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Nanomaterials 2010
1. Trends & Opportunities
For Nanomaterials
Tim Harper
Cientifica Ltd / Envision ALR
Nanomaterials 2010
Tuesday, 8 June 2010
2. Trends & Opportunities
For Nanomaterials
Tim Harper
Cientifica Ltd / Envision ALR
Nanomaterials 2010
Tuesday, 8 June 2010
3. Tim Harper
• Engineer at European Space
Agency
• Serial Entrepreneur
• Founder of European
NanoBusiness Association
• Chair / Chief Advisor of
Several National Funding
Bodies
• World Economic Forum
Emerging Technologies
Council / Tech Pioneers
• President, Nanotechnologies
at Envision ALR
2
Tuesday, 8 June 2010
4. We Wrote The Book on
“Nano” in 2002
“The Nanotechnology
Opportunity Report is a
breakthrough - it is the first
complete report of the state
of our field”
-Meyya Meyyappan director of
the Center for Nanotechnology at
NASA Ames, March 2002
3
Tuesday, 8 June 2010
5. And Rewrote It In 2008
"Almost a billion dollars of investors
cash has been poured down the drain
by investors who did not understand
the crucial difference between a
science project and a successful
company, egged on by a plethora of
nanotech ‘experts,’ while large
corporations have laughed all the way
to the bank”
4
Tuesday, 8 June 2010
6. Envision ALR
Envision A Living Revolution (“Envision”) was
launched in 2006 with the vision of becoming a
leading integrated operating company in the
markets of
• Healthcare
• Energy
• Green Chemicals & Materials
• Water
Tuesday, 8 June 2010
7. Envision ALR
Envision builds strategic and profitable positions in these markets by
acquiring & commercialising underexploited technology platforms in the
scientific fields of:
• Regenerative Medicine
• Nanotechnology
• Industrial Biotechnology
Envision employs an integrated operating model and full life-cycle
funding approach allowing it to drive commercialization from the point
of technology acquisition all the way through manufacturing and
marketing
Envision develops products that can be marketed under Envision’s own
brand, or marketed by partners, under their own brands
Tuesday, 8 June 2010
8. Nanotechnologies -
From A Passive To An
Active Role
7
Tuesday, 8 June 2010
9. Global Population Growth
11,000,000
10,250,000
9,500,000
8,750,000
8,000,000
7,250,000
6,500,000
2010 2015 2020 2025 2030 2035 2040 2045 2050
Medium High Low
Tuesday, 8 June 2010
15. 5000 Years of Science
Humans have
12
Tuesday, 8 June 2010
16. 5000 Years of Science
Humans have
• Been observing the
world for 5000 years
12
Tuesday, 8 June 2010
17. 5000 Years of Science
Humans have
• Been observing the
world for 5000 years
• Significantly changing it
for 100 years
12
Tuesday, 8 June 2010
18. 5000 Years of Science
Humans have
• Been observing the
world for 5000 years
• Significantly changing it
for 100 years
• Understanding our
actions for 20 years
12
Tuesday, 8 June 2010
19. Control Over Materials
Materials Have Always Been
Vital to Humanity
• Clothing,
• Heating, hunting tools
• Coal, iron, oil, copper
• Semiconductors
• Satellites
13
Tuesday, 8 June 2010
20. Materials Have Shaped
Our Culture
10,000
BC 1000 BC 0 1800 1900’s 2000 2010
Stone
& Wood Iron Cement Steel Polymers Synthetic Biology
Composites Nanotechnology
Adapted from Herrmann, W. Chem. Eng. Technol. 21(7), 549 (1998)
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Tuesday, 8 June 2010
21. Science Enables New
Technologies
Complexity
Control
1650 1950 2050 15
Tuesday, 8 June 2010
22. Science Enables New
Technologies
Complexity
Control
1650 1950 2050 15
Tuesday, 8 June 2010
23. Science Enables New
Technologies
Complexity
Control
1650 1950 2050 15
Tuesday, 8 June 2010
24. Science Enables New
Technologies
Complexity
Control
1650 1950 2050 15
Tuesday, 8 June 2010
25. Science Enables New
Technologies
Complexity
Control
1650 1950 2050 15
Tuesday, 8 June 2010
26. Science Enables New
Technologies
Complexity
Control
1650 1950 2050 15
Tuesday, 8 June 2010
27. Science Enables New
Technologies
Complexity
Control
Semiconductors
1650 1950 2050 15
Tuesday, 8 June 2010
28. Science Enables New
Technologies
Complexity
Control
Biotechnology
Semiconductors
1650 1950 2050 15
Tuesday, 8 June 2010
29. Science Enables New
Technologies
Complexity
Nanotechnologies
Control
Biotechnology
Semiconductors
1650 1950 2050 15
Tuesday, 8 June 2010
30. Science Enables New
Technologies
Synthetic Biology
Complexity
Nanotechnologies
Control
Biotechnology
Semiconductors
1650 1950 2050 15
Tuesday, 8 June 2010
31. Science Enables New
Technologies
Geoengineering?
