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Predictive Modeling in Health
Care
San Jose, June 2015
GitPro
Taposh Dutta-Roy
2
Introduction
Health Care industry
Analytics in Health Care
Examples of Predictive Models in Health Care
Predictive Modeling Process & Tools
Kaggle – Bike Sharing Predictive Modeling
Health Care industry
Taposh Dutta Roy
4
“Providers”	
  
Employers	
  
“Payers”	
  
Retail	
  Pharmacies	
  
Tech	
  Players	
  
Healthcare	
  Ecosystem	
  
Pharmaceu8cal/	
  
Life	
  Sciences	
  
Examples:	
  
•  Hospitals	
  
•  Physicians	
  
•  Primary	
  Care	
  Centers	
  
•  Specialty	
  Clinics	
  
•  Nursing	
  Homes	
  
Examples:	
  
•  Blue	
  Cross	
  Blue	
  Shield	
  
•  Aetna	
  
•  Unitedhealth	
  
•  Kaiser	
  Permanente	
  
•  Medicaid/Medicare	
  
Examples:	
  
•  CVS	
  
•  Walgreens	
  
•  Wal-­‐Mart	
  
Examples:	
  
•  MedAnaly8cs	
  
•  Optum	
  
•  Medicity	
  
•  Allscripts	
  
Pa8ents/	
  
Consumer	
  
Categorized	
  by:	
  
•  Size	
  (Small,	
  Mid,	
  Large,	
  
Na8onal	
  Accounts)	
  
•  Funding	
  arrangement	
  (Fully	
  
insured,	
  Self-­‐Insured,	
  ASO)	
  
http://www.beckershospitalreview.com/hospital-management-administration/the-new-healthcare-ecosystem-5-emerging-relationships.html
5
“The	
  healthcare	
  ecosystem	
  is	
  made	
  up	
  of	
  many	
  
players	
  –	
  some	
  misaligned	
  incen9ves	
  exist	
  across	
  
stakeholders”
Source : Booz & Company
Recent Trends in Health Care industry
U.S.	
  hospitals	
  face	
  increasing	
  financial	
  pressures	
  in	
  the	
  marketplace,	
  
threatening	
  opera9ng	
  margins	
  
7
Average	
  Opera9ng	
  Margin,	
  US	
  Hospitals	
  	
  
5%	
  
4%	
  
3%	
  
2%	
  
1%	
  
0	
  
2014	
  2012	
  2010	
  2008	
  2006	
  
-9%
Avg.	
  Opera9ng	
  Margin	
  (%)	
  
Contribu9ng	
  Factors	
  
v  Uncompensated	
  (i.e.	
  charity)	
  
and	
  low	
  reimbursement	
  (i.e.	
  
Medicaid)	
  care	
  levels	
  growing	
  
faster	
  than	
  increase	
  in	
  net	
  
pa8ent	
  revenue	
  
v  Misaligned	
  financial	
  
incen8ves	
  between	
  physicians	
  
and	
  hospitals	
  contribute	
  to	
  
overu8liza8on	
  and	
  excessive	
  
labor/non-­‐labor	
  costs	
  
Source: http://healthcare.thomsonreuters.com/thought-leadership/assets/HospOperatingTrendsQuarterlyMarch2011.pdf
Healthcare	
  spend	
  is	
  set	
  to	
  grow	
  almost	
  50%	
  by	
  2019	
  –	
  hospital	
  spend	
  and	
  
nursing	
  home	
  spend	
  are	
  fastest	
  growing	
  
Hospital	
  Care	
  
(Acute	
  &	
  	
  
Emergent)	
  
Outpa9ent	
  Care	
  (Primary	
  &	
  Specialty)	
  
Rx	
  and	
  	
  
Medical	
  Devices	
  
Other	
  Prof.	
  	
