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Trends & Opportunities
               For Nanomaterials



                               Tim Harper
                       Cientifica Ltd / Envision ALR
                           Nanomaterials 2010
Tuesday, 8 June 2010
Trends & Opportunities
               For Nanomaterials



                               Tim Harper
                       Cientifica Ltd / Envision ALR
                           Nanomaterials 2010
Tuesday, 8 June 2010
Tim Harper
       • Engineer at European Space
             Agency
       • Serial Entrepreneur
       • Founder of European
             NanoBusiness Association
       • Chair / Chief Advisor of
             Several National Funding
             Bodies
       • World Economic Forum
             Emerging Technologies
             Council / Tech Pioneers
       • President, Nanotechnologies
             at Envision ALR
                                        2
Tuesday, 8 June 2010
We Wrote The Book on
               “Nano” in 2002
             “The Nanotechnology
              Opportunity Report is a
              breakthrough - it is the first
              complete report of the state
              of our field”
         	

 	

   -Meyya Meyyappan director of
              the Center for Nanotechnology at
              NASA Ames, March 2002




                                                  3

Tuesday, 8 June 2010
And Rewrote It In 2008

         "Almost a billion dollars of investors
            cash has been poured down the drain
            by investors who did not understand
            the crucial difference between a
            science project and a successful
            company, egged on by a plethora of
            nanotech ‘experts,’ while large
            corporations have laughed all the way
            to the bank”



                                                    4

Tuesday, 8 June 2010
Envision ALR
                  Envision A Living Revolution (“Envision”) was
                  launched in 2006 with the vision of becoming a
                  leading integrated operating company in the
                  markets of
                       •   Healthcare
                       •   Energy
                       •   Green Chemicals & Materials
                       •   Water


Tuesday, 8 June 2010
Envision ALR
                  Envision builds strategic and profitable positions in these markets by
                  acquiring & commercialising underexploited technology platforms in the
                  scientific fields of:
                       •   Regenerative Medicine
                       •   Nanotechnology
                       •   Industrial Biotechnology
                  Envision employs an integrated operating model and full life-cycle
                  funding approach allowing it to drive commercialization from the point
                  of technology acquisition all the way through manufacturing and
                  marketing
                  Envision develops products that can be marketed under Envision’s own
                  brand, or marketed by partners, under their own brands



Tuesday, 8 June 2010
Nanotechnologies -
                   From A Passive To An
                       Active Role


                            7
Tuesday, 8 June 2010
Global Population Growth
               11,000,000


               10,250,000


                 9,500,000


                 8,750,000


                 8,000,000


                 7,250,000


                 6,500,000
                          2010   2015   2020   2025   2030   2035    2040   2045   2050

                                        Medium        High     Low


Tuesday, 8 June 2010
Tuesday, 8 June 2010
Tuesday, 8 June 2010
Population Pressure
              World Average Income Per Capita
                           2007   2022
2007 Population                                                               2007 Expenditure
  Distribution                                                                   Per Capita
    30%                                                                                  1

                                                                                         0.9
    25%
                                                                                         0.8

                                                                                         0.7
    20%
                                                                                         0.6

    15%                                                                                  0.5

                                                                                         0.4
    10%
                                                                                         0.3

                                                                                         0.2
    5%
                                                                                         0.1

    0%                                                                                   0
                       0




                             00




                                    00




                                           00




                                                   00




                                                           00




                                                                   00




                                                                         00




                                                                                    00
          0




                  00




                             ,0




                                    ,0




                                           ,0




                                                   ,0




                                                          ,0




                                                                   ,0




                                                                         ,0




                                                                                   ,0
                  5,




                            10




                                   15




                                          20




                                                  25




                                                         30




                                                                  35




                                                                        40




                                                                                  45
                                   GDP per capita (in 2000 USD)

Tuesday, 8 June 2010
Can Technology Avoid
               War, Famine, Pestilence
                     or Worse?

                          11
Tuesday, 8 June 2010
5000 Years of Science




                             12
Tuesday, 8 June 2010
5000 Years of Science
                 Humans have




                               12
Tuesday, 8 June 2010
5000 Years of Science
                 Humans have

                       •   Been observing the
                           world for 5000 years




                                                  12
Tuesday, 8 June 2010
5000 Years of Science
                 Humans have

                       •   Been observing the
                           world for 5000 years

                       •   Significantly changing it
                           for 100 years




                                                      12
Tuesday, 8 June 2010
5000 Years of Science
                 Humans have

                       •   Been observing the
                           world for 5000 years

                       •   Significantly changing it
                           for 100 years

                       •   Understanding our
                           actions for 20 years



                                                      12
Tuesday, 8 June 2010
Control Over Materials

             Materials Have Always Been
             Vital to Humanity
         •   Clothing,
         •   Heating, hunting tools
         •   Coal, iron, oil, copper
         •   Semiconductors
         •   Satellites




                                          13

Tuesday, 8 June 2010
Materials Have Shaped
                    Our Culture
 10,000
   BC            1000 BC        0      1800              1900’s                  2000               2010




 Stone
& Wood                 Iron   Cement   Steel           Polymers                     Synthetic Biology
                                                      Composites          Nanotechnology




                                       Adapted from Herrmann, W. Chem. Eng. Technol. 21(7), 549 (1998)
                                                                                                         14

Tuesday, 8 June 2010
Science Enables New
                       Technologies
   Complexity




                                             Control
                       1650   1950   2050   15

Tuesday, 8 June 2010
Science Enables New
                       Technologies
   Complexity




                                             Control
                       1650   1950   2050   15

Tuesday, 8 June 2010
Science Enables New
                       Technologies
   Complexity




