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Health care
M&A snapshot
Grant Thornton Corporate Finance July 2012




Reviewing the 2011
health care industry
A dynamic climate                                                        The other major ruling partially upheld the Medicaid
The past year has been exciting for health care M&A, with            expansion under the PPACA. However, the penalty clause that
approximately 1,250 transactions reported during 2011 in a           allowed the federal government to withhold all Medicaid funds
nearly 10% increase from 2010, making it one of the most active      from states refusing to comply with the expansion was struck
deal markets in history. Issues such as health care reform, rising   down. Compliance with the new Medicaid eligibility standards
costs of care, expiring patents and the move toward digital          will now be decided on a state-by-state basis.
health records are fueling a lively deal market and have powered         While some of the significant provisions in the PPACA do
significant M&A activity. The aging of the U.S. population is        not take effect until 2014, the act has certainly influenced the
another issue with widespread implications, though its impact        M&A markets. Compliance cost concerns have driven many small
tends to be a secondary factor in M&A trends. In the next few        organizations to consider selling to larger rivals, and we expect
pages, we will delve into some of these issues, highlighting their   this trend to continue. As the ultimate impact of the legislation
impact on the deal market and commenting on how future               unfolds, M&A will play a key role as businesses take advantage
M&A trends might be affected.                                        of new opportunities and attempt to mitigate new risk factors.
                                                                                                                            continued >
The Patient Protection and Affordable Care Act
The Patient Protection and Affordable Care Act (PPACA),
signed into law on March 23, 2010, requires major changes to
current health care legislation. The Supreme Court held the
individual mandate, one of the most controversial aspects of the
law and one of the major areas under consideration by the
court, valid under the taxing power of the U.S. Congress.
Widespread cost pressure                                                                        One other notable recent development is the FTC’s recent
Softening revenues and rising costs throughout the health care                             ruling that ProMedica Health System’s August 2010 acquisition
industry have put many smaller or less well-capitalized providers                          of rival St. Luke’s Hospital was likely to substantially lessen
under significant financial stress. Many of these facilities face                          competition and increase prices for general acute care and
the stark choice of either joining a larger organization or risking                        obstetric inpatient hospital services sold to commercial health
financial distress on their own. In some cases, facilities that chose                      plans in the Toledo, Ohio, area. The ruling calls for ProMedica
to weather the storm ended up in bankruptcy, with either a sale                            to unwind the transaction by selling St. Luke’s Hospital and
or closure as the ultimate outcome.                                                        supporting the transition to a new qualified owner. Whether
                                                                                           this ruling signals a trend in FTC action or a one-time event,
Health care facility M&A/bankruptcy                                                        operators on either side of an M&A transaction need to be
Hospitals and other health care entities have felt significant                             aware of the competitive environment and take steps to address
effects from both increased costs and decreased revenues due to                            potential FTC concerns proactively.
a combination of reimbursement rate pressure and collections                                    Further, in a somewhat less well publicized decision, the
issues. In response, health care facility M&A activity has risen                           Supreme Court agreed to hear a case involving the acquisition
markedly as providers seek to take advantage of economies of                               of Palmyra Medical Center (PMC) by the Hospital Authority
scale by acquiring smaller or less well-capitalized organizations.                         of Albany-Dougherty County (Georgia). As a state-run entity,
    The number of health care facility M&A transactions                                    acquisitions by the Authority are currently immune to FTC
increased 32% in 2011, as hospitals, clinics and other medical                             oversight. By agreeing to hear the case, the Supreme Court will
facilities combined in order to address financial and strategic                            set law on whether the FTC can intervene when a state-created
concerns. Deal value declined by 11% from $15 billion to                                   entity is involved, potentially leading to expanded oversight
$13.3 billion as a result of two sizable deals in 2011: Ventas’                            authority for the agency.
acquisition of Atria Senior Living for $3.1 billion and Universal
Health Services’ purchase of Psychiatric Solutions for more than                           Insurers quietly buying medical practices
$3 billion. Excluding the impact of these two transactions, deal                           Insurers have a vested interest in controlling costs, and some
value increased 52% in 2011.                                                               carriers are experimenting with acquiring physician groups in an
    Going forward, health care facility M&A activity is likely                             attempt to align doctors’ incentives with their own. The concept
to remain active. Despite the slight uptick in the U.S. economy,                           is straightforward: A private physician group is financially
cost pressure will continue to affect health care facilities and fuel                      motivated to maximize billings by performing large numbers
M&A transactions. While the PPACA is intended to address                                   of medically justified tests and procedures, while a group owned
some of these issues, its ultimate effects are still in question.                          by an insurer can have an incentive structure that is focused
                                                                                           on minimizing the use of diagnostic tests, albeit in a medically
Health care facility M&A activity                                                          responsible way. Many people believe there is a gap between
                                                                                           what patients actually need in terms of tests and what doctors
    Number of transactions
    Deal value ($B)                                                                        often order. They believe bringing patient care under the same
    Deal value ($B)*                                                                       corporate umbrella as insurance can help close that gap and
                                                                                           stem rising health care costs. Further, certain provisions of the
Number of                                                                     Deal value
transactions                                                                        ($B)   PPACA have invigorated this trend and will likely continue to
400                                                                                $30     fuel M&A in this area.
                                                                                                Recent examples of insurers buying physician practices and
                                                                                   $25     hospitals include the following:
300                                                                                        •	 UnitedHealth Group (NYSE: UNH), a health insurance
                                                                                   $20          company, acquired Monarch, an association of physicians in
                                                                                                private practice in California, during 2011.
200                                                                                $15
                                                                                           •	 In August 2011, WellPoint (NYSE: WLP), a $60 billion
                                                                                                health benefits company, closed on its acquisition of
                                                                                   $10
100
                                                                                                CareMore Health Group, a senior medical group and
                                                                                   $5           health plan provider.
                                                                                                                                                   continued >

