Liver function tests (LFTs) can reveal important information about underlying liver conditions or other systemic diseases. This document provides guidance on interpreting abnormal LFT results in primary care settings. It recommends a tiered testing approach based on the pattern of abnormal LFT findings and risk factors. First tier tests include full blood count, glucose, lipids, iron studies, and hepatitis/alcohol screens. Second tier tests may involve ultrasound, autoantibody screens, or other tests depending on clues from history, examination, and first tier results. The goal is to identify potential causes and determine if follow up testing or referral is needed.