                                             Control
                       1650   1950   2050   15

Tuesday, 8 June 2010
Science Enables New
                       Technologies
   Complexity




                                             Control
                       1650   1950   2050   15

Tuesday, 8 June 2010
Science Enables New
                       Technologies
   Complexity




                                             Control
                       1650   1950   2050   15

Tuesday, 8 June 2010
Science Enables New
                       Technologies
   Complexity




                                             Control
                       1650   1950   2050   15

Tuesday, 8 June 2010
Science Enables New
                       Technologies
   Complexity




                                                       Control
                              Semiconductors
                       1650    1950            2050   15

Tuesday, 8 June 2010
Science Enables New
                       Technologies
   Complexity




                                                       Control
                                    Biotechnology
                              Semiconductors
                       1650    1950            2050   15

Tuesday, 8 June 2010
Science Enables New
                       Technologies
   Complexity




                                       Nanotechnologies




                                                           Control
                                    Biotechnology
                              Semiconductors
                       1650    1950            2050       15

Tuesday, 8 June 2010
Science Enables New
                       Technologies



                                           Synthetic Biology
   Complexity




                                       Nanotechnologies




                                                                Control
                                    Biotechnology
                              Semiconductors
                       1650    1950            2050            15

Tuesday, 8 June 2010
Science Enables New
                       Technologies


                                               Geoengineering?
                                           Synthetic Biology
   Complexity




                                       Nanotechnologies




                                                             Control
                                    Biotechnology
                              Semiconductors
                       1650    1950            2050         15

Tuesday, 8 June 2010
Moving From Control Of
                 Materials to Control of
                         Things




                           16
Tuesday, 8 June 2010
Moving From Control Of
                 Materials to Control of
                         Things
                Materials
           •    Metals

           •    Semiconductors

           •    Food Processing

                  Passive
                                  16
Tuesday, 8 June 2010
Moving From Control Of
                 Materials to Control of
                         Things
                Materials              Things
           •    Metals                 •   Crops

           •    Semiconductors         •   Cells

           •    Food Processing        •   The Planet?

                  Passive              Active
                                  16
Tuesday, 8 June 2010
9 global trends selected for discussion

                               Climate change, environment,                 Carbon productivity and adaptation becoming an
                        1
                               and sustainability                           increasingly dominant factor in all business decisions




                                                                                                                                                   Working Draft - Last Modified 19.11.2009 10:26:59
                        2      Rapidly growing demand for energy            Energy security becoming a bigger geopolitical concern


                        3      Limited resources                            Resource demand rapidly outpaces supply (oil, gas, coal, water,
                                                                            biomass, and other raw materials), price volatility

                               Increasing scarcity and unequal              Demand for clean water rapidly outpaces supply in regions where
                        4
                               distribution of water                        majority of the world's population lives*

                               Growing demand for food, nutrition, and      Agricultural production struggling to satisfy increasing demand for
                        5
                               health                                       high-calorie quality food and health care




                                                                                                                                                   Printed 03.11.2009 13:57:36
                        6      Demographics, including shifting             Over 1 billion new consumers (e.g., China and India); ageing
                               populations and mobility                     population; exploding demand for transport

                        7      Shifting centers of economic activity        Dramatic realignment of GDP, urbanization, new geo-political
                                                                            balance

                        8      Social life in a technological world         Connectivity transforms the way we live and interact


                        9      Corporate global citizenship                 Companies increasingly consider all stakeholders, particularly
                                                                            with respect to environmental sustainability


                              * By 2030, 40% of global GDP and 85% of the world's population will be in regions where water demand exceeds
                                supply (HBR July-August 2009, p. 1)
                        Source: McKinsey; inputs from WELCOM call 21 July 2009; bilateral discussions at World Economic Forum                 17
Tuesday, 8 June 2010
Huge Potential: Tiny
                           Rewards




Tuesday, 8 June 2010
A History of Technology
                    Push 1
                  Oxonica
                       •   Spun out in 1998 from University of Oxford

                       •   Raised £12.5m from investors

                       •   AIM flotation in June 2005 raised additional
                           £7.5m

                       •   Market Cap of £150m in 2005

                       •   Market Cap of £1.5m and delisted in 2009



Tuesday, 8 June 2010
Why Did They Fail?
               • All products were based on nanoparticles
               • Manufacturing was outsourced
               • Products were quickly commoditised
                       • Margins always under pressure
               • Lone acquisition did nothing to secure
                 markets, supply chains or diversify
               • Messy and costly IP disputes


Tuesday, 8 June 2010
A History of Technology
                    Push 2
                  Carbon Nanotechnologies Inc
                   • February 2005: 30 patents issued, 70
                     applications pending and were hoping to
                     corner the world market
                   • March 2007: Acquired for $5.4m in stock by
                     Arrowhead Research and merged with Unidym
                   • February 2009: Unidym replaces CEO and
                     closes old CNI facilities in Houston
                   • July 2009: “Zero employees”


Tuesday, 8 June 2010
Why Did ey Fail?
         CNI HAS THE BRAINS, THE CASH, NOW ALL IT NEEDS
           IS THE MARKET

         Carbon Nanotechnologies Inc. seems to have it all – a Nobel
           laureate as its co-founder, a veteran management team, $15
           million in angel funding and a working pilot plant. What the
           carbon nanotube producer lacks is a commercial product and a
           market. CNI is positioning itself to dominate once that
           happens by building its business and production capabilities
           simultaneously.
                                                             -July 29, 2002



Tuesday, 8 June 2010
A Rather Obvious
                          Conclusion




Tuesday, 8 June 2010
A Rather Obvious
                          Conclusion
               • Technology Push Doesn’t Work!
               • Hundreds of millions of dollars and twenty
                 years of research have yielded little of value
                 – why?
               • Basic business premise was to push the
                 technology onto an agnostic market




