This document provides an overview of osmotic drug delivery systems. It discusses the basic components and principles of osmosis that osmotic drug delivery systems utilize. The key components discussed include the drug, osmogen, semipermeable membrane, and factors that affect drug release such as solubility, osmotic pressure, delivery orifice size, and membrane type. A variety of osmotic pump designs are also briefly mentioned.
Osmotic drug delivery uses the osmotic pressure of drug or other solutes (osmogens or osmagents) for controlled delivery of drugs. Osmotic drug delivery has come a long way since Australian physiologists Rose and Nelson developed an implantable pump in 1955.
This document provides an overview of osmotic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the basic components and classifications of osmotic pumps, including elementary osmotic pumps, multi-chamber osmotic pumps, and controlled porosity osmotic pumps. Factors that can affect drug release from these systems are discussed, such as solubility, osmotic pressure, membrane properties, and use of excipients. Approaches to modify drug solubility for osmotic systems are also summarized.
OSMOTIC AND ENZYMATIC DRUG DELIVERY SYSTEMAravindgowda6
This document provides an overview of osmotic and enzymatic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the principles of osmotic drug delivery systems, which use osmotic pressure to release drugs in a controlled manner. The document classifies different types of osmotic pumps and discusses formulation considerations like drugs, semipermeable membranes, and osmogens. It also briefly introduces enzymatic drug delivery systems that rely on enzymatic activation to release drugs. Examples of marketed osmotic drug delivery products are also mentioned.
Osmotic drug delivery system by Mr. kailash vilegaveKailash Vilegave
INTRODUCTION
ADVANTAGES OF OSMOTIC DRUG DELIVERY SYSTEM
DISADVANTAGES OF OSMOTIC DRUG DELIVERY SYSTEM
REPORTED CASES REGARDING LIMITATIONS AND ADVERSE EFFECTS OF OSMOTIC DRUG DELIVERY SYSTEM
PRINCIPLE OF OSMOSIS
BASIC COMPONENTS OF OSMOTIC PUMP
Osmotic drug delivery system by Mr. kailash vilegaveKailash Vilegave
This document provides an overview of osmotic drug delivery systems. It discusses the advantages such as achievable zero-order delivery and independence from gastric conditions. Potential disadvantages include dose dumping and rapid tolerance development. The document explains the principles of osmosis and key components of osmotic pumps such as drugs, osmotic agents, and semipermeable membranes. Various osmotic pump designs are also outlined including multi-chamber and elementary osmotic pumps.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
The document discusses osmotic drug delivery systems (ODDS). It begins by defining osmosis and describing how osmotic pressure drives the movement of water across a semi-permeable membrane. It then discusses the advantages of ODDS such as zero-order delivery kinetics and independence from gastric pH. The document classifies several types of ODDS including elementary osmotic pumps, controlled porosity pumps, and push-pull pumps. It also describes components like the semi-permeable membrane and osmotic agents. In vitro evaluation methods and factors affecting ODDS performance are briefly covered.
This document provides an overview of osmotic drug delivery systems. It discusses the basic components and principles of osmosis that osmotic drug delivery systems utilize. The key components discussed include the drug, osmogen, semipermeable membrane, and factors that affect drug release such as solubility, osmotic pressure, delivery orifice size, and membrane type. A variety of osmotic pump designs are also briefly mentioned.
Osmotic drug delivery uses the osmotic pressure of drug or other solutes (osmogens or osmagents) for controlled delivery of drugs. Osmotic drug delivery has come a long way since Australian physiologists Rose and Nelson developed an implantable pump in 1955.
This document provides an overview of osmotic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the basic components and classifications of osmotic pumps, including elementary osmotic pumps, multi-chamber osmotic pumps, and controlled porosity osmotic pumps. Factors that can affect drug release from these systems are discussed, such as solubility, osmotic pressure, membrane properties, and use of excipients. Approaches to modify drug solubility for osmotic systems are also summarized.
OSMOTIC AND ENZYMATIC DRUG DELIVERY SYSTEMAravindgowda6
This document provides an overview of osmotic and enzymatic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the principles of osmotic drug delivery systems, which use osmotic pressure to release drugs in a controlled manner. The document classifies different types of osmotic pumps and discusses formulation considerations like drugs, semipermeable membranes, and osmogens. It also briefly introduces enzymatic drug delivery systems that rely on enzymatic activation to release drugs. Examples of marketed osmotic drug delivery products are also mentioned.
