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Nanotechnology?
Why Small is Having a Big
       Impact

       Tim Harper
       Cientifica Ltd
What Do I Know?




       2
What Do I Know?




       2
What Do I Know?

• Former Engineer at European
   Space Agency




                                2
What Do I Know?

• Former Engineer at European
   Space Agency
• Serial Entrepreneur




                                2
What Do I Know?

• Former Engineer at European
   Space Agency
• Serial Entrepreneur
• Chair / Chief Advisor of
   Several National Funding
   Bodies




                                2
What Do I Know?

• Former Engineer at European
   Space Agency
• Serial Entrepreneur
• Chair / Chief Advisor of
   Several National Funding
   Bodies
• World Economic Forum
   Emerging Technologies
   Council / Tech Pioneers




                                2
What Do I Know?

• Former Engineer at European
   Space Agency
• Serial Entrepreneur
• Chair / Chief Advisor of
   Several National Funding
   Bodies
• World Economic Forum
   Emerging Technologies
   Council / Tech Pioneers
• Advise Governments & Private
   Clients

                                 2
5000 Years of Science




          7
5000 Years of Science

•   We have been observing
    the world for 5000 years




                               7
5000 Years of Science

•   We have been observing
    the world for 5000 years

•   Significantly changing it
    for 100 years




                               7
5000 Years of Science

•   We have been observing
    the world for 5000 years

•   Significantly changing it
    for 100 years

•   Understanding our
    actions for 20 years




                               7
Materials Have Shaped Our
             Culture & Economy
10,000 BC
            1000 BC      0      1800                     1900’s                         2000              2010




  Stone
 & Wood       Iron    Cement    Steel                                                            Synthetic Biology
                                                       Polymers
                                                      Composites                  Nanotechnology




                               Adapted from Herrmann, W. Chem. Eng. Technol. 21(7), 549 (1998)
                                                                                                                 8
Control Over Materials

    Materials Have Always Been Vital
    to Humanity
•   Clothing,
•   Heating, hunting tools
•   Coal, iron, oil, copper
•   Semiconductors
•   Satellites




                                       9
Control Over Materials




                         9
Science Enables New
                 Technologies
Complexity




                1650   1950   2050   10
Science Enables New
                 Technologies
Complexity




                1650   1950   2050   10
Science Enables New
                 Technologies
Complexity




                1650   1950   2050   10
Science Enables New
                 Technologies
Complexity




                1650   1950   2050   10
Science Enables New
                 Technologies
Complexity




                1650   1950   2050   10
Science Enables New
                 Technologies
Complexity




                       Semiconductors

                1650    1950            2050   10
Science Enables New
                 Technologies
Complexity




                               Biotechnology
                       Semiconductors

                1650    1950                   2050   10
Science Enables New
                 Technologies




                                   Nanotechnologies
Complexity




                               Biotechnology
                       Semiconductors

                1650    1950                   2050   10
Science Enables New
                 Technologies



                                        Synthetic Biology
                                   Nanotechnologies
Complexity




                               Biotechnology
                       Semiconductors

                1650    1950                   2050         10
Science Enables New
                 Technologies



                                               Geoengineering?
                                        Synthetic Biology
                                   Nanotechnologies
Complexity




                               Biotechnology
                       Semiconductors

                1650    1950                   2050              10
Science Enables New
                 Technologies



                                               Geoengineering?
                                        Synthetic Biology
                                   Nanotechnologies
Complexity




                               Biotechnology




                                                                  Control
                       Semiconductors

                1650    1950                   2050              10
10 Years of Nanotech




         11
10 Years of Nanotech
 Household Cleaners                            Sporting Equipment

              Food              Displays       Drug Delivery
Insulation
                               Paints
              Sunscreen                    Water Treatment
                                                         Construction
      Cosmetics              Lighting         Filtration
                        Anti Corrosion       Data Storage
             Textiles
                              Computer Memory
             Coatings
Catalysis               Tissue Engineering
                                 11
10 Years of Nanotech




         11
Government
  $68Bn
Government
  $68Bn




 Private
 $183Bn
$250
Billion
“Anyone talking about trillion dollar markets,
thousands of start-ups and billions of dollars of
VC money is missing the point of
nanotechnology.

...most of the effects will not be called nano, and
they will be off the radar of most nano pundits &
gurus"

               -   Tim Harper 2003
Nanotechnology&Market&Evolu;on&2006?15&

                       1,600,000%


                       1,400,000%


                       1,200,000%
Value&(US$&Million)&




                       1,000,000%                                                                                                   Aero+Defence%
                                                                                                                                    Automo:ve%
                        800,000%
                                                                                                                                    Chemicals%
                                                                                                                                    General%
                        600,000%
                                                                                                                                    Food%
                                                                                                                                    Healthcare%
                        400,000%


                        200,000%


                               0%
                                2005%   2006%    2007%   2008%   2009%   2010%      2011%   2012%   2013%   2014%   2015%   2016%