Tuesday, 8 June 2010
A Rather Obvious
                           Conclusion
                       Need to incorporate
                         nanomaterials in
                         products which
                       address real markets
                          and problems
Tuesday, 8 June 2010
Nanomaterials Already
                 In Widespread Use




                          24
Tuesday, 8 June 2010
Nanomaterials Already
                 In Widespread Use

               • Composite Materials
               • Conducting Polymers
               • Thin Film Photovoltaics


                                    24
Tuesday, 8 June 2010
Nanomaterials Already
                 In Widespread Use




                          24
Tuesday, 8 June 2010
Composite Applications

               • Automotive body parts
               • Aerospace composites & coatings
               • Packaging
               • Conducting polymers

                                   25
Tuesday, 8 June 2010
Nanocomposite
                          Materials
            • Polymer + nanoparticle, nanofibre or clay
            • Increases strength & rigidity
            • Lowers weight
            • Much of value is in the formulation rather
                  than the filler



                                   26
Tuesday, 8 June 2010
Nanocomposite
                           Materials
            • Polymer + nanoparticle, nanofibre or clay
            • Increases strength & rigidity
            • Lowers weight
            • Much of value is in the formulation rather
                  than the filler


                       Abalone Shell - Nanoscale Engineering
                                        26
Tuesday, 8 June 2010
Nanocomposite Use In
                Automotive Industry
               •       Conducting composites
                       for better paintability

               •       Moulding cycle time
                       reduction

               •       Improved mechanical
                       properties

               •       High scratch resistance
                       paints


                                                 27
Tuesday, 8 June 2010
Replacing Indium With
                  Conductive Inks
               • Demand Drivers
                • Rising demand for touch screens and flat
                         panel displays
                       • Increasing use of thin film solar panels
                       • Solar applications and displays require
                         better materials than Indium Tin Oxide
                       • Global supply of Indium is limited
                                           28
Tuesday, 8 June 2010
Conducting Polymers at
                   Envision




                       29
Tuesday, 8 June 2010
30

Tuesday, 8 June 2010
iLab




                        31
Tuesday, 8 June 2010
A Paradigm Shift in
                           Medical Diagnostics
                  Broad range of Point-of-Care applications
            •     Complete blood profiling
            •     HIV/STD testing
            •     Infectious diseases
            •     Molecular Diagnostics:
                       •   Cardiovascular diseases
                       •   Cancer diagnostics
            •     Animal health

                                                32
Tuesday, 8 June 2010
Nanosolar




                                   33

Tuesday, 8 June 2010
Nanosolar




                                   33

Tuesday, 8 June 2010
market volume (Billion $)


                       200
                                           Silicon                             Printed
                                    semiconductors                      semiconductors
                       150


                       100



                         50


                           0
                                    85




                                                    95




                                                                   05




                                                                               15




                                                                                           25
                            80




                                            90




                                                             00




                                                                         10




                                                                                     20




                                                                                                 30
                                  19




                                                  19




                                                                  20




                                                                              20




                                                                                          20
                          19




                                          19




                                                            20




                                                                        20




                                                                                    20




                                                                                                20
                       Market forecast SIA, IDTechEx 2006
                                                                                                      34

Tuesday, 8 June 2010
market volume (Billion $)


                       200
                                           Silicon                             Printed
                                    semiconductors                      semiconductors
                       150


                       100



                         50


                           0
                                    85




                                                    95




                                                                   05




                                                                               15




                                                                                           25
                            80




                                            90




                                                             00




                                                                         10




                                                                                     20




                                                                                                 30
                                  19




                                                  19




                                                                  20




                                                                              20




                                                                                          20
                          19




                                          19




                                                            20




                                                                        20




                                                                                    20




                                                                                                20
                       Market forecast SIA, IDTechEx 2006
                                                                                                      34

Tuesday, 8 June 2010
No Quick Returns?




                               35
Tuesday, 8 June 2010
No Quick Returns?
               • It will take ten to twenty years for new
                       sources for renewables to become
                       competitive with existing sources




                                         35
Tuesday, 8 June 2010
No Quick Returns?
               • It will take ten to twenty years for new
                       sources for renewables to become
                       competitive with existing sources
               • Market forces will drive up the cost of
                       dwindling resources in the meantime




                                         35
Tuesday, 8 June 2010
No Quick Returns?
               • It will take ten to twenty years for new
                       sources for renewables to become
                       competitive with existing sources
               • Market forces will drive up the cost of
                       dwindling resources in the meantime
               • Current investment levels in renewables
                       have priced many investors out of the
                       market

                                          35
Tuesday, 8 June 2010
It Takes $1Bn To Get In
                   The Solar Game




                          36
Tuesday, 8 June 2010
It Takes $1Bn To Get In
                   The Solar Game
               • Konarka Technologies burned through over
                       $100 million in VC funding




                                          36
Tuesday, 8 June 2010
It Takes $1Bn To Get In
                   The Solar Game
               • Konarka Technologies burned through over
                       $100 million in VC funding
               • Nanosolar has raised $295 million to date



                                          36
Tuesday, 8 June 2010
It Takes $1Bn To Get In
                   The Solar Game
               • Konarka Technologies burned through over
                       $100 million in VC funding
               • Nanosolar has raised $295 million to date
               • Realistic opportunities are enabled by
                       organic solar, not producing solar



                                           36
Tuesday, 8 June 2010
Resources Are Getting
                      Scarcer
               •       Global competition for
                       resources

               •       Demand driven by
                       increasing and
                       increasingly affluent
                       population