Synthetic Biology
Complexity
Nanotechnologies
Control
Biotechnology
Semiconductors
1650 1950 2050 15
Tuesday, 8 June 2010
32. Moving From Control Of
Materials to Control of
Things
16
Tuesday, 8 June 2010
33. Moving From Control Of
Materials to Control of
Things
Materials
• Metals
• Semiconductors
• Food Processing
Passive
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Tuesday, 8 June 2010
34. Moving From Control Of
Materials to Control of
Things
Materials Things
• Metals • Crops
• Semiconductors • Cells
• Food Processing • The Planet?
Passive Active
16
Tuesday, 8 June 2010
35. 9 global trends selected for discussion
Climate change, environment, Carbon productivity and adaptation becoming an
1
and sustainability increasingly dominant factor in all business decisions
Working Draft - Last Modified 19.11.2009 10:26:59
2 Rapidly growing demand for energy Energy security becoming a bigger geopolitical concern
3 Limited resources Resource demand rapidly outpaces supply (oil, gas, coal, water,
biomass, and other raw materials), price volatility
Increasing scarcity and unequal Demand for clean water rapidly outpaces supply in regions where
4
distribution of water majority of the world's population lives*
Growing demand for food, nutrition, and Agricultural production struggling to satisfy increasing demand for
5
health high-calorie quality food and health care
Printed 03.11.2009 13:57:36
6 Demographics, including shifting Over 1 billion new consumers (e.g., China and India); ageing
populations and mobility population; exploding demand for transport
7 Shifting centers of economic activity Dramatic realignment of GDP, urbanization, new geo-political
balance
8 Social life in a technological world Connectivity transforms the way we live and interact
9 Corporate global citizenship Companies increasingly consider all stakeholders, particularly
with respect to environmental sustainability
* By 2030, 40% of global GDP and 85% of the world's population will be in regions where water demand exceeds
supply (HBR July-August 2009, p. 1)
Source: McKinsey; inputs from WELCOM call 21 July 2009; bilateral discussions at World Economic Forum 17
Tuesday, 8 June 2010
37. A History of Technology
Push 1
Oxonica
• Spun out in 1998 from University of Oxford
• Raised £12.5m from investors
• AIM flotation in June 2005 raised additional
£7.5m
• Market Cap of £150m in 2005
• Market Cap of £1.5m and delisted in 2009
Tuesday, 8 June 2010
38. Why Did They Fail?
• All products were based on nanoparticles
• Manufacturing was outsourced
• Products were quickly commoditised
• Margins always under pressure
• Lone acquisition did nothing to secure
markets, supply chains or diversify
• Messy and costly IP disputes
Tuesday, 8 June 2010
39. A History of Technology
Push 2
Carbon Nanotechnologies Inc
• February 2005: 30 patents issued, 70
applications pending and were hoping to
corner the world market
• March 2007: Acquired for $5.4m in stock by
Arrowhead Research and merged with Unidym
• February 2009: Unidym replaces CEO and
closes old CNI facilities in Houston
• July 2009: “Zero employees”
Tuesday, 8 June 2010
40. Why Did ey Fail?
CNI HAS THE BRAINS, THE CASH, NOW ALL IT NEEDS
IS THE MARKET
Carbon Nanotechnologies Inc. seems to have it all – a Nobel
laureate as its co-founder, a veteran management team, $15
million in angel funding and a working pilot plant. What the
carbon nanotube producer lacks is a commercial product and a
market. CNI is positioning itself to dominate once that
happens by building its business and production capabilities
simultaneously.
-July 29, 2002
Tuesday, 8 June 2010
42. A Rather Obvious
Conclusion
• Technology Push Doesn’t Work!
• Hundreds of millions of dollars and twenty
years of research have yielded little of value
– why?