Osmotic drug delivery system by Mr. kailash vilegaveKailash Vilegave
INTRODUCTION
ADVANTAGES OF OSMOTIC DRUG DELIVERY SYSTEM
DISADVANTAGES OF OSMOTIC DRUG DELIVERY SYSTEM
REPORTED CASES REGARDING LIMITATIONS AND ADVERSE EFFECTS OF OSMOTIC DRUG DELIVERY SYSTEM
PRINCIPLE OF OSMOSIS
BASIC COMPONENTS OF OSMOTIC PUMP
Osmotic drug delivery system by Mr. kailash vilegaveKailash Vilegave
This document provides an overview of osmotic drug delivery systems. It discusses the advantages such as achievable zero-order delivery and independence from gastric conditions. Potential disadvantages include dose dumping and rapid tolerance development. The document explains the principles of osmosis and key components of osmotic pumps such as drugs, osmotic agents, and semipermeable membranes. Various osmotic pump designs are also outlined including multi-chamber and elementary osmotic pumps.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
The document discusses osmotic drug delivery systems (ODDS). It begins by defining osmosis and describing how osmotic pressure drives the movement of water across a semi-permeable membrane. It then discusses the advantages of ODDS such as zero-order delivery kinetics and independence from gastric pH. The document classifies several types of ODDS including elementary osmotic pumps, controlled porosity pumps, and push-pull pumps. It also describes components like the semi-permeable membrane and osmotic agents. In vitro evaluation methods and factors affecting ODDS performance are briefly covered.
This document provides an overview of three types of rate controlled drug delivery systems: hydrodynamically balanced systems, osmotic pressure controlled systems, and pH dependent/independent systems.
Hydrodynamically balanced systems, also known as floating drug delivery systems, remain buoyant in the stomach for prolonged periods of time to increase bioavailability. Osmotic pressure controlled systems use osmotic pressure to provide zero-order drug release kinetics over extended times. pH dependent systems target drug delivery to specific regions of the GI tract based on pH, while pH independent systems aim to release drugs at a constant rate regardless of varying GI pH.
This document discusses osmotic drug delivery systems. It begins with an introduction to how osmotic drug delivery uses osmotic pressure for controlled drug delivery. It then covers the basic principles of osmosis, classification of osmotic delivery systems, factors affecting drug release, and basic components. The document lists advantages like achievable zero-order release and independence from gastric conditions. Disadvantages include potential for dose dumping. Materials used in formulation are also outlined.
Osmotic Drug Delivery System and basic components of Osmotic systemDhanashreeDavare
Introduction to Osmotic Drug Delivery System . Various Advantages and Disadvantages. Principle of osmosis.Basic components of Osmotic System. Osmotic Pumps
OSMOTIC drug delivery system slideshare.pptxPratik Shinde
Introduction of osmotic drug delivery system.
Mechanism of osmosis.
Basic Components of Osmotic drug delivery System.
Classification of Osmotic Drug Delivery System.
Advantage & Disadvantage of Osmotic drug delivery system.
Newer technology in Osmotic drug delivery system.
Evaluation parameters of osmotic drug delivery system.
Marketed Formulations of Osmotic drug delivery system.
Case Study about osmotic drug delivery system.
This document defines osmosis and osmotic pressure, and describes how osmotic systems utilize these principles for controlled drug delivery. It discusses the basic components of osmotic systems, including drugs, osmotic agents, semi-permeable membranes, and plasticizers. It also describes various types of osmotic systems for both oral and implantable drug delivery, including elementary osmotic pumps, push-pull osmotic pumps, and implantable mini-osmotic pumps. The document provides equations to describe drug release from these systems driven by osmotic pressure.
This document discusses osmotic drug delivery systems, specifically ALZET pumps. It begins by defining osmosis and osmotic pressure, and explaining how these principles are used in osmotic drug delivery. The basic components of osmotic drug delivery systems are then outlined, including the drug, semipermeable membrane, osmogens, and coatings. ALZET pumps are introduced as implantable osmotic pumps used in laboratory animals. Factors that affect drug release from these systems include drug solubility, osmotic pressure, delivery orifice size, and membrane properties. Evaluation methods and advantages like zero-order release and long duration of action are also summarized.
This document discusses general methods for designing and evaluating osmotic pumps. It begins by introducing osmotic pumps and their advantages over other controlled drug delivery systems. It then describes the process of osmosis and differentiates it from diffusion. Various materials used in formulating osmotic pumps are outlined, including semi-permeable membranes, polymers, wicking agents, osmogens, and others. Different types of osmotic pumps are explained, such as implantable pumps and orally administered pumps. Specific examples of osmotic pumps are provided.
