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CASE PRESENTATION
Dr. SK. Tasnuva Alam
MS Resident ,Phase-B
(Obs and Gynae)
Unit-IV
Name – Yeasmin akter
Age - 30yrs
Husband’s name -Boshir Ahmed
Occupation -House wife.
Address - Rangamati ,
Date of admission -30.01.2017
Date of examination-27.04.201
PARTICULARS OF THE PATIENT
CHIEF COMPLAINTS
 Known case of invasive mole
 patient on chemotherapy
H/O OF PRESENT ILLNESS
 According to the patients statement she was alright one year back then she
became amenorrhoeic for 1.5 months, her pregnancy test was positive .
 At 3 month of her pregnancy she noticed irregular p/v bleeding, which was
small in amount . With this complain she visited at GOPD, Rangamati
General Hospital .
 She was treated with tab. metherspan 1 tab. TDS for 3 days on 11.07.16
but her p/v bleeding continued irregularly for a month which was moderate in
amount .
 With this complain again she was admitted to the same hospital & advised
to do a USG of L/A & diagnosed as a case of incomplete abortion. She was
advised for MVA.
 Her MVA was done on 10.08.16 by a staff nurse at Rangamati General
Hospital . The attending nurse mentioned that the product of conception
was grape like , but it was not sent for any examination & her bleeding
continued about a month after evacuation .
 Then she attended GOPD at rangamati general hospital on 14.09.16 [0ne month after
evacuation] this time she was attended by a senior Gynae consultant and was advised
to do a s.β HCG from chittagong city [ done from chevron ; 61000 m IU/l ,5.09.16 ] .
With this report she was referred to CMCH for further management .
 But she got admitted in a private hospital & received two unit of blood trasnsfusion ,
had some investigation s: [s.β HCG-8800.30 m IU /L ,11.09.16] referred to CMCH
for further Rx.
 she went to AD –Din Hospital Dhaka ,
 Diagnosed as a case of incomplete abortion
 D & C done on ( 19.09.16 )[ 2nd time ]
 investigations done at AD Din hospital :
 s.β HCG 1782 m IU /L ( 21.09.16)
 CBC :
 HB%- 9.6 g/dl
 ESR- 40 mm in 1st hr
 WBC :
 TC-8.63X10^3/ uL
 Platelet -405x10^3/ uL
 Histopatology report : suggestive of product of conception .
 s.β HCG 3861 m IU /L ( 25. 09.16)
 s.β HCG 3162m IU /L ( 01.10.16)
 After that her bleeding stopped she returned to Rangamati with advice to came
F/U after two weeks .
 But her bleeding starts 3/4 days after her discharge ,then she admitted herself
at AD – Din hospital after admission she had a
 USG of L/A
impression : Suggestive of persistent trophoblastic disease with right ovarian
cyst.
 so her gynecologist advised for hysterectomy but she refused .
 Then she consulted with an other gynecologist of AD-Din was advised for
D & C. ;
 .
 On 6th november she had her 3rd D n C .
 Tissue Send For Histopathology
Report :
Fragments of endometrial tissue show invasive foci of trophoblastic cells.
Features are suggestive mole or choriocarcinoma.
 They referred her to DMC for further management . but she refused to take
treatment and went home .
 She had on and off p/v bleeding which was not alarming . That’s why she didn’t
came for follow up .
 Then around three months after she had severe p/v bleeding followed by
unconsciousness was admitted to Rangamati medical college on 29.01.17 .
there she was managed with two units of blood & referred to CMCH for
further management .
 She admitted on our unit as an emergency case on 30.01 .17at 9.00 pm
 On admission
 Appearance –anxious
 Anaemia – ++
 BP- 90/70 mm of Hg
 PULSE – 110 b/min
 R/R –30 b/min
 Heart – NAD
 Lungs –NAD
 U/O -100 ml
 P/A/E: NAD
 P/V/E:
 Ut- bulky
 Os – Closed
 Bleeding – +
Management :
 Diet : liquid
 O2 inhalation 4-6 litter
 INJ : plasmasol 500 ml
IV running
 INJ. Hartsol 1L
IV running then
 inj. Cefron 1 gm
IV stat then BD
 cap. Omep 20 mg
1+0+1
continious catheterization
Blood trasnfusion 2 unit
(31.01.17)
 CBC: Hb%- 8.8 gm/dl
 S.β HCG – 225OOO m IU / ml
 CXR-Normal

 USG of L/A : ( Doppler study) :
suggestive of invasive mole
Packed cell 2 unit
 With this report we gave on call to the radiation oncology department on 01.02.17 ,
they scheduled chemotherapy (EMA/CO) two weekly for the patient .
 The patient had her 6th cycles of chemotherapy on 29/04/17.