               •       Some resources are
                       almost exhausted



                                                37
Tuesday, 8 June 2010
Scarce Resources
                       Metal                     Remaining Supply*
                       Indium                    5-10 years
                       Antinomy                  15-20 years
                       Platinum                  15 years
                       Hafnium                   10 years
                       Tantalum                  20-30 years
                       Uranium                   30-40 years


                                   Armin Reller, U. Augsburg, Tom Graedel, Yale
                                  * Pre Global Economic Crisis
                                                                                  38

Tuesday, 8 June 2010
The Rare Earth
               • Global demand for rare earths has tripled
                       from 40,000 tonnes to 120,000 tonnes over
                       the past 10 years
               • China now controls 97% of the global supply
                       of 17 rare earths
               • 25% of new green technologies rely on
                       minor metals and rare earths


                                           39
Tuesday, 8 June 2010
A Fuel Efficient
                              Resource Hog
               • Each electric Prius motor
                       requires 1 Kg of
                       neodymium

               • Each battery uses 10 to
                       15 kg of lanthanum

               • The most rare earth
                       intensive product on the
                       planet



                                                  40
Tuesday, 8 June 2010
Uses of Indium
                          Global Market for Transparent
                                  Conductors                                 Touch Screens,
                                                                             & other electronics
       3,500,000


     $3.0B
      3,000,000



     $2.5B
      2,500,000
                                                                              Solar Cells


     $2.0B
      2,000,000



     $1.5B
      1,500,000

                                                                             LCD Displays
       1,000,000
     $1.0B

       500,000
     $0.5B

             -
                   1          2          3          4          5        6

                       2006       2007       2008       2009   2010   2011


                                                                                                   41

Tuesday, 8 June 2010
He Could Be Right!


                 “Rare earths are to China
                 as oil is to the Middle East”

                 - Deng Xiaoping (1992)




                                                 42
Tuesday, 8 June 2010
What Can We Do?



                              43
Tuesday, 8 June 2010
We Have The Tools




                               44
Tuesday, 8 June 2010
How To Use Them?




                              45
Tuesday, 8 June 2010
Using Emerging
                             Technologies
               •       Emerging technologies are critical to long-term
                       global prosperity
               •       Innovative technologies do not conform to
                       conventional technology development
                       paradigms
               •       Effective policies for nurturing and employing
                       emerging technologies are largely absent or
                       poorly formed in government, industry and
                       other stakeholder organisations

                                            46
Tuesday, 8 June 2010
Understanding Nature




                          47
Tuesday, 8 June 2010
A Top Down Approach




                         48
Tuesday, 8 June 2010
A Bottom Up Approach




                       49
Tuesday, 8 June 2010
By Copying This Trick

                  Reducing friction between container ships hull
                  & water could
                       • Save 1% of global oil consumption or
                       • 850,000 barrels per day


                                          50
Tuesday, 8 June 2010
An Old Trick For
                           Textiles




                              51
Tuesday, 8 June 2010
Synthetic Biology
                                               Longest Published DNA
                                                     Sequence


                                    Source: Rob Carlson synthesis.cc
                               52
Tuesday, 8 June 2010
A Lot Like Moore’s Law
                       53
Tuesday, 8 June 2010
Not Just Biofuels

                  Converting waste products into feedstock
            • Wheat & Rice Straw to Sugars
              ➡Sugars to Glycol
              ➡Glycol to Bioplastics

                                      54
Tuesday, 8 June 2010
Reducing Our Dependence On This
                           55
Tuesday, 8 June 2010
Cleaning Up The Mess



Tuesday, 8 June 2010
What We Need
                Sector             Need                       Solution
                                Improve Yields
                                                                GM Crops
                  Food        Address Malnutrition
                                                                Golden Rice

                             Reduce Consumption                 Composites
                Energy       Generate Clean energy             Photovoltaics
                                                                Wind/ Tidal

                                Alternative Fuels            Industrial Biotech
              Climate      Make Better Use of What We
                                      Have
                                                             Synthetic Biology
                                                               Nanomaterials

                                                              Synthetic Biology
                           Earlier & Cheaper Detection
               Disease          Effective Treatment
                                                         Targeted Nanoparticle Drug
                                                                  Delivery

                                       57
Tuesday, 8 June 2010
Can We Do It?




                             58
Tuesday, 8 June 2010
Can We Do It?

                  Well...




                                  58
Tuesday, 8 June 2010
Can We Do It?

                  Well...
            • The innovation process is inefficient



                                   58
Tuesday, 8 June 2010
Can We Do It?

                  Well...
            • The innovation process is inefficient
            • Capital for Emerging Technologies is Poorly
                  Educated




                                   58
Tuesday, 8 June 2010
Can We Do It?

                  Well...
            • The innovation process is inefficient
            • Capital for Emerging Technologies is Poorly
                  Educated
            • Governments Lack Foresight

                                   58
Tuesday, 8 June 2010
Inefficient Innovation




                                 59
Tuesday, 8 June 2010
Inefficient Innovation

                  To get there we need




                                     59
Tuesday, 8 June 2010
Inefficient Innovation

                  To get there we need
            • Scientists to realise commercial potential




                                     59
Tuesday, 8 June 2010
Inefficient Innovation

                  To get there we need
            • Scientists to realise commercial potential
            • Investor to both ‘get it’ and have liquidity



                                     59
Tuesday, 8 June 2010
Inefficient Innovation

                  To get there we need
            • Scientists to realise commercial potential
            • Investor to both ‘get it’ and have liquidity
            • Quality management to take it to market