Osmotic drug delivery systems use osmotic pressure to provide controlled release of drugs over extended periods of time. They consist of a drug core surrounded by a semipermeable membrane with a delivery orifice. When exposed to fluids, osmotic pressure causes water to enter the system, dissolving the drug and pushing it out through the orifice at a controlled rate. The three main types are Rose-Nelson pumps, elementary osmotic pumps, and controlled porosity osmotic pumps. These systems offer advantages over traditional methods for conditions requiring prolonged, consistent drug levels.
This document discusses general methods for designing and evaluating osmotic pumps. It begins by introducing osmotic pumps and their advantages over other drug delivery systems. It then describes the key components of osmotic pumps including semi-permeable membranes, osmogens, and polymers. Finally, it discusses various types of osmotic pumps including elementary osmotic pumps, push-pull osmotic pumps, and controlled porosity osmotic pumps. The document provides an overview of the materials and mechanisms involved in osmotic pump drug delivery systems.
it is consist osmotic drug delivery system. and its new approaches. its advantage & disadvantage.. principle. etc
and basic camponents and osmotic pump......
This document provides an overview of osmotic drug delivery systems. It defines osmotic pressure and discusses how osmotic pumps use osmotic pressure to control drug delivery over extended periods of time. The key components of osmotic systems are a drug core containing an osmogen, a semipermeable membrane coating, and a delivery orifice. Factors like solubility, osmotic pressure, membrane properties, and orifice size influence drug release rates. Various polymers, osmogens, and other excipients are discussed for formulating different osmotic pump designs.
Osmotic drug delivery uses osmotic pressure to control drug release rates. It offers advantages like zero-order release kinetics and delivery rates unaffected by environmental conditions. The document discusses the principles of osmosis, components of osmotic pumps like drugs, osmogens, and semipermeable membranes. It also describes early osmotic pumps developed by Rose and Nelson as well as various types of modern osmotic pumps and some reported cases of adverse effects.
The document discusses osmotic drug delivery systems. It defines osmosis and osmotic pressure, and describes the basic components of osmotic drug delivery systems including semipermeable membranes, osmogens, and drug formulations. It classifies osmotic systems as implantable or oral, and describes several types of oral osmotic pumps including elementary, modified, multi-chamber, controlled porosity, and monolithic systems. Key factors that affect drug release are also outlined. The document concludes by listing several marketed osmotic products.
This document provides an overview of osmotic drug delivery systems. It discusses the history, principles, components, advantages, and types of osmotic pumps. Some key points include: Osmotic pumps use osmotic pressure to control drug release rates; They were first developed in the 1950s and improved upon in the 1970s; Common components include semipermeable membranes, osmogens, and drug formulations; Advantages include zero-order release and increased bioavailability; Types discussed are Rose-Nelson, Higuchi-Leeper, Higuchi-Theeuwes, sandwiched osmotic tablets, and controlled porosity osmotic pumps.
Osmotically Regulated Control System By Ashish Guptaashishmedatwal87
This document provides an overview of osmotically controlled drug delivery systems. It begins with an introduction to novel drug delivery systems and their advantages. It then discusses the principles of osmosis and factors that affect drug release rates from these systems such as osmotic pressure, membrane properties, and orifice size. The document classifies different types of osmotic delivery systems including oral, implantable, and advanced systems. It provides examples of components, commercially available products, and evaluation methods. In summary, the document reviews the fundamentals and design of osmotically controlled drug delivery to provide sustained and targeted drug release.
Osmotic activated Drug Delivery System Seminar(DDS).pptxankushawatale09
The document discusses osmotic activated drug delivery systems, which use osmotic pressure to control drug release through semi-permeable membranes. It describes the basic components, types including implantable pumps and oral pumps, marketed products, advantages of controlled release and improved compliance, and disadvantages like potential toxicity. Examples of marketed products incorporating various pump technologies are provided.
The document discusses osmotic drug delivery systems, which use osmotic pressure to control drug release. It describes the principles of osmosis, advantages and disadvantages of osmotic systems, components of osmotic pumps like semipermeable membranes and osmogens, and various types of osmotic pumps. The document provides details on the design and working of osmotic pumps for controlled drug delivery.
This document reviews osmotically controlled drug delivery systems. It discusses how these systems use osmotic principles to provide controlled release of drugs from formulations. The systems typically consist of a drug core coated with a semipermeable membrane. When exposed to water, a soluble additive is released from the membrane, and the drug is released at a constant zero-order rate over an extended period of time. The document outlines the key components of these systems, including the semipermeable membrane, osmotic agents, and coatings. It also discusses the advantages such as improved tolerability and compliance compared to conventional dosage forms.
