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Adrenocorticoids and Their Uses

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The document discusses adrenocorticosteroids and their uses. It describes the adrenal glands and hormones they produce, including mineralocorticoids, glucocorticoids, and adrenal androgens. It outlines the therapeutic uses of adrenocorticosteroids in treating adrenal insufficiency, Cushing's syndrome, inflammatory disorders, and more. Side effects are noted if used long-term or withdrawn abruptly.

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Adrenocorticosteroids and Adrenocortical Antagonists Ma. Victoria M. Villarica, M.D. Fatima College of Medicine
Objectives ,[object Object],[object Object],[object Object]
 
Types of steroid hormones ,[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenal Gland ,[object Object],[object Object]
 
Adrenal Cortex ,[object Object],[object Object],[object Object],[object Object]
ACTH ,[object Object],[object Object],[object Object],[object Object]
ACTH ,[object Object],[object Object]
Regulation of ACTH secretion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Control of Endocrine Activity ,[object Object],[object Object]
 
 
[object Object],[object Object],Steroid hormones
cholesterol Extracellular lipoprotein Cholesterol pool LH ATP cAMP PKA+ Pregnenolone Progesterone Androstenedione TESTOSTERONE 3  HSD P450c17 17  HSD acetate
Steroid hormone production ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Steroidogenic Enzymes Common name "Old" name Current name Side-chain cleavage enzyme; desmolase P450 SCC CYP11A1 3 beta-hydroxysteroid dehydrogenase 3 beta-HSD 3 beta-HSD 17 alpha-hydroxylase/17,20 lyase P450 C17 CYP17 21-hydroxylase P450 C21 CYP21A2 11 beta-hydroxylase P450 C11 CYP11B1 Aldosterone synthase P450 C11AS CYP11B2 Aromatase P450 aro CYP19
Adrenocorticosteroids ,[object Object],[object Object],[object Object],[object Object]
A. Mineralocorticoids ,[object Object],[object Object],[object Object],[object Object],[object Object]
B. Glucocorticoids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CBG (transcortin) ,[object Object],[object Object]
C. Adrenal Androgens ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Physiologic effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiologic effects (cont.): ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiologic effects (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiologic effects (cont.): ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Synthetic Steroids ,[object Object],[object Object],[object Object],[object Object]
Classification of Glucocorticoids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
II. Intermediate-acting glucocorticoids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],IV. Mineralocorticoids
Uses: ,[object Object],[object Object]
Therapeutic Uses : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
1. Adrenal Insufficiency (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
 
Therapeutic Uses (cont.) 2. Adrenocortical hypofunctioning and hyperfunctioning ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Therapeutic Uses 2. Adrenocortical hypofunctioning and hyperfunctioning (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
B. Stimulation of fetal lung maturation – betamethasone 12mg ffed by 12mg 18-24 hrs. later ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
C. Non-Adrenal Diseases (cont.) ,[object Object],[object Object],[object Object],[object Object]
C. Non- Adrenal Diseases (cont.) ,[object Object],[object Object]
C. Non-Adrenal Diseases (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object]
C. Non-Adrenal Diseases (cont.) ,[object Object],[object Object],[object Object],[object Object]
C. Non-Adrenal Diseases (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
C. Non-Adrenal Diseases (cont.) ,[object Object],[object Object],[object Object]
D. Diagnostic Application – dexamethasone: suppress production of ACTH ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Toxicity: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Supplemental measures: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antagonists of Adrenocortical Agents ,[object Object],[object Object],[object Object],[object Object]
Synthetic inhibitors and glucocorticoid antagonists (cont.) ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Synthetic inhibitors and glucocorticoid antagonists (cont.)
[object Object],[object Object],[object Object],Synthetic inhibitors and glucocorticoid antagonists (cont.)
 
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Classification of topical corticosteroids based on their potencies ,[object Object],[object Object],[object Object],[object Object],[object Object]
Classification of topical corticosteroids based on their potencies (continued) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Classification of topical corticosteroids based on their potencies (continued) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Classification of topical corticosteroids based on their potencies (continued) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Common side effects of topical corticosteroids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Summary of adrenocortical agonists and antagonists…… ,[object Object],[object Object],[object Object]
[object Object]

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Adrenocorticoids and Their Uses

  • 1. Adrenocorticosteroids and Adrenocortical Antagonists Ma. Victoria M. Villarica, M.D. Fatima College of Medicine
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  • 15. cholesterol Extracellular lipoprotein Cholesterol pool LH ATP cAMP PKA+ Pregnenolone Progesterone Androstenedione TESTOSTERONE 3  HSD P450c17 17  HSD acetate
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  • 18. Steroidogenic Enzymes Common name "Old" name Current name Side-chain cleavage enzyme; desmolase P450 SCC CYP11A1 3 beta-hydroxysteroid dehydrogenase 3 beta-HSD 3 beta-HSD 17 alpha-hydroxylase/17,20 lyase P450 C17 CYP17 21-hydroxylase P450 C21 CYP21A2 11 beta-hydroxylase P450 C11 CYP11B1 Aldosterone synthase P450 C11AS CYP11B2 Aromatase P450 aro CYP19
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