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A brief picture of gonorrhoea in
             New Zealand

         Kerry Sexton, Public Health Physician, ESR

NZSHS conference 2012, gonorrhoea workshop, 30 August 2012



                         Specialist Science Solutions

                             Manaaki Tangata Taiao Hoki
               protecting people and their environment through science
Outline
  • National burden of gonorrhoea
         Historical
         Recent trends
  • Demographic distribution of cases
  • Other risk factors for gonorrhoea
  • Testing for gonorrhoea
         Testing rates and test positivity


  • Not going to discuss:
         NAAT testing for gonorrhoea
         Antimicrobial resistance


© ESR 2012
National burden of gonorrhoea


                                                                                             1976 (lab data)
                                                                                             208 per 100,000
                                                                                             6482 cases




     Platts, W. M. (1979). "Epidemiology of gonorrhoea and syphilis in New Zealand." Br J Vener Dis 55: 138-141.


© ESR 2012
National burden of gonorrhoea cont...




Lyttle, P. H. (1994). "Surveillance report: disease trends at New Zealand sexually transmitted disease clinics 1977-1993."
Genitourin Med 70: 329-335.

© ESR 2012
Gonorrhoea rates in selected DHBs, 1998-2011




© ESR 2012
Estimated national gonorrhoea rate, 2008-2011




                                           67 = NZ rate 2011
                                           44 = Australia 2010
                     M:F ratio 2011: 1.4
                                           30 = UK 2010
                                           101 = US 2010




© ESR 2012
Gonorrhoea rates by age group and sex, 2008-2011

                                            Females                          Males
                                      450
Cases per 100 000 female population




                                      400
                                      350
                                      300
                                      250
                                      200
                                      150
                                      100
                                       50
                                        0
                                        2008     2009          2010   2011
                                                        Year




                        © ESR 2012
Gonorrhoea rates by ethnicity




© ESR 2012
Age standardised gonorrhoea incidence rates by
  ethnicity and sex, Bay of Plenty, 2003 to 2007




© ESR 2012
Gonorrhoea rates by DHB, 2011




© ESR 2012
Other risk/protective factors
       • Greater number of sexual contacts
              -   Auckland SHS case-control study1
                     -   Cases of gonorrhoea reported more sexual contacts in the
                         preceding 3 months than did controls (p=0.05)

       • MSM
              -   Gay Auckland Periodic Sex Survey2
            - 3.3% reported gonorrhoea in last 12 months
            - 17.3% reported a diagnosis of gonorrhoea in their lifetime
       • Condom use
              -   Auckland SHS case-control study1
                     -   Consistent condom use was found to lower the risk of gonorrhoea
                         (p=0.009)

1Azariah and Perkins (2007). Risk factors and characteristics of patients with gonorrhoea presenting to Auckland Sexual Health Service,
New Zealand. NZMJ 120(1252):2491.
2Saxton, Dickson and Hughes (2006). GAPSS 2006: Findings from the Gay Auckland Periodic Sex Survey. Auckland: New Zealand

AIDS Foundation.


   © ESR 2012
Site of infection, non-urogenital gonorrhoea cases in
  SHCs, males, 2006-2011


                                     anorectal          epididymitis            pharynx      other site


                               60
                                                                                                          80-90%
             Number of cases




                               50
                                                                                                          urogenital
                               40
                               30
                               20
                               10
                                0
                                    2006         2007      2008          2009         2010   2011

                                                                  Year


© ESR 2012
Relative gonorrhoea testing volumes, selected
  DHBs, 2002-2011




© ESR 2012
Gonorrhoea incidence & testing rates by age group, females, BOP,
2003-2007

      Incidence




                                 Testing rates




 © ESR 2012
Gonorrhoea incidence & testing rates by TA, Bay of Plenty, 2003 to 2007




