio de Mesquira Filho,
UNESP, SP, Brazil.
(060) Evaluation of the antitumor activity of naturally occurring and synthetic
retinoids in primary gastric cancer cells and gastric cancer cells from a liver
metastasis.
Natalia Ortíz, Universidad de Costa Rica, Costa Rica.
(068) Pro12ala polymorphism PPARγ 2 gene associated with food intake and body
mass index.
Susana Siewert, Universidad Nacional de San Luis , Argentina.

9. (070) Isocaloric high-fat diet induces insulin resistance in rats.
Tatiane Mieko de Meneses Fujii, Department of Nutrition, School of Public Health,
São Paulo University, Brazil.
(071) Isocaloric intake of high-fat diet impaired metabolic profile in rats.
Tatiane Mieko de Meneses Fujii , Department of Nutrition, School of Public Health,
São Paulo University, Brazil.
(074) Análisis proteómico en tejido adiposo del efecto de los ácidos grasos omega 3
en un modelo con síndrome metabólico inducido por la dieta. Lyssia Castellanos
Tapia, México.
TOPIC 2: The impact of Nutrigenomics on biomarkers of health and disease
(039) Multipronged approach in nutrigenomics guarantees better suppression
of oxidative stress in diethylnitrosamine-initiated rat hepatocarcinogenesis:
Experimental evaluation of individual and synergistic adminidtration of
Resveratrol, Sulforaphane and Guggulsterone in diethylnitrosamine-initiated
rat hepatocarcinogenesis. Ammad Farooqi , Laboratory for Translational
Oncology and Personalized Medicine, Pakistan.
TOPIC 3: Personalized medicine and nutrition
(064) Interdisciplinary, Investigative and Educational Programme for the
comprehensive management of patients diagnosed with Type 2 Diabetes Mellitus .
Santa Rosa Hospital in Tenjo.
Doris Amanda Ramirez de Peña , -Universidad Nacional de Colombia,
Facultad de Medicina, Colombia.
TOPIC 6: Funtional Foods
(059) Approaching to metabolic pathway of urolithin production from blackberry
juice .
Cristina García , Corporación Colombiana de Investigación Agropecuaria, Colombia.
(069) Changes in Profiles of Folates, Carotenoids and Ascorbic Acid during Ripening of
Papaya Fruit (Carica papaya cv. Maradol).
Carmen Hernández Brenes , Tecnológico de Monterrey, México.
* This is a Preliminary Version of the Agenda; it will be subject to changes