The document discusses osmotic drug delivery systems (ODDS). It begins with an introduction that explains how ODDS use osmotic pressure to control drug release independently of physiological factors. It then covers key topics such as the concept of osmosis, principles of osmosis, basic components of ODDS, classification into implantable and oral systems, factors influencing design, and evaluation parameters. The document provides an overview of the technology and science behind ODDS for controlled drug delivery.
This document provides an overview of three types of rate controlled drug delivery systems: hydrodynamically balanced systems, osmotic pressure controlled systems, and pH dependent/independent systems.
Hydrodynamically balanced systems, also known as floating drug delivery systems, remain buoyant in the stomach for prolonged periods of time to increase bioavailability. Osmotic pressure controlled systems use osmotic pressure to provide zero-order drug release kinetics over extended times. pH dependent systems target drug delivery to specific regions of the GI tract based on pH, while pH independent systems aim to release drugs at a constant rate regardless of varying GI pH.
This document discusses osmotic drug delivery systems. It begins with an introduction to how osmotic drug delivery uses osmotic pressure for controlled drug delivery. It then covers the basic principles of osmosis, classification of osmotic delivery systems, factors affecting drug release, and basic components. The document lists advantages like achievable zero-order release and independence from gastric conditions. Disadvantages include potential for dose dumping. Materials used in formulation are also outlined.
Osmotic Drug Delivery System and basic components of Osmotic systemDhanashreeDavare
Introduction to Osmotic Drug Delivery System . Various Advantages and Disadvantages. Principle of osmosis.Basic components of Osmotic System. Osmotic Pumps
OSMOTIC drug delivery system slideshare.pptxPratik Shinde
Introduction of osmotic drug delivery system.
Mechanism of osmosis.
Basic Components of Osmotic drug delivery System.
Classification of Osmotic Drug Delivery System.
Advantage & Disadvantage of Osmotic drug delivery system.
Newer technology in Osmotic drug delivery system.
Evaluation parameters of osmotic drug delivery system.
Marketed Formulations of Osmotic drug delivery system.
Case Study about osmotic drug delivery system.
This document defines osmosis and osmotic pressure, and describes how osmotic systems utilize these principles for controlled drug delivery. It discusses the basic components of osmotic systems, including drugs, osmotic agents, semi-permeable membranes, and plasticizers. It also describes various types of osmotic systems for both oral and implantable drug delivery, including elementary osmotic pumps, push-pull osmotic pumps, and implantable mini-osmotic pumps. The document provides equations to describe drug release from these systems driven by osmotic pressure.
This document discusses osmotic drug delivery systems, specifically ALZET pumps. It begins by defining osmosis and osmotic pressure, and explaining how these principles are used in osmotic drug delivery. The basic components of osmotic drug delivery systems are then outlined, including the drug, semipermeable membrane, osmogens, and coatings. ALZET pumps are introduced as implantable osmotic pumps used in laboratory animals. Factors that affect drug release from these systems include drug solubility, osmotic pressure, delivery orifice size, and membrane properties. Evaluation methods and advantages like zero-order release and long duration of action are also summarized.
This document discusses general methods for designing and evaluating osmotic pumps. It begins by introducing osmotic pumps and their advantages over other controlled drug delivery systems. It then describes the process of osmosis and differentiates it from diffusion. Various materials used in formulating osmotic pumps are outlined, including semi-permeable membranes, polymers, wicking agents, osmogens, and others. Different types of osmotic pumps are explained, such as implantable pumps and orally administered pumps. Specific examples of osmotic pumps are provided.
Osmotic drug delivery systems use osmotic pressure to provide controlled release of drugs over extended periods of time. They consist of a drug core surrounded by a semipermeable membrane with a delivery orifice. When exposed to fluids, osmotic pressure causes water to enter the system, dissolving the drug and pushing it out through the orifice at a controlled rate. The three main types are Rose-Nelson pumps, elementary osmotic pumps, and controlled porosity osmotic pumps. These systems offer advantages over traditional methods for conditions requiring prolonged, consistent drug levels.
This document discusses general methods for designing and evaluating osmotic pumps. It begins by introducing osmotic pumps and their advantages over other drug delivery systems. It then describes the key components of osmotic pumps including semi-permeable membranes, osmogens, and polymers. Finally, it discusses various types of osmotic pumps including elementary osmotic pumps, push-pull osmotic pumps, and controlled porosity osmotic pumps. The document provides an overview of the materials and mechanisms involved in osmotic pump drug delivery systems.
it is consist osmotic drug delivery system. and its new approaches. its advantage & disadvantage.. principle. etc
and basic camponents and osmotic pump......
