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customized solutions for your research




Our Focus
We are a preclinical histopathology CRO specialized in resin
histopathology for medical devices that are either fully implanted or
partially inserted into the body. We also offer general histology and
immunohistochemistry services (GLP and non-GLP).




202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




We operate like an extension of your lab.
- Flexible, customized research solutions.
- Reach research milestones faster and more efficiently.
- Consultative approach to adapt to differing project needs.
- Save on infrastructure: access experts when you need them.




202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




Resin Histology: Medical Device & Bone
- Soft and hard tissues, implanted medical devices, and bone.
- Custom protocols.
- Imaging and data analysis.
- Work with a variety of resins to best match the material/device:
         - Methyl Methacrylate (MMA)
         - Glycol Methacrylate (GMA)
         - Spurr's Epoxy



202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




Sample Devices
- Stents
- Artificial muscle
- Heart valves
- Silk and artificial fibres
- Bio-absorptive materials
- Sutures
- Polymers



202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




Imaging & Analysis
- Digital microscopy imaging.
- Digital whole slide scanning: high-resolution imaging
  permits real-time zoom for regions of interest.
- Staining quantification: semi-automated IHC quantification permits
  data acquisition of area scored, total positive pixels, average positive
  pixels, total staining intensity, and average staining intensity, all of
  which are separated amongst weakly and strongly stained.



202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




Imaging & Analysis
- Pathological scoring/analysis: our Pathologists work with you to
  determine an appropriate scoring criteria.
- Report generation: quantified data can be collated into a
  presentation-ready report or PowerPoint presentation, while images
  can be professionally edited for publication-ready submission.




202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




Our Pathologists
- U.S. board certified Pathologists with 35 + years experience in
  Veterinary Pathology and Toxicologic Pathology.
- Experienced in Pathology reporting for NDA filing.
- Pathological scoring/analysis: our Pathologists work with you to
  determine an appropriate scoring criteria.
- Report generation: quantified data can be collated into a
  presentation-ready report or PowerPoint presentation, while images
  can be professionally edited for publication-ready submission.

202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




General Histology (Discovery, Preclinical, GLP)
- Paraffin and frozen services - grossing, processing, embedding,
  sectioning , and slide staining (H&E and special stains).
- GLP histopathology for preclinical toxicology studies.
- Full Pathology reporting (GLP and non GLP).
- Digital microscopy imaging, digital whole slide scanning, staining
  quantification, Pathological scoring/analysis, report generation.




202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




Immunohistochemistry Expertise
- Background literature research and sourcing of optimal antibodies
- Antibody optimization
- Cross-reactivity studies
- Protocol development
- Routine IHC staining (manual and automated)
- Slide analysis: digital microscopy imaging, digital whole
  slide scanning, staining quantification, Pathological scoring/analysis,
  and report generation.

202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




In-House Tissue Bank
- Collection of tissues from multiple species including mouse, rat, pig,
  rabbit, and monkey.
- Identify proteins of interest in multiple tissues on a single slide for a
  truly macroscopic view of protein distribution, and a complete
  antibody cross-reactivity profile.




202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
customized solutions for your research




Get in Touch
Website: www.waxitinc.com | Phone: 604.822.1595
Tanya troberts@waxitinc.com | Aruna asomasiri@waxitinc.com




202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com

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Wax it-overview-resin

  • 1. customized solutions for your research Our Focus We are a preclinical histopathology CRO specialized in resin histopathology for medical devices that are either fully implanted or partially inserted into the body. We also offer general histology and immunohistochemistry services (GLP and non-GLP). 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 2. customized solutions for your research We operate like an extension of your lab. - Flexible, customized research solutions. - Reach research milestones faster and more efficiently. - Consultative approach to adapt to differing project needs. - Save on infrastructure: access experts when you need them. 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 3. customized solutions for your research Resin Histology: Medical Device & Bone - Soft and hard tissues, implanted medical devices, and bone. - Custom protocols. - Imaging and data analysis. - Work with a variety of resins to best match the material/device: - Methyl Methacrylate (MMA) - Glycol Methacrylate (GMA) - Spurr's Epoxy 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 4. customized solutions for your research Sample Devices - Stents - Artificial muscle - Heart valves - Silk and artificial fibres - Bio-absorptive materials - Sutures - Polymers 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 5. customized solutions for your research Imaging & Analysis - Digital microscopy imaging. - Digital whole slide scanning: high-resolution imaging permits real-time zoom for regions of interest. - Staining quantification: semi-automated IHC quantification permits data acquisition of area scored, total positive pixels, average positive pixels, total staining intensity, and average staining intensity, all of which are separated amongst weakly and strongly stained. 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 6. customized solutions for your research Imaging & Analysis - Pathological scoring/analysis: our Pathologists work with you to determine an appropriate scoring criteria. - Report generation: quantified data can be collated into a presentation-ready report or PowerPoint presentation, while images can be professionally edited for publication-ready submission. 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 7. customized solutions for your research Our Pathologists - U.S. board certified Pathologists with 35 + years experience in Veterinary Pathology and Toxicologic Pathology. - Experienced in Pathology reporting for NDA filing. - Pathological scoring/analysis: our Pathologists work with you to determine an appropriate scoring criteria. - Report generation: quantified data can be collated into a presentation-ready report or PowerPoint presentation, while images can be professionally edited for publication-ready submission. 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 8. customized solutions for your research General Histology (Discovery, Preclinical, GLP) - Paraffin and frozen services - grossing, processing, embedding, sectioning , and slide staining (H&E and special stains). - GLP histopathology for preclinical toxicology studies. - Full Pathology reporting (GLP and non GLP). - Digital microscopy imaging, digital whole slide scanning, staining quantification, Pathological scoring/analysis, report generation. 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 9. customized solutions for your research Immunohistochemistry Expertise - Background literature research and sourcing of optimal antibodies - Antibody optimization - Cross-reactivity studies - Protocol development - Routine IHC staining (manual and automated) - Slide analysis: digital microscopy imaging, digital whole slide scanning, staining quantification, Pathological scoring/analysis, and report generation. 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 10. customized solutions for your research In-House Tissue Bank - Collection of tissues from multiple species including mouse, rat, pig, rabbit, and monkey. - Identify proteins of interest in multiple tissues on a single slide for a truly macroscopic view of protein distribution, and a complete antibody cross-reactivity profile. 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com
  • 11. customized solutions for your research Get in Touch Website: www.waxitinc.com | Phone: 604.822.1595 Tanya troberts@waxitinc.com | Aruna asomasiri@waxitinc.com 202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | info@waxitinc.com | 604.822.1595 | www.waxitinc.com