WIWE Mobile ECG Machine Introduction and their usage by UNO Hospital Solutions. Clinical-quality results after 1 minute. Prevention and health promotion: 3 out of 4 deaths can be prevented!

1. WIWE
Message from the heart

2. Summary:
•Used for recording and transfering ECG, SpO2 and Pedometer data to the WIWE application for evaluation
•Capable of recording without a smartphone/tablet
•Battery indicator LEDs on top and process indicator LEDs on the front
•Runs with battery chargable through microUSB plug
2 important „developer” functions:
•Hard reset: pushing the ON/OFF button for 10 seconds continously restarts the WIWE device (usefulness:
connectivity, freezing issues)
•Data deletion: connecting the WIWE device to a microUSB cable then pushing the button swiftly 5 times
deletes the stored data of the WIWE device (usefulness: owner account, stepcounter issues mainly)
WIWE Device
Process LED functions
•The lights runing through
•The last green LED flashing
•The last green LED glowing
constantly

3. Summary:
•Connects to the WIWE device through Bluetooth LE/4.0
•Evaluates the recorded data transferred by the WIWE device
•Creates a result summary and details in the form of graphs
•Stores all the recordings
•Pedometer function to summarize activity
Important „developer” functions:
•#*Test_User*# account makes the „developer” functions’ settings
visible in the „Settings” menu
•NoSPO – turns OFF the SpO2 recording function (minimizing the
noise levels further for the ECG recording)
•ECG and SpO2 raw data to CSV file – stores the data of the recording
into a separate file outside the app database (possibility of further
detailed evaluation in specific cases)
•Logging into files – storing the events throughout the running of the
application (connection, measuring, possible crashes,
syncrhonization, etc.)
WIWE Application

4. Measurement techniques
To get the most accurate results from your recordings
with the WIWE you need to have a basic technique
for the measurements.
We determined two basic ways to efficiently take a
recording:
1. Put your thumbs on the 2 sensors/electrodes of
the WIWE and support your palms on your lap
on a table (any flat surface is fine)
2. Put your index fingers on the 2
sensors/electrodes of the WIWE and your
forearms should rest on the table
In both cases you need to follow a couple single
„rules”:
1. Your fingers should only touch the sensors, only
the contact of the two surface is enough for the
recording
2. Be relaxed – not necessarily yourself, mainly
your fingers/hands
3. Your other fingers shouldn’t touch each other
throughout the recording

5. ECG:
•Shows if there is any deviation in the measured ECG parameters (Lead I – PQ, QRS, QTc)
•The measured parameteres ofthis function are quite stable for the patient (there should only be
small differences in the results mainly because of the recordings made with different circumstances
[body pose, state of relaxation, technique of the measurements, etc.], otherwise they should be
stable
•If something triggers a symptom in one of the parameters then its indication (eg. broad QRS
complex) should be there independently from the circumstances of the recording
AR/AF:
•Shows if there was any heart rate fluctuation throughout the measurement or if there is a possible
Atrial Fibrillation present
•This function shows the state of the heart rythm according to the one minute recording and since
these kind of symptoms not always last long, the „bad” results of the recording not necessarily
need to be there in every recording („catching” the event is most essential basically)
VH - Ventricular repolarizational heterogeneity
•Describes the state of bioelectrical connections between heart muscle cells. Sharp deterioration
may lead to severe ventricular arrhythmias, also Sudden Cardiac Arrest.
•This is a mainly risk assessing function, so the results shouldn’t differ too much between each
recording in normal cases
SpO2 – Blood oxygen saturation
Heart rate
Result screen

6. ECG
PQ (PR interval)
It reflects the conduction through the AV node
•Normal interval – 120-200 ms
•Over 200 ms – first degree heart block (electrolyte
imbalance, delayed conduction through the AV node,
doubles the risk of developing AF)
•Under 120 ms – suggests pre-excitation (pathway
between atria and ventricle, faster than normal conducting
through this) or AV nodal (junctional) rythm
QRS complex – depolarisation of the ventricles
•Normal interval – 60-100 ms
•Broad complexes - QRS > 100 ms – ventricular origin or
aberrant conduction (bundle branch block, hyperkalaemia)
•Narrow complexes – QRS < 100 ms – supraventricular
origin
QT interval (corrected to 60 bpm for comparison)
Time taken for the ventricular depolarisation and depolarisation
•Normal interval – 350-430 ms
•QTc>430 ms – hypokalaemia, hypomagnesaemia,
hypocalcaemia, hypothermia, etc.
•QTc<350 ms – eg. hypercalcaemia
Details of the ECG I parameters measured by WIWE

