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Endoscopic
CycloPhotocoagulation



 Martin Uram MD,
  MPH
Laser Endoscope




           ENDOSCOPIC CYCLOPHOTOCOAGULATION
                          Martin Uram, M.D., M.P.H.
E2 Laser and Endoscopy System




             ENDOSCOPIC CYCLOPHOTOCOAGULATION
                            Martin Uram, M.D., M.P.H.
4 Skills for ECP

Watching Video Monitor
⇒


Accessing ciliary procesesses given
⇒


approach and lens status
Inflating ciliary sulcus
⇒


Controlling long duration, invisible
⇒


wavelength laser


                ENDOSCOPIC CYCLOPHOTOCOAGULATION
                               Martin Uram, M.D., M.P.H.
Anesthesia


   ENDOSCOPIC CYCLOPHOTOCOAGULATION
                  Martin Uram, M.D., M.P.H.
Incision


  ENDOSCOPIC CYCLOPHOTOCOAGULATION
                 Martin Uram, M.D., M.P.H.
ECP Tr eatment
    Principle
⇒
    L NS B H
     E    E IND IRIS: VISCOE AST
                            L IC
⇒
    SINGL CH B R E : INF
         E AM E YE         USION

        AVOID HYPOTONY



                ENDOSCOPIC CYCLOPHOTOCOAGULATION
                               Martin Uram, M.D., M.P.H.
Inflating the Ciliar y
Sulcus




          ENDOSCOPIC CYCLOPHOTOCOAGULATION
                         Martin Uram, M.D., M.P.H.
Combined Procedures:
Limbal, Over Ba g / PC-IOL

                            
                                Click to edit the
                                outline text format
                                
                                    Second Outline
                                    Level
                                   Third Outline
                                    −
                                   Level
                                     
                                        Fourth
                                        Outline
                                        Level
                  ENDOSCOPIC CYCLOPHOTOCOAGULATION
                                         − Fifth
                                 Martin Uram, M.D., M.P.H.
No PPL for Phakic Eyes




          ENDOSCOPIC CYCLOPHOTOCOAGULATION
                         Martin Uram, M.D., M.P.H.
Curved Probe, Limbal


                    
                        Click to edit the
                        outline text format
                        Second Outline
                        


                        Level
                  
                     ClickThird Outline
                         − to edit the
                     outline text format
                           Level
                      
                        Second Outline
                             
                                Fourth
                        Level   Outline
          ENDOSCOPIC CYCLOPHOTOCOAGULATION
                                Level
                         Martin Uram, M.D., M.P.H.
                         − Third Outline
Desired Tissue Ef fect


                        
                            Click to edit the
  ⇒
    Whiten ciliary          outline text format
  processes
                            Second Outline
                            
   ⇒
    Shrink ciliary
                            Level
  processes           
                         ClickThird Outline
                             − to edit the
   ⇒
    Treat entire         outline text format
                               Level
  ciliary process
                          
                            Second Outline
                                 
                                    Fourth
                            Level   Outline
              ENDOSCOPIC CYCLOPHOTOCOAGULATION
                                    Level
                             Martin Uram, M.D., M.P.H.
                             − Third Outline
Inflating the Ciliar y
Sulcus




          ENDOSCOPIC CYCLOPHOTOCOAGULATION
                         Martin Uram, M.D., M.P.H.
Complete Treatment

    INADEQUATE TREATMENT
    RESULTS IN:
⇒
    POOR IOP CONTROL
⇒
    ONLY TEMPORARY “GOOD” RESULT



               ENDOSCOPIC CYCLOPHOTOCOAGULATION
                              Martin Uram, M.D., M.P.H.
Treatment Zone




        ENDOSCOPIC CYCLOPHOTOCOAGULATION
                       Martin Uram, M.D., M.P.H.
ECP: Post-Op Meds


⇒
     SAME AS PHACO ALONE
⇒
     IOP SPIKE PROPHYLAXIS
⇒
     PARACENTESIS


               ENDOSCOPIC CYCLOPHOTOCOAGULATION
                              Martin Uram, M.D., M.P.H.
ECP COLLABORATIVE STUDY
                 GROUP
5824 PATIENTS
              COMPLICATIONS

   IOP Spike                         14.5%
   Hemorrhage                         3.8%
   Serous Choroidal Effusion                 0.36%
   IOL Dislocation                   0.36%
   CME                       1.03%
   RD                                0.27%
   Massive Choroidal Hemorrhage      0.09%
   Hypotony or Phthisis              0.12%
   NLP Vision                        0.12%
   Cataract                          24.5%
   Acute Graft Rejection             5.3%
   Chronic Graft Rejection           0
   Chronic Inflammation              0
   Flat AC                           0
   Endophthalmitis                   0
   Diplopia                          0
   Wound Leak                0
   Bleb Complications                0
Phaco-ECP vs Phaco Alone
    Stanley J. Berke, M.D., FACS, et. al..



