Daily Steroids during infections in frequently relapsing Nephrotic syndrome

Journal Club Dr Sidharth Kumar Sethi MD, Fellowship [IPNA, ISN, ISPN] https://www.pediatric-nephrology.com

Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Infections and Relapses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Short term daily steroids during infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Research Question ,[object Object]

Aim of the study ,[object Object],[object Object],[object Object],[object Object],[object Object]

Study Design ,[object Object],[object Object],[object Object],[object Object]

Inclusion criteria ,[object Object],[object Object],[object Object],[object Object]

Exclusion Criteria ,[object Object],[object Object],[object Object],[object Object]

Standard Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Randomisation ,[object Object],[object Object],[object Object],[object Object]

Intervention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Follow up ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Relapse definition and management ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Follow up ,[object Object],[object Object],[object Object],[object Object]

Serious Infections ,[object Object],[object Object],[object Object],[object Object]

Outcomes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Premature termination ,[object Object],[object Object],[object Object],[object Object]

Sample Size ,[object Object],[object Object],[object Object],[object Object]

Statistical Analysis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Incidence Density Rates ,[object Object],[object Object]

Example of Relapse Rates ,[object Object],[object Object],[object Object]

Rate Ratio ,[object Object],[object Object],[object Object]

Number needed to Treat ,[object Object],[object Object],[object Object]

NNT Example Prophylaxis RF No RF Total Risk Yes 15 285 300 0.05 No 49 251 300 0.16 ARR 0.11 NNT 9

68 patients alternate-day prednisolone alone (strata 1) 32 received alternate-day prednisolone and levamisole (strata 2)

Relapse rates @ 12 months ,[object Object],[object Object]

Infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Adjusted Analysis & Number Needed to Treat ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Treatment failures and Add on therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Discussion: Salient points of results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Previous studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Previous studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

More infections in intervention group! ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Critical Appraisal ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Limitations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Conclusions ,[object Object],[object Object]

Daily Steroids during infections in frequently relapsing Nephrotic syndrome

Empfohlen

Empfohlen

Weitere ähnliche Inhalte

Was ist angesagt?

Was ist angesagt? (19)

Ähnlich wie Daily Steroids during infections in frequently relapsing Nephrotic syndrome

Ähnlich wie Daily Steroids during infections in frequently relapsing Nephrotic syndrome (20)

Kürzlich hochgeladen

Kürzlich hochgeladen (20)

Daily Steroids during infections in frequently relapsing Nephrotic syndrome