1. By Chibesa Mumba

2.  What it is?
 What its made up of?
 Exocrine and endocrine cells?
 Pancreatic diseases
 Thought-provoking question

3.  A gland that secretes digestive enzymes into
the gut

4.  Composed 99% of acini cells
 Pancreatic duct
 Islet of Langerhans

5.  Discovered by Paul Langerhans in 1869
 Group of cells that stand out from surrounding
cells
 Cells inside islet include A,B,D,F & Epsilon
cells

6.  Alpha cells produce glucagon
 Beta cells produce insulin & amylin
 Delta cells produce somatostatin
 F/PP cells produce pancreatic polypeptide
 Epsilon cells produce ghrelin

7. Type of Gland Location Cell Function Comments/Key points
Endocrine Islet periphery Alpha Glucagon production Glucagon is a hormone that increases the sugar in the blood
Endocrine Islet center Beta Insulin & amylin production Insulin decreases the sugar level in the blood & amylin gives humans a full feeling
Endocrine Inside islet or islet periphery Delta Somatostatin production Somatostatin is a growth inhibiting hormone
Endocrine Islet periphery PP (F) Pancreatic Polypeptide production Pancreatic polypeptide controls the activities of the pancreas
Endocrine Inside islet Epsilon Gherin production Gherin is a hormone that stimulates hungar
Exocrine Around exterior of pancreas Acini Digetive enzyme production and secretion Acini makes 99% of the pancreas

8.  Pancreatitis
 Pancreatic cancer
 Diabetes Mellitus

9.  Severe abdominal pain occurs suddenly
 Can cause internal bleeding or shock
 Excess alcohol ingestion & gallstones are
causes
 Caused pancreatic trauma

10.  Also called pancreatic carcinoma
 Common type are exocrine tumors
 Endocrine tumors are usually malignant

11.  A group of metabolic diseases which are
caused by high blood sugar
 High blood sugar caused by insulin problems
(insulin resistance or no insulin)
 types of diabetes are type 1 (IDDM), type 2
(NIDDM) and Gestational

12.  Impact of amylin on weight control
 Impact of somatostatin on ageing

13. THE END