Antiretroviral Medication Administration Which of the following are important instructions for HIV/AIDS antiretroviral medication administration? Select all that apply. A. Administer in evenly spaced intervals around the clock to ensure steady-state levels B. Give on an empty stomach C. Instruct the patient to remain upright while administering the medication and for up to 30 minutes afterward to prevent esophageal ulceration D. If the patient experiences trouble breathing, fever, changes in oral mucosa (opportunistic infection), notify the prescriber immediately.