This document provides an overview of osmotic drug delivery systems. It defines osmotic pressure and discusses how osmotic pumps use osmotic pressure to control drug delivery over extended periods of time. The key components of osmotic systems are a drug core containing an osmogen, a semipermeable membrane coating, and a delivery orifice. Factors like solubility, osmotic pressure, membrane properties, and orifice size influence drug release rates. Various polymers, osmogens, and other excipients are discussed for formulating different osmotic pump designs.
Osmotic drug delivery uses osmotic pressure to control drug release rates. It offers advantages like zero-order release kinetics and delivery rates unaffected by environmental conditions. The document discusses the principles of osmosis, components of osmotic pumps like drugs, osmogens, and semipermeable membranes. It also describes early osmotic pumps developed by Rose and Nelson as well as various types of modern osmotic pumps and some reported cases of adverse effects.
The document discusses osmotic drug delivery systems. It defines osmosis and osmotic pressure, and describes the basic components of osmotic drug delivery systems including semipermeable membranes, osmogens, and drug formulations. It classifies osmotic systems as implantable or oral, and describes several types of oral osmotic pumps including elementary, modified, multi-chamber, controlled porosity, and monolithic systems. Key factors that affect drug release are also outlined. The document concludes by listing several marketed osmotic products.
This document provides an overview of osmotic drug delivery systems. It discusses the history, principles, components, advantages, and types of osmotic pumps. Some key points include: Osmotic pumps use osmotic pressure to control drug release rates; They were first developed in the 1950s and improved upon in the 1970s; Common components include semipermeable membranes, osmogens, and drug formulations; Advantages include zero-order release and increased bioavailability; Types discussed are Rose-Nelson, Higuchi-Leeper, Higuchi-Theeuwes, sandwiched osmotic tablets, and controlled porosity osmotic pumps.
Osmotically Regulated Control System By Ashish Guptaashishmedatwal87
This document provides an overview of osmotically controlled drug delivery systems. It begins with an introduction to novel drug delivery systems and their advantages. It then discusses the principles of osmosis and factors that affect drug release rates from these systems such as osmotic pressure, membrane properties, and orifice size. The document classifies different types of osmotic delivery systems including oral, implantable, and advanced systems. It provides examples of components, commercially available products, and evaluation methods. In summary, the document reviews the fundamentals and design of osmotically controlled drug delivery to provide sustained and targeted drug release.
Osmotic activated Drug Delivery System Seminar(DDS).pptxankushawatale09
The document discusses osmotic activated drug delivery systems, which use osmotic pressure to control drug release through semi-permeable membranes. It describes the basic components, types including implantable pumps and oral pumps, marketed products, advantages of controlled release and improved compliance, and disadvantages like potential toxicity. Examples of marketed products incorporating various pump technologies are provided.
The document discusses osmotic drug delivery systems, which use osmotic pressure to control drug release. It describes the principles of osmosis, advantages and disadvantages of osmotic systems, components of osmotic pumps like semipermeable membranes and osmogens, and various types of osmotic pumps. The document provides details on the design and working of osmotic pumps for controlled drug delivery.
This document reviews osmotically controlled drug delivery systems. It discusses how these systems use osmotic principles to provide controlled release of drugs from formulations. The systems typically consist of a drug core coated with a semipermeable membrane. When exposed to water, a soluble additive is released from the membrane, and the drug is released at a constant zero-order rate over an extended period of time. The document outlines the key components of these systems, including the semipermeable membrane, osmotic agents, and coatings. It also discusses the advantages such as improved tolerability and compliance compared to conventional dosage forms.
The document discusses osmotic drug delivery systems (ODDS). It begins with an introduction that explains how ODDS use osmotic pressure to control drug release independently of physiological factors. It then covers key topics such as the concept of osmosis, principles of osmosis, basic components of ODDS, classification into implantable and oral systems, factors influencing design, and evaluation parameters. The document provides an overview of the technology and science behind ODDS for controlled drug delivery.
