Pharmacokinetics icu setting_2007_nagoya

Gesundheit & Medizin Sport Technologie

薬物動態のレクチャー用スライドです。

10

L

100mg 2μg/ml(=2mg/L)
100(mg)/2(mg/L)=50L
1kg 1L

12

(L)= (mg)/ (mg/L)

Vd (L/kg)

0.3

0.5-1

>1

17

1.5mg/kg ×
10

50kg Vd

×Vd 50kg×1.1L/kg L

kg×1.5mg/kg× mg

mg / L mg/L =μg/ml

18

1.5mg/kg ×

50kg Vd
Vd=1.1L/kg
×Vd 50kg×1.1L/kg 55 L

kg×1.5mg/kg× 150 mg

150 mg / 55 L 2.7 mg/L =μg/ml

2-5μg/ml

19

17mg/kg
3.6 30

50kg Vd

×Vd 50kg×1.9L/kg L

kg×17mg/kg mg

mg / L mg/L =μg/ml

20

17mg/kg

50kg
Vd Vd=1.9L/kg

×Vd 50kg×1.9L/kg 95 L

kg×17mg/kg 850 mg

850 mg / 95 L 8.95 mg/L =μg/ml

4-10μg/ml

21

50kg 250mg

50kg Vd

×Vd 50kg×0.5L/kg L

250mg

mg / L mg/L =μg/ml

→

22

50kg 250mg

50kg Vd
Vd=0.5L/kg

×Vd 50kg×0.5L/kg 25 L

250mg

250 mg / 25 L 10 mg/L =μg/ml

5-15μg/ml >20μg/ml

→

10μg/ml 20μg/ml

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