7. Heartbeat - ECG

8. ECG I parameters
Examined ECG I parameters by the WIWE as seen in the application
The average majority cycle is what we use to measure the parameters
(it means that the result will be more accurate and when calculating
the average cycle we also use filters)
The whole ECG curve is also stored and can be checked – important
for doctors it’s easy to check (it can be enlarged and it has the same
scaling as the one they normally use)

9. Arrhythmia examination
We have analyzed the accuracy of our algorithm with the help
of more than 10.000, 30 seconds long ECG recordings taken
from PhysioNET.
The sensitivity of WIWE is 98,69%, which is the chance of
determining the real abnormal patterns.
Specificity is 99,59%, which means that we can determine the
healthy patterns with such precision.
Our algorithm determines if there is AF based on two things:
•Was there a significant heart rate fluctuation
throughout the recording?
•Was there no significant P wave throughout the
recording?
Both event need to be present for a possible AF.

10. AF – Stroke connection
Stroke is the second leading cause of
deaths worldwide, causing more than five
million deaths a year. WIWE gives you risk
assessment especially on stroke caused by
atrial fibrillation, which is the largest
proportion of ischaemic strokes.
Ischaemic stroke:
•Oxygen deficiency in the brain tissue
•Main reason of ischaemic strokes is the
blockage of blood supplying arteries, which may
be caused by blood clots drifting in the vessels
•Atrial fibrillation is the most common cause of
strokes originated from the heart
•15% of strokes are due to atrial fibrillation

11. Ventricular repolarizational heterogeneity
Assessing the ventricular heterogenity
provides a feedback about the
coordinated operation of the heart
muscle cells, meaning we can esteem the
state of the cardiac muscle.
This function is – as stated before – a risk
assessment. The result itself shows how
big is the chance for a possible – and
dangerous – ventricular arrhythmia.
If the evaluation of the recording gives
back a „red” result then there is a much
higher chance for a VT/VF to develop or
even for an SCA/SCD.
This function of the WIWE is
worldwide unique – no other
competing product is capable to do this!

12. Sudden Cardiac Arrest
Sudden cardiac arrest:
•Heart abnormalities resulting in death. No
more than an hour goes by between the start
of symptoms and loss of life.
•It is due to ventricular arrhythmia,
ventricular fibrillation.
•The blood pump function of heart ceases,
circulation stops.
•Resuscitation should start within minutes,
or else the patient’s life can not be saved.
Sudden cardiac arrest can happen with
anyone, anytime and anywhere, it kills 7
million people a year. It should be
pointed out, that sudden cardiac arrest
and heart attacks are two different
events.

13. The comparative table below shows the competing products that are currently on the market. We should
highlight Kardia (AliveCor), which is currently the best-known ECG recording device on the market. In addition
we investigated CheckMePro (Viata Shenzhen Technology Co., Ltd.), WeCardio ECG (Borsam Medical
Instruments Co., Ltd.) and CardioQvark (L Kard LLC).
Product Price Evaluation Accuracy
Additional
costs
Non-ECG
based
features
Availability
Kardia 99 $ ECG, AF, arrhythmia 97% Yes Yes
Australia, Canada, Ireland, India,
Hong Kong, USA, UK
CheckMePro 449 $
ECG, arrhythmia,
SpO2, HRV
? No Yes Worldwide
WeCardio
ECG
149$
ECG, arrhythmia,
HRV
? No No
North America, Western and
Eastern Europe, Southeast Asia,
East Asia, Middle East, Oceania,
Africa
CardioQvark 135 $
ECG, AF,
arrhythmia, HRV
94,5% Yes No Russia, expanding in 2017
WIWE 418$
ECG, AF, ventricular
heterogeneity,
arrhythmia, SpO2
98% No Yes
Europe, expected to be available
worldwide from autumn 2017
Competition

14. Competition II.
Kardia
WIWE
WeCardio
CheckMePro
CardioQvark

15. If we know it, we can
change it
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mywiwe.com
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