  
Services	
  
Incl.	
  Dental	
  
Nursing	
  and	
  
	
  Home	
  Care	
  
+42%	
  2010	
  Healthcare	
  Spend,	
  USD	
  Tr	
   2019	
  Healthcare	
  Spend,	
  USD	
  Tr	
  
Source:	
  CMS	
  hWp://www.cms.gov/Research-­‐Sta8s8cs-­‐Data-­‐and-­‐Systems/Sta8s8cs-­‐Trends-­‐and-­‐Reports/Na8onalHealthExpendData/index.html?redirect=/Na8onalHealthExpendData/	
  	
  
2.6	
  Tr	
  
3.7	
  Tr	
  
Taposh Dutta Roy
10
“The share of economic activity (gross
domestic product, or GDP) devoted to health
care has increased from 7.2% in 1970 to
17.9% in 2009 and 2010”
Taposh Dutta Roy
11
• In 2010, the U.S. spent $2.6 trillion on health care, an
average of $8,402 per person.
• Half of health care spending is used to treat just 5% of
population.
• Although only 10% of total health expenditures,
spending on prescription drugs has received considerable
attention because of its rapid growth (114% from 2000 to
2010).
• Many policy experts believe new technologies and the
spread of existing ones account for a large portion of
medical spending & its growth.
Source : https://kaiserfamilyfoundation.files.wordpress.com/2013/01/7670-03.pdf
Key Facts
Taposh Dutta Roy
12
As	
  Health	
  Exchanges	
  are	
  established,	
  the	
  market	
  will	
  increasingly	
  move	
  
toward	
  a	
  more	
  compe99ve,	
  transparent,	
  retail	
  environment	
  
Prebacked 2013. All Rights Reserved.
Analytics in Health Care
Trends in analytics used in Health Care
14
Analytics in HealthCare has been used for a very long
time.
Taposh Dutta Roy
15
Source : https://www.youtube.com/watch?v=ZHOy6hiUcyA
(Circa	
  1950)	
  	
  Basic	
  Sta9s9cs	
  Uncovered	
  Kuru	
  :	
  A	
  medical	
  detec9ve	
  Story	
  
Taposh Dutta Roy
16
(1950-­‐1964)	
  	
  Dr.	
  Michael	
  Alpers	
  saved	
  data	
  for	
  decades	
  to	
  get	
  to	
  a	
  final	
  
realiza9on,	
  what	
  causes	
  Kuru	
  using	
  Data	
  Analysis.	
  
Taposh Dutta Roy
Source: https://hbr.org/video/2386816175001/business-analytics-defined
“Tradi9onal	
  
	
  Reports”
“Correla9on”
“Correla9on	
  &	
  
Causa9on”
Taposh Dutta Roy
“Predic9ve	
  analy9cs	
  has	
  been	
  part	
  of	
  
healthcare	
  for	
  several	
  decades.	
  Its	
  applying	
  
what	
  doctors	
  have	
  been	
  doing	
  on	
  a	
  bigger	
  
scale.	
  What	
  has	
  changed	
  with	
  big	
  data	
  is	
  our	
  
ability	
  to	
  process	
  more	
  data(quan9ty),	
  
combine	
  variety	
  of	
  data	
  and	
  measure	
  faster.”	
  