                                     59
Tuesday, 8 June 2010
Inefficient Innovation

                  To get there we need
            • Scientists to realise commercial potential
            • Investor to both ‘get it’ and have liquidity
            • Quality management to take it to market
            • Market pull rather than technology push

                                     59
Tuesday, 8 June 2010
The Capital Gap
                  VC investments are highly concentrated
                   • 6 of 17 industries receive >73% of investment
                   • “Me too” company investments are common

                  Sectors are selected with inexperience
                   • Example: $ Billions invested into biofuels

            •     Investments have unrealistic expectations
                   • > $100 MM in annual revenue targets
                   • Ignoring advances and “foundation technologies”

                                             60
Tuesday, 8 June 2010
Government Foresight

               • Huge pressure on finances
               • Hard to second guess the market
               • Governments have a poor record of picking
                       winners



                                   61
Tuesday, 8 June 2010
In The End...




                             62
Tuesday, 8 June 2010
In The End...

               • Technology has lead every economic and
                       social advance for the last 10,000 years




                                           62
Tuesday, 8 June 2010
In The End...

               • Technology has lead every economic and
                       social advance for the last 10,000 years
               • It can create and clear up problems (e.g
                       Ozone layer depletion)




                                           62
Tuesday, 8 June 2010
In The End...

               • Technology has lead every economic and
                       social advance for the last 10,000 years
               • It can create and clear up problems (e.g
                       Ozone layer depletion)
               • It is human nature to innovate

                                           62
Tuesday, 8 June 2010
Conclusions




                            63
Tuesday, 8 June 2010
Conclusions

                  Nanotechnologies and biosciences will be as
                  important to the 21st Century as oil,
                  polymers and semiconductors were to the
                  20th Century




                                      63
Tuesday, 8 June 2010
Conclusions

                  Nanotechnologies and biosciences will be as
                  important to the 21st Century as oil,
                  polymers and semiconductors were to the
                  20th Century
                  We have the tools, lets use them wisely