   © ESR 2012
Summary
  • National gonorrhoea burden peaked in the 1970s,
    smaller peak 2006
  • Estimated national rate stable over last 4 years,
    67 per 100,000 in 2011
  • Highest risk groups: 15-24y olds and Māori and
    Pacific, MSM
  • Tairawhiti DHB rate 5x national rate
  • Increasing anorectal and pharyngeal positives
  • Testing mismatch versus incidence




© ESR 2012
© ESR 2012
© ESR 2012
Gonorrhoea testing rates/test positivity by TA, Bay of Plenty, 2003 to 2007




   © ESR 2012
Platts, W. M. (1979). "Epidemiology of gonorrhoea and syphilis in New Zealand." Br J Vener Dis 55: 138-141.

© ESR 2012
Gonorrhoea Prevalence
     •    MSM, phone survey, 1996
     •    Any gonorrhoea 16.8% (penile 13.6%, anal 4.4%, oral 3.0%; signif higher in
          those HIV positive)



     Dunedin cohort
     • Gonorrhoea 1 (2.6) 5 (5.6) 1 (1.4) 0 (0
     • Gonorrhoea up to 21 Male 1 (2.6) Female 5 (5.6) 21 to 26 Male 1 (1.4)
        Female 0 (0.0) 26 to 32 Male 0 (0.0) Female 0 (0.0)




Saxton, Hughes and Robinson (2002). "Sexually transmitted diseases and hepatitis in a national sample of men who have
sex with men in New Zealand." NZMJ 115(1158).

  © ESR 2012
Gonorrhoea rates by DHB, 2007 to 2011
                                                                                         2007               2008                       2009              2010                         2011
                                  400

                                  350

                                  300
    Rate per 100 000 population




                                  250

                                  200

                                  150

                                  100

                                  50

                                                                                                                                                        **                                                       **
                                   0
                                                     Auckland region




                                                                                                                                                                                                                      Wairarapa


                                                                                                                                                                                                                                  West Coast


                                                                                                                                                                                                                                               Southern
                                                                                                                                                             Whanganui
                                                                                                                           Taranaki²
                                        Northland¹




                                                                       Waikato




                                                                                                                                                                                             Wellington region
                                                                                                           Tairawhiti




                                                                                                                                                                         MidCentral
                                                                                 Lakes


                                                                                           Bay of Plenty




                                                                                                                                          Hawke's Bay




                                                                                                                        District Health Board

                                    Note: Additional labs began reporting in 2010 in Northland and 2011 in Taranaki
© ESR 2012

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A brief picture of gonorrhoea in New Zealand