                        !200,000%


                                                                            Year&
Nanotechnology&Market&Evolu;on&2006?15&

                       1,600,000%


                       1,400,000%


                       1,200,000%
Value&(US$&Million)&




                       1,000,000%                                                                                                   Aero+Defence%
                                                                                                                                    Automo:ve%
                        800,000%
                                                                                                                                    Chemicals%
                                                                                                                                    General%
                        600,000%
                                                                                                                                    Food%
                                                                                                                                    Healthcare%
                        400,000%


                        200,000%


                               0%
                                2005%   2006%    2007%   2008%   2009%   2010%      2011%   2012%   2013%   2014%   2015%   2016%

                        !200,000%


                                                                            Year&
Understanding Nature
Building From The
   Bottom Up
Genome contains 3.2Bn base pairs
Genome contains 3.2Bn base pairs
20-25,000 distinct genes encoded by 2
             bits (CGAT)
Genome contains 3.2Bn base pairs
20-25,000 distinct genes encoded by 2
             bits (CGAT)



        800 Mb
Genome contains 3.2Bn base pairs
20-25,000 distinct genes encoded by 2
             bits (CGAT)



        800 Mb
Genome contains 3.2Bn base pairs
20-25,000 distinct genes encoded by 2
             bits (CGAT)
         1.3Gb
        800 Mb
Using only chitin nature creates something

• strong & resilient
• breathable
• waterproof and
• creates colour through structure
Nature uses a few polymers
chitin, cellulose, starch,
protein, nucleic acid
We use thousands, many oil
based, to achieve the same
properties
Diagnosing Disease
Drug Delivery
Even Textiles
Nanotech
+ Biotech
+ IT
  ???????
Longest Published DNA Sequence




Synthetic Biology
                                  Source: Rob Carlson synthesis.cc
                         33
A Lot Like Moore’s Law
          34
Is It Just Smaller Faster
       Better Stuff?
Addressing the Challenge
Addressing the Challenge

 Sustained & responsible technology innovation is the
 only way that the world has supported six billion
 people and will continue to sustain 9 billion people by
 2050.
  ‣ WEF Global Agenda Council on Emerging
     Technologies
Is It Possible?
New & Sustainable
Investment Models
    Required?
Profiting From The
    Challenge
Profiting From The
       Challenge
• Sustainability is on everyones
 agenda now
Profiting From The
       Challenge
• Sustainability is on everyones
 agenda now
• Increasing regulatory pressure
Profiting From The
       Challenge
• Sustainability is on everyones
 agenda now
• Increasing regulatory pressure
• Nano/bio/IT convergence is a
 once a century opportunity
Finally




   43
Finally

Nanotechnologies and biosciences will
be as important to the 21st Century
as oil, polymers and semiconductors
were to the 20th Century




                 43
Finally

Nanotechnologies and biosciences will
be as important to the 21st Century
as oil, polymers and semiconductors
were to the 20th Century
We have the tools, lets use them
wisely