                                       63
Tuesday, 8 June 2010
tim.harper@envisionalr.com
                       Twitter: @tim_harper




Tuesday, 8 June 2010

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Nanomaterials 2010

  • 1. Trends & Opportunities For Nanomaterials Tim Harper Cientifica Ltd / Envision ALR Nanomaterials 2010 Tuesday, 8 June 2010
  • 2. Trends & Opportunities For Nanomaterials Tim Harper Cientifica Ltd / Envision ALR Nanomaterials 2010 Tuesday, 8 June 2010
  • 3. Tim Harper • Engineer at European Space Agency • Serial Entrepreneur • Founder of European NanoBusiness Association • Chair / Chief Advisor of Several National Funding Bodies • World Economic Forum Emerging Technologies Council / Tech Pioneers • President, Nanotechnologies at Envision ALR 2 Tuesday, 8 June 2010
  • 4. We Wrote The Book on “Nano” in 2002 “The Nanotechnology Opportunity Report is a breakthrough - it is the first complete report of the state of our field” -Meyya Meyyappan director of the Center for Nanotechnology at NASA Ames, March 2002 3 Tuesday, 8 June 2010
  • 5. And Rewrote It In 2008 "Almost a billion dollars of investors cash has been poured down the drain by investors who did not understand the crucial difference between a science project and a successful company, egged on by a plethora of nanotech ‘experts,’ while large corporations have laughed all the way to the bank” 4 Tuesday, 8 June 2010
  • 6. Envision ALR Envision A Living Revolution (“Envision”) was launched in 2006 with the vision of becoming a leading integrated operating company in the markets of • Healthcare • Energy • Green Chemicals & Materials • Water Tuesday, 8 June 2010
  • 7. Envision ALR Envision builds strategic and profitable positions in these markets by acquiring & commercialising underexploited technology platforms in the scientific fields of: • Regenerative Medicine • Nanotechnology • Industrial Biotechnology Envision employs an integrated operating model and full life-cycle funding approach allowing it to drive commercialization from the point of technology acquisition all the way through manufacturing and marketing Envision develops products that can be marketed under Envision’s own brand, or marketed by partners, under their own brands Tuesday, 8 June 2010
  • 8. Nanotechnologies - From A Passive To An Active Role 7 Tuesday, 8 June 2010
  • 9. Global Population Growth 11,000,000 10,250,000 9,500,000 8,750,000 8,000,000 7,250,000 6,500,000 2010 2015 2020 2025 2030 2035 2040 2045 2050 Medium High Low Tuesday, 8 June 2010
  • 12. Population Pressure World Average Income Per Capita 2007 2022 2007 Population 2007 Expenditure Distribution Per Capita 30% 1 0.9 25% 0.8 0.7 20% 0.6 15% 0.5 0.4 10% 0.3 0.2 5% 0.1 0% 0 0 00 00 00 00 00 00 00 00 0 00 ,0 ,0 ,0 ,0 ,0 ,0 ,0 ,0 5, 10 15 20 25 30 35 40 45 GDP per capita (in 2000 USD) Tuesday, 8 June 2010
  • 13. Can Technology Avoid War, Famine, Pestilence or Worse? 11 Tuesday, 8 June 2010
  • 14. 5000 Years of Science 12 Tuesday, 8 June 2010
  • 15. 5000 Years of Science Humans have 12 Tuesday, 8 June 2010
  • 16. 5000 Years of Science Humans have • Been observing the world for 5000 years 12 Tuesday, 8 June 2010
  • 17. 5000 Years of Science Humans have • Been observing the world for 5000 years • Significantly changing it for 100 years 12 Tuesday, 8 June 2010
  • 18. 5000 Years of Science Humans have • Been observing the world for 5000 years • Significantly changing it for 100 years • Understanding our actions for 20 years 12 Tuesday, 8 June 2010
  • 19. Control Over Materials Materials Have Always Been Vital to Humanity • Clothing, • Heating, hunting tools • Coal, iron, oil, copper • Semiconductors • Satellites 13 Tuesday, 8 June 2010
  • 20. Materials Have Shaped Our Culture 10,000 BC 1000 BC 0 1800 1900’s 2000 2010 Stone & Wood Iron Cement Steel Polymers Synthetic Biology Composites Nanotechnology Adapted from Herrmann, W. Chem. Eng. Technol. 21(7), 549 (1998) 14 Tuesday, 8 June 2010
  • 21. Science Enables New Technologies Complexity Control 1650 1950 2050 15 Tuesday, 8 June 2010
  • 22. Science Enables New Technologies Complexity Control 1650 1950 2050 15 Tuesday, 8 June 2010
  • 23. Science Enables New Technologies Complexity Control 1650 1950 2050 15 Tuesday, 8 June 2010
  • 24. Science Enables New Technologies Complexity Control 1650 1950 2050 15 Tuesday, 8 June 2010
  • 25. Science Enables New Technologies Complexity Control 1650 1950 2050 15 Tuesday, 8 June 2010
  • 26. Science Enables New Technologies Complexity Control 1650 1950 2050 15 Tuesday, 8 June 2010
  • 27. Science Enables New Technologies Complexity Control Semiconductors 1650 1950 2050 15 Tuesday, 8 June 2010
  • 28. Science Enables New Technologies Complexity Control Biotechnology Semiconductors 1650 1950 2050 15 Tuesday, 8 June 2010
  • 29. Science Enables New Technologies Complexity Nanotechnologies Control Biotechnology Semiconductors 1650 1950 2050 15 Tuesday, 8 June 2010
  • 30. Science Enables New Technologies Synthetic Biology Complexity Nanotechnologies Control Biotechnology Semiconductors 1650 1950 2050 15 Tuesday, 8 June 2010
  • 31. Science Enables New Technologies Geoengineering? Synthetic Biology Complexity Nanotechnologies Control Biotechnology Semiconductors 1650 1950 2050 15 Tuesday, 8 June 2010
  • 32. Moving From Control Of Materials to Control of Things 16 Tuesday, 8 June 2010
  • 33. Moving From Control Of Materials to Control of Things Materials • Metals • Semiconductors • Food Processing Passive 16 Tuesday, 8 June 2010
  • 34. Moving From Control Of Materials to Control of Things Materials Things • Metals • Crops • Semiconductors • Cells • Food Processing • The Planet? Passive Active 16 Tuesday, 8 June 2010