Taposh Dutta Roy
Common Use Cases of Predictive
Modeling:
1.  Clinical Decision Support
2.  Readmissions
3.  Chronic Disease management
4.  Patient Matching
Taposh Dutta Roy
20
Clinical Decision Support – Sepsis Alert
Use Case:
Very common use case. Implementation of a cloud
based alerting system for variety of inpatient activities
– care, Labs.
KPI: Better quality of care and sending less patients to
emergencies. Cost reduction for patients and hospitals.
Taposh Dutta Roy
Implementation of a
cloud-based alerting
system and change
management were
associated with a
53% drop in sepsis
mortality in a
single-site study.
http://www.medscape.com/viewarticle/845051
Clinical Decision Support Reduces Sepsis
Taposh Dutta Roy
Use Case: Recent changes to Centers for Medicare and
Medicaid Services (CMS) compensation will no longer
cover hospital expenses for congestive heart failure
(CHF) patients who are readmitted within 30 days of
discharge. In addition to the risk of degraded
health outcomes, the hospital faces financial loss for
preventable CHF readmits.
KPI: An improved understanding of the prime drivers
affecting readmission will benefit both the quality of
care and business revenues.
Readmissions
http://www.commonwealthfund.org/~/media/Files/Publications/Case%20Study/2011/Apr/1473_SilowCarroll_readmissions_synthesis_web_version.pdf
Taposh Dutta Roy
23
Taposh Dutta Roy
Predictive Analytics Process & Tools
Taposh Dutta Roy
Contents
•  Collect Data
•  Visualizing & Understanding Data
•  Determine Metrics – ROC, AUC (C-stat),
Sensitivity/Specificity
•  Dividing Data into Training, Validation, & Test
•  Factor Engineering
•  Applying Algorithm(s)
•  Reviewing Training Results.
•  Scoring
•  Feedback new data into collection set
Predictive Modeling Process
Taposh Dutta Roy
Tools
R
H2O Package
Python
Python + Dato
Weka
Vowpal Wabbit
Taposh Dutta Roy
Survey on top tools used by Data Scientist
http://blog.revolutionanalytics.com/2014/01/in-data-scientist-survey-r-is-the-most-used-tool-other-than-databases.html
Taposh Dutta Roy
Example – Kaggle Bike Sharing
Taposh Dutta Roy
About Bike Share
Competition:
http://www.kaggle.com/c/bike-sharing-demand
Challenge:
Forecast use of a city’s bike share system
Taposh Dutta Roy
Publication :
Fanaee-T, Hadi, and Gama, Joao, Event
labeling combining ensemble detectors and
background knowledge, Progress in
Artificial Intelligence (2013): pp. 1-15,
Springer Berlin Heidelberg.
Source : Bike-Share Data
Taposh Dutta Roy
Data Ingest
The goal is to predict counts either based on
sum of casual & registered or directly
Taposh Dutta Roy
Data Fields
Datetime : hourly date + timestamp
Season : 1 = spring, 2 = summer, 3 = fall, 4 = winter
Holiday : whether the day is considered a holiday
Workingday : whether the day is neither a weekend nor holiday
Weather :
1: Clear, Few clouds, Partly cloudy, Partly cloudy
2: Mist + Cloudy, Mist + Broken clouds, Mist + Few clouds, Mist
3: Light Snow, Light Rain + Thunderstorm + Scattered clouds, Light Rain +
Scattered clouds
4: Heavy Rain + Ice Pallets + Thunderstorm + Mist, Snow + Fog
Temp : temperature in Celsius
Atemp : "feels like" temperature in Celsius
Humidity : relative humidity
Windspeed : wind speed
Casual : number of non-registered user rentals initiated
Registered : number of registered user rentals initiated
Count : number of total rental
Taposh Dutta Roy
Data - Continuous
Taposh Dutta Roy
Workday busy hours
Taposh Dutta Roy
Data
Taposh Dutta Roy
Pairs Command - R
Taposh Dutta Roy
Using R
Taposh Dutta Roy
Feature Engineering
Taposh Dutta Roy
Models
Taposh Dutta Roy
Taposh Dutta Roy
Thank You !!

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Predictive modeling healthcare

