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E. Udaya Rajitha
III B. Pharmacy
V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
CONTENTS :
 DEFINITION
 BIOSYNTHESIS
 CHEMISTRY
 TYPES
 ACTIONS & PATHOPHYSIOLOGICAL ROLS
 USAGE IN PREGNANCY
 SIDE...
Prostaglandins:
Any of a group of potent hormone like
substances that are produced in various
mammalian tissues, are deriv...
BIOSYNTHESIS:
PGD2
V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
CHEMISTRY:
Chemically prostaglandins may be considered
as to be derivatives of prostanoic acid.
Prostanoic acid
V. V. Inst...
General structure of prostaglandins:
V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
TYPES OF PROSTAGLANDINS:
Prostaglandin – D2
Prostaglandin – E2
V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
Prostaglandin – F2
Prostaglandin – G2
V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
Prostaglandin – I2
Prostaglandin – H2
V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
PG – F2 :
Acting on FP receptors
• Myometrial contraction
• Broncho constriction
• Vasodilatation
• Ocular inflammation
PG...
PG – E2 :
 Acting on EP 1 receptors
• Broncho constriction
• GI tract smooth muscle contraction
 Acting on EP 2 receptor...
• It causes vasodilatation
• Inhibition of platelet aggregation
• Relaxation of GI & uterine muscles
PG – D2 :
Acting on D...
PGE2 :
• Promotes cervical ripening
• Exogenous PGE2 is used as pessaries or gels in the
induction of labour.
Prostaglandi...
PGF2 :
• Increases intracellular calcium, which increases myometrial
contractility
• Majorly used due to less side effects...
PGI2 (Prostacyclin) :
• Inhibits uterine contractility (role unclear)
V. V. Institute of Pharmaceutical Sciences, Gudlaval...
• Asthma
• Fall in blood pressure
• Clotting time increases
PG – D2 :
PG – E2 :
• Watery diarrhoea
• Diuresis
• Rise the b...
PG – F2 :
• Contraction of uterus
• Dysmenorrhoea
• Asthma
PG – I2 :
• Diuretic effect
• Fever
• Algesia
• Inflammation
• ...
V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
CONCLUSION
V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
REFERENCES
• Biochemistry by u. satyanarayana & u. chakrapani
Ch...
THANK YOU
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Prostaglandins

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Any of a group of potent hormone like substances that are produced in various mammalian tissues, are derived from arachidonic acid, and mediate a wide range of physiological functions, such as control of blood pressure, contraction of uterine, smooth muscle, and modulation of inflammation.

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Prostaglandins

  1. 1. E. Udaya Rajitha III B. Pharmacy V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  2. 2. CONTENTS :  DEFINITION  BIOSYNTHESIS  CHEMISTRY  TYPES  ACTIONS & PATHOPHYSIOLOGICAL ROLS  USAGE IN PREGNANCY  SIDE EFFECTS V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  3. 3. Prostaglandins: Any of a group of potent hormone like substances that are produced in various mammalian tissues, are derived from arachidonic acid, and mediate a wide range of physiological functions, such as control of blood pressure, contraction of uterine, smooth muscle, and modulation of inflammation. V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  4. 4. BIOSYNTHESIS: PGD2 V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  5. 5. CHEMISTRY: Chemically prostaglandins may be considered as to be derivatives of prostanoic acid. Prostanoic acid V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  6. 6. General structure of prostaglandins: V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  7. 7. TYPES OF PROSTAGLANDINS: Prostaglandin – D2 Prostaglandin – E2 V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  8. 8. Prostaglandin – F2 Prostaglandin – G2 V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  9. 9. Prostaglandin – I2 Prostaglandin – H2 V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  10. 10. PG – F2 : Acting on FP receptors • Myometrial contraction • Broncho constriction • Vasodilatation • Ocular inflammation PG – I2 : Acting on IP receptors • Vasodilatation • Inhibit platelet aggregation • Broncho dilatation • Hyperalgesic effect V. V. Institute of Pharmaceutical Sciences, Gudlavalleru. ACTIONS & PATHOPHYSIOLOGICAL ROLS OF PGS
  11. 11. PG – E2 :  Acting on EP 1 receptors • Broncho constriction • GI tract smooth muscle contraction  Acting on EP 2 receptors • Broncho dilatation • GI tract smooth muscle relaxation • Vasodilatation • Decrease gastric acid secretion • Increase gastric mucus secretion • Uterus contraction (when pregnant) • GI tract smooth muscle contraction  Acting on EP 3 receptors V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  12. 12. • It causes vasodilatation • Inhibition of platelet aggregation • Relaxation of GI & uterine muscles PG – D2 : Acting on DP receptors PG – G2 & H2 : • These are the vasoconstrictors but often produce vasodilatation due to rapid conversion to other prostaglandins V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  13. 13. PGE2 : • Promotes cervical ripening • Exogenous PGE2 is used as pessaries or gels in the induction of labour. Prostaglandins used in pregnancy : V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  14. 14. PGF2 : • Increases intracellular calcium, which increases myometrial contractility • Majorly used due to less side effects V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  15. 15. PGI2 (Prostacyclin) : • Inhibits uterine contractility (role unclear) V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  16. 16. • Asthma • Fall in blood pressure • Clotting time increases PG – D2 : PG – E2 : • Watery diarrhoea • Diuresis • Rise the body temparature • Pain • Sedation • No closure of ductus arteriosus V. V. Institute of Pharmaceutical Sciences, Gudlavalleru. SIDE EFFECTS:
  17. 17. PG – F2 : • Contraction of uterus • Dysmenorrhoea • Asthma PG – I2 : • Diuretic effect • Fever • Algesia • Inflammation • Clotting time increases V. V. Institute of Pharmaceutical Sciences, Gudlavalleru.
  18. 18. V. V. Institute of Pharmaceutical Sciences, Gudlavalleru. CONCLUSION
  19. 19. V. V. Institute of Pharmaceutical Sciences, Gudlavalleru. REFERENCES • Biochemistry by u. satyanarayana & u. chakrapani Chapter no: 32 (prostaglandins and related compounds); page no: 645, 647,646,644. • Essentials of medical pharmacology by KD. Tripathi Chapter no: 13 (Prostaglandins , leukotrienes & platelet activating factor); Page no : 181,182,183,184,186,187,188,193.
  20. 20. THANK YOU

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