  • 35. 9 global trends selected for discussion Climate change, environment, Carbon productivity and adaptation becoming an 1 and sustainability increasingly dominant factor in all business decisions Working Draft - Last Modified 19.11.2009 10:26:59 2 Rapidly growing demand for energy Energy security becoming a bigger geopolitical concern 3 Limited resources Resource demand rapidly outpaces supply (oil, gas, coal, water, biomass, and other raw materials), price volatility Increasing scarcity and unequal Demand for clean water rapidly outpaces supply in regions where 4 distribution of water majority of the world's population lives* Growing demand for food, nutrition, and Agricultural production struggling to satisfy increasing demand for 5 health high-calorie quality food and health care Printed 03.11.2009 13:57:36 6 Demographics, including shifting Over 1 billion new consumers (e.g., China and India); ageing populations and mobility population; exploding demand for transport 7 Shifting centers of economic activity Dramatic realignment of GDP, urbanization, new geo-political balance 8 Social life in a technological world Connectivity transforms the way we live and interact 9 Corporate global citizenship Companies increasingly consider all stakeholders, particularly with respect to environmental sustainability * By 2030, 40% of global GDP and 85% of the world's population will be in regions where water demand exceeds supply (HBR July-August 2009, p. 1) Source: McKinsey; inputs from WELCOM call 21 July 2009; bilateral discussions at World Economic Forum 17 Tuesday, 8 June 2010
  • 36. Huge Potential: Tiny Rewards Tuesday, 8 June 2010
  • 37. A History of Technology Push 1 Oxonica • Spun out in 1998 from University of Oxford • Raised £12.5m from investors • AIM flotation in June 2005 raised additional £7.5m • Market Cap of £150m in 2005 • Market Cap of £1.5m and delisted in 2009 Tuesday, 8 June 2010
  • 38. Why Did They Fail? • All products were based on nanoparticles • Manufacturing was outsourced • Products were quickly commoditised • Margins always under pressure • Lone acquisition did nothing to secure markets, supply chains or diversify • Messy and costly IP disputes Tuesday, 8 June 2010
  • 39. A History of Technology Push 2 Carbon Nanotechnologies Inc • February 2005: 30 patents issued, 70 applications pending and were hoping to corner the world market • March 2007: Acquired for $5.4m in stock by Arrowhead Research and merged with Unidym • February 2009: Unidym replaces CEO and closes old CNI facilities in Houston • July 2009: “Zero employees” Tuesday, 8 June 2010
  • 40. Why Did ey Fail? CNI HAS THE BRAINS, THE CASH, NOW ALL IT NEEDS IS THE MARKET Carbon Nanotechnologies Inc. seems to have it all – a Nobel laureate as its co-founder, a veteran management team, $15 million in angel funding and a working pilot plant. What the carbon nanotube producer lacks is a commercial product and a market. CNI is positioning itself to dominate once that happens by building its business and production capabilities simultaneously. -July 29, 2002 Tuesday, 8 June 2010
  • 41. A Rather Obvious Conclusion Tuesday, 8 June 2010
  • 42. A Rather Obvious Conclusion • Technology Push Doesn’t Work! • Hundreds of millions of dollars and twenty years of research have yielded little of value – why? • Basic business premise was to push the technology onto an agnostic market Tuesday, 8 June 2010
  • 43. A Rather Obvious Conclusion Need to incorporate nanomaterials in products which address real markets and problems Tuesday, 8 June 2010
  • 44. Nanomaterials Already In Widespread Use 24 Tuesday, 8 June 2010
  • 45. Nanomaterials Already In Widespread Use • Composite Materials • Conducting Polymers • Thin Film Photovoltaics 24 Tuesday, 8 June 2010
  • 46. Nanomaterials Already In Widespread Use 24 Tuesday, 8 June 2010
  • 47. Composite Applications • Automotive body parts • Aerospace composites & coatings • Packaging • Conducting polymers 25 Tuesday, 8 June 2010
  • 48. Nanocomposite Materials • Polymer + nanoparticle, nanofibre or clay • Increases strength & rigidity • Lowers weight • Much of value is in the formulation rather than the filler 26 Tuesday, 8 June 2010
  • 49. Nanocomposite Materials • Polymer + nanoparticle, nanofibre or clay • Increases strength & rigidity • Lowers weight • Much of value is in the formulation rather than the filler Abalone Shell - Nanoscale Engineering 26 Tuesday, 8 June 2010
  • 50. Nanocomposite Use In Automotive Industry • Conducting composites for better paintability • Moulding cycle time reduction • Improved mechanical properties • High scratch resistance paints 27 Tuesday, 8 June 2010
  • 51. Replacing Indium With Conductive Inks • Demand Drivers • Rising demand for touch screens and flat panel displays • Increasing use of thin film solar panels • Solar applications and displays require better materials than Indium Tin Oxide • Global supply of Indium is limited 28 Tuesday, 8 June 2010
  • 52. Conducting Polymers at Envision 29 Tuesday, 8 June 2010
  • 54. iLab 31 Tuesday, 8 June 2010
  • 55. A Paradigm Shift in Medical Diagnostics Broad range of Point-of-Care applications • Complete blood profiling • HIV/STD testing • Infectious diseases • Molecular Diagnostics: • Cardiovascular diseases • Cancer diagnostics • Animal health 32 Tuesday, 8 June 2010
  • 56. Nanosolar 33 Tuesday, 8 June 2010
  • 57. Nanosolar 33 Tuesday, 8 June 2010
  • 58. market volume (Billion $) 200 Silicon Printed semiconductors semiconductors 150 100 50 0 85 95 05 15 25 80 90 00 10 20 30 19 19 20 20 20 19 19 20 20 20 20 Market forecast SIA, IDTechEx 2006 34 Tuesday, 8 June 2010
  • 59. market volume (Billion $) 200 Silicon Printed semiconductors semiconductors 150 100 50 0 85 95 05 15 25 80 90 00 10 20 30 19 19 20 20 20 19 19 20 20 20 20 Market forecast SIA, IDTechEx 2006 34 Tuesday, 8 June 2010
  • 60. No Quick Returns? 35 Tuesday, 8 June 2010
  • 61. No Quick Returns? • It will take ten to twenty years for new sources for renewables to become competitive with existing sources 35 Tuesday, 8 June 2010
  • 62. No Quick Returns? • It will take ten to twenty years for new sources for renewables to become competitive with existing sources • Market forces will drive up the cost of dwindling resources in the meantime 35 Tuesday, 8 June 2010
  • 63. No Quick Returns? • It will take ten to twenty years for new sources for renewables to become competitive with existing sources • Market forces will drive up the cost of dwindling resources in the meantime • Current investment levels in renewables have priced many investors out of the market 35 Tuesday, 8 June 2010
  • 64. It Takes $1Bn To Get In The Solar Game 36 Tuesday, 8 June 2010
  • 65. It Takes $1Bn To Get In The Solar Game • Konarka Technologies burned through over $100 million in VC funding 36 Tuesday, 8 June 2010
  • 66. It Takes $1Bn To Get In The Solar Game • Konarka Technologies burned through over $100 million in VC funding • Nanosolar has raised $295 million to date 36 Tuesday, 8 June 2010