       707 Patients

       626 Randomized to Phaco-ECP Group

       81 Randomized to Phaco Alone

       5 Surgeons

       Parameters such as VA, IOP, Meds, &
                          complications were
       followed

       Mean follow-up was 3.2 years (0.5 to 5.8 years)

                        ENDOSCOPIC CYCLOPHOTOCOAGULATION
                                       Martin Uram, M.D., M.P.H.
Phaco-ECP vs Phaco Alone


           Pre-op   Post-op     P      Pre-op   Post-op     P
            IOP       IOP              Meds      Meds
           mmHg     mmHg                 (#)      (#)

  Phaco-   19.08    15.73      4.48    1.53      0.65      1.23
   ECP       ±        ±         X       ±         ±         X
            4.14     3.00     10 -72    0.89     0.95     10 -85
  Phaco    18.16    18.93              1.20      1.20
  Alone      ±        ±        .01      ±         ±       0.50
            3.38     4.12               0.83     0.87



                      ENDOSCOPIC CYCLOPHOTOCOAGULATION
                                     Martin Uram, M.D., M.P.H.
Phaco-ECP vs Phaco Alone:
Medications at End of Follow-Up

           Phaco-ECP                 Phaco Alone
                             
                                 Click to edit the
                                 outline text format
                                  11%
                  27%            
                                     Second Outline
                               12%
                                     Level
                      5%
 
     Click to
         68% edit the          
                                  ClickThird Outline
                                      − to edit the
                                         77%

     outline text format          outline text format
                                        Level
     
        Second Outline            
                                     Second Outline
                                         
                                           Fourth
             no change   increase   decrease
        Level                        Level Outline
         − Third Outline                   Level
                                      − Third Outline
Phaco-ECP vs Phaco Alone:
Post-Op IOP Change

        Phaco-ECP                   Phaco Alone
                                
                                    Click to edit the
                                         2%
                          IOP
             9%                     outline text format
                    12%             Second Outline
                                    

                               38%
                                    Level
         79%
 
     Click to edit the        
                                     −  to 60% the
                                 ClickThird Outline
                                            edit
     outline text format         outline text format
                                       Level
     
        Second Outline           
                                    Second Outline
                                         
                                           Fourth
             no change increase    decrease
        Level                       Level  Outline
         − Third Outline                   Level
                                     − Third Outline
Phaco-ECP vs Phaco Alone:
Mean IOP Over Time
        20
                  1.53 Meds               Phaco-ECP
mmHg
                                          Phaco Alone
        19
                                                            1.20 Meds

        18
                 1.20 Meds

        17

        16                                                     0.65 Meds


        15

        14        Pre-Op     6 Months   1 Year   2 Years   3 Years
   Phaco-ECP      19.08       16.03     16.14     16.09     16.03
   Phaco Alone    18.16       17.62     16.28     16.87     18.93
Phaco-ECP vs Phaco Alone

Complications


    No serious complications
   were reported in either group

     1 patient in each group
         developed CME
Phaco-ECP vs Phaco Alone
 Glaucoma Medication Cost Analysis

                                          Pre-Op        Post-Op      Savings/Loss

  Phaco-ECP monthly patient cost          $220.08       $94.78         $125.30

  Phaco-ECP annual patient cost          $2,640.92    $1,137.35       $1,503.57

  Phaco Alone monthly patient cost        $144.45      $160.28         ($15.83)

  Phaco Alone annual patient cost        $1,733.40    $1,923.36        ($189.96)

  Estimated US annual savings*                                      $846,765,000




* 2.5 million cataract procedures annually. 20% of cataract surgery patients
concurrently treated with glaucoma medications.
Phaco-ECP:
    Conclusion
⇒
    Hard to get in trouble
⇒
    It usually works
⇒
    It’s fun!

