1. By;
WARDA SHAKIL

3. Other Names for this Disease:-
•Postpartum hypopituitarism
•Postpartum
panhypopituitarism
•Postpartum panhypopituitary
syndrome
•Postpartum pituitary necrosis
•Simmond's disease

4. DEFINATION:-
Characteristically caused by ischemic necrosis of
most of the anterior pituitary gland which results
from spasm in its arterioles, occurring at the time of
severe hemorrhage or shock (usually postpartum)
complicating child birth.
4% of women who loose large amount of blood
suffer some degree of damage to Anterior Pituitary
Gland.
8% suffer moderately
50% suffer severely ; having postpartum
hypopituitarism ending up in shock.

6. CAUSES:-
Sheehan syndrome is caused by severe blood loss
during or after childbirth. Blood loss at that time can
be particularly damaging to the pituitary gland
(which enlarges during pregnancy), destroying
hormone-producing tissue so that the gland cannot
function properly.

7. CLINICS:-
In the fully developed syndrome; which is only seen
when 95% of the Anterior Pituitary Gland is
destroyed, all functions:-
Lactogenic
Thyrotropic
Corticotropic
Somatotropic are IMPAIRED

8. SIGNS:-
Agalactia is the first and foremost most sign
Amenorrhea
Evidence of Hypothyroidism
Decreased insulin tolerance- Hypoglycemia
Signs of Adreno-cortical failure:-
(axillary sweating absent, loss of axillary and pubic hair, decrease in
skin pigmentation)
Weakness
Fatigue
Dizziness
Oligomenorrhea (infrequent menstrual periods)
Hot flashes
Decreased libido
Low blood pressure
Slowed mental functioning
Weight gain
Difficulty staying warm

9. These women also have moderate anemia- by lack of pituitary
erytropoetic factor
Severe atrophy of all genital organs including reproductive organs
Loss of breast tissue
Dry vaginal mucous
Atrophy of subcutaneous fat
Premature Aging

11. DIAGNOSE:-
Clinical Signs And Patient History
Lab Analysis of various hormonal levels
CT-Scan/ MRI of Brain (targeting Pituitary Gland)

13. TREATMENT:-
Treatment involved lifelong estrogen and
progesterone hormone replacement therapy. Thyroid
and adrenal hormones also must be taken.

14. By;
WARDA SHAKIL

16. Simmond’s Syndrome and Sheehan’s Syndrome are
quite similar and according to various literature
there is no such difference between the two but in
reality they do have few differences which goes as
follows:-
SIMMOND’S SYNDROME:-
 Etiology:-
Inflammatory disease of Brain or Pituitary Tumor
 Clinical Sign:-
Significant weight loss (Hypophyseal Cachexia)
 Treatment:-
Antibiotic Therapy or Surgery