PETALUTE: Preclinical Applications of the Modified Rosette for FAST-Flexible Contrast MR(S)I
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PETALUTE: Preclinical Applications of the Modified Rosette for FAST-Flexible Contrast MR(S)I
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PETALUTE: Preclinical Applications of the Modified Rosette for FAST-Flexible Contrast MR(S)I
- 1. Stephen Sawiak, University of Cambridge, UK Uzay Emir, Purdue University, USA with Matthew Scarpelli, Joseph Rispoli, Gregory Tamer Jr, Thejas Vishnu Ramesh, Jessica Leigh Veenstra, Alexander Lipka, Deng-Yuan Chang PETALUTE
- 2. PETALUTE An ultrashort echo-time (UTE) sequence with high efficiency and incoherence, ideal for acceleration 𝐾𝑥 = 𝐾𝑚𝑎𝑥 cos 𝜙 sin 𝜔1𝑡 cos 𝜔2𝑡 + 𝛽 𝐾𝑦 = 𝐾𝑚𝑎𝑥 cos 𝜙 sin 𝜔1𝑡 sin 𝜔2𝑡 + 𝛽 𝐾𝑧 = 𝐾𝑚𝑎𝑥 sin 𝜙 sin 𝜔1𝑡 Centre out 𝜔1 = 𝜋Δ𝐵𝑊 2𝑁 …and back again 𝜔1 = 𝜋Δ𝐵𝑊 𝑁 𝐾𝑥 = 𝐾𝑚𝑎𝑥 cos 𝜙 sin 𝜔1𝑡 cos 𝜔2𝑡 + 𝛽 𝐾𝑦 = 𝐾𝑚𝑎𝑥 cos 𝜙 sin 𝜔1𝑡 sin 𝜔2𝑡 + 𝛽 𝐾𝑧 = 𝐾𝑚𝑎𝑥 sin 𝜙 sin 𝜔1𝑡 𝐾𝑥 = 𝐾𝑚𝑎𝑥 cos 𝜙 sin 𝜔1𝑡 cos 𝜔2𝑡 + 𝛽 𝐾𝑦 = 𝐾𝑚𝑎𝑥 cos 𝜙 sin 𝜔1𝑡 sin 𝜔2𝑡 + 𝛽 𝐾𝑧 = 𝐾𝑚𝑎𝑥 sin 𝜙 sin 𝜔1𝑡 𝐾𝑥 = 𝐾𝑚𝑎𝑥 cos 𝜙 sin 𝜔1𝑡 cos 𝜔2𝑡 + 𝛽 𝐾𝑦 = 𝐾𝑚𝑎𝑥 cos 𝜙 sin 𝜔1𝑡 sin 𝜔2𝑡 + 𝛽 𝐾𝑧 = 𝐾𝑚𝑎𝑥 sin 𝜙 sin 𝜔1𝑡 Shen X., Özen A. C., Sunjar A., Ilbey S., Sawiak S., Shi R., Chiew M., Emir U., Magn. Reson. Med. 89, 508–521 (2023).
- 3. PETALUTE Fast, flexible contrast with high acceleration factors possible 23Na imaging at 3T 1H pulmonary imaging at 3T Magnetisation transfer at 7T 31P MRS imaging
- 4. PETALUTE Versatile implementation for PV6.1, PV7.0
- 5. PETALUTE Bone imaging BioSpec 70/30 Volume coil TR 500ms TE 16µs 105µm3 isotropic resolution 147,456 petals 30 minute (fully sampled)
- 6. PETALUTE Mouse abdominal T1 mapping ~2 minutes BioSpec 70/30 volume coil T1 mapping FA 4°/20° Dual TE 16µs/2ms 240µm3 isotropic resolution 18,192 petals 4× acceleration
- 7. PETALUTE 31P MRSI 48 minutes BioSpec 70/30 1H/31P surface coil TR 500ms TE 16µs 1mm3 isotropic resolution 4 averages 1,444 petals 6.5kHz spectral bandwidth
- 8. PETALUTE GABA 1H MRSI with MEGA spectral editing GABA-edited spectra in 8.5 minutes BioSpec 94/20 4ch mouse brain coil semi-LASER localisation 1mm3 isotropic resolution 256 petals Dual-band suppression pulses for MEGA
- 10. PETALUTE Fast, flexible contrast with high acceleration factors possible Demonstrated utility in imaging, relaxometry, MRSI across nuclei, species and scales High-quality images and spectra, integrated clinical and preclinical platforms for translational studies Better understanding of complex structure and physiology in health and disease Albert Thomas UCLA Alex Lipka DKFZ Heidelberg Matthew Scarpelli Purdue University Uzay Emir Purdue University Ali Ozen University of Freiburg Stephen Sawiak University of Cambridge Mark Chiew University of Toronto Xin Shen UCSF Peder Larson UCSF Lijing Xin EPFL Yen-Yu Ian Sh UNC Rachel K Surowiec Purdue University