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Uram ecp course

  • 2. Laser Endoscope ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 3. E2 Laser and Endoscopy System ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 4. 4 Skills for ECP Watching Video Monitor ⇒ Accessing ciliary procesesses given ⇒ approach and lens status Inflating ciliary sulcus ⇒ Controlling long duration, invisible ⇒ wavelength laser ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 5. Anesthesia ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 6. Incision ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 7. ECP Tr eatment Principle ⇒ L NS B H E E IND IRIS: VISCOE AST L IC ⇒ SINGL CH B R E : INF E AM E YE USION AVOID HYPOTONY ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 8. Inflating the Ciliar y Sulcus ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 9. Combined Procedures: Limbal, Over Ba g / PC-IOL  Click to edit the outline text format  Second Outline Level Third Outline − Level  Fourth Outline Level ENDOSCOPIC CYCLOPHOTOCOAGULATION − Fifth Martin Uram, M.D., M.P.H.
  • 10. No PPL for Phakic Eyes ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 11. Curved Probe, Limbal  Click to edit the outline text format Second Outline  Level  ClickThird Outline − to edit the outline text format Level  Second Outline  Fourth Level Outline ENDOSCOPIC CYCLOPHOTOCOAGULATION Level Martin Uram, M.D., M.P.H. − Third Outline
  • 12. Desired Tissue Ef fect  Click to edit the ⇒ Whiten ciliary outline text format processes Second Outline  ⇒ Shrink ciliary Level processes  ClickThird Outline − to edit the ⇒ Treat entire outline text format Level ciliary process  Second Outline  Fourth Level Outline ENDOSCOPIC CYCLOPHOTOCOAGULATION Level Martin Uram, M.D., M.P.H. − Third Outline
  • 13. Inflating the Ciliar y Sulcus ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 14. Complete Treatment INADEQUATE TREATMENT RESULTS IN: ⇒ POOR IOP CONTROL ⇒ ONLY TEMPORARY “GOOD” RESULT ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 15. Treatment Zone ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 16. ECP: Post-Op Meds ⇒ SAME AS PHACO ALONE ⇒ IOP SPIKE PROPHYLAXIS ⇒ PARACENTESIS ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 17. ECP COLLABORATIVE STUDY GROUP 5824 PATIENTS COMPLICATIONS IOP Spike 14.5% Hemorrhage 3.8% Serous Choroidal Effusion 0.36% IOL Dislocation 0.36% CME 1.03% RD 0.27% Massive Choroidal Hemorrhage 0.09% Hypotony or Phthisis 0.12% NLP Vision 0.12% Cataract 24.5% Acute Graft Rejection 5.3% Chronic Graft Rejection 0 Chronic Inflammation 0 Flat AC 0 Endophthalmitis 0 Diplopia 0 Wound Leak 0 Bleb Complications 0
  • 18. Phaco-ECP vs Phaco Alone Stanley J. Berke, M.D., FACS, et. al..  707 Patients  626 Randomized to Phaco-ECP Group  81 Randomized to Phaco Alone  5 Surgeons  Parameters such as VA, IOP, Meds, & complications were followed  Mean follow-up was 3.2 years (0.5 to 5.8 years) ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 19. Phaco-ECP vs Phaco Alone Pre-op Post-op P Pre-op Post-op P IOP IOP Meds Meds mmHg mmHg (#) (#) Phaco- 19.08 15.73 4.48 1.53 0.65 1.23 ECP ± ± X ± ± X 4.14 3.00 10 -72 0.89 0.95 10 -85 Phaco 18.16 18.93 1.20 1.20 Alone ± ± .01 ± ± 0.50 3.38 4.12 0.83 0.87 ENDOSCOPIC CYCLOPHOTOCOAGULATION Martin Uram, M.D., M.P.H.
  • 20. Phaco-ECP vs Phaco Alone: Medications at End of Follow-Up Phaco-ECP Phaco Alone  Click to edit the outline text format 11% 27%  Second Outline 12% Level 5%  Click to 68% edit the  ClickThird Outline − to edit the 77% outline text format outline text format Level  Second Outline  Second Outline  Fourth no change increase decrease Level Level Outline − Third Outline Level − Third Outline
  • 21. Phaco-ECP vs Phaco Alone: Post-Op IOP Change Phaco-ECP Phaco Alone  Click to edit the 2% IOP 9% outline text format 12% Second Outline  38% Level 79%  Click to edit the  − to 60% the ClickThird Outline edit outline text format outline text format Level  Second Outline  Second Outline  Fourth no change increase decrease Level Level Outline − Third Outline Level − Third Outline
  • 22. Phaco-ECP vs Phaco Alone: Mean IOP Over Time 20 1.53 Meds Phaco-ECP mmHg Phaco Alone 19 1.20 Meds 18 1.20 Meds 17 16 0.65 Meds 15 14 Pre-Op 6 Months 1 Year 2 Years 3 Years Phaco-ECP 19.08 16.03 16.14 16.09 16.03 Phaco Alone 18.16 17.62 16.28 16.87 18.93
  • 23. Phaco-ECP vs Phaco Alone Complications No serious complications were reported in either group 1 patient in each group developed CME
  • 24. Phaco-ECP vs Phaco Alone Glaucoma Medication Cost Analysis Pre-Op Post-Op Savings/Loss Phaco-ECP monthly patient cost $220.08 $94.78 $125.30 Phaco-ECP annual patient cost $2,640.92 $1,137.35 $1,503.57 Phaco Alone monthly patient cost $144.45 $160.28 ($15.83) Phaco Alone annual patient cost $1,733.40 $1,923.36 ($189.96) Estimated US annual savings* $846,765,000 * 2.5 million cataract procedures annually. 20% of cataract surgery patients concurrently treated with glaucoma medications.
  • 25. Phaco-ECP: Conclusion ⇒ Hard to get in trouble ⇒ It usually works ⇒ It’s fun!