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Masterclass:
       Biomedical applications of
       Additive Manufacturing


 Practical case study 3: Veterinary case studies –
successful AM manufactured bone replacements
   AIMME’s mission
   AIMME’s biomedical activities
   Veterinary case studies
     • Case of « Argos »
     • Case of « Fito »
     • Case of « Baby »
        Including a short video




Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              2
AIMME’s mission
                                            Foster and improve the competitivity of metal
                                            working SMEs through R&D and technology
                                            transfer.
                                               Development of R&D projects
                                               Advanced technological services
                                               Testing and laboratory analysis
                                               Foster technological education of SMEs
                                               Recompiling and dissemination of novelties,
                                                news and advances of interest for the metal
                                                working sector
                                                                                                    Laboratories for surface
                                                                                                     treatment, corrosion,
                                                                             Design, prototyping,     mech testing, chem
                                                             Chemical &       management, CE              testing, etc.
                                                                                marking, etc.
                                        Advanced           environmental
                                       manufacturing        technologies
                                        processes
Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                                               3
AIMME’s biomedical activities
Based on extensive expertise and know how with additive technologies, in
particular metal processing ALM
Consists in:
• development of new materials to be processed on existing systems


• improvement of technology for improved biomedical performance


• development of new ideas and concepts for high value added medical devices


• development of new bussiness models for medical device supply chain


• technical advice and DFM for ALM technologies

 Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                               4
AIMME’s biomedical activities




                                                                             …




Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              5
Veterinary case studies collaboration
                                                                                       Biomedical design
                                                                                       Numerical modeling




                           Medical treatment
                           CT imaging
                           Surgical intervention
                           Postoperatory care
                                                                                       Design for manufacturing
                                                                                       EBM expertise
                                                                                       Implant fabrication



Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                                  6
1. Case of “Argos”
Argos is an 8-month Bordeaux Mastiff of 50kg. He was diagnosed a bilateral hip
dysplasia with grade I patella luxation in the right knee.




Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              7
1. Case of “Argos”
Initially, the surgeon
performed a triple
pelvis osteotomy on
the right side using a
standard commercial
plate.

Only 3 days after the
surgical intervention,
during the first
control, a loosening
of fixation screws was
detected.



 Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                               8
1. Case of “Argos”


The proposed
measure was to
increase the size of
the screws from M3.5
to M4.5.




 Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                               9
1. Case of “Argos”
In order to prevent risks of screw loosening, the surgeon sought for a more feasible
solution for the left hip side - a customized plate made on EBM




 Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                               10
1. Case of “Argos”
As expected, the
revision revealed
that the screws on
the     right  hip
(commercial plate)
started to migrate
again
while the screws
on the left hip
customized plate)
stood as tight as
after          the
intervention.




 Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                               11
2. Case of “Fito”
Fito:
- German sheppard
- 4-years old
- 40kg.

He was hit by a car
and suffered
a multiple diaphysal
fracture   with  big
bone splinters.




  Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                                12
2. Case of “Fito”
                                                    • The bone fracture was repaired with a
                                                    standard titanium plate and 12 screws of
                                                    M3.5.

                                                    • During the intervention, the surgeon
                                                    noticed that the plate had to be
                                                    modified by hand to fit the damaged
                                                    zone.

                                                    • Surgeon was modeling the plate with a pair
                                                    of surgical pliers, and verifying visually that
                                                    the plate was fitting properly.




Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              13
2. Case of “Fito”
                                               • The drawback appeared after only 3
                                               days.

                                               • Fito started to limp severely.

                                               • An angular deformation in the
                                               femoral zone was detected.

                                               • The plate suffered a fracture and
                                               completely lost its functionality.


Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              14
2. Case of “Fito”




Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              15
2. Case of “Fito”
                                                        • The operation was successful.

                                                        • According to the last news Fito
                                                        has a normal functionality in the
                                                        injured leg.

                                                        • Unfortunately, postoperatory
                                                        images were never received.




Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              16
3. Case of “Baby”
• Baby is a 3-year old Yorkshire Terrier.
• Abandoned and found by pro-animal activists in a difficult health conditions.
• Admitted in December 2009 presenting a radius-cubital diaphysal oblicuous
fracture with severe loss of radiographic density due to osteoporosis and
disuse of the leg in question.
• Approx. 20-25% of radius-cubital length had been lost.


• A challenging experimental case with few chances of success
• No commercially available plate of this size and capable of being
adapted to the damaged zone
• The surgeon and CIMA researchers decided to design a customized
titanium plate.



Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              17
3. Case of “Baby”




Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              18
3. Case of “Baby”




Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              19
3. Case of “Baby”
Implanted into the patient




 Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                               20
Short                     video (6mins)



Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              21
Thanks                           for your attention!



Masterclass: Biomedical applications of Additive Manufacturing   Organized by SIRRIS the 12th of March 2013
                                                                                                              22

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2013 03-12-masterclass-biomedical-applications-of-am aimme-veterinary-cases

  • 1. Masterclass: Biomedical applications of Additive Manufacturing Practical case study 3: Veterinary case studies – successful AM manufactured bone replacements
  • 2. AIMME’s mission  AIMME’s biomedical activities  Veterinary case studies • Case of « Argos » • Case of « Fito » • Case of « Baby »  Including a short video Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 2
  • 3. AIMME’s mission Foster and improve the competitivity of metal working SMEs through R&D and technology transfer.  Development of R&D projects  Advanced technological services  Testing and laboratory analysis  Foster technological education of SMEs  Recompiling and dissemination of novelties, news and advances of interest for the metal working sector Laboratories for surface treatment, corrosion, Design, prototyping, mech testing, chem Chemical & management, CE testing, etc. marking, etc. Advanced environmental manufacturing technologies processes Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 3
  • 4. AIMME’s biomedical activities Based on extensive expertise and know how with additive technologies, in particular metal processing ALM Consists in: • development of new materials to be processed on existing systems • improvement of technology for improved biomedical performance • development of new ideas and concepts for high value added medical devices • development of new bussiness models for medical device supply chain • technical advice and DFM for ALM technologies Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 4
  • 5. AIMME’s biomedical activities … Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 5
  • 6. Veterinary case studies collaboration Biomedical design Numerical modeling Medical treatment CT imaging Surgical intervention Postoperatory care Design for manufacturing EBM expertise Implant fabrication Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 6
  • 7. 1. Case of “Argos” Argos is an 8-month Bordeaux Mastiff of 50kg. He was diagnosed a bilateral hip dysplasia with grade I patella luxation in the right knee. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 7
  • 8. 1. Case of “Argos” Initially, the surgeon performed a triple pelvis osteotomy on the right side using a standard commercial plate. Only 3 days after the surgical intervention, during the first control, a loosening of fixation screws was detected. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 8
  • 9. 1. Case of “Argos” The proposed measure was to increase the size of the screws from M3.5 to M4.5. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 9
  • 10. 1. Case of “Argos” In order to prevent risks of screw loosening, the surgeon sought for a more feasible solution for the left hip side - a customized plate made on EBM Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 10
  • 11. 1. Case of “Argos” As expected, the revision revealed that the screws on the right hip (commercial plate) started to migrate again while the screws on the left hip customized plate) stood as tight as after the intervention. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 11
  • 12. 2. Case of “Fito” Fito: - German sheppard - 4-years old - 40kg. He was hit by a car and suffered a multiple diaphysal fracture with big bone splinters. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 12
  • 13. 2. Case of “Fito” • The bone fracture was repaired with a standard titanium plate and 12 screws of M3.5. • During the intervention, the surgeon noticed that the plate had to be modified by hand to fit the damaged zone. • Surgeon was modeling the plate with a pair of surgical pliers, and verifying visually that the plate was fitting properly. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 13
  • 14. 2. Case of “Fito” • The drawback appeared after only 3 days. • Fito started to limp severely. • An angular deformation in the femoral zone was detected. • The plate suffered a fracture and completely lost its functionality. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 14
  • 15. 2. Case of “Fito” Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 15
  • 16. 2. Case of “Fito” • The operation was successful. • According to the last news Fito has a normal functionality in the injured leg. • Unfortunately, postoperatory images were never received. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 16
  • 17. 3. Case of “Baby” • Baby is a 3-year old Yorkshire Terrier. • Abandoned and found by pro-animal activists in a difficult health conditions. • Admitted in December 2009 presenting a radius-cubital diaphysal oblicuous fracture with severe loss of radiographic density due to osteoporosis and disuse of the leg in question. • Approx. 20-25% of radius-cubital length had been lost. • A challenging experimental case with few chances of success • No commercially available plate of this size and capable of being adapted to the damaged zone • The surgeon and CIMA researchers decided to design a customized titanium plate. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 17
  • 18. 3. Case of “Baby” Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 18
  • 19. 3. Case of “Baby” Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 19
  • 20. 3. Case of “Baby” Implanted into the patient Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 20
  • 21. Short video (6mins) Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 21
  • 22. Thanks for your attention! Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013 22