its a naturally occuring plan product.it is used to trat common ailments & used as a n antibiotic against some microbes.

1. Presented by,
T.SHIVA RAM

2.  Vanillin is a herbal drug obtained from the
dried pods of Vanilla planifolia
 synonym:vanilla beans, vanilla pods
 Family: Orchidaceae

3.  Chemically vanillin is,
4-hydroxy 3-methoxy benzaldehyde.

4.  To synthesise the semisynthetic derivatives
of vanillin which are used in our daily
biological activities.

5.  To optimize the biological activity of the compounds
selected in the study.
 The compounds selected for the study are volatile in
nature, formation of non volatile derivative with a
better activity avoids the wastage through
vaporization and also increases the potency.
 The compounds to be synthesized in this study are
very simple derivatives and follow one or two step
reactions, thus there is very less chance for the
degradation of the starting compound.
 The compounds synthesized in this study will be
subjected for TLC, physical and spectral analysis in
order to identify purity, and to interpret the
structure of the derivatives synthesized.

6.  Based on this concept the present work was
designed to synthesize semisynthetic
derivatives of some commonly used
phytoconstituent’s. In the present study
semisynthetic derivatives of vanilla are
synthesized. These derivatives are chosen
due to their wide pharmacological activity
and are used in our day to day life.

7. Experimental work
procedure
 Take about 1 gm of hydrazine
sulphate, 0.8 gm of sodium
acetate in little quantity of
distilled water and shaken well,
added 2 gm of vanillin and
shaken well till it becomes clear
solution, if necessary add
ethanol to dissolve the contents.

8.  The thoroughly dried substance
is to be subjected for analytical
work
 In this experiment vanillin is
treated with semicarbazide in the
presence of sodium acetate.
 The resulted product is
Hydrazine methylidene vanillin

9.  The entire mixture warmed on
water bath continuously for
about 1 hour under reflux and
allowed to cool to get the
compound hydrazine di methyl
vanillin, which is filtered and
subjected for recrystallization
with suitable solvent like
alcohol.

11. uses
 The uses of the newly generated product are
 Analgesic
 Antibacterial
 Anti helmenthic

12.  Flavouring agent
 Perfumary
 Masking agent

13.  The literature survey reveals that some
activities like Antibacterial, Antioxidant &
analgesic activities etc… which are found
weak, to increase its biological activity,a
modification of functional groups in the
structure/ modification of structure, may
increase their pharmacological actions.

14.  Satyajit D Sarker, Lutfun Nahar, “Chemistry For
Pharmacy students General , Organic and natural
Product Chemistry”, Nat prod chem, John Wiley
& Sons Ltd, chapter 6,pg no.283-289, 2004.
 Dr. C. K. Kokate, A. P. Purohit, S. B. Gokhale,
“Pharmacognosy”,Nirali prakashan ; Pune, thirty
eighth edition, p.no:1-6,2007
 Newman DJ, Cragg GM. “Natural products as
sources of new drugs over the last 25 years” J
Nat Prod, 70, 461-477 (2007).
 Dan Bensky, Steven Clavey, Erich Stoger, and
Andrew Gamble “Chinese Herbal Medicine:
Materia Medica” Third Edition 2004.