Dicer - A Molecular Ruler

Dicer - A Molecular Ruler Structural Basis for Double-Stranded RNA Processing by Dicer Ian J. MacRae, Kaihong Zhou, Fei Li, Adrian Repic, Angela N. Brooks, W. Zacheus Cande, Paul D. Adams, Jennifer A. Doudna. Science , 2006, 311 , 195-198.

Carl D. Novina and P hillip A. Sharp; Nature 430 , 161-164 (2004) Short RNA’s in Gene Silencing

Carl D. Novina and P hillip A. Sharp; Nature 430 , 161-164 (2004) siRNA pathway RNAi pathways

Carl D. Novina and P hillip A. Sharp; Nature 430 , 161-164 (2004) miRNA pathway RNAi pathways

Classes of RNase ,[object Object],[object Object],[object Object],[object Object],[object Object]

Acid-Base mechanism of ribonuclease A

Michelle A. Carmell, G regory J. Hannon Nature Structural & Molecular Biology , 11 , 214 - 218 ( 2004 ) Classes of RNase III

Dicer Activity in Giardia intestinalis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Fig. 1. Giardia encodes an active Dicer enzyme.

Fig. 2. Crystal structure of Giardia Dicer.

Fig. 3. Structural features of the Dicer PAZ domain.

Michelle A. Carmell, G regory J. Hannon Nature Structural & Molecular Biology , 11 , 214 - 218 ( 2004 )

Fig. 4 . A model for dsRNA processing by Dicer.

Fig. 5. Giardia Dicer supports RNAi in vivo.

Dicer - A Molecular Ruler

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Dicer - A Molecular Ruler