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05 diagnostic tests cwq
- 3. Section A Diagnosis and Diagnostic Testing
- 9. Section B Assessment on Diagnostic Testing
- 21. DIAGNOSTIC ACCURACY OF A TEST Definition The extent to which the results of a diagnostic test reflect true disease status Terminology Accuracy / Validity interchangeable
- 22. Indicators for assessing diagnostic test
- 51. Likelihood Ratios and Post-Test Disease Probability
- 58. Clinical interpretation of post-test probability Disease ruled out Disease ruled in
- 62. Figure 1a : Likelihood Ratio Nomogram
- 63. Figure 1b : Likelihood Ratio Nomogram
- 64. Developmental characteristics: Cut-points and Receiver Operating Characteristic (ROC) Healthy
- 65. Developmental characteristics: Cut-points and Receiver Operating Characteristic (ROC) Healthy Sick
- 66. Developmental characteristics: Cut-points and Receiver Operating Characteristic (ROC) Fals pos= 20% True pos=82%
- 67. Developmental characteristics: Cut-points and Receiver Operating Characteristic (ROC) F pos= 100% T pos=100%
- 68. Developmental characteristics: Cut-points and Receiver Operating Characteristic (ROC) Fals pos= 9% True pos=70%
- 69. Developmental characteristics: Cut-points and Receiver Operating Characteristic (ROC) T neg= 100% F neg=100%
- 70. Developmental characteristics: Cut-points and Receiver Operating Characteristic (ROC) “ F pos + T pos “ is the highest
- 72. Developmental characteristics: Cut-points and Receiver Operating Characteristic (ROC) Receiver Operating Characteristic (ROC)
- 73. Developmental characteristics: Cut-points and Receiver Operating Characteristic (ROC) Receiver Operating Characteristic (ROC)
- 87. Effect of prevalence on predictive value(Se=70%, Sp=90%) 93.0 50,000 Clinical suspicious prostatic nodule 5.6 500 Men, age 75or greater 0.4 35 General population PPV (%) Prevalence (case/100,000) Setting
- 88. Lead Time 1990 1997 2000 death Diagnosis and treatment Biologic onset of disease 1990 1994 2000 death Biologic onset of disease Screening: diagnosis & treatment
- 89. Length Bias 1995 2000 death Biologic onset of disease 1989 1994 death Biologic onset of disease Screening: diagnosis & treatment 2002 1994 Screening:
- 90. Thanks!!!