          2007            2008           2009            2010           2011

* Discounts two transactions that transpired in 2010
Sources: GTCF research; certain financial information provided by S&P Capital IQ




2 Health care M&A snapshot June 2012
In what is perhaps an even bolder move, an east coast-
based, independent licensee of the Blue Cross and Blue Shield
Association, announced its intent in 2011 to purchase a large
regional hospital system comprised of a financially distressed
operator of five hospitals.
    There are factors that might reverse this trend, however.
The prospect of changing the incentive structure for physicians
raises legitimate concerns about the quality of care. Patients
don’t want cost to their insurer to be a factor in determining
their treatment. If insurers can convince consumers that the
current standards of care will be preserved and the expected
cost savings actually materialize, the acquisition trend might
continue; however, if patients resist these practices or costs do
not decline as expected, insurers may abandon this strategy.
    Cost pressure on insurers, care providers and other entities
in the health care space is an ongoing issue that is exacerbated
by the aging of the U.S. population (although the additional
care associated with the aging of the boomers presents revenue
opportunities). This is also a political hot-button issue, with                                       2011, recently acquired King Pharmaceuticals, a specialty
widespread disagreement as to both causes and potential                                               pharmaceutical discovery and clinical development company, for
solutions. In the near term, it appears that costs will continue to                                   $3.6 billion in cash. Pfizer believes the acquisition diversifies its
increase, contributing to, among other things, strong incentives                                      product revenue and expands its presence in pain management.
for companies to seek efficiencies and strategic partnerships                                             Another example is the Sanofi-Aventis acquisition of U.S.
through M&A activity.                                                                                 biotechnology company Genzyme for almost $20 billion. The
                                                                                                      deal is intended to help Sanofi rebuild its pipeline given its loss of
The patent cliff                                                                                      patent protection on Lovenox in 2010 and its loss of protection
Pharmaceutical companies also face substantial strategic and                                          on Plavix in 2012.
financial challenges in the current market. For example, nine of                                          While this patent cliff is a somewhat extraordinary event, the
the top 10 best-selling drugs have lost or are scheduled to lose                                      motivation for M&A in the pharmaceutical sector remains strong
patent protection in the next five to six years — a time period                                       because of the tremendous investment in R&D needed to bring
often referred to as the patent cliff. In response, pharmaceutical                                    a single drug to market. If they are acquired, smaller R&D firms
companies have stepped up R&D and implemented cost-                                                   with promising drugs can often recoup some of their investment
efficiency programs. Further, many companies are embracing                                            and better the chances that their drug will make it through the
M&A as a way to supplement R&D during their quest for the                                             onerous approval process. Likewise, larger companies with the
next lucrative drug.                                                                                  capital to pursue acquisitions invest heavily in their courtship of
    For example, Pfizer, which lost exclusivity on the underlying                                     up-and-coming firms. Given today’s economic pressures,
formula for Lipitor in the United States during November                                              we expect this trend to continue.
                                                                                                                                                                  continued >

Top 10 drugs for 2010 by U.S. sales

                                                                                                                          2010 U.S. product
  Rank                    Drug                            Treatments                             Marketers                                            U.S. patent expiry
                                                                                                                            sales ($MM)
     1                  Plavix                             Blood clots                Bristol-Myers Squibb + Sanofi            $6,154                       2012
     2                  Lipitor                            Cholesterol                             Pfizer                      $5,329                       2011
     3              Seretide/Advair                          Asthma                           GlaxoSmithKline                  $4,026                       2016
     4                 Seroquel                         Mental disorders                       AstraZeneca                     $3,747                       2012
     5              Epogen/Procrit                           Anemia                   Amgen + Johnson & Johnson                $3,594                       2013
     6                  Actos                               Diabetes                              Takeda                       $3,582                       2012
     7                  Abilify                         Mental disorders              Otsuka + Bristol-Myers Squibb            $3,348                       2015
     8                  Enbrel                         Arthritis/ psoriasis                   Amgen + Pfizer                   $3,304                       2028*
     9                 Singulair                        Asthma/allergies                       Merck & Co.                     $3,219                       2012
    10                Remicade                         Arthritis/ psoriasis                Johnson & Johnson                   $3,088                       2018

