Techniques to Enhance Drug Solubility

[object Object],[object Object],[object Object],[object Object],[object Object],TECHNIQUES OF SOLUBILIZATION

CONTENTS ,[object Object],[object Object],[object Object],[object Object],[object Object]

INTRODUCTION ,[object Object],[object Object],[object Object]

[object Object],[object Object],Definition Parts of solvent required for one part of solute Very soluble < 1 Freely soluble 1 - 10 Soluble 10 - 30 Sparingly soluble 30 - 100 Slightly soluble 100 - 1000 Very slightly soluble 1000 - 10,000 Insoluble > 10,000

Process of solubilization Step 1: Holes opens in the solvent Step2 : Molecules of the solid breaks away from the bulk Step 3:The freed solid molecule is integrated into the hole in the solvent

Factors affecting solubility:- ,[object Object],[object Object],Where, S = is the solubility of infinitely large particles S= is the solubility of fine particles V= is molar volume γ = is the surface tension of the solid r =is the radius of the fine particle

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

A. Particle size reduction: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Other techniques for reduction of the particle size ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object]

B. Modification of the crystal habit: ,[object Object],[object Object],[object Object],[object Object],[object Object]

C.Drug dispersion in carriers: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

E. Solubilization by surfactants: ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

References: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Techniques to Enhance Drug Solubility

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Techniques to Enhance Drug Solubility