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1. Shock
Scott G. Sagraves, MD, FACS
Assistant Professor
Trauma & Surgical Critical Care
Associate Director of Trauma
UHS of Eastern Carolina
2. Objectives
⢠Define & classify shock
⢠Outline management principles
⢠Discuss goals of fluid resuscitation
⢠Understand the concepts of oxygen
supply and demand in managing shock.
⢠Describe the physiologic effects of
vasopressors and inotropic agents
3. Goals
⢠Review hemodynamic techniques in the ICU
⢠Introduce the concept of the cardiac cycle
⢠Review of the pulmonary artery catheter
parameters
⢠Utilize the presentation to analyze clinical
cases and to feel comfortable with pa-c
parameters.
5. Hypotension
⢠In Adults:
â systolic BP ⤠90 mm Hg
â mean arterial pressure ⤠60 mm Hg
ď ď˛ systolic BP > 40 mm Hg from the
patientâs baseline pressure
8. Pathophysiology
ATP + H2O â ADP + Pi + H+
+ Energy
Acidosis results from the accumulation of acid
when during anaerobic metabolism the
creation of ATP from ADP is slowed.
H+
shift extracellularly and a metabolic acidosis
develops
9. Pathophysiology
⢠ATP production fails, the Na+
/K+
pump
fails resulting in the inability to correct
the cell electronic potential.
⢠Cell swelling occurs leading to rupture
and death.
⢠Oxidative Phosphorylation stops &
anaerobic metabolism begins leading to
lactic acid production.
10. Why Monitor?
⢠Essential to understanding their disease
⢠Describe the patientâs physiologic
status
⢠Facilitates diagnosis and treatment of
shock
11. History
⢠1960âs
â low BP = shock; MSOF resulted after BP
restored
⢠1970âs
â Swan & Ganz - flow-directed catheter
â thermistor â cardiac output
⢠1980âs
â resuscitation based on oxygen delivery,
consumption & oxygen transport balance.
17. Standard Parameters
⢠Measured
â Blood pressure
â Pulmonary A.
pressure
â Heart rate
â Cardiac Output
â Stroke volume
â Wedge pressure
â CVP
⢠Calculated
â Mean BP
â Mean PAP
â Cardiac Index
â Stroke volume
index
â SVRI
â LVSWI
â BSA
18. Why Index?
⢠Body habitus and size is individual
⢠Inter-patient variability does not allow
ânormalâ ranges
⢠âIndexingâ to patient with BSA allows for
reproducible standard
19. Index Example
PATIENT A
⢠60 yo male
⢠50 kg
⢠CO = 4.0 L/min
⢠BSA = 1.86
CI = 2.4 L/min/m2
PATIENT B
⢠60 yo male
⢠150 kg
⢠CO = 4.0 L/min
⢠BSA = 2.64
CI = 1.5 L/min/m2
26. Cardiac Index
C.I. = HR x SVI
SVI measures the amount of blood ejected by the
ventricle with each cardiac contraction.
Total blood flow = beats per minute x blood volume ejected per beat
27. Vascular Resistance Index
SYSTEMIC (SVRI)
MAP - CVP
CI
â SVR = vasoconstriction
â SVR = vasodilation
PULMONARY (PVRI)
MPAP - PAOP
CI
âPVR = constriction
PE, hypoxia
x 80 x 80
Vascular resistance = change in pressure/blood flow
28. Stroke Work
LVSWI = (MAP-PAOP) x SVI x 0.0136
normal = 43 - 62
VSWI describe how well the ventricles
are contracting and can be used to
identify patients who have poor
cardiac function.
ventricular stroke work = â pressure x vol. ejected
30. Definitions
⢠O2 Delivery - volume of gaseous O2
delivered to the LV/min.
⢠O2 Consumption - volume of gaseous
O2 which is actually used by the
tissue/min.
⢠O2 Demand - volume of O2 actually
needed by the tissues to function in an
aerobic manner
Demand > consumption = anaerobic metabolism
31. Rationale for Improving
O2 Delivery
Insult
Tissue Hypoxia
Increased Delivery
Increased Consumption
Demands are met
32. Critical O2 Delivery
VO2I
DO2I
The critical value is
variable
& is dependent upon the
patient, disease, and the
metabolic demands of the
patient.
33. Oxygen Calculations
⢠Arterial Oxygen Content
(CaO2)
⢠Venous Oxygen Content
(CvO2)
⢠Arteriovenous Oxygen
Difference (avDO2)
⢠Delivery (O2AVI)
⢠Consumption (VO2I)
Efficiency of
the
oxygenation
of blood and
the rates of
oxygen
delivery and
consumption
34. Arterial Oxygen Content
CaO2 = (1.34 x Hgb x SaO2) + (PaO2 x 0.0031)
If low, check hemoglobin or pulmonary gas
exchange
36. Oxygen Delivery (DO2I)
O2AVI = CI x CaO2 x 10
Normal values suggests that the heart
& lungs are working efficiently to
provide oxygen to the tissues.
< 400 is bad sign
37. Oxygen Consumption
VO2I = CI x (CaO2 - CvO2)
If VO2I < 100 suggest tissues are not
getting enough oxygen
40. Resuscitation Goals
⢠CI = 4.5 L/min/m2
⢠DO2I = 600 mL/min/m2
⢠VO2I = 170 mL/min/m2
NOT ALL PATIENTS CAN ACHIEVE THESE GOALS
Critically ill patients who can respond to their disease states by
spontaneously or artificially meeting these goals do show a
better survival.