* Enbrel was originally set to expire in 2012 in the U.S., but it has been extended for another 16 years.
Source: EvaluatePharma




3 Health care M&A snapshot June 2012
Electronic health records
                                                                       U.S. target announced health care information technology M&A
Digitization of health records has been accelerating for a number
of years as providers throughout the health care sector have               Number of transactions
                                                                           Deal value ($B)
sought ways to offer more efficient and effective care while
maximizing the benefits to the patient and minimizing risk             Number of                                                                     Deal value
                                                                       transactions                                                                        ($B)
associated with incomplete medical records. In response, the
health information technology (HIT) industry is expanding              125                                                                                     $7

significantly as competitors vie to provide new applications                                                                                                   $6
within the lucrative and growing health care market. M&A               100
activity has been a natural mode of competition, allowing                                                                                                      $5
companies to secure new technologies and capture additional             75
                                                                                                                                                               $4
market share.
    Further, the American Recovery and Reinvestment Act                 50
                                                                                                                                                               $3
of 2009, commonly known as the stimulus bill, includes
                                                                                                                                                               $2
approximately $27 billion in incentives for eligible institutions
                                                                        25
(including hospitals) that install and “meaningfully use”                                                                                                      $1
electronic health records (EHR). These federal subsidy payments
commenced in 2011 and diminish in each subsequent year until                      2007            2008            2009            2010             2011
2015, when providers start facing penalties for noncompliance.
                                                                       Sources: GTCF research; certain financial information provided by S&P Capital IQ
While the inclusion of funds was in response to underlying care
and economic factors, the stimulus money is driving increased
growth in the HIT sector and fueling expanded M&A activity.
    As depicted in the chart to the right, the number of
U.S.-based HIT M&A transactions rose by almost 7% in 2011,
while deal value increased 72%. The dramatic rise in value
was partially due to the acquisition of Emdeon by private              U.S. target announced health care M&A activity
equity firms Blackstone Capital and Hellman & Friedman for
                                                                           Number of transactions
nearly $3.5 billion. Emdeon offers payment cycle and revenue
                                                                           Disclosed deal value ($B)
management solutions to thousands of providers and payers                  Disclosed deal value ($B)*
within the U.S. health care system.
                                                                       Number of                                                                         Deal value
    Continued M&A activity is expected in this market as
                                                                       transactions                                                                            ($B)
technology quickly evolves to provide better, faster access to
                                                                       1400                                                                                      $250
patient records across a broader spectrum of care providers.
                                                                       1200
                                                                                                                                                                 $200
Trends in the metrics
                                                                       1000
M&A activity
The number of U.S.-based health care M&A transactions rose                                                                                                       $150
                                                                        800
nearly 10% — from 1,141 transactions in 2010 to 1,248 in
                                                                        600
2011 — which is not surprising given the improved economic                                                                                                       $100
outlook and credit markets. Deal value increased more                   400
significantly, rising almost 43% from $118 billion in 2010 to                                                                                                    $50
$170 billion in 2011; this amount exceeded 16% of total M&A             200

value in the United States for the year. Taking a closer look at
deals from an industry subsegment perspective, we see a sharp                     2005       2006      2007       2008       2009       2010       2011
uptick in the number of health care facility transactions over the     * Excludes two mega deals: Pfizer’s acquisition of Wyeth and Merck’s purchase of Schering-Plough
past two years.                                                        Sources: GTCF research; certain financial information provided by S&P Capital IQ

                                                         continued >




4 Health care M&A snapshot June 2012
U.S. target announced health care M&A activity by segment (Number of U.S. transactions)

    2009                      2010                      2011


Pharmaceuticals/
biotechnologies


Health care facilities/
providers


Health care information
technology


Health care
intermediaries


Health insurance
companies


                               0                       100                         200               300                400               500                 600