Ähnlich wie DDS : osmotic drug delivery system ppt.pptx (20)
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
TEST BANK For Community and Public Health Nursing: Evidence for Practice, 3rd...Donc Test
TEST BANK For Community and Public Health Nursing: Evidence for Practice, 3rd Edition by DeMarco, Walsh, Verified Chapters 1 - 25, Complete Newest Version TEST BANK For Community and Public Health Nursing: Evidence for Practice, 3rd Edition by DeMarco, Walsh, Verified Chapters 1 - 25, Complete Newest Version TEST BANK For Community and Public Health Nursing: Evidence for Practice, 3rd Edition by DeMarco, Walsh, Verified Chapters 1 - 25, Complete Newest Version Test Bank For Community and Public Health Nursing: Evidence for Practice 3rd Edition Pdf Chapters Download Test Bank For Community and Public Health Nursing: Evidence for Practice 3rd Edition Pdf Download Stuvia Test Bank For Community and Public Health Nursing: Evidence for Practice 3rd Edition Study Guide Test Bank For Community and Public Health Nursing: Evidence for Practice 3rd Edition Ebook Download Stuvia Test Bank For Community and Public Health Nursing: Evidence for Practice 3rd Edition Questions and Answers Quizlet Test Bank For Community and Public Health Nursing: Evidence for Practice 3rd Edition Studocu Test Bank For Community and Public Health Nursing: Evidence for Practice 3rd Edition Quizlet Test Bank For Community and Public Health Nursing: Evidence for Practice 3rd Edition Stuvia Community and Public Health Nursing: Evidence for Practice 3rd Edition Pdf Chapters Download Community and Public Health Nursing: Evidence for Practice 3rd Edition Pdf Download Course Hero Community and Public Health Nursing: Evidence for Practice 3rd Edition Answers Quizlet Community and Public Health Nursing: Evidence for Practice 3rd Edition Ebook Download Course hero Community and Public Health Nursing: Evidence for Practice 3rd Edition Questions and Answers Community and Public Health Nursing: Evidence for Practice 3rd Edition Studocu Community and Public Health Nursing: Evidence for Practice 3rd Edition Quizlet Community and Public Health Nursing: Evidence for Practice 3rd Edition Stuvia Community and Public Health Nursing: Evidence for Practice 3rd Edition Test Bank Pdf Chapters Download Community and Public Health Nursing: Evidence for Practice 3rd Edition Test Bank Pdf Download Stuvia Community and Public Health Nursing: Evidence for Practice 3rd Edition Test Bank Study Guide Questions and Answers Community and Public Health Nursing: Evidence for Practice 3rd Edition Test Bank Ebook Download Stuvia Community and Public Health Nursing: Evidence for Practice 3rd Edition Test Bank Questions Quizlet Community and Public Health Nursing: Evidence for Practice 3rd Edition Test Bank Studocu Community and Public Health Nursing: Evidence for Practice 3rd Edition Test Bank Quizlet Community and Public Health Nursing: Evidence for Practice 3rd Edition Test Bank Stuvia
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
DDS : osmotic drug delivery system ppt.pptx
1. SCHOOL OF PHARMACEUTICAL SCIENCES, MOHAN BABU UNIVERSITY
TITLE : OSMOTIC ACTIVATED DRUG DELIVERY SYSTEMS
SUBJECT : DRUG DELIVERY SYSTEMS
ACADEMIC YEAR : 2023-2024
Presented by :
N. Thanuja
M pharmacy – 1st year
Department of pharmaceutics
01
3. Introduction
Osmotic pressure is used as the
driving force for osmotic to
release the drug in a controlled
manner.
Osmotic controlled drug
delivery system generally
consist of a core including the
drug an osmotic
agent, excipients and
semipermeable membrane
coat.
Osmotic pressure gives zero
order drug delivery which
is driven force for release of
drug from dosage form.
03
4. PRINCIPLE OF OSMOSIS
Osmosis refers to the process of movement of solvent from lower
concentration of solute towards higher concentration of solute across a
semipermeable membrane.
04
5. Continuation ;
Abbe Nollet first reported osmotic effect in 1748, but Pfeffer in 1877 had the
pioneer of quantitative measurement of osmotic effect.
Pfeffer measured the effect by utilizing a membrane which is selectively
permeable to water but impermeable to sugar. The membrane separated
sugar solution from pure water. Pfeffer observed flow of water into the sugar
solution that was halted when a pressure p was applied to the sugar solution
Pfeffer postulated that this pressure, the osmotic pressure π of the sugar solution
is proportional to the solution concentration and absolute temperature.
Van't Hoff established the analogy between the Pfeffer results and the ideal gas
laws by the expression.
Where, n2 represent the molar concentration of sugar or other solute in the
solution, R represent the gas constant and T represent the absolute
temperature.
Another method of obtaining a good approximation of osmotic pressure is by
utilizing vapor pressure measurements and by using expression.
π = n2 RT
05
6. Continuation ;
Where Po represent the vapor pressure of the pure solvent, P is the
vapor pressure of the solution and v is the molar volume of the solvent. As
vapor pressure can be measured with less effort than osmotic pressure this
expression is frequently used.
Osmotic pressure for soluble solutes is extremely high. This high osmotic
pressure is responsible for high water flow across semipermeable
membrane.
The rate of water flow by osmotic pressure can be given by following
equation.
Where dv/dt represents the water flow across the membrane, area A and
thickness I with permeability θ.
Δπ depicts the difference in osmotic pressure between the two
solution on either side of the membrane.