• Basic business premise was to push the
technology onto an agnostic market
Tuesday, 8 June 2010
43. A Rather Obvious
Conclusion
Need to incorporate
nanomaterials in
products which
address real markets
and problems
Tuesday, 8 June 2010
47. Composite Applications
• Automotive body parts
• Aerospace composites & coatings
• Packaging
• Conducting polymers
25
Tuesday, 8 June 2010
48. Nanocomposite
Materials
• Polymer + nanoparticle, nanofibre or clay
• Increases strength & rigidity
• Lowers weight
• Much of value is in the formulation rather
than the filler
26
Tuesday, 8 June 2010
49. Nanocomposite
Materials
• Polymer + nanoparticle, nanofibre or clay
• Increases strength & rigidity
• Lowers weight
• Much of value is in the formulation rather
than the filler
Abalone Shell - Nanoscale Engineering
26
Tuesday, 8 June 2010
50. Nanocomposite Use In
Automotive Industry
• Conducting composites
for better paintability
• Moulding cycle time
reduction
• Improved mechanical
properties
• High scratch resistance
paints
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Tuesday, 8 June 2010
51. Replacing Indium With
Conductive Inks
• Demand Drivers
• Rising demand for touch screens and flat
panel displays
• Increasing use of thin film solar panels
• Solar applications and displays require
better materials than Indium Tin Oxide
• Global supply of Indium is limited
28
Tuesday, 8 June 2010
55. A Paradigm Shift in
Medical Diagnostics
Broad range of Point-of-Care applications
• Complete blood profiling
• HIV/STD testing
• Infectious diseases
• Molecular Diagnostics:
• Cardiovascular diseases
• Cancer diagnostics
• Animal health
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Tuesday, 8 June 2010
61. No Quick Returns?
• It will take ten to twenty years for new
sources for renewables to become
competitive with existing sources
35
Tuesday, 8 June 2010
62. No Quick Returns?
• It will take ten to twenty years for new
sources for renewables to become
competitive with existing sources
• Market forces will drive up the cost of
dwindling resources in the meantime
35
Tuesday, 8 June 2010
63. No Quick Returns?
• It will take ten to twenty years for new
sources for renewables to become
competitive with existing sources
• Market forces will drive up the cost of
dwindling resources in the meantime
• Current investment levels in renewables
have priced many investors out of the
market
35
Tuesday, 8 June 2010
64. It Takes $1Bn To Get In
The Solar Game
36
Tuesday, 8 June 2010
65. It Takes $1Bn To Get In
The Solar Game
• Konarka Technologies burned through over
$100 million in VC funding
36
Tuesday, 8 June 2010
66. It Takes $1Bn To Get In
The Solar Game
• Konarka Technologies burned through over
$100 million in VC funding
• Nanosolar has raised $295 million to date
36
Tuesday, 8 June 2010
67. It Takes $1Bn To Get In
The Solar Game
• Konarka Technologies burned through over
$100 million in VC funding
• Nanosolar has raised $295 million to date
• Realistic opportunities are enabled by
organic solar, not producing solar
36
Tuesday, 8 June 2010
68. Resources Are Getting
Scarcer
• Global competition for
resources
• Demand driven by
increasing and
increasingly affluent
population
• Some resources are
almost exhausted
37
Tuesday, 8 June 2010
69. Scarce Resources
Metal Remaining Supply*
Indium 5-10 years
Antinomy 15-20 years
Platinum 15 years
Hafnium 10 years
Tantalum 20-30 years
Uranium 30-40 years
Armin Reller, U. Augsburg, Tom Graedel, Yale
* Pre Global Economic Crisis
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Tuesday, 8 June 2010
70. The Rare Earth
• Global demand for rare earths has tripled
from 40,000 tonnes to 120,000 tonnes over
the past 10 years
• China now controls 97% of the global supply
of 17 rare earths
• 25% of new green technologies rely on
minor metals and rare earths
39
Tuesday, 8 June 2010
71. A Fuel Efficient
Resource Hog
• Each electric Prius motor
requires 1 Kg of
neodymium
• Each battery uses 10 to
15 kg of lanthanum
• The most rare earth
intensive product on the
planet
40
Tuesday, 8 June 2010
72. Uses of Indium
Global Market for Transparent
Conductors Touch Screens,
& other electronics
3,500,000
$3.0B
3,000,000
$2.5B
2,500,000
Solar Cells
$2.0B
2,000,000
$1.5B
1,500,000
LCD Displays
1,000,000
$1.0B
500,000
$0.5B
-
1 2 3 4 5 6
2006 2007 2008 2009 2010 2011
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Tuesday, 8 June 2010
73. He Could Be Right!
“Rare earths are to China
as oil is to the Middle East”
- Deng Xiaoping (1992)
42
Tuesday, 8 June 2010
77. Using Emerging
Technologies
• Emerging technologies are critical to long-term
global prosperity
• Innovative technologies do not conform to
conventional technology development
paradigms
• Effective policies for nurturing and employing
emerging technologies are largely absent or
poorly formed in government, industry and
other stakeholder organisations
46
Tuesday, 8 June 2010
81. By Copying This Trick
Reducing friction between container ships hull
& water could
• Save 1% of global oil consumption or
• 850,000 barrels per day
50
Tuesday, 8 June 2010
82. An Old Trick For
Textiles
51
Tuesday, 8 June 2010
83. Synthetic Biology
Longest Published DNA
Sequence
Source: Rob Carlson synthesis.cc
52
Tuesday, 8 June 2010
84. A Lot Like Moore’s Law
53
Tuesday, 8 June 2010
85. Not Just Biofuels
Converting waste products into feedstock
• Wheat & Rice Straw to Sugars
➡Sugars to Glycol
➡Glycol to Bioplastics
54
Tuesday, 8 June 2010
88. What We Need
Sector Need Solution
Improve Yields
GM Crops
Food Address Malnutrition
Golden Rice
Reduce Consumption Composites
Energy Generate Clean energy Photovoltaics
Wind/ Tidal
Alternative Fuels Industrial Biotech
Climate Make Better Use of What We
Have
Synthetic Biology
Nanomaterials
Synthetic Biology
Earlier & Cheaper Detection
Disease Effective Treatment
Targeted Nanoparticle Drug
Delivery
57
Tuesday, 8 June 2010
91. Can We Do It?
Well...
• The innovation process is inefficient
58
Tuesday, 8 June 2010
92. Can We Do It?
Well...
• The innovation process is inefficient
• Capital for Emerging Technologies is Poorly
Educated
58
Tuesday, 8 June 2010
93. Can We Do It?
Well...
• The innovation process is inefficient
• Capital for Emerging Technologies is Poorly
Educated
• Governments Lack Foresight
58
Tuesday, 8 June 2010
96. Inefficient Innovation
To get there we need
• Scientists to realise commercial potential
59
Tuesday, 8 June 2010
97. Inefficient Innovation
To get there we need
• Scientists to realise commercial potential
• Investor to both ‘get it’ and have liquidity
59
Tuesday, 8 June 2010
98. Inefficient Innovation
To get there we need
• Scientists to realise commercial potential
• Investor to both ‘get it’ and have liquidity
• Quality management to take it to market
59
Tuesday, 8 June 2010
99. Inefficient Innovation
To get there we need
• Scientists to realise commercial potential
• Investor to both ‘get it’ and have liquidity
• Quality management to take it to market
• Market pull rather than technology push
59
Tuesday, 8 June 2010
100. The Capital Gap
VC investments are highly concentrated
• 6 of 17 industries receive >73% of investment
• “Me too” company investments are common
Sectors are selected with inexperience
• Example: $ Billions invested into biofuels
• Investments have unrealistic expectations
• > $100 MM in annual revenue targets
• Ignoring advances and “foundation technologies”
60
Tuesday, 8 June 2010
101. Government Foresight
• Huge pressure on finances
• Hard to second guess the market
• Governments have a poor record of picking
winners
61
Tuesday, 8 June 2010
103. In The End...
• Technology has lead every economic and
social advance for the last 10,000 years
62
Tuesday, 8 June 2010
104. In The End...
• Technology has lead every economic and
social advance for the last 10,000 years
• It can create and clear up problems (e.g
Ozone layer depletion)
62
Tuesday, 8 June 2010
105. In The End...
• Technology has lead every economic and
social advance for the last 10,000 years
• It can create and clear up problems (e.g
Ozone layer depletion)
• It is human nature to innovate
62
Tuesday, 8 June 2010
107. Conclusions
Nanotechnologies and biosciences will be as
important to the 21st Century as oil,
polymers and semiconductors were to the
20th Century
63
Tuesday, 8 June 2010
108. Conclusions
Nanotechnologies and biosciences will be as
important to the 21st Century as oil,
polymers and semiconductors were to the
20th Century
We have the tools, lets use them wisely
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Tuesday, 8 June 2010