Sources: GTCF research; certain financial information provided by S&P Capital IQ


    Notable transactions announced in 2011 include                                            •	 In April 2011, Johnson & Johnson (NYSE: JNJ) announced
the following:                                                                                   its intent to acquire Synthes Inc. (SWX: SYST.VX),
•	 Express Scripts Holding Company (Nasdaq: ESRX)                                                a medical device company, for approximately $20 billion.
    acquired Medco Health Solutions for $33 billion. This deal                                   The combined company would have greater product
    closed despite months of lobbying by pharmacy benefit                                        development capabilities and a stronger global reach.
    managers who believed the merger would create a monopoly.                                    Moreover, Johnson & Johnson would gain a significant share
    The deal was ultimately approved because representatives                                     of the trauma device market. The deal closed on June 14, 2012.
    from both sides of the deal convinced the FTC that the
    merger would create efficiencies, allowing the combined                                   Public company performance
    company to drive down consumer costs. This deal closed                                    The Grant Thornton Corporate Finance LLC (GTCF)
    in April 2012.                                                                            Health Care Index reflects data from health care participants
                                                                                              that are broadly categorized as pharmaceuticals/biotechnologies;
Grant Thornton Corporate Finance health care index                                            facilities; HIT; intermediaries (e.g., distributors, equipment and
                                                                                              supply manufacturers, service providers); and health insurance
    Pharmaceuticals/biotechnologies                Health insurance companies
    Health care intermediaries                     Heath care information technology          companies. Reviewing the relative performance of these
    Health care facilities/providers               S&P                                        companies against a benchmark, such as the S&P 500, can provide
                                                                                              insight into how the industry is perceived by well-informed
200%
                                                                                              investors and what is expected in terms of future performance.
175%                                                                                              The public market information indicates that all indices
                                                                                              have generally increased since March 2009, with the HIT index
150%
                                                                                              growing at the strongest pace. The only index that has consistently
125%                                                                                          underperformed the S&P 500 is the insurance sector. However, as
100%                                                                                          shown at left, it has recently started to perform on par with (and
                                                                                              even outperform) the broader market. Going forward, this sector
 75%
                                                                                              will likely gain momentum. Corporate Research Group estimates
 50%                                                                                          steady profit growth of 8% for the insurance sector over the next
 25%                                                                                          year in its Outlook for Managed Care 2012 report. Managed
                                                                                              care is an important driver of the overall health insurance market
   Dec–07              Dec–08              Dec–09               Dec–10              Dec–11    because a majority of people with private health insurance are
                                                                                              covered by a preferred provider organization (PPO) or health
Sources: Public company filings; certain financial information provided by S&P Capital IQ     maintenance organization (HMO) plan.
Note: The GTCF health care index reflects the average stock price for all companies in each
category relative to 12/31/07.                                                                                                                         continued >


5 Health care M&A snapshot June 2012
Average metrics

                                                             % of 52 week high                 Enterprise value ($mm)                     LTM EBITDA %                        LTM EV/EBITDA
Pharmaceuticals/biotechnologies                                    87.7%                               $49,203                               32.1%                                 8.6x
Health care facilities/providers                                   62.3%                                $5,653                                8.9%                                 6.2x
Health care information technology                                 73.2%                                $3,638                               20.7%                                17.9x
Health care intermediaries                                         69.6%                                $8,331                               15.7%                                 9.4x
Health insurance companies                                         82.9%                               $10,784                                6.9%                                 5.7x
Average                                                            75.2%                              $15,522                                16.8%                                 9.6x

As of 12/31/2011
Sources: Public company filings; certain financial information provided by S&P Capital IQ



    As shown in the chart above, EBITDA multiples averaged                                                 M&A can offer buyers and sellers a quick way to capture
9.6x at the end of 2011. Of the five health care segments GTCF                                         additional market share, secure a new technology or patent,
has identified, HIT companies were trading at the highest                                              or create economies of scale that set them apart from
multiple — almost 18x.                                                                                 competitors. Furthermore, fundamental challenges in the
                                                                                                       industry suggest that significant changes must occur. Whether
Conclusion                                                                                             because of insurers seeking new business models that align
Health care remains one of the bright spots in today’s economy,                                        incentives, pharmaceutical companies looking for additional
with strong performance across many segments. Rising costs                                             financial backing as they chase the next big-money drug,
continue to plague the industry, and while measures are being                                          hospitals balancing the desire to maintain their independence
taken at the company, sector and federal levels to address this                                        against the prospect (or reality) of budgetary distress, or
issue, cost pressure will remain problematic for at least                                              HIT companies acquiring market share and technologies to
the near term. Politics aside, health care companies that wish                                         meet evolving demand, M&A will continue to play a crucial role
to stay in business must not only figure out how to mitigate                                           in this dynamic sector.
the impact of rising costs, but also find ways to benefit from
changes in the industry.




 Contact information

 Erik Egerer
 Manager, Grant Thornton
 Corporate Finance
 T 248.213.4227
 E erik.egerer@us.gt.com

 Nisha Raghava
 Senior Associate, Grant Thornton
 Corporate Finance
 T 248.215.6029
 E nisha.raghava@us.gt.com



About Grant Thornton Corporate Finance LLC
Grant Thornton Corporate Finance LLC provides boutique investment banking services to privately held middle-market businesses in the United States and around the world. As a recognized advisor
on middle-market mergers and acquisitions, we offer a range of investment banking services including sell-side advisory, buy-side advisory, management buyouts, restructurings and capital raising.
Grant Thornton LLP provides investment banking services through its wholly owned broker-dealer subsidiary Grant Thornton Corporate Finance LLC, member FINRA, SIPC.