  • 1. Predictive Modeling in Health Care San Jose, June 2015 GitPro Taposh Dutta-Roy
  • 2. 2 Introduction Health Care industry Analytics in Health Care Examples of Predictive Models in Health Care Predictive Modeling Process & Tools Kaggle – Bike Sharing Predictive Modeling
  • 4. Taposh Dutta Roy 4 “Providers”   Employers   “Payers”   Retail  Pharmacies   Tech  Players   Healthcare  Ecosystem   Pharmaceu8cal/   Life  Sciences   Examples:   •  Hospitals   •  Physicians   •  Primary  Care  Centers   •  Specialty  Clinics   •  Nursing  Homes   Examples:   •  Blue  Cross  Blue  Shield   •  Aetna   •  Unitedhealth   •  Kaiser  Permanente   •  Medicaid/Medicare   Examples:   •  CVS   •  Walgreens   •  Wal-­‐Mart   Examples:   •  MedAnaly8cs   •  Optum   •  Medicity   •  Allscripts   Pa8ents/   Consumer   Categorized  by:   •  Size  (Small,  Mid,  Large,   Na8onal  Accounts)   •  Funding  arrangement  (Fully   insured,  Self-­‐Insured,  ASO)   http://www.beckershospitalreview.com/hospital-management-administration/the-new-healthcare-ecosystem-5-emerging-relationships.html
  • 5. 5 “The  healthcare  ecosystem  is  made  up  of  many   players  –  some  misaligned  incen9ves  exist  across   stakeholders” Source : Booz & Company
  • 6. Recent Trends in Health Care industry
  • 7. U.S.  hospitals  face  increasing  financial  pressures  in  the  marketplace,   threatening  opera9ng  margins   7 Average  Opera9ng  Margin,  US  Hospitals     5%   4%   3%   2%   1%   0   2014  2012  2010  2008  2006   -9% Avg.  Opera9ng  Margin  (%)   Contribu9ng  Factors   v  Uncompensated  (i.e.  charity)   and  low  reimbursement  (i.e.   Medicaid)  care  levels  growing   faster  than  increase  in  net   pa8ent  revenue   v  Misaligned  financial   incen8ves  between  physicians   and  hospitals  contribute  to   overu8liza8on  and  excessive   labor/non-­‐labor  costs   Source: http://healthcare.thomsonreuters.com/thought-leadership/assets/HospOperatingTrendsQuarterlyMarch2011.pdf
  • 8. Healthcare  spend  is  set  to  grow  almost  50%  by  2019  –  hospital  spend  and   nursing  home  spend  are  fastest  growing   Hospital  Care   (Acute  &     Emergent)   Outpa9ent  Care  (Primary  &  Specialty)   Rx  and     Medical  Devices   Other  Prof.     Services   Incl.  Dental   Nursing  and    Home  Care   +42%  2010  Healthcare  Spend,  USD  Tr   2019  Healthcare  Spend,  USD  Tr   Source:  CMS  hWp://www.cms.gov/Research-­‐Sta8s8cs-­‐Data-­‐and-­‐Systems/Sta8s8cs-­‐Trends-­‐and-­‐Reports/Na8onalHealthExpendData/index.html?redirect=/Na8onalHealthExpendData/     2.6  Tr   3.7  Tr  
  • 10. 10 “The share of economic activity (gross domestic product, or GDP) devoted to health care has increased from 7.2% in 1970 to 17.9% in 2009 and 2010”
  • 11. Taposh Dutta Roy 11 • In 2010, the U.S. spent $2.6 trillion on health care, an average of $8,402 per person. • Half of health care spending is used to treat just 5% of population. • Although only 10% of total health expenditures, spending on prescription drugs has received considerable attention because of its rapid growth (114% from 2000 to 2010). • Many policy experts believe new technologies and the spread of existing ones account for a large portion of medical spending & its growth. Source : https://kaiserfamilyfoundation.files.wordpress.com/2013/01/7670-03.pdf Key Facts
  • 12. Taposh Dutta Roy 12 As  Health  Exchanges  are  established,  the  market  will  increasingly  move   toward  a  more  compe99ve,  transparent,  retail  environment   Prebacked 2013. All Rights Reserved.
  • 13. Analytics in Health Care Trends in analytics used in Health Care
  • 14. 14 Analytics in HealthCare has been used for a very long time.
  • 15. Taposh Dutta Roy 15 Source : https://www.youtube.com/watch?v=ZHOy6hiUcyA (Circa  1950)    Basic  Sta9s9cs  Uncovered  Kuru  :  A  medical  detec9ve  Story  
  • 16. Taposh Dutta Roy 16 (1950-­‐1964)    Dr.  Michael  Alpers  saved  data  for  decades  to  get  to  a  final   realiza9on,  what  causes  Kuru  using  Data  Analysis.  
