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Submitted To: Dr.Mujeeb Ur Rehman Sohoo
      Submitted By: Waqas Nawaz
                     11-arid-975
                   DVM 1ST Semester
“Embryology Of The Heart”
     Middle Of 3rd Week                      Rotation Of Cardiogenic Area



                                                                                18
                                                                                Days

                                                                                21
                                                                                Days

                                                                                22
                                                                                Days



 Fusion Of The Heart Tubes                       Myoepicardial Mantle




                                1.Myoblast

                                2.Mesothelial Cells




The formation of Cardiac Loop             The formation of Cardiac Loop

    (“bending of the heart”)              (“bending of the heart at 28th day)
The IV foramen and AV canal 4th-5th week   Partitioning of AV canal 4th-5th week




  Partitioning of AV canal 4th-5th week        Development of AV valves




           Septum formation                Partitioning of Primitive ventricles

                                                     (end of 4th week)
Partitioning of Atrium                  The Sinus Venosus

     (end of 4th week)




Fate of the Sinus Venosus             Fate of the Sino-atrial valves

                                    5 weeks                  newborn




 The Truncus Arteriosus             Development of Semilunar valves




                         8th week
“Heart”



       Size,Shape.Location of the heart

Approximately the size of your fist

     Wt. = 250-300 grams

Location

       In the mediastinum between the lungs]

       Superior surface of diaphragm

       ⅔’s of it lies to the left of the midsternal line

       Anterior to the vertebral column, posterior to
       the sternum

                  Heart Skeleton

Consists of plate of fibrous connective tissue
between atria and ventricles

Fibrous rings around valves to support

Serves as electrical insulation between atria
and ventricles

Provides site for muscle attachment
Pericardial Layers of the Heart




                  Heart Wall



Three layers of tissue:

Epicardium: This serous membrane of smooth
outer surface of heart

Myocardium: Middle layer composed of cardiac
muscle cell and responsibility for heart
contracting

Endocardium: Smooth inner surface of heart
chambers
“Cardiac Muscle”
               Cardiac Muscle

Elongated, branching cells containing 1-
2 centrally located nuclei
Contains actin and myosin myofilaments
Intercalated disks: Specialized cell-cell
contacts
Desmosomes hold cells together and
gap junctions allow action potentials
Electrically, cardiac muscle behaves as
single unit
“Arteries,Veins”




Endothelium- prevents platelet aggregation

secretes substances that control diameter of blood
vessel

Tunica media- smooth muscle and connective
tissue. Innervated by sympathetic nerves
(vasoconstriction)

Missing in smallest arteries

Tunica externa- connective tissue; is vascularized

Tunica interna-smooth continuous lining
Major Vessels of the Heart

                                                           Vessels returning blood to the heart
                                                           include:

                                                           Superior and inferior venae cavae

                                                              Open into the right atrium

                                                              Return deoxygenated blood from body cells

                                                           Coronary sinus

                                                              Opens into the right atrium

                                                              Returns deoxygenated blood from heart

                                                              muscle (coronary veins)

                                                           Right and left pulmonary veins

                                                              Open into the left atrium

                                                              Return oxygenated blood from lungs


                Major Vessels of the Heart

Vessels conveying blood away from the heart
include:

Pulmonary trunk

Carries deoxygenated blood from right ventricle to lungs

Splits into right and left pulmonary arteries

Ascending aorta

Carries oxygenated blood away from left atrium to body
organs

Three major branches:

   --Brachiocephalic

   --Left common carotid,

   --Left subclavian artery
“To A Special Teacher”
              When I started a school,
           This day seemed so far away,
          Now it’s here & I can’t believe
         That time has passed so quickly…
   But through your encouragement & guidance.
     I feel I’m ready for tomorrow’s challenges.
 Teachers play such an important part in shaping &
                     guiding…
            Especially teacher like you.

      (Dr.Mujeeb-ur-
         Rehman)
           Thank you for caring so much.

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Embryology & histology of cardiovascular system

  • 1. Submitted To: Dr.Mujeeb Ur Rehman Sohoo Submitted By: Waqas Nawaz 11-arid-975 DVM 1ST Semester
  • 2. “Embryology Of The Heart” Middle Of 3rd Week Rotation Of Cardiogenic Area 18 Days 21 Days 22 Days Fusion Of The Heart Tubes Myoepicardial Mantle 1.Myoblast 2.Mesothelial Cells The formation of Cardiac Loop The formation of Cardiac Loop (“bending of the heart”) (“bending of the heart at 28th day)
  • 3. The IV foramen and AV canal 4th-5th week Partitioning of AV canal 4th-5th week Partitioning of AV canal 4th-5th week Development of AV valves Septum formation Partitioning of Primitive ventricles (end of 4th week)
  • 4. Partitioning of Atrium The Sinus Venosus (end of 4th week) Fate of the Sinus Venosus Fate of the Sino-atrial valves 5 weeks newborn The Truncus Arteriosus Development of Semilunar valves 8th week
  • 5. “Heart” Size,Shape.Location of the heart Approximately the size of your fist Wt. = 250-300 grams Location In the mediastinum between the lungs] Superior surface of diaphragm ⅔’s of it lies to the left of the midsternal line Anterior to the vertebral column, posterior to the sternum Heart Skeleton Consists of plate of fibrous connective tissue between atria and ventricles Fibrous rings around valves to support Serves as electrical insulation between atria and ventricles Provides site for muscle attachment
  • 6. Pericardial Layers of the Heart Heart Wall Three layers of tissue: Epicardium: This serous membrane of smooth outer surface of heart Myocardium: Middle layer composed of cardiac muscle cell and responsibility for heart contracting Endocardium: Smooth inner surface of heart chambers
  • 7. “Cardiac Muscle” Cardiac Muscle Elongated, branching cells containing 1- 2 centrally located nuclei Contains actin and myosin myofilaments Intercalated disks: Specialized cell-cell contacts Desmosomes hold cells together and gap junctions allow action potentials Electrically, cardiac muscle behaves as single unit
  • 8. “Arteries,Veins” Endothelium- prevents platelet aggregation secretes substances that control diameter of blood vessel Tunica media- smooth muscle and connective tissue. Innervated by sympathetic nerves (vasoconstriction) Missing in smallest arteries Tunica externa- connective tissue; is vascularized Tunica interna-smooth continuous lining
  • 9. Major Vessels of the Heart Vessels returning blood to the heart include: Superior and inferior venae cavae Open into the right atrium Return deoxygenated blood from body cells Coronary sinus Opens into the right atrium Returns deoxygenated blood from heart muscle (coronary veins) Right and left pulmonary veins Open into the left atrium Return oxygenated blood from lungs Major Vessels of the Heart Vessels conveying blood away from the heart include: Pulmonary trunk Carries deoxygenated blood from right ventricle to lungs Splits into right and left pulmonary arteries Ascending aorta Carries oxygenated blood away from left atrium to body organs Three major branches: --Brachiocephalic --Left common carotid, --Left subclavian artery
  • 10. “To A Special Teacher” When I started a school, This day seemed so far away, Now it’s here & I can’t believe That time has passed so quickly… But through your encouragement & guidance. I feel I’m ready for tomorrow’s challenges. Teachers play such an important part in shaping & guiding… Especially teacher like you. (Dr.Mujeeb-ur- Rehman) Thank you for caring so much.