About Grant Thornton LLP
The people in the independent firms of Grant Thornton International Ltd provide personalized attention and the highest-quality service to public and private clients in more than 100 countries.
Grant Thornton LLP is the U.S. member firm of Grant Thornton International Ltd, one of the six global audit, tax and advisory organizations. Grant Thornton International Ltd and its member firms are not
a worldwide partnership, as each member firm is a separate and distinct legal entity.

The factual statements and data from third-party sources contained herein are taken from sources believed to be reliable, but such statements are made without representation as to accuracy or
completeness or otherwise. Grant Thornton Corporate Finance LLC does not engage in the business of recommending or effecting transactions in securities. The above information is presented
solely in connection with describing Grant Thornton Corporate Finance LLC’s mergers and acquisitions services, and should not be considered as constituting a research report or as providing
information reasonably sufficient upon which to base an investment decision.

© 2012 Grant Thornton LLP All rights reserved U.S. member firm of Grant Thornton International Ltd




6 Health care M&A snapshot June 2012

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Grant Thornton - Healthcare M&A Snapshot 2012

  • 1. Health care M&A snapshot Grant Thornton Corporate Finance July 2012 Reviewing the 2011 health care industry A dynamic climate The other major ruling partially upheld the Medicaid The past year has been exciting for health care M&A, with expansion under the PPACA. However, the penalty clause that approximately 1,250 transactions reported during 2011 in a allowed the federal government to withhold all Medicaid funds nearly 10% increase from 2010, making it one of the most active from states refusing to comply with the expansion was struck deal markets in history. Issues such as health care reform, rising down. Compliance with the new Medicaid eligibility standards costs of care, expiring patents and the move toward digital will now be decided on a state-by-state basis. health records are fueling a lively deal market and have powered While some of the significant provisions in the PPACA do significant M&A activity. The aging of the U.S. population is not take effect until 2014, the act has certainly influenced the another issue with widespread implications, though its impact M&A markets. Compliance cost concerns have driven many small tends to be a secondary factor in M&A trends. In the next few organizations to consider selling to larger rivals, and we expect pages, we will delve into some of these issues, highlighting their this trend to continue. As the ultimate impact of the legislation impact on the deal market and commenting on how future unfolds, M&A will play a key role as businesses take advantage M&A trends might be affected. of new opportunities and attempt to mitigate new risk factors. continued > The Patient Protection and Affordable Care Act The Patient Protection and Affordable Care Act (PPACA), signed into law on March 23, 2010, requires major changes to current health care legislation. The Supreme Court held the individual mandate, one of the most controversial aspects of the law and one of the major areas under consideration by the court, valid under the taxing power of the U.S. Congress.
  • 2. Widespread cost pressure One other notable recent development is the FTC’s recent Softening revenues and rising costs throughout the health care ruling that ProMedica Health System’s August 2010 acquisition industry have put many smaller or less well-capitalized providers of rival St. Luke’s Hospital was likely to substantially lessen under significant financial stress. Many of these facilities face competition and increase prices for general acute care and the stark choice of either joining a larger organization or risking obstetric inpatient hospital services sold to commercial health financial distress on their own. In some cases, facilities that chose plans in the Toledo, Ohio, area. The ruling calls for ProMedica to weather the storm ended up in bankruptcy, with either a sale to unwind the transaction by selling St. Luke’s Hospital and or closure as the ultimate outcome. supporting the transition to a new qualified owner. Whether this ruling signals a trend in FTC action or a one-time event, Health care facility M&A/bankruptcy operators on either side of an M&A transaction need to be Hospitals and other health care entities have felt significant aware of the competitive environment and take steps to address effects from both increased costs and decreased revenues due to potential FTC concerns proactively. a combination of reimbursement rate pressure and collections Further, in a somewhat less well publicized decision, the issues. In response, health care facility M&A activity has risen Supreme Court agreed to hear a case involving the acquisition markedly as providers seek to take advantage of economies of of Palmyra Medical Center (PMC) by the Hospital Authority scale by acquiring smaller or less well-capitalized organizations. of Albany-Dougherty County (Georgia). As a state-run entity, The number of health care facility M&A transactions acquisitions by the Authority are currently immune to FTC increased 32% in 2011, as hospitals, clinics and other medical oversight. By agreeing to hear the case, the Supreme Court will facilities combined in order to address financial and strategic set law on whether the FTC can intervene when a state-created concerns. Deal value declined