GREEN CHEMISTRY

1. 1
“Environmentally Benign Synthetic Strategies
For Potentially Active Compounds.”
• Dr.Gurumeet C Wadhawa ,Assistant Professor,
Department of Chemistry.
Rayat Shikshan sansthas Veer Wajekar ASC
College,Phunde,Uran

2. 2
Advantages of Non-conventional methods over
Conventional
• The non-conventional methods like Microwave induced
reactions, Ultrasound assisted synthesis, grinding etc. are now
a days used in Organic synthesis. These methods are preferred
owing to their various advantages e.g.
1) Cleaner Methods
2) Yields are higher
3) Eco-friendly.

3. 3
• The heterocyclic compounds like chromone and their derivatives are
found to possess excellent physiological activities.
• Our strategy will be to combine various heterocycles with pyrazole,
benzo- -pyrone and quinoline moiety and study the combined effect
of the resulting products.

4. 4
Sonochemistry- Green approach for Organic Synthesis
• What is Sonochemistry?
Study of chemical changes that occur in presence of sound or
ultra-sound.
• Some properties of sonochemical / Ultrasound radiations
. Frequency ranges from 20 KHz to 10 MHz
(Human hearing upper limit is 18 KHz)
. Region 20-100 KHz is best for chemical transformation
. Frequency range 1-10 MHz are suitable for ultrasound
imaging of body organs

5. 5
• Various Organic transformations using Ultrasound radiations was reported those are
• Esterification
• Saponification
• Hydrolysis
• Substitution
RCOOH + R-OH RCOOR'
H2SO4,rt
))))))))
COOCH3 COOH
-
OH/ H2O
)))))) ,60 min.
Ar CN Ar COOH
-
OH/ H2O
)))))) ,60 min.
R Cl
O
R CN
O
KCN, MeCN
)))))))),50 C

6. 6
Microwave assisted reactions as an greener approach in
Organic Chemistry
• Microwave induced organic reaction enhancement (MORE) chemistry are
extremely fast cleaner than conventional reactions and lead to higher atom
economy, because of -
• Short reaction time
• Ease of workability
• Eco-friendly
• Greener technique
• Higher Selectivity

7. 7
Various Organic transformations using Microwave radiations
OR1
O O
+ H2N NH2
X
N
H
NH
R
R1O
O
X
MW, 300 Mz
X = O, S.
RCHO
(1) (2) (3) (4a-t)
Zn (OAC)2
•Biginelli reaction Under Microwave Irradiation
•Knoevenagel reaction Under Microwave Irradiation
R1
R2
R3
R4
O
O
CHO N
N
C
H3
O Ph
O
R1
R2
R3
R4 O H
N
N
CH3
O
Ph
MW
Basic alumina
+
R1
R2
R3
R4
O
O
CHO N
N
C
H3
O Ph
O
R1
R2
R3
R4 O H
N
N
CH3
O
Ph
MW
+ Acidic alumina

8. 8
Aims
The present investigation is aimed at
• Synthesizing some new heterocycles
• Establishing their structures and stereochemistry
• Evaluating their therapeutic values
• An attempts will be made to synthesize these
compounds by conventional as well as by non –
conventional methods like MWI, Ultrasonication etc..

9. 9