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Human papilloma virus 
& vaccine-preventable diseases 
By Zeena Nackerdien
•Comparison Page Layout 
Classification, incidence of types of associated cancers 
LOW-RISK HPV & DISEASES 
HIGH-RISK HPV & CANCERS 
HPV 18 HPV 16 
Others: 31, 33, 
35, 39, 41, 45, 
51, 52, 56, 58, 
59 & 66 (2) 
~70% of cervical cancers (HPV 
16/18) (1) 
HPV 
11 
HPV 
6 
Benign/low-grade cervical 
changes, 
Ano-genital warts, juvenile or 
recurrent respiratory 
papillomatosis (1) 
1. US Centers for Disease Control and Prevention. Manual for the Surveillance of Vaccine-Preventable Diseases - Chapter 5 (5th edition): Human Papillomavirus (HPV) 2011 
http://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html 
2. Cutts F.T., Franceschi S., Goldie S. ea. Bulletin of the World Health Organization. Human papillomavirus and HPV vaccines: a review. Volume 85, Number 9, September 2007, 719-726 
http://www.who.int/bulletin/volumes/85/9/06-038414/en/#
•Prevention with approved vaccines 
ACOG recommendations for target populations (3) 
Sexually active 
women (13-26 y) 
Counseling, some 
efficacy, ongoing 
cervical cytology 
in women ≥21 y 
Sexually active 
women (>26 y) 
Vaccine not 
approved for this 
purpose; case-by-case 
off-label use 
may provide 
marginal benefit 
Bivalent and quadrivalent vaccines 
Adolescents & 
young women* 
Vaccines can be 
given, with 
emphasis on 
limited benefits 
and continued 
management 
Pregnant & 
lactating women 
HPV vaccination 
during pregnancy 
not 
recommended; 
Lactating women 
can receive either 
approved 
vaccine. 
Immunosuppressed 
patients 
Immune response 
may be less robust, 
but disease status is 
not a contra-indication 
“Routinely recommending HPV vaccination as cancer prevention to be co-administered 
with other vaccines at age 11 years can improve vaccination rates. (3) 
*cervical intracellular epithelial neoplasia or genital warts 
. The American Committee of Obstetricians and Gynecology (Committee on Adolescent Health Care Opinion): Human Papilloma Virus Vaccination. Number 588 2014. 
1. http://www.acog.org/-/media/Committee-Opinions/Committee-on-Adolescent-Health-Care/co588.pdf?dmc=1&ts=20141015T1435561626. 
4. Perkins RB, Clark JA, Apte G, Vercruysse JL, Sumner JJ, Wall-Haas CL, et al. Missed Opportunities for HPV Vaccination in Adolescent Girls: A Qualitative Study. Pediatrics. 2014 (e-pub)

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2014 ACOG guidelines on human papilloma virus vaccination

  • 1. Human papilloma virus & vaccine-preventable diseases By Zeena Nackerdien
  • 2. •Comparison Page Layout Classification, incidence of types of associated cancers LOW-RISK HPV & DISEASES HIGH-RISK HPV & CANCERS HPV 18 HPV 16 Others: 31, 33, 35, 39, 41, 45, 51, 52, 56, 58, 59 & 66 (2) ~70% of cervical cancers (HPV 16/18) (1) HPV 11 HPV 6 Benign/low-grade cervical changes, Ano-genital warts, juvenile or recurrent respiratory papillomatosis (1) 1. US Centers for Disease Control and Prevention. Manual for the Surveillance of Vaccine-Preventable Diseases - Chapter 5 (5th edition): Human Papillomavirus (HPV) 2011 http://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html 2. Cutts F.T., Franceschi S., Goldie S. ea. Bulletin of the World Health Organization. Human papillomavirus and HPV vaccines: a review. Volume 85, Number 9, September 2007, 719-726 http://www.who.int/bulletin/volumes/85/9/06-038414/en/#
  • 3. •Prevention with approved vaccines ACOG recommendations for target populations (3) Sexually active women (13-26 y) Counseling, some efficacy, ongoing cervical cytology in women ≥21 y Sexually active women (>26 y) Vaccine not approved for this purpose; case-by-case off-label use may provide marginal benefit Bivalent and quadrivalent vaccines Adolescents & young women* Vaccines can be given, with emphasis on limited benefits and continued management Pregnant & lactating women HPV vaccination during pregnancy not recommended; Lactating women can receive either approved vaccine. Immunosuppressed patients Immune response may be less robust, but disease status is not a contra-indication “Routinely recommending HPV vaccination as cancer prevention to be co-administered with other vaccines at age 11 years can improve vaccination rates. (3) *cervical intracellular epithelial neoplasia or genital warts . The American Committee of Obstetricians and Gynecology (Committee on Adolescent Health Care Opinion): Human Papilloma Virus Vaccination. Number 588 2014. 1. http://www.acog.org/-/media/Committee-Opinions/Committee-on-Adolescent-Health-Care/co588.pdf?dmc=1&ts=20141015T1435561626. 4. Perkins RB, Clark JA, Apte G, Vercruysse JL, Sumner JJ, Wall-Haas CL, et al. Missed Opportunities for HPV Vaccination in Adolescent Girls: A Qualitative Study. Pediatrics. 2014 (e-pub)