by 11% from $15 billion to entity is involved, potentially leading to expanded oversight $13.3 billion as a result of two sizable deals in 2011: Ventas’ authority for the agency. acquisition of Atria Senior Living for $3.1 billion and Universal Health Services’ purchase of Psychiatric Solutions for more than Insurers quietly buying medical practices $3 billion. Excluding the impact of these two transactions, deal Insurers have a vested interest in controlling costs, and some value increased 52% in 2011. carriers are experimenting with acquiring physician groups in an Going forward, health care facility M&A activity is likely attempt to align doctors’ incentives with their own. The concept to remain active. Despite the slight uptick in the U.S. economy, is straightforward: A private physician group is financially cost pressure will continue to affect health care facilities and fuel motivated to maximize billings by performing large numbers M&A transactions. While the PPACA is intended to address of medically justified tests and procedures, while a group owned some of these issues, its ultimate effects are still in question. by an insurer can have an incentive structure that is focused on minimizing the use of diagnostic tests, albeit in a medically Health care facility M&A activity responsible way. Many people believe there is a gap between what patients actually need in terms of tests and what doctors Number of transactions Deal value ($B) often order. They believe bringing patient care under the same Deal value ($B)* corporate umbrella as insurance can help close that gap and stem rising health care costs. Further, certain provisions of the Number of Deal value transactions ($B) PPACA have invigorated this trend and will likely continue to 400 $30 fuel M&A in this area. Recent examples of insurers buying physician practices and $25 hospitals include the following: 300 • UnitedHealth Group (NYSE: UNH), a health insurance $20 company, acquired Monarch, an association of physicians in private practice in California, during 2011. 200 $15 • In August 2011, WellPoint (NYSE: WLP), a $60 billion health benefits company, closed on its acquisition of $10 100 CareMore Health Group, a senior medical group and $5 health plan provider. continued > 2007 2008 2009 2010 2011 * Discounts two transactions that transpired in 2010 Sources: GTCF research; certain financial information provided by S&P Capital IQ 2 Health care M&A snapshot June 2012
  • 3. In what is perhaps an even bolder move, an east coast- based, independent licensee of the Blue Cross and Blue Shield Association, announced its intent in 2011 to purchase a large regional hospital system comprised of a financially distressed operator of five hospitals. There are factors that might reverse this trend, however. The prospect of changing the incentive structure for physicians raises legitimate concerns about the quality of care. Patients don’t want cost to their insurer to be a factor in determining their treatment. If insurers can convince consumers that the current standards of care will be preserved and the expected cost savings actually materialize, the acquisition trend might continue; however, if patients resist these practices or costs do not decline as expected, insurers may abandon this strategy. Cost pressure on insurers, care providers and other entities in the health care space is an ongoing issue that is exacerbated by the aging of the U.S. population (although the additional care associated with the aging of the boomers presents revenue opportunities). This is also a political hot-button issue, with 2011, recently acquired King Pharmaceuticals, a specialty widespread disagreement as to both causes and potential pharmaceutical discovery and clinical development company, for solutions. In the near term, it appears that costs will continue to $3.6 billion in cash. Pfizer believes the acquisition diversifies its increase, contributing to, among other things, strong incentives product revenue and expands its presence in pain management. for companies to seek efficiencies and strategic partnerships Another example is the Sanofi-Aventis acquisition of U.S. through M&A activity. biotechnology company Genzyme for almost $20 billion. The deal is intended to help Sanofi rebuild its pipeline given its loss of The patent cliff patent protection on Lovenox in 2010 and its loss of protection Pharmaceutical companies also face substantial strategic and on Plavix in 2012. financial challenges in the current market. For example, nine of While this patent cliff is a somewhat extraordinary event, the the top 10 best-selling drugs have lost or are scheduled to lose motivation for M&A in the pharmaceutical sector remains strong patent protection in the next five to six years — a time period because of the tremendous investment in R&D needed to bring often referred to as the patent cliff. In response, pharmaceutical a single drug to market. If they are acquired, smaller R&D firms companies have stepped up R&D and implemented cost- with promising drugs can often recoup some of their investment efficiency programs. Further, many companies are embracing and better the chances that their drug will make it through the M&A as a way to supplement R&D during their quest for the onerous approval process. Likewise, larger companies with the next lucrative drug. capital to pursue acquisitions invest heavily in their courtship of For example, Pfizer, which lost exclusivity on the underlying up-and-coming firms. Given today’s economic pressures, formula for Lipitor in the United States during November we expect this trend to continue. continued > Top 10 drugs for 2010 by U.S. sales 2010 U.S. product Rank Drug Treatments Marketers U.S. patent expiry sales ($MM) 1 Plavix Blood clots Bristol-Myers Squibb + Sanofi $6,154 2012 2 Lipitor Cholesterol Pfizer $5,329 2011 3 Seretide/Advair Asthma GlaxoSmithKline $4,026 2016 4 Seroquel Mental disorders AstraZeneca $3,747 2012 5 Epogen/Procrit Anemia Amgen + Johnson & Johnson $3,594 2013 6 Actos Diabetes Takeda $3,582 2012 7 Abilify Mental disorders Otsuka + Bristol-Myers Squibb $3,348 2015 8 Enbrel Arthritis/ psoriasis Amgen + Pfizer $3,304 2028* 9 Singulair Asthma/allergies Merck & Co. $3,219 2012 10 Remicade Arthritis/ psoriasis Johnson & Johnson $3,088 2018 * Enbrel was originally set to expire in 2012 in the U.S., but it has been extended for another 16 years. Source: EvaluatePharma 3 Health care M&A snapshot June 2012