Date β HCG
5/9/2016
20/09/16
25/09/16
1/10/2016
31/01/17
8/2/2017
23/02/17
9/3/2017
23/3/17
7/4/2017
-61774
1782
3861
3162
225000
212610
16783
133
20
5
SERUM Β .HCG CHART :
0
50000
100000
150000
200000
250000 Series 1
Series 1
H/O past illness:
She gave no H/O HTN,DM,Asthma
she gave h/o chronic constipation.
Personal History:
No H/o smoking and betel nut chewing.
Family history :
Nothing contributory.
Socioeconomic History:
She came from middle class
family.
Drug History:
Nothing significant
MENSTRUAL HISTORY
Menarche at - 13 years
MP/MC : 3-4 d/28-30 d
LMP : can’t mention
Contraceptive history-
She took ocp irregularly for last 3 year
now she is using barrier method
OBSTETRIC HISTORY
Married for 11 years
Para-2( NVD)+1( invasive mole )
ALC-5 yrs
OBSTETRIC CHART:
Sl
no.
Date
of
Delive
-ry
Dura
tion
of
Preg
nancy
with
ANC
Compli-
cation
in
preg.
Labour
Home /
Hospital
Complica-
tion
Mode
of
deli
very
Puerpe-
rium
Infant
alive/
dead
Breast
feeding
Weight
Rem-
arks
1. 2007 40 wks
No ANC
Nil Home NVD Normal
Dead (
due to
heart
disease)
Breast
feeding
Avg Wt
No
2. 2012 3 8 wks
Had
ANC
Nil Home NVD Normal Alive
BF
,Avg Wt
No
PHYSICAL EXAMINATION
General examination:
Appearance- anxious
Body builds and nutrition- average
Anaemia- absent
Jaundice- absent
Edema- absent
Lymph nodes-not palpable
Pulse- 80 beats /min
BP- 110/80 mm of Hg
Temperature- 98.4° F
Respiratory rate-14 breaths/min
Heart- NAD
Lungs- NAD
Thyroid gland – Not enlarged
Breasts- No abnormality detected
P/A EXAMINATION
No abnormality detected.
PELVIC EXAMINATION:
Inspection:
vulva & perineum looks healthy.
Per speculum:
not done
Bi manual examination:
Not done
Per rectal exam:
Not done
INVESTIGATION (21.04.17)
 CBC
Hb-11.8 gm/dl
ESR-40mm/1st hour
TC- 8800/cmm
Platelet count-2,33000/cm m
 SGPT – 25 U/L
 SGOT-23 U/L
 S.urea -20.9 mg/dl
 S. billirubin - .2 mg/dl
 S.creatinine- .7 mg/d
MANAGEMENT
 General management:
 Counselling
 Improvement of general health.
Definitive management:
 chemotherapy
THANK YOU
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Pgtd

  • 1. CASE PRESENTATION Dr. SK. Tasnuva Alam MS Resident ,Phase-B (Obs and Gynae) Unit-IV
  • 2. Name – Yeasmin akter Age - 30yrs Husband’s name -Boshir Ahmed Occupation -House wife. Address - Rangamati , Date of admission -30.01.2017 Date of examination-27.04.201 PARTICULARS OF THE PATIENT
  • 3. CHIEF COMPLAINTS  Known case of invasive mole  patient on chemotherapy
  • 4. H/O OF PRESENT ILLNESS  According to the patients statement she was alright one year back then she became amenorrhoeic for 1.5 months, her pregnancy test was positive .  At 3 month of her pregnancy she noticed irregular p/v bleeding, which was small in amount . With this complain she visited at GOPD, Rangamati General Hospital .  She was treated with tab. metherspan 1 tab. TDS for 3 days on 11.07.16 but her p/v bleeding continued irregularly for a month which was moderate in amount .  With this complain again she was admitted to the same hospital & advised to do a USG of L/A & diagnosed as a case of incomplete abortion. She was advised for MVA.  Her MVA was done on 10.08.16 by a staff nurse at Rangamati General Hospital . The attending nurse mentioned that the product of conception was grape like , but it was not sent for any examination & her bleeding continued about a month after evacuation .
  • 5.  Then she attended GOPD at rangamati general hospital on 14.09.16 [0ne month after evacuation] this time she was attended by a senior Gynae consultant and was advised to do a s.β HCG from chittagong city [ done from chevron ; 61000 m IU/l ,5.09.16 ] . With this report she was referred to CMCH for further management .  But she got admitted in a private hospital & received two unit of blood trasnsfusion , had some investigation s: [s.β HCG-8800.30 m IU /L ,11.09.16] referred to CMCH for further Rx.  she went to AD –Din Hospital Dhaka ,  Diagnosed as a case of incomplete abortion  D & C done on ( 19.09.16 )[ 2nd time ]  investigations done at AD Din hospital :  s.β HCG 1782 m IU /L ( 21.09.16)  CBC :  HB%- 9.6 g/dl  ESR- 40 mm in 1st hr  WBC :  TC-8.63X10^3/ uL  Platelet -405x10^3/ uL  Histopatology report : suggestive of product of conception .
