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Hodgkin's Lymphoma
1. What second-line regimen should we use for recurrent
Hodgkin lymphoma prior to stem cell transplant?
Pankaj Malhotra, MD
PGI, Chandigarh, India
2. Outline of talk
⢠Why auto is better than continuing chemo in relapsed HL?
⢠Results of auto transplant in relapsed HL
⢠Predictors of transplant outcome
⢠Chemotherapy regimens used before transplant
⢠Does any specific chemotherapy regimen make diff in outcome?
⢠Upcoming therapies
6. ABMTR data and multicentric studies data on
autologous SCT in relapsed HL
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13. Summary
⢠Autologous stem cell transplantation improves EFS and PFS in
relapsed HL
Factors predicting poor outcome
⢠B symptoms
⢠Stage IV disease at relapse
⢠Residual disease at the time of transplantation
⢠More than three prior chemotherapies (chemo-resistant disease)
36. Conclusions
⢠ORR of salvage chemotherapy regimens in relapsed refractory HL vary
from 60-80%
⢠CR rates vary from 20-40%
⢠Brentuximab as a single agent is able to achieve ORR and CR rates
similar to chemotherapy regimens
⢠The available data is thus compelling enough to recommend use of
Brentuximab in relapsed refractory HL before auto or allogeneic stem
cell transplantation