  • 4. Electronic health records U.S. target announced health care information technology M&A Digitization of health records has been accelerating for a number of years as providers throughout the health care sector have Number of transactions Deal value ($B) sought ways to offer more efficient and effective care while maximizing the benefits to the patient and minimizing risk Number of Deal value transactions ($B) associated with incomplete medical records. In response, the health information technology (HIT) industry is expanding 125 $7 significantly as competitors vie to provide new applications $6 within the lucrative and growing health care market. M&A 100 activity has been a natural mode of competition, allowing $5 companies to secure new technologies and capture additional 75 $4 market share. Further, the American Recovery and Reinvestment Act 50 $3 of 2009, commonly known as the stimulus bill, includes $2 approximately $27 billion in incentives for eligible institutions 25 (including hospitals) that install and “meaningfully use” $1 electronic health records (EHR). These federal subsidy payments commenced in 2011 and diminish in each subsequent year until 2007 2008 2009 2010 2011 2015, when providers start facing penalties for noncompliance. Sources: GTCF research; certain financial information provided by S&P Capital IQ While the inclusion of funds was in response to underlying care and economic factors, the stimulus money is driving increased growth in the HIT sector and fueling expanded M&A activity. As depicted in the chart to the right, the number of U.S.-based HIT M&A transactions rose by almost 7% in 2011, while deal value increased 72%. The dramatic rise in value was partially due to the acquisition of Emdeon by private U.S. target announced health care M&A activity equity firms Blackstone Capital and Hellman & Friedman for Number of transactions nearly $3.5 billion. Emdeon offers payment cycle and revenue Disclosed deal value ($B) management solutions to thousands of providers and payers Disclosed deal value ($B)* within the U.S. health care system. Number of Deal value Continued M&A activity is expected in this market as transactions ($B) technology quickly evolves to provide better, faster access to 1400 $250 patient records across a broader spectrum of care providers.   1200 $200 Trends in the metrics 1000 M&A activity The number of U.S.-based health care M&A transactions rose $150 800 nearly 10% — from 1,141 transactions in 2010 to 1,248 in 600 2011 — which is not surprising given the improved economic $100 outlook and credit markets. Deal value increased more 400 significantly, rising almost 43% from $118 billion in 2010 to $50 $170 billion in 2011; this amount exceeded 16% of total M&A 200 value in the United States for the year. Taking a closer look at deals from an industry subsegment perspective, we see a sharp 2005 2006 2007 2008 2009 2010 2011 uptick in the number of health care facility transactions over the * Excludes two mega deals: Pfizer’s acquisition of Wyeth and Merck’s purchase of Schering-Plough past two years. Sources: GTCF research; certain financial information provided by S&P Capital IQ continued > 4 Health care M&A snapshot June 2012
  • 5. U.S. target announced health care M&A activity by segment (Number of U.S. transactions) 2009 2010 2011 Pharmaceuticals/ biotechnologies Health care facilities/ providers Health care information technology Health care intermediaries Health insurance companies 0 100 200 300 400 500 600 Sources: GTCF research; certain financial information provided by S&P Capital IQ Notable transactions announced in 2011 include • In April 2011, Johnson & Johnson (NYSE: JNJ) announced the following: its intent to acquire Synthes Inc. (SWX: SYST.VX), • Express Scripts Holding Company (Nasdaq: ESRX) a medical device company, for approximately $20 billion. acquired Medco Health Solutions for $33 billion. This deal The combined company would have greater product closed despite months of lobbying by pharmacy benefit development capabilities and a stronger global reach. managers who believed the merger would create a monopoly. Moreover, Johnson & Johnson would gain a significant share The deal was ultimately approved because representatives of the trauma device market. The deal closed on June 14, 2012. from both sides of the deal convinced the FTC that the merger would create efficiencies, allowing the combined Public company performance company to drive down consumer costs. This deal closed The Grant Thornton Corporate Finance LLC (GTCF) in April 2012. Health Care Index reflects data from health care participants that are broadly categorized as pharmaceuticals/biotechnologies; Grant Thornton Corporate Finance health care index facilities; HIT; intermediaries (e.g., distributors, equipment and supply manufacturers, service providers); and health insurance Pharmaceuticals/biotechnologies Health insurance companies Health care intermediaries Heath care information technology companies. Reviewing the relative performance of these Health care facilities/providers S&P companies against a benchmark, such as the S&P 500, can provide insight into how the industry is perceived by well-informed 200% investors and what is expected in terms of future performance. 