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Stem cells and potential clinical applications āļĢāļĻ .  āļ­āļēāļ—āļīāļ•āļĒāđŒ āļ­āļąāļ‡āļāļēāļ™āļ™āļ—āđŒ āļ āļēāļ„āļ§āļīāļŠāļēāļ­āļēāļĒāļļāļĢāļĻāļēāļŠāļ•āļĢāđŒ āļ„āļ“āļ°āđāļžāļ—āļĒāļĻāļēāļŠāļ•āļĢāđŒāđ‚āļĢāļ‡āļžāļĒāļēāļšāļēāļĨāļĢāļēāļĄāļēāļ˜āļīāļšāļ”āļĩ āļĄāļŦāļēāļ§āļīāļ—āļĒāļēāļĨāļąāļĒāļĄāļŦāļīāļ”āļĨ
Embryo development http :// www . youtube . com / watch?v = mUcE1Y_bOQE
Capabilities of stem cell ,[object Object],[object Object]
Promise of stem cells research Regenerative Medicine .  Department of Health and Human Services. August 2006.
Stem cell heirachy One kind of tissue Monopotent stem cells Tissues in same germ layer Multipotent stem cells Embryo Pleuripotent stem cells Embryo and placenta Totipotent stem cells Capability of development Type of stem cells
Sources of stem cells ,[object Object],[object Object],[object Object],[object Object],[object Object]
Reprogramming Scientific Breakthrough of the Year 2008  (Science Magazine) Mature, specialized adult cells Induced Pleuripotent Stem Cells (ES cells liked) Four genes inserted Patient specific cells ,[object Object],[object Object],Another type of specialized cells Pancreatic exocrine cells to beta cells
Do stem cells exist in adult? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Why bone marrow? http :// stemcells . nih . gov / info / scireport / chapter5 . asp
Stem cell enrichment ,[object Object],[object Object]
Potentials ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hematopoietic stem cell transplantation ,[object Object],[object Object],[object Object]
Concept ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Allogeneic transplantation ,[object Object],[object Object],[object Object],[object Object]
HLA system ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
HLA system inheritance āļžāđˆāļ­ āđāļĄāđˆ
HLA compatibility āļœāļđāđ‰āļ›āđˆāļ§āļĒ HLA identical Haploidentical Unidentical
Donor  āļ­āļ·āđˆāļ™ āļ™āļ­āļāđ€āļŦāļ™āļ·āļ­āļˆāļēāļāļžāļĩāđˆāļ™āđ‰āļ­āļ‡ ,[object Object],[object Object],[object Object],[object Object]
āļāļēāļĢāđƒāļŠāđ‰  BMT  āđ€āļ›āđ‡āļ™  supportive measure ,[object Object],[object Object],[object Object],[object Object]
Procedure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Stem cell collection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Indications of HSCT ,[object Object],[object Object],[object Object],[object Object],[object Object]
Immunosuppression ,[object Object],[object Object],[object Object],[object Object]
Post transplantation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Graft versus host disease ,[object Object],[object Object],[object Object],[object Object]
Chimerism – the beauty of HSCT ,[object Object],[object Object],[object Object]
The Graft-versus-”Disease” Effect ,[object Object],[object Object],[object Object]
HSCT offers beyond the effects of chemotherapy ,[object Object],[object Object],[object Object]
Potential in CardioVascular Diseases ,[object Object],[object Object]
Potential sources of stem cells used for heart diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Lunde, et al (Norway) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Assmus, et al (Frankfurt Germany) ,[object Object],[object Object],[object Object],[object Object]
Schachinger, et al (Frankfurt Germany) ,[object Object],[object Object],[object Object],[object Object]
Other approach ,[object Object],[object Object]
Unanswered questions ,[object Object],[object Object],[object Object],There is definitely a role of stem cells in cardiac repair.
Stem cells and nervous system ,[object Object],[object Object],[object Object],[object Object]
Potential in Neurologic diseases ,[object Object],[object Object],[object Object],[object Object],[object Object]
Parkinson’s disease ,[object Object],[object Object],[object Object]
Parkinson’s Disease ,[object Object],[object Object],[object Object],[object Object]
Other neuron loss: challenging issues ,[object Object],[object Object]
Peripheral vascular diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],Huang PP, et al .  Thromb Haemost .  2007;98 ( 6 ): 1335-42 .
Diabetes ,[object Object],[object Object],[object Object],[object Object],Edmonton protocol
Facial contour defects ,[object Object],[object Object],Weiss RA, et al .  Dermatol Surg .  2007;33 ( 3 ): 263-8 .
Further readings ,[object Object]

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Stem Cells And Potential Clinical Applications

  • 1. Stem cells and potential clinical applications āļĢāļĻ . āļ­āļēāļ—āļīāļ•āļĒāđŒ āļ­āļąāļ‡āļāļēāļ™āļ™āļ—āđŒ āļ āļēāļ„āļ§āļīāļŠāļēāļ­āļēāļĒāļļāļĢāļĻāļēāļŠāļ•āļĢāđŒ āļ„āļ“āļ°āđāļžāļ—āļĒāļĻāļēāļŠāļ•āļĢāđŒāđ‚āļĢāļ‡āļžāļĒāļēāļšāļēāļĨāļĢāļēāļĄāļēāļ˜āļīāļšāļ”āļĩ āļĄāļŦāļēāļ§āļīāļ—āļĒāļēāļĨāļąāļĒāļĄāļŦāļīāļ”āļĨ
  • 2. Embryo development http :// www . youtube . com / watch?v = mUcE1Y_bOQE
  • 3.
  • 4. Promise of stem cells research Regenerative Medicine . Department of Health and Human Services. August 2006.
  • 5. Stem cell heirachy One kind of tissue Monopotent stem cells Tissues in same germ layer Multipotent stem cells Embryo Pleuripotent stem cells Embryo and placenta Totipotent stem cells Capability of development Type of stem cells
  • 6.
  • 7.
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  • 9. Why bone marrow? http :// stemcells . nih . gov / info / scireport / chapter5 . asp
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  • 16. HLA system inheritance āļžāđˆāļ­ āđāļĄāđˆ
  • 17. HLA compatibility āļœāļđāđ‰āļ›āđˆāļ§āļĒ HLA identical Haploidentical Unidentical
  • 18.
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