  • 1. A brief picture of gonorrhoea in New Zealand Kerry Sexton, Public Health Physician, ESR NZSHS conference 2012, gonorrhoea workshop, 30 August 2012 Specialist Science Solutions Manaaki Tangata Taiao Hoki protecting people and their environment through science
  • 2. Outline • National burden of gonorrhoea  Historical  Recent trends • Demographic distribution of cases • Other risk factors for gonorrhoea • Testing for gonorrhoea  Testing rates and test positivity • Not going to discuss:  NAAT testing for gonorrhoea  Antimicrobial resistance © ESR 2012
  • 3. National burden of gonorrhoea 1976 (lab data) 208 per 100,000 6482 cases Platts, W. M. (1979). "Epidemiology of gonorrhoea and syphilis in New Zealand." Br J Vener Dis 55: 138-141. © ESR 2012
  • 4. National burden of gonorrhoea cont... Lyttle, P. H. (1994). "Surveillance report: disease trends at New Zealand sexually transmitted disease clinics 1977-1993." Genitourin Med 70: 329-335. © ESR 2012
  • 5. Gonorrhoea rates in selected DHBs, 1998-2011 © ESR 2012
  • 6. Estimated national gonorrhoea rate, 2008-2011 67 = NZ rate 2011 44 = Australia 2010 M:F ratio 2011: 1.4 30 = UK 2010 101 = US 2010 © ESR 2012
  • 7. Gonorrhoea rates by age group and sex, 2008-2011 Females Males 450 Cases per 100 000 female population 400 350 300 250 200 150 100 50 0 2008 2009 2010 2011 Year © ESR 2012
  • 8. Gonorrhoea rates by ethnicity © ESR 2012
  • 9. Age standardised gonorrhoea incidence rates by ethnicity and sex, Bay of Plenty, 2003 to 2007 © ESR 2012
  • 10. Gonorrhoea rates by DHB, 2011 © ESR 2012
  • 11. Other risk/protective factors • Greater number of sexual contacts - Auckland SHS case-control study1 - Cases of gonorrhoea reported more sexual contacts in the preceding 3 months than did controls (p=0.05) • MSM - Gay Auckland Periodic Sex Survey2 - 3.3% reported gonorrhoea in last 12 months - 17.3% reported a diagnosis of gonorrhoea in their lifetime • Condom use - Auckland SHS case-control study1 - Consistent condom use was found to lower the risk of gonorrhoea (p=0.009) 1Azariah and Perkins (2007). Risk factors and characteristics of patients with gonorrhoea presenting to Auckland Sexual Health Service, New Zealand. NZMJ 120(1252):2491. 2Saxton, Dickson and Hughes (2006). GAPSS 2006: Findings from the Gay Auckland Periodic Sex Survey. Auckland: New Zealand AIDS Foundation. © ESR 2012
  • 12. Site of infection, non-urogenital gonorrhoea cases in SHCs, males, 2006-2011 anorectal epididymitis pharynx other site 60 80-90% Number of cases 50 urogenital 40 30 20 10 0 2006 2007 2008 2009 2010 2011 Year © ESR 2012
  • 13. Relative gonorrhoea testing volumes, selected DHBs, 2002-2011 © ESR 2012
  • 14. Gonorrhoea incidence & testing rates by age group, females, BOP, 2003-2007 Incidence Testing rates © ESR 2012
  • 15. Gonorrhoea incidence & testing rates by TA, Bay of Plenty, 2003 to 2007 © ESR 2012
  • 16. Summary • National gonorrhoea burden peaked in the 1970s, smaller peak 2006 • Estimated national rate stable over last 4 years, 67 per 100,000 in 2011 • Highest risk groups: 15-24y olds and Māori and Pacific, MSM • Tairawhiti DHB rate 5x national rate • Increasing anorectal and pharyngeal positives • Testing mismatch versus incidence © ESR 2012
  • 19. Gonorrhoea testing rates/test positivity by TA, Bay of Plenty, 2003 to 2007 © ESR 2012
  • 20. Platts, W. M. (1979). "Epidemiology of gonorrhoea and syphilis in New Zealand." Br J Vener Dis 55: 138-141. © ESR 2012
  • 21. Gonorrhoea Prevalence • MSM, phone survey, 1996 • Any gonorrhoea 16.8% (penile 13.6%, anal 4.4%, oral 3.0%; signif higher in those HIV positive) Dunedin cohort • Gonorrhoea 1 (2.6) 5 (5.6) 1 (1.4) 0 (0 • Gonorrhoea up to 21 Male 1 (2.6) Female 5 (5.6) 21 to 26 Male 1 (1.4) Female 0 (0.0) 26 to 32 Male 0 (0.0) Female 0 (0.0) Saxton, Hughes and Robinson (2002). "Sexually transmitted diseases and hepatitis in a national sample of men who have sex with men in New Zealand." NZMJ 115(1158). © ESR 2012
  • 22. Gonorrhoea rates by DHB, 2007 to 2011 2007 2008 2009 2010 2011 400 350 300 Rate per 100 000 population 250 200 150 100 50 ** ** 0 Auckland region Wairarapa West Coast Southern Whanganui Taranaki² Northland¹ Waikato Wellington region Tairawhiti MidCentral Lakes Bay of Plenty Hawke's Bay District Health Board Note: Additional labs began reporting in 2010 in Northland and 2011 in Taranaki © ESR 2012