                 43
tim.harper@cientifica.com
       Twitter: @tim_harper

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Nanotech 101 For Investors

  • 1.
  • 2. Nanotechnology? Why Small is Having a Big Impact Tim Harper Cientifica Ltd
  • 3. What Do I Know? 2
  • 4. What Do I Know? 2
  • 5. What Do I Know? • Former Engineer at European Space Agency 2
  • 6. What Do I Know? • Former Engineer at European Space Agency • Serial Entrepreneur 2
  • 7. What Do I Know? • Former Engineer at European Space Agency • Serial Entrepreneur • Chair / Chief Advisor of Several National Funding Bodies 2
  • 8. What Do I Know? • Former Engineer at European Space Agency • Serial Entrepreneur • Chair / Chief Advisor of Several National Funding Bodies • World Economic Forum Emerging Technologies Council / Tech Pioneers 2
  • 9. What Do I Know? • Former Engineer at European Space Agency • Serial Entrepreneur • Chair / Chief Advisor of Several National Funding Bodies • World Economic Forum Emerging Technologies Council / Tech Pioneers • Advise Governments & Private Clients 2
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15. 5000 Years of Science 7
  • 16. 5000 Years of Science • We have been observing the world for 5000 years 7
  • 17. 5000 Years of Science • We have been observing the world for 5000 years • Significantly changing it for 100 years 7
  • 18. 5000 Years of Science • We have been observing the world for 5000 years • Significantly changing it for 100 years • Understanding our actions for 20 years 7
  • 19. Materials Have Shaped Our Culture & Economy 10,000 BC 1000 BC 0 1800 1900’s 2000 2010 Stone & Wood Iron Cement Steel Synthetic Biology Polymers Composites Nanotechnology Adapted from Herrmann, W. Chem. Eng. Technol. 21(7), 549 (1998) 8
  • 20. Control Over Materials Materials Have Always Been Vital to Humanity • Clothing, • Heating, hunting tools • Coal, iron, oil, copper • Semiconductors • Satellites 9
  • 22. Science Enables New Technologies Complexity 1650 1950 2050 10
  • 23. Science Enables New Technologies Complexity 1650 1950 2050 10
  • 24. Science Enables New Technologies Complexity 1650 1950 2050 10
  • 25. Science Enables New Technologies Complexity 1650 1950 2050 10
  • 26. Science Enables New Technologies Complexity 1650 1950 2050 10
  • 27. Science Enables New Technologies Complexity Semiconductors 1650 1950 2050 10
  • 28. Science Enables New Technologies Complexity Biotechnology Semiconductors 1650 1950 2050 10
  • 29. Science Enables New Technologies Nanotechnologies Complexity Biotechnology Semiconductors 1650 1950 2050 10
  • 30. Science Enables New Technologies Synthetic Biology Nanotechnologies Complexity Biotechnology Semiconductors 1650 1950 2050 10
  • 31. Science Enables New Technologies Geoengineering? Synthetic Biology Nanotechnologies Complexity Biotechnology Semiconductors 1650 1950 2050 10
  • 32. Science Enables New Technologies Geoengineering? Synthetic Biology Nanotechnologies Complexity Biotechnology Control Semiconductors 1650 1950 2050 10
  • 33. 10 Years of Nanotech 11
  • 34. 10 Years of Nanotech Household Cleaners Sporting Equipment Food Displays Drug Delivery Insulation Paints Sunscreen Water Treatment Construction Cosmetics Lighting Filtration Anti Corrosion Data Storage Textiles Computer Memory Coatings Catalysis Tissue Engineering 11
  • 35. 10 Years of Nanotech 11
  • 36.
  • 38. Government $68Bn Private $183Bn
  • 39.
  • 41. “Anyone talking about trillion dollar markets, thousands of start-ups and billions of dollars of VC money is missing the point of nanotechnology. ...most of the effects will not be called nano, and they will be off the radar of most nano pundits & gurus" - Tim Harper 2003
  • 42. Nanotechnology&Market&Evolu;on&2006?15& 1,600,000% 1,400,000% 1,200,000% Value&(US$&Million)& 1,000,000% Aero+Defence% Automo:ve% 800,000% Chemicals% General% 600,000% Food% Healthcare% 400,000% 200,000% 0% 2005% 2006% 2007% 2008% 2009% 2010% 2011% 2012% 2013% 2014% 2015% 2016% !200,000% Year&
  • 43. Nanotechnology&Market&Evolu;on&2006?15& 1,600,000% 1,400,000% 1,200,000% Value&(US$&Million)& 1,000,000% Aero+Defence% Automo:ve% 800,000% Chemicals% General% 600,000% Food% Healthcare% 400,000% 200,000% 0% 2005% 2006% 2007% 2008% 2009% 2010% 2011% 2012% 2013% 2014% 2015% 2016% !200,000% Year&
  • 45. Building From The Bottom Up
  • 46.
  • 47.
  • 48. Genome contains 3.2Bn base pairs
  • 49. Genome contains 3.2Bn base pairs 20-25,000 distinct genes encoded by 2 bits (CGAT)
  • 50. Genome contains 3.2Bn base pairs 20-25,000 distinct genes encoded by 2 bits (CGAT) 800 Mb
  • 51. Genome contains 3.2Bn base pairs 20-25,000 distinct genes encoded by 2 bits (CGAT) 800 Mb
  • 52. Genome contains 3.2Bn base pairs 20-25,000 distinct genes encoded by 2 bits (CGAT) 1.3Gb 800 Mb
  • 53.
  • 54. Using only chitin nature creates something • strong & resilient • breathable • waterproof and • creates colour through structure
  • 55. Nature uses a few polymers chitin, cellulose, starch, protein, nucleic acid We use thousands, many oil based, to achieve the same properties
  • 56.
  • 57.
  • 59.
  • 60.
  • 61.
  • 63.
  • 65.
  • 66.
  • 67.
  • 68.
  • 69.
  • 70.
  • 71.
  • 73. Longest Published DNA Sequence Synthetic Biology Source: Rob Carlson synthesis.cc 33
  • 74. A Lot Like Moore’s Law 34
  • 75.
  • 76. Is It Just Smaller Faster Better Stuff?
  • 77.
  • 78.
  • 79.
  • 80.
  • 82. Addressing the Challenge Sustained & responsible technology innovation is the only way that the world has supported six billion people and will continue to sustain 9 billion people by 2050. ‣ WEF Global Agenda Council on Emerging Technologies
  • 84.
  • 85.
  • 86.
  • 87.
  • 88.
  • 89.
  • 90. New & Sustainable Investment Models Required?
  • 91. Profiting From The Challenge
  • 92. Profiting From The Challenge • Sustainability is on everyones agenda now
  • 93. Profiting From The Challenge • Sustainability is on everyones agenda now • Increasing regulatory pressure
  • 94. Profiting From The Challenge • Sustainability is on everyones agenda now • Increasing regulatory pressure • Nano/bio/IT convergence is a once a century opportunity
  • 95. Finally 43
  • 96. Finally Nanotechnologies and biosciences will be as important to the 21st Century as oil, polymers and semiconductors were to the 20th Century 43
  • 97. Finally Nanotechnologies and biosciences will be as important to the 21st Century as oil, polymers and semiconductors were to the 20th Century We have the tools, lets use them wisely 43
  • 98. tim.harper@cientifica.com Twitter: @tim_harper