  • 6.  s.β HCG 3861 m IU /L ( 25. 09.16)  s.β HCG 3162m IU /L ( 01.10.16)  After that her bleeding stopped she returned to Rangamati with advice to came F/U after two weeks .  But her bleeding starts 3/4 days after her discharge ,then she admitted herself at AD – Din hospital after admission she had a  USG of L/A impression : Suggestive of persistent trophoblastic disease with right ovarian cyst.  so her gynecologist advised for hysterectomy but she refused .  Then she consulted with an other gynecologist of AD-Din was advised for D & C. ;  .
  • 7.  On 6th november she had her 3rd D n C .  Tissue Send For Histopathology Report : Fragments of endometrial tissue show invasive foci of trophoblastic cells. Features are suggestive mole or choriocarcinoma.  They referred her to DMC for further management . but she refused to take treatment and went home .  She had on and off p/v bleeding which was not alarming . That’s why she didn’t came for follow up .  Then around three months after she had severe p/v bleeding followed by unconsciousness was admitted to Rangamati medical college on 29.01.17 . there she was managed with two units of blood & referred to CMCH for further management .
  • 8.  She admitted on our unit as an emergency case on 30.01 .17at 9.00 pm  On admission  Appearance –anxious  Anaemia – ++  BP- 90/70 mm of Hg  PULSE – 110 b/min  R/R –30 b/min  Heart – NAD  Lungs –NAD  U/O -100 ml  P/A/E: NAD  P/V/E:  Ut- bulky  Os – Closed  Bleeding – +
  • 9. Management :  Diet : liquid  O2 inhalation 4-6 litter  INJ : plasmasol 500 ml IV running  INJ. Hartsol 1L IV running then  inj. Cefron 1 gm IV stat then BD  cap. Omep 20 mg 1+0+1 continious catheterization Blood trasnfusion 2 unit
  • 10. (31.01.17)  CBC: Hb%- 8.8 gm/dl  S.β HCG – 225OOO m IU / ml  CXR-Normal   USG of L/A : ( Doppler study) : suggestive of invasive mole Packed cell 2 unit  With this report we gave on call to the radiation oncology department on 01.02.17 , they scheduled chemotherapy (EMA/CO) two weekly for the patient .  The patient had her 6th cycles of chemotherapy on 29/04/17.
  • 11.
  • 13. SERUM Β .HCG CHART : 0 50000 100000 150000 200000 250000 Series 1 Series 1
  • 14. H/O past illness: She gave no H/O HTN,DM,Asthma she gave h/o chronic constipation. Personal History: No H/o smoking and betel nut chewing. Family history : Nothing contributory.
  • 15. Socioeconomic History: She came from middle class family. Drug History: Nothing significant
  • 16. MENSTRUAL HISTORY Menarche at - 13 years MP/MC : 3-4 d/28-30 d LMP : can’t mention Contraceptive history- She took ocp irregularly for last 3 year now she is using barrier method
  • 17. OBSTETRIC HISTORY Married for 11 years Para-2( NVD)+1( invasive mole ) ALC-5 yrs
  • 18. OBSTETRIC CHART: Sl no. Date of Delive -ry Dura tion of Preg nancy with ANC Compli- cation in preg. Labour Home / Hospital Complica- tion Mode of deli very Puerpe- rium Infant alive/ dead Breast feeding Weight Rem- arks 1. 2007 40 wks No ANC Nil Home NVD Normal Dead ( due to heart disease) Breast feeding Avg Wt No 2. 2012 3 8 wks Had ANC Nil Home NVD Normal Alive BF ,Avg Wt No
  • 19. PHYSICAL EXAMINATION General examination: Appearance- anxious Body builds and nutrition- average Anaemia- absent Jaundice- absent Edema- absent Lymph nodes-not palpable
  • 20. Pulse- 80 beats /min BP- 110/80 mm of Hg Temperature- 98.4° F Respiratory rate-14 breaths/min Heart- NAD Lungs- NAD Thyroid gland – Not enlarged Breasts- No abnormality detected
  • 21. P/A EXAMINATION No abnormality detected. PELVIC EXAMINATION: Inspection: vulva & perineum looks healthy. Per speculum: not done Bi manual examination: Not done Per rectal exam: Not done
  • 22. INVESTIGATION (21.04.17)  CBC Hb-11.8 gm/dl ESR-40mm/1st hour TC- 8800/cmm Platelet count-2,33000/cm m  SGPT – 25 U/L  SGOT-23 U/L  S.urea -20.9 mg/dl  S. billirubin - .2 mg/dl  S.creatinine- .7 mg/d
  • 23. MANAGEMENT  General management:  Counselling  Improvement of general health. Definitive management:  chemotherapy