2. •Comparison Page Layout
Classification, incidence of types of associated cancers
LOW-RISK HPV & DISEASES
HIGH-RISK HPV & CANCERS
HPV 18 HPV 16
Others: 31, 33,
35, 39, 41, 45,
51, 52, 56, 58,
59 & 66 (2)
~70% of cervical cancers (HPV
16/18) (1)
HPV
11
HPV
6
Benign/low-grade cervical
changes,
Ano-genital warts, juvenile or
recurrent respiratory
papillomatosis (1)
1. US Centers for Disease Control and Prevention. Manual for the Surveillance of Vaccine-Preventable Diseases - Chapter 5 (5th edition): Human Papillomavirus (HPV) 2011
http://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html
2. Cutts F.T., Franceschi S., Goldie S. ea. Bulletin of the World Health Organization. Human papillomavirus and HPV vaccines: a review. Volume 85, Number 9, September 2007, 719-726
http://www.who.int/bulletin/volumes/85/9/06-038414/en/#
3. •Prevention with approved vaccines
ACOG recommendations for target populations (3)
Sexually active
women (13-26 y)
Counseling, some
efficacy, ongoing
cervical cytology
in women ≥21 y
Sexually active
women (>26 y)
Vaccine not
approved for this
purpose; case-by-case
off-label use
may provide
marginal benefit
Bivalent and quadrivalent vaccines
Adolescents &
young women*
Vaccines can be
given, with
emphasis on
limited benefits
and continued
management
Pregnant &
lactating women
HPV vaccination
during pregnancy
not
recommended;
Lactating women
can receive either
approved
vaccine.
Immunosuppressed
patients
Immune response
may be less robust,
but disease status is
not a contra-indication
“Routinely recommending HPV vaccination as cancer prevention to be co-administered
with other vaccines at age 11 years can improve vaccination rates. (3)
*cervical intracellular epithelial neoplasia or genital warts
. The American Committee of Obstetricians and Gynecology (Committee on Adolescent Health Care Opinion): Human Papilloma Virus Vaccination. Number 588 2014.
1. http://www.acog.org/-/media/Committee-Opinions/Committee-on-Adolescent-Health-Care/co588.pdf?dmc=1&ts=20141015T1435561626.
4. Perkins RB, Clark JA, Apte G, Vercruysse JL, Sumner JJ, Wall-Haas CL, et al. Missed Opportunities for HPV Vaccination in Adolescent Girls: A Qualitative Study. Pediatrics. 2014 (e-pub)