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Complications
of Pancreatitis
By Mohamed Saeed
Complications
Acute Chronic
Local Systemic Mainly Local
Acute Pancreatitis- Local complication
● Pseudocyst :
● Walled-off collection of edema/fluid
• Contain minimal or no necrosis
“Pseudo” because no epithelium
• Granulation/fibrous tissue surrounds fluid
• Usually outside the pancreas
• Require 4 weeks to “mature”
• Diagnosed by CT or MRI imaging
• Chronic pancreatitis (10% of patients)
Lesser Sac
Acute Pancreatitis- Local complication
● Pseudocysts often resolves without intervention
• Sometimes requires drainage
• Feared outcome is rupture→peritonitis
• Can also lead to fistulas, obstruction
• Can become infected ( Pancreatic abscess) E.coli
Presents as fever, failure to improve clinically
Lesser Sac
● Fat necrosis: Indicate poor prognosis
● Inflammation can involve fat surrounding pancreas
• Can lead to hypocalcemia
• Enzymes (lipase) may release free fatty acids
• Fatty acids can bind calcium (“saponification”)
Acute Pancreatitis- Local complication
● Systemic Inflammatory Response Syndrome (SIRS)
● Clinical syndrome of dysregulated inflammation
• Temperature >38.3°C or <36°C
• Heart rate > 90bpm
• Respiratory rate > 20 breaths/min
• WBC > 12,00
Sepsis = SIRS + infection
Indicate sever disease
Acute Pancreatitis- systemic complication
● ARDS
Acute Pancreatitis- systemic complication
● ARDS, CXR
Acute Pancreatitis- systemic complication
Looks like P. edema
But PCWP is normal
● DIC: disseminated intravascular Coagulation
Acute Pancreatitis- systemic complication
Chronic pancreatitis
● Splenic Vein Thrombosis:
● Results in gastric varices via engorgement of short gastric veins and bleeding
Treatment ??
splenectomy
● Pancreatic Insufficiency:
- Result of chronic pancreatitis
• Fat malabsorption and steatorrhea
• Fat-soluble vitamin deficiencies
• Diabetes (loss of insulin)
Vitamin B12 Deficiency??
Thus, meaglobalstic anemia
Chronic pancreatitis
THANKS!!!

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Pancreatitis Complications - pptx

  • 2.
  • 4. Acute Pancreatitis- Local complication ● Pseudocyst : ● Walled-off collection of edema/fluid • Contain minimal or no necrosis “Pseudo” because no epithelium • Granulation/fibrous tissue surrounds fluid • Usually outside the pancreas • Require 4 weeks to “mature” • Diagnosed by CT or MRI imaging • Chronic pancreatitis (10% of patients) Lesser Sac
  • 5. Acute Pancreatitis- Local complication ● Pseudocysts often resolves without intervention • Sometimes requires drainage • Feared outcome is rupture→peritonitis • Can also lead to fistulas, obstruction • Can become infected ( Pancreatic abscess) E.coli Presents as fever, failure to improve clinically Lesser Sac
  • 6. ● Fat necrosis: Indicate poor prognosis ● Inflammation can involve fat surrounding pancreas • Can lead to hypocalcemia • Enzymes (lipase) may release free fatty acids • Fatty acids can bind calcium (“saponification”) Acute Pancreatitis- Local complication
  • 7. ● Systemic Inflammatory Response Syndrome (SIRS) ● Clinical syndrome of dysregulated inflammation • Temperature >38.3°C or <36°C • Heart rate > 90bpm • Respiratory rate > 20 breaths/min • WBC > 12,00 Sepsis = SIRS + infection Indicate sever disease Acute Pancreatitis- systemic complication
  • 8. ● ARDS Acute Pancreatitis- systemic complication
  • 9. ● ARDS, CXR Acute Pancreatitis- systemic complication Looks like P. edema But PCWP is normal
  • 10. ● DIC: disseminated intravascular Coagulation Acute Pancreatitis- systemic complication
  • 11. Chronic pancreatitis ● Splenic Vein Thrombosis: ● Results in gastric varices via engorgement of short gastric veins and bleeding Treatment ?? splenectomy
  • 12. ● Pancreatic Insufficiency: - Result of chronic pancreatitis • Fat malabsorption and steatorrhea • Fat-soluble vitamin deficiencies • Diabetes (loss of insulin) Vitamin B12 Deficiency?? Thus, meaglobalstic anemia Chronic pancreatitis

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