  • 17. Taposh Dutta Roy Source: https://hbr.org/video/2386816175001/business-analytics-defined “Tradi9onal    Reports” “Correla9on” “Correla9on  &   Causa9on”
  • 18. Taposh Dutta Roy “Predic9ve  analy9cs  has  been  part  of   healthcare  for  several  decades.  Its  applying   what  doctors  have  been  doing  on  a  bigger   scale.  What  has  changed  with  big  data  is  our   ability  to  process  more  data(quan9ty),   combine  variety  of  data  and  measure  faster.”  
  • 19. Taposh Dutta Roy Common Use Cases of Predictive Modeling: 1.  Clinical Decision Support 2.  Readmissions 3.  Chronic Disease management 4.  Patient Matching
  • 20. Taposh Dutta Roy 20 Clinical Decision Support – Sepsis Alert Use Case: Very common use case. Implementation of a cloud based alerting system for variety of inpatient activities – care, Labs. KPI: Better quality of care and sending less patients to emergencies. Cost reduction for patients and hospitals.
  • 21. Taposh Dutta Roy Implementation of a cloud-based alerting system and change management were associated with a 53% drop in sepsis mortality in a single-site study. http://www.medscape.com/viewarticle/845051 Clinical Decision Support Reduces Sepsis
  • 22. Taposh Dutta Roy Use Case: Recent changes to Centers for Medicare and Medicaid Services (CMS) compensation will no longer cover hospital expenses for congestive heart failure (CHF) patients who are readmitted within 30 days of discharge. In addition to the risk of degraded health outcomes, the hospital faces financial loss for preventable CHF readmits. KPI: An improved understanding of the prime drivers affecting readmission will benefit both the quality of care and business revenues. Readmissions http://www.commonwealthfund.org/~/media/Files/Publications/Case%20Study/2011/Apr/1473_SilowCarroll_readmissions_synthesis_web_version.pdf
  • 24. Taposh Dutta Roy Predictive Analytics Process & Tools
  • 25. Taposh Dutta Roy Contents •  Collect Data •  Visualizing & Understanding Data •  Determine Metrics – ROC, AUC (C-stat), Sensitivity/Specificity •  Dividing Data into Training, Validation, & Test •  Factor Engineering •  Applying Algorithm(s) •  Reviewing Training Results. •  Scoring •  Feedback new data into collection set Predictive Modeling Process
  • 26. Taposh Dutta Roy Tools R H2O Package Python Python + Dato Weka Vowpal Wabbit
  • 27. Taposh Dutta Roy Survey on top tools used by Data Scientist http://blog.revolutionanalytics.com/2014/01/in-data-scientist-survey-r-is-the-most-used-tool-other-than-databases.html
  • 28. Taposh Dutta Roy Example – Kaggle Bike Sharing
  • 29. Taposh Dutta Roy About Bike Share Competition: http://www.kaggle.com/c/bike-sharing-demand Challenge: Forecast use of a city’s bike share system
  • 30. Taposh Dutta Roy Publication : Fanaee-T, Hadi, and Gama, Joao, Event labeling combining ensemble detectors and background knowledge, Progress in Artificial Intelligence (2013): pp. 1-15, Springer Berlin Heidelberg. Source : Bike-Share Data
  • 31. Taposh Dutta Roy Data Ingest The goal is to predict counts either based on sum of casual & registered or directly
  • 32. Taposh Dutta Roy Data Fields Datetime : hourly date + timestamp Season : 1 = spring, 2 = summer, 3 = fall, 4 = winter Holiday : whether the day is considered a holiday Workingday : whether the day is neither a weekend nor holiday Weather : 1: Clear, Few clouds, Partly cloudy, Partly cloudy 2: Mist + Cloudy, Mist + Broken clouds, Mist + Few clouds, Mist 3: Light Snow, Light Rain + Thunderstorm + Scattered clouds, Light Rain + Scattered clouds 4: Heavy Rain + Ice Pallets + Thunderstorm + Mist, Snow + Fog Temp : temperature in Celsius Atemp : "feels like" temperature in Celsius Humidity : relative humidity Windspeed : wind speed Casual : number of non-registered user rentals initiated Registered : number of registered user rentals initiated Count : number of total rental
  • 33. Taposh Dutta Roy Data - Continuous
  • 36. Taposh Dutta Roy Pairs Command - R