  • 67. It Takes $1Bn To Get In The Solar Game • Konarka Technologies burned through over $100 million in VC funding • Nanosolar has raised $295 million to date • Realistic opportunities are enabled by organic solar, not producing solar 36 Tuesday, 8 June 2010
  • 68. Resources Are Getting Scarcer • Global competition for resources • Demand driven by increasing and increasingly affluent population • Some resources are almost exhausted 37 Tuesday, 8 June 2010
  • 69. Scarce Resources Metal Remaining Supply* Indium 5-10 years Antinomy 15-20 years Platinum 15 years Hafnium 10 years Tantalum 20-30 years Uranium 30-40 years Armin Reller, U. Augsburg, Tom Graedel, Yale * Pre Global Economic Crisis 38 Tuesday, 8 June 2010
  • 70. The Rare Earth • Global demand for rare earths has tripled from 40,000 tonnes to 120,000 tonnes over the past 10 years • China now controls 97% of the global supply of 17 rare earths • 25% of new green technologies rely on minor metals and rare earths 39 Tuesday, 8 June 2010
  • 71. A Fuel Efficient Resource Hog • Each electric Prius motor requires 1 Kg of neodymium • Each battery uses 10 to 15 kg of lanthanum • The most rare earth intensive product on the planet 40 Tuesday, 8 June 2010
  • 72. Uses of Indium Global Market for Transparent Conductors Touch Screens, & other electronics 3,500,000 $3.0B 3,000,000 $2.5B 2,500,000 Solar Cells $2.0B 2,000,000 $1.5B 1,500,000 LCD Displays 1,000,000 $1.0B 500,000 $0.5B - 1 2 3 4 5 6 2006 2007 2008 2009 2010 2011 41 Tuesday, 8 June 2010
  • 73. He Could Be Right! “Rare earths are to China as oil is to the Middle East” - Deng Xiaoping (1992) 42 Tuesday, 8 June 2010
  • 74. What Can We Do? 43 Tuesday, 8 June 2010
  • 75. We Have The Tools 44 Tuesday, 8 June 2010
  • 76. How To Use Them? 45 Tuesday, 8 June 2010
  • 77. Using Emerging Technologies • Emerging technologies are critical to long-term global prosperity • Innovative technologies do not conform to conventional technology development paradigms • Effective policies for nurturing and employing emerging technologies are largely absent or poorly formed in government, industry and other stakeholder organisations 46 Tuesday, 8 June 2010
  • 78. Understanding Nature 47 Tuesday, 8 June 2010
  • 79. A Top Down Approach 48 Tuesday, 8 June 2010
  • 80. A Bottom Up Approach 49 Tuesday, 8 June 2010
  • 81. By Copying This Trick Reducing friction between container ships hull & water could • Save 1% of global oil consumption or • 850,000 barrels per day 50 Tuesday, 8 June 2010
  • 82. An Old Trick For Textiles 51 Tuesday, 8 June 2010
  • 83. Synthetic Biology Longest Published DNA Sequence Source: Rob Carlson synthesis.cc 52 Tuesday, 8 June 2010
  • 84. A Lot Like Moore’s Law 53 Tuesday, 8 June 2010
  • 85. Not Just Biofuels Converting waste products into feedstock • Wheat & Rice Straw to Sugars ➡Sugars to Glycol ➡Glycol to Bioplastics 54 Tuesday, 8 June 2010
  • 86. Reducing Our Dependence On This 55 Tuesday, 8 June 2010
  • 87. Cleaning Up The Mess Tuesday, 8 June 2010
  • 88. What We Need Sector Need Solution Improve Yields GM Crops Food Address Malnutrition Golden Rice Reduce Consumption Composites Energy Generate Clean energy Photovoltaics Wind/ Tidal Alternative Fuels Industrial Biotech Climate Make Better Use of What We Have Synthetic Biology Nanomaterials Synthetic Biology Earlier & Cheaper Detection Disease Effective Treatment Targeted Nanoparticle Drug Delivery 57 Tuesday, 8 June 2010
  • 89. Can We Do It? 58 Tuesday, 8 June 2010
  • 90. Can We Do It? Well... 58 Tuesday, 8 June 2010
  • 91. Can We Do It? Well... • The innovation process is inefficient 58 Tuesday, 8 June 2010
  • 92. Can We Do It? Well... • The innovation process is inefficient • Capital for Emerging Technologies is Poorly Educated 58 Tuesday, 8 June 2010
  • 93. Can We Do It? Well... • The innovation process is inefficient • Capital for Emerging Technologies is Poorly Educated • Governments Lack Foresight 58 Tuesday, 8 June 2010
  • 94. Inefficient Innovation 59 Tuesday, 8 June 2010
  • 95. Inefficient Innovation To get there we need 59 Tuesday, 8 June 2010
  • 96. Inefficient Innovation To get there we need • Scientists to realise commercial potential 59 Tuesday, 8 June 2010
  • 97. Inefficient Innovation To get there we need • Scientists to realise commercial potential • Investor to both ‘get it’ and have liquidity 59 Tuesday, 8 June 2010
  • 98. Inefficient Innovation To get there we need • Scientists to realise commercial potential • Investor to both ‘get it’ and have liquidity • Quality management to take it to market 59 Tuesday, 8 June 2010
  • 99. Inefficient Innovation To get there we need • Scientists to realise commercial potential • Investor to both ‘get it’ and have liquidity • Quality management to take it to market • Market pull rather than technology push 59 Tuesday, 8 June 2010
  • 100. The Capital Gap VC investments are highly concentrated • 6 of 17 industries receive >73% of investment • “Me too” company investments are common Sectors are selected with inexperience • Example: $ Billions invested into biofuels • Investments have unrealistic expectations • > $100 MM in annual revenue targets • Ignoring advances and “foundation technologies” 60 Tuesday, 8 June 2010
  • 101. Government Foresight • Huge pressure on finances • Hard to second guess the market • Governments have a poor record of picking winners 61 Tuesday, 8 June 2010
  • 102. In The End... 62 Tuesday, 8 June 2010
  • 103. In The End... • Technology has lead every economic and social advance for the last 10,000 years 62 Tuesday, 8 June 2010
  • 104. In The End... • Technology has lead every economic and social advance for the last 10,000 years • It can create and clear up problems (e.g Ozone layer depletion) 62 Tuesday, 8 June 2010
  • 105. In The End... • Technology has lead every economic and social advance for the last 10,000 years • It can create and clear up problems (e.g Ozone layer depletion) • It is human nature to innovate 62 Tuesday, 8 June 2010
  • 106. Conclusions 63 Tuesday, 8 June 2010
  • 107. Conclusions Nanotechnologies and biosciences will be as important to the 21st Century as oil, polymers and semiconductors were to the 20th Century 63 Tuesday, 8 June 2010
  • 108. Conclusions Nanotechnologies and biosciences will be as important to the 21st Century as oil, polymers and semiconductors were to the 20th Century We have the tools, lets use them wisely 63 Tuesday, 8 June 2010
  • 109. tim.harper@envisionalr.com Twitter: @tim_harper Tuesday, 8 June 2010