π = RTIn(Po/P)/v
dv/dt = Aθπ/L
06
7. Continuation ;
When a single osmotic driving agent is used, the pumping rate of the osmotic device
(volume per unit time) is define by Q/t = PwSm [m(πs-πe)(ΔPd+ΔPe)]
Pw is permeability of semipermeable membrane of water, Sm is effective surface area of
the membrane and Ym is osmotic reflection coefficient of the membrane.
πs and πe are the osmotic pressure of saturated solution of osmotic driving agent and of
the environment where device is located, respectively.
ΔPd is elevation of internal pressure generated in the drug formulation compartment as
the result of water influx into osmotic agent compartment and ΔPe is pressure required
to deform drug formulation compartment inward.
If the net osmotic pressure gradient [ym(πs-πe)] is constant and
the hydrostatic pressure(ΔPd+ΔPe) is negligibly small, can be simplified to
Q/t = PwSm[ym(πs-πe)
07
9. Drug itself may act as an osmogen and shows good
aqueous solubility.
But if the drug does not possess an osmogenic
property, osmogenic salt and other osmotic sugars can
be incorporated in the formulation.
Drug should have short half-life 2-6 hrs.
Used for prolonged treatment.
Solubility of drug should be moderate (i.e not be very
high or very low).
Examples :- Nifedipine , Metoprolol , Verapamil
1)DRUG :-
09
10. 2) OSMOTIC AGENT :-
Also called Osmogens (or) Osmogents. It is responsible
for creating osmotic pressure inside the system.
If solubility of drug is low, then drug will show slow rate
zero order release. The osmotic agent is used to enhance
the release rate by creating very high osmotic pressure
gradient inside the system.
Types of Osmotic agents :-
Water soluble salts of Inorganic acids: Magnesium
sulphate, NaCL, KCL, Sodium bicarbonate, Sodium sulphate.
Water soluble salts of organic acids: Potassium
acetate, Magnesium succinate, Sodium citrate, Sodium
benzoate.
Carbohydrates : Mannose, Sucrose, Maltose,
Lactose.
10
11. 3)
SEMIPERMEABLE
MEMBRANE :-
It is made up of polymer, that is permeable to water but
impermeable to solute(drug & excipients), can be used as
coating material in osmotic devices.
CRITERIA : -
Semipermeable membrane must have sufficient wet strength
and water permeability so that it retain its
dimensional integrity throughout the operational lifetime
of device.
Should stable both outside and inside environment of device.
Should be Biocompatible and rigid.
Examples :-
Cellulose Acetate, Cellulose Triacetate, Ethyl Cellulose.
11
12. 4) WICKING AGENT :-
A wicking agent is defined as a material with the
ability to draw water into the porous network of
delivery device.
A wicking agent is of either swellable (or) non-
swellable nature.
The function of the wicking agent is
to draw water to surfaces inside the core of the
tablet, thereby creating channels (or) a
network of increased surface area.
Examples :- SLS, PVP, Bentonite.
12
13. 5) SOLUBILIZING
AGENT :-
Non-swellable solubilizing agent are classified into
three groups,
Agents that inhibits crystal formation of the drugs (or)
otherwise act by complexation of drug.
Example :- PVP
A high HLB micelle forming surfactant, particularly
anionic surfactants.
Example :- Tween 20, 60, 80
Citrate esters and their combinations with anionic
surfactants.
Example :- Alkyl esters.
13
14. 6) SURFACTANTS :-
7) COATING
SOLVENTS :-
They are added to wall forming agents.
The surfactants act by regulating the surface energy of
materials to improve their blending in to
the composite and maintain their integrity in the
environment of use during the drug release period.
Examples :- poly oxyethylenated castor oil.
Solvents suitable for making polymeric solution that is
used for manufacturing the wall of osmotic device
include inert Inorganic and Organic solvents.
Examples :- Acetone : Water (90:10),
Acetone : Methanol (80:20).
14
15. 8) PLASTICIZERS :-
9) FLUX REGULATOR :-
Plasticizers increase the workability, flexibility and permeability
of the fluids.
Permeability of membranes can be increased by adding plastic
which increases the water diffusion coefficient.
Examples :- Phthalates, Benzoates, TEC.
Flux regulating agents/Flux enhancing agents/Flux decreasing
agents are added to the wall forming material; it assists in
regulating fluid permeability through membrane.
Examples :- Poly propylene, Poly butylene.
15
16. 10) PORE FORMING
AGENT :-
These agents are particularly used in the pumps
developed for poorly water soluble drug and in
the development of controlled porosity.
These pore-forming agents cause the formation of
micro porous membrane.
