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Respiratory system
• Human Anatomy and Physiology (HAP) II -
Bio 1520
• Joseph E. Muscolino
2
Topics
•Introduction
•Structures of the respiratory system
•Respiratory air volumes and
capacities
•Neural control of breathing
•Nonrespiratory air movements
3
Introduction
• Big picture: Why do we breathe?
• Intake of O2 and elimination of CO2
• Why do we need O2?
• Where/how is CO2 formed?
4
Role of oxygen and carbon
dioxide...
5
Steps of respiration
• Movement of air in and out of lungs (ventilation).
• Exchange of O2 and CO2 in the lungs between air
spaces and blood (external respiration).
• Transport of O2 and CO2 in the bloodstream
(circulation).
• Exchange of O2 and CO2 between blood and
cells (internal respiration)
• Use of O2 and production of CO2 (cellular
respiration).
6
Structures of the respiratory
system
• Nose/mouth
• Pharynx
• Larynx
• Trachea
• Lungs/bronchial tree
7
Nose
• Nasal cavity lined with mucous membrane which is rich
in goblet cells that secrete mucus.
• Olfactory receptors for the sense of smell
• Air that is breathed in...
• air is warmed
• air is moistened
• particles are trapped (cilia beats toward the
pharynx... why?)
8
Nasal cavity
9
Sinuses
• Air-filled spaces within bones of the skull
• Reduce weight and add resonance to the voice
• frontal
• maxillary
• sphenoid
• ethmoid
• Why do people have sinus problems?
10
Pharynx
• Throat
• Posterior to the nasal cavity and oral cavity
• Three parts:
• nasopharynx/oropharynxlaryngopharynx
• Dual passageway for:
• air into the larynx
• food into the esophagus
11
Larynx
• Passageway for air into the trachea.
• Composed of cartilages and muscles... and
houses the vocal cords (vocal folds of tissue)
• Thyroid cartilage: Adam’s Apple (why named?)
• Epiglottis... function?
12
Laryngeal
cartilages
13
Epiglottis
14
Vocal folds
15
Trachea
• Windpipe
• Between the larynx and the bronchi of the
lungs
• Anterior to the esophagus
• Contains C-shaped cartilages...
16
Trachea
17
Tracheostomy
18
Bronchial tree
• Series of passageways within the lungs
• Primary bronchi (lungs)
• Secondary (lobar) bronchi (lobes)
• Tertiary bronchi (bronchopulmonary segments)
• Intralobular bronchioles
• Terminal bronchioles
• Respiratory bronchioles
• Alveolar ducts, sacs, alveoli
19
Bronchial tree figure
20
Bronchial “tree”
21
Respiratory tubes (cilia...?)
22
Capillary exchange
23
Right-sided circulation of the
heart
24
Drug addiction: Smoking...
• #1 preventable cause of death!
• Cilia slowed/paralyzed/destroyed
• excess mucus clogs airways (decreased air intake and increased
infections)
• bronchial lining thickening, decrease elasticity of airways
• coughing ruptures alveolar sacs
• emphysema (15x nonsmokers)
• lung cancer (80% due to smoking)
• heart disease/stroke
• Addiction due to nicotine
• Many changes are reversible if a person quits...
25
Environmental tobacco
smoke (ETS)
• Second-hand smoke
• 4000 chemicals in cigarette smoke
• Estimated 53,000 nonsmokers die each year in
the US from ETS
• (46,000 heart disease, 3,400 lung cancer, 2-
3,000 infant deaths...)
• In areas where new laws ban smoking in bars,
restaurants, and workplaces, hospital admission
for heart attacks have dropped 20%!
26
The Diaphragm
27
Respiratory air volumes and
capacities
• Tidal volume (500 ml)
• Inspiratory reserve volume (3000 ml)
• Expiratory reserve volume (1100 ml)
• Vital capacity (4600 ml)
• Residual capacity (1200 ml)
• Total lung capacity (5800 ml)
• note: anatomic dead space (150 ml)
28
Air volumes and capacities
29
Neural control
of breathing -
medulla and
pons
30
Nonrespiratory air
movements
• Coughing
• Sneezing
• Hiccuping
• Yawning
• Laughing

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C 13a respiratory_hap_2_p_pt-_2-2-11