50. Treatment - Hypovolemic
⢠Reverse hypovolemia vs. hemorrhage
control
⢠Crystalloid vs. Colloid
⢠PASG role?
⢠Pressors?
51. Resuscitation
⢠Transport times < 15 minutes showed
pre-hospital fluids were ineffective,
however, if transport time > 100 minutes
fluid was beneficial.
⢠Penetrating torso trauma benefited from
limited resuscitation prior to bleeding
control. Not applicable to BLUNT
victims.
52. Fluid Administration
⢠1 L crystalloid â 250 ml colloid
⢠crystalloids are cheaper
⢠blood must supplement either
⢠FFP for coagulopathy, NOT volume
⢠Watch for hyperchloremic metabolic acidosis
when large volumes of NaCl are infused
⢠NO survival benefit with colloids
53. Role of PASG?
⢠Houston - Higher mortality rate in penetrating
thoracic, cardiac trauma
⢠No benefit in penetrating cardiac trauma
⢠Role undefined in rural, blunt trauma
⢠Splinting role
54. Cardiogenic Shock
⢠Cause
â defect in cardiac function
⢠Signs
ď ď˛ cardiac output
ď ďą PAOP
ď ďą SVR
ď ď˛ left ventricular stroke work (LVSW)
58. SIRS - Distributive Shock
⢠Prompt volume replacement - fill the tank
⢠Early antibiotic administration - treat the cause
⢠Inotropes - first try Dopamine
⢠If MAP < 60
â Dopamine = 2 - 3 Âľg/kg/min
â Norepinephrine = titrate (1-100 Âľg/min)
⢠R/O missed injury
59. Adrenal Crisis
Distributive Shock
⢠Causes
â Autoimmune adrenalitis
â Adrenal apoplexy = B hemorrhage or infarct
â heparin may predispose
⢠Steroids may be lifesaving in the patient
who is unresponsive to fluids, inotropic,
and vasopressor support. Which one?
66. Dobutamine
â β-agonist
⢠5 - 20 ¾g/kg/min
⢠potent inotrope, variable chronotrope
⢠caution in hypotension (inadequate volume)
may precipitate tachycardia or worsen
hypotension
67. Norepinephrine
⢠Potent ι-adrenergic vasopressor
⢠Some β-adrenergic, inotropic, chronotropic
⢠Dose 1 - 100 ¾g/min
⢠Unproven effect with low-dose dopamine to
protect renal and mesenteric flow.
68. Epinephrine
â Îą- and β-adrenergic effects
⢠potent inotrope and chronotrope
⢠dose 1 - 10 ¾g/min
⢠increases myocardial oxygen consumption
particularly in coronary heart disease
69. Amrinone
⢠Phosphodiesterase inhibitor, positive inotropic
and vasodilatory effects
⢠increased cardiac stroke output without an
increase in cardiac stroke work
⢠most often added with dobutamine as a second
agent
⢠load dose = 0.75 -1.5 mg/kg â 5 - 10 Âľg/kg/min
drip
⢠main side-effect - thrombocytopenia
73. GSW
⢠24 year old male victim of a
shotgun blast to his right lower
quadrant/groin at close range.
⢠Hemodynamically unstable in the
field and his right lower extremity
was cool and pulseless upon
arrival to the trauma resuscitation
area.
75. Post-op
⢠Patient received 12 L crystalloid, 15
units of blood, 6 units of FFP, and 2 6
packs of platelets.
⢠HR 130, BP 96/48, T 34.7° C
⢠PAWP 8, CVP 6, CI 4.2, SVRI 2700,
LVSWI 42.
Diagnosis? Treatment?
81. Auto-Pedestrian Crash
⢠Thrown from the
rear bed of pick up
truck during a MVC
at 60 mph.
⢠Hemodynamically
unstable
⢠Pain to palpation of
the pelvis
⢠Hematuria with
FoleyÂŽ
insertion
85. Sepsis
⢠Fluids
⢠Correct the cause
⢠Antibiotics
⢠Debridement
⢠Vasopressors
â Phenylephrine
â Levophed
86. Initial Resuscitation
⢠CVP: 8- 12 mm Hg
⢠MAP ⼠65 mm Hg
⢠UOP ⼠0.5 cc/kg/hr
⢠Mixed venous Oxygen Sat ⼠70%
⢠Consider:
â Transfusion to Hgb ⼠10
â Dobutamine up to 20 Âľg/kg/min
87. Vasopressors
⢠Assure adequate fluid volume
⢠Administer via CVL
⢠Do not use dopamine for renal
protection
⢠Requires arterial line placement
⢠Vasopressin:
â Refractory shock
â Infusion rate 0.01 â 0.04 Units/min
88. Steroid Use in Sepsis
⢠Refractory shock 200-300 mg/day of
hydrocortisone in divided doses for
7 days
⢠ACTH test
⢠Once septic shock resolves, taper
dose
⢠Add fludrocortisone 50 ¾g po q day
89. Geriatric Trauma
⢠70 year old female
⢠MVC while talking on
her cell phone
⢠ruptured diaphragm
and spleen s/p OR
⢠Intubated and PA-C