Examples :- Calcium nitrate, Sucrose, Sorbitol,
Mannitol, Mannose, Potassium sulphate
16
17. ADVANTAGES
It gives zero order release profile after an initial lag.
Drug release is independent of gastric PH, GI motility and
hydrodynamic condition.
Enhanced Bioavailability of drug and reduced interpatient variability.
Decrease dosing frequency.
Improve patient compliance.
Ease of administration.
Greater effectiveness in the treatment of chronic conditions.
Production scale up is easy.
17
18. DISADVANTAGES
Dose dumping
Expensive
Rapid development of tolerance
Hypersensitivity reaction may occur after implantation.
Integrity and consistency are difficult.
Special equipment is required for making orifice in the
system.
18
20. 1. IMPLANTABLE
OSMOTIC DRUG
DELIVERY SYESTEM :-
ROSE NELSON PUMP :
The first osmotic pump
developed in 1955 for the
delivery of drugs to the sheep
and cattle gut.
Composed of three chambers.
20
21. A. Rose Nelson pump :-
The pump composed of three chambers : a drug
chamber, a salt chamber holding solid salt and a
water chamber.
A semi permeable membrane separates the salt
from water chamber.
The major problem associated with Rose Nelson
pumps was that the osmotic action begin whenever
water came in contact with the semipermeable
membrane.
This needed pumps to be stored empty and water
to be loaded prior to use.
21
22. B.(a) Higuchi Leeper osmotic pump :-
It has no water chamber, and the activation of
the device occurs after imbibition of the water
from surrounding environment.
Widely employed for Veterinary use. It is
either swallowed or implanted in body of an
animal for delivery of antibiotics
growth hormones to animal.
Modification : A layer of low melting waxy
solid, is used in place of movable separator to
separate drug and osmotic chamber.
22
23. B.(b) Higuchi Theeuwes osmotic pump :-
The release of the drug from the device is governed by
the salt used in the salt chamber and the permeability
characteristics of outer membrane.
Diffusional loss of the drug from the device is
minimized by making the delivery port in shape of a
long thin tube.
Small osmotic pumps of this form are available under
the trade name Alzet.
Delivery of DNA by agarose hydrogel implant
facilitate genetic immunization in cattle
by using Alzet osmotic pumps.
23
24. C) ALZET OSMOTIC PUMP :-
ALZET osmotic pumps are
miniature, infusion pumps for the
continuous dosing of laboratory
animals as small as mice and young
rats. These minipumps provide
researchers with a convenient and
reliable method for controlled
agent delivery in vivo.
24
25. PRINCIPLE OF OPERATION
ALZET pumps have 3 concentric layers :
a) Rate-controlling , semi-permeable membrane
b) Osmotic layer
c) Impermeable drug reservoir
ALZET pumps work by osmotic displacement. Water
enters the pump across the outer, semipermeable
membrane due to the presence of a high concentration
of sodium chloride in the osmotic chamber. The entry of
water causes the osmotic chamber to expand, thereby
compressing the flexible reservoir and delivering the
drug solution through the delivery portal.
25
27. APPLICATIONS
CANCER - 9 Silicone rod implants are used for delivery of
testosterone propionate in prostate cancer patients.
Eg:- Zola dex
IMMUNIZATION - Ethylene vinyl acetate co-polymer pellets having
Bovin serum, it helps in better immune response.
DENTAL APPLICATION - Many dental implant have developed for
local prolonged local administration.
Eg:- Stannous floride
DIABETES – Insulin containing implants are used in diabetes for
prolonged action.
NORCOTIC ANTAGONIST - Long term narcotic antagonist activity.
Eg:- Naltrexon
27
28. REFERENCES
Ali N., (2021), Review article on osmotic drug delivery system ,
http://dx.doi.org/10.13140/RG.2.2.13449.77920.
Syed SM., (2015), osmotic drug delivery system, International
journal of pharmaceutical research and allied science, 4(3),
10-20.
Keraliya RA., Patel C., Patel P., Keraliya V., Soni TG., Patel RC.,
Patel MM., (2022), osmotic drug delivery system as a part of
modified release dosage form, ISRN pharm.,
http://dx.doi.org/10.13140/RG.2.2.13449.77920.
Gupta RN., Gupta R., Basniwal P., Rathore GS., (2010),
osmotically controlled oral drug delivery system: a review,
International journal of pharmaceutical sciences, 1(2), 269-
275.
Khatri N., Nikram S., Bilandi A., (2016), oral osmotic drug
delivery system : a review, International journal of
pharmaceutical sciences and research, 2302-2312.
10.13040/IJPSR.0975-8232.7(6).2302-12.
28