175% The public market information indicates that all indices have generally increased since March 2009, with the HIT index 150% growing at the strongest pace. The only index that has consistently 125% underperformed the S&P 500 is the insurance sector. However, as 100% shown at left, it has recently started to perform on par with (and even outperform) the broader market. Going forward, this sector 75% will likely gain momentum. Corporate Research Group estimates 50% steady profit growth of 8% for the insurance sector over the next 25% year in its Outlook for Managed Care 2012 report. Managed care is an important driver of the overall health insurance market Dec–07 Dec–08 Dec–09 Dec–10 Dec–11 because a majority of people with private health insurance are covered by a preferred provider organization (PPO) or health Sources: Public company filings; certain financial information provided by S&P Capital IQ maintenance organization (HMO) plan. Note: The GTCF health care index reflects the average stock price for all companies in each category relative to 12/31/07. continued > 5 Health care M&A snapshot June 2012
  • 6. Average metrics % of 52 week high Enterprise value ($mm) LTM EBITDA % LTM EV/EBITDA Pharmaceuticals/biotechnologies 87.7% $49,203 32.1% 8.6x Health care facilities/providers 62.3% $5,653 8.9% 6.2x Health care information technology 73.2% $3,638 20.7% 17.9x Health care intermediaries 69.6% $8,331 15.7% 9.4x Health insurance companies 82.9% $10,784 6.9% 5.7x Average 75.2% $15,522 16.8% 9.6x As of 12/31/2011 Sources: Public company filings; certain financial information provided by S&P Capital IQ As shown in the chart above, EBITDA multiples averaged M&A can offer buyers and sellers a quick way to capture 9.6x at the end of 2011. Of the five health care segments GTCF additional market share, secure a new technology or patent, has identified, HIT companies were trading at the highest or create economies of scale that set them apart from multiple — almost 18x. competitors. Furthermore, fundamental challenges in the industry suggest that significant changes must occur. Whether Conclusion because of insurers seeking new business models that align Health care remains one of the bright spots in today’s economy, incentives, pharmaceutical companies looking for additional with strong performance across many segments. Rising costs financial backing as they chase the next big-money drug, continue to plague the industry, and while measures are being hospitals balancing the desire to maintain their independence taken at the company, sector and federal levels to address this against the prospect (or reality) of budgetary distress, or issue, cost pressure will remain problematic for at least HIT companies acquiring market share and technologies to the near term. Politics aside, health care companies that wish meet evolving demand, M&A will continue to play a crucial role to stay in business must not only figure out how to mitigate in this dynamic sector. the impact of rising costs, but also find ways to benefit from changes in the industry. Contact information Erik Egerer Manager, Grant Thornton Corporate Finance T 248.213.4227 E erik.egerer@us.gt.com Nisha Raghava Senior Associate, Grant Thornton Corporate Finance T 248.215.6029 E nisha.raghava@us.gt.com About Grant Thornton Corporate Finance LLC Grant Thornton Corporate Finance LLC provides boutique investment banking services to privately held middle-market businesses in the United States and around the world. As a recognized advisor on middle-market mergers and acquisitions, we offer a range of investment banking services including sell-side advisory, buy-side advisory, management buyouts, restructurings and capital raising. Grant Thornton LLP provides investment banking services through its wholly owned broker-dealer subsidiary Grant Thornton Corporate Finance LLC, member FINRA, SIPC. About Grant Thornton LLP The people in the independent firms of Grant Thornton International Ltd provide personalized attention and the highest-quality service to public and private clients in more than 100 countries. Grant Thornton LLP is the U.S. member firm of Grant Thornton International Ltd, one of the six global audit, tax and advisory organizations. Grant Thornton International Ltd and its member firms are not a worldwide partnership, as each member firm is a separate and distinct legal entity. The factual statements and data from third-party sources contained herein are taken from sources believed to be reliable, but such statements are made without representation as to accuracy or completeness or otherwise. Grant Thornton Corporate Finance LLC does not engage in the business of recommending or effecting transactions in securities. The above information is presented solely in connection with describing Grant Thornton Corporate Finance LLC’s mergers and acquisitions services, and should not be considered as constituting a research report or as providing information reasonably sufficient upon which to base an investment decision. © 2012 Grant Thornton LLP All rights reserved U.S. member firm of Grant Thornton International Ltd 6 Health care M&A snapshot June 2012