By: Fiona Fitzgerald, GE Healthcare Canada At Sherbrooke International Life Sciences Summit - 2nd edition | September 28/29/30 2015 www.sils-sherbrooke.com

1. Imagination at work.
Fiona Fitzgerald
29 Sept, 2015
Innovation in GE Healthcare

2. GE confidential
Imagining things others don’t | Building the things others can’t | Delivering outcomes that make the world work better
We Are GE
version 4/2015

3. GE confidential
Providing our aviation
customers with the most
technologically advanced &
productive engines, systems &
services for their success
Leading globally in power
generation & water
technologies
Our Businesses deliver value
Revenue: $27.6B
Profit: $5.4B
Pushing the boundaries of
technology in oil & gas to bring
energy to the world
Enabling utilities and industry
to efficiently manage electricity
from the point of generation to
the point of consumption
Revenue: $18.7B
Profit: $2.6B
Revenue: $7.3B
Profit: $0.2B
Revenue: $24.0B
Profit: $5.0B
Developing transformational
medical technologies &
services that are shaping a
new age of patient care
Being a global technology
leader & supplier to the
railroad, mining, marine,
stationary power & drilling
industries
Answering real-life needs,
defining trends & simplifying
routines. Leading a global
lighting revolution to deliver
innovative solutions
Investing financial, human &
intellectual capital to help our
customers build their
businesses
Revenue: $18.3B
Profit: $3.0B
Revenue: $5.7B
Profit: $1.1B
Revenue: $8.4B
Profit: $0.4B
Source: 2014 GE Annual Report

4. GE confidential

5. GE confidential
$17 Bn global business unit of GE
53,000 employees worldwide
$1 Bn annual investment in R&D
Core strengths in biomedical
sciences, technology & business
GE Healthcare
Serving healthcare systems 
hospitals  clinics 
governments 
pharmaceutical &
biopharmaceutical industries
 genetics & bio-science
researchers  academia

6. GE confidential
GE’s broad solutions in healthcare
Diagnostic
& clinical
equipment
Advancing every
phase of patient
care, from
diagnostic imaging
to routine testing to
life-critical care
Information
technology &
services
Clinical & financial
IT solutions that
enable better
decisions and
outcomes for
businesses and
patients
Life sciences
& molecular
medicine
Enabling next-
generation bio-
therapeutics &
diagnostics in
precision medicine
Leading contrast
agents, PET &
nuclear medicine
for diagnostic
imaging
6

7. GE confidential
7
GE Title or job number
10/13/2015
GE Healthcare Life Sciences
Title or Job See 7
Accelerating precision medicine with tools for biotechnology R&D, biopharma manufacturing,
cell therapy & regenerative medicine, diagnostic imaging, molecular & precision diagnostics
Research &
Applied Markets
Tools for drug R&D
Protein purification
interaction &
analytics
Cell technologies
Human ID &
environmental
analysis
BioProcess
Tools for biopharma
manufacturing &
cell culture
Chromatography &
filtration systems
Process
Development
Single-use systems
and turn-key
Enterprise Solutions
InVitro
Diagnostics
Advanced oncology
diagnostics services
Next-Generation
sequencing
Pharma biomarker
collaborations
Services
Lab-wide strategic
solutions
System life-cycle
services
Scientific asset
management
Validation
Core Imaging
Leading-edge
contrast agents for
diagnostic imaging
Nuclear medicine &
PET tracers for
diagnostic imaging
& research
Five product business units  10 000 people  100+ countries  UK HQ
Manufacturing, research & development in US, Europe and Asia

8. GE confidential
8
GE Title or job number
10/13/2015
Where is GE Healthcare Life
Sciences? UK
Amersham Place
The Grove Centre
Gloucester
Cardiff
Maidstone
Yeovil
Eire
Cork -
US
Princeton, NJ
Aliso Viejo, CA
Austin, TX
Arlington Heights, IL
South Plainfield, NJ
Piscataway NJ
Westborough MA
Northampton MA
Marlborough, MA
Issaquah, WA
Canada
Ontario -
LS
Sweden
Umea
Uppsala
Staffanstorp
Norway
Oslo
Lindesnes
The Netherlands
Eindhoven
Germany
Braunschweig
Colbe
Dassel
Austria
Pasching
China
Shanghai
Tonglu
India
Bangalore, Delhi
Brazil
São Paulo
Japan
Tokyo
Australia
Rydalmere

9. 9
GE Title or job number
10/13/2015
Trends in Industry
Internet
of things1 Innovative
machines2 Big Data
3 Analytics
4Machines, data,
and people
Clinically advanced,
productive, patient
friendly
Predictive
medicine
Precision
medicine
9

10. 10
GE Title or job number
10/13/2015
Industrial Internet in Healthcare:
Asset
Optimization
Operational
Optimization
Clinical
Workflow
Integrated Care
Max Equipment
Performance
No Wait States Connect Care
Pathways
Focus on Outcomes
and Cost
• Predict part
failures
• Improved Asset
utilization
• Safe and
Optimized
protocols
• Devices talk to
each other
• Anticipate
bottklenecks
• Unify distinct
systems
• Eliminate
waste/
inefficiency
• Safe and
efficient
operations
• Enterprise
imaging
• Diagnostic
workflows
• Specialist
workflows and
analytics
• Decision
support
cockpits
• Population Health
• Financial Risk
Mgt
• Care delivery Mgt
• Care coordination
• Wellness mgt

11. 11
GE Title or job number
10/13/2015
Connecting productivity with care:
Innovation
Productivity
Care
Outcome
-----------
Cost
= Value

12. Principles for Innovation at GE:
1. Invest in a deep understanding of our customers.
Our goal is to know them better than they know
themselves.
2. Build an innovation system focused on people and
expertise- not processes.
3. Measure how much and how fast you are learning
per unit of effort
Title or Job Number | XX Month 201X See tutorial regarding
confidentiality disclosures.
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13. Build an innovation system: Build, Measure,
Learn
In GE Innovation is based on the Principles of validating Learning and
Experimentation.
Title or Job Number | XX Month 201X See tutorial regarding
confidentiality disclosures.
13
1) Problem
Statement
Define customer
problem…longterm
vision to solve
2)Leap of faith
Assumptions
Identify Assumptions
that need to be true to
achieve the vision
3) Build a Series
of tests to
validate
assumptions
4) Learning metrics
Identify and track
leading indicators and
validate learnings
5) Pivot or
Persevere
Adjust strategy
based on
validated
learnings
Its moving leaders from playing Caesar with their thumbs up and down on every idea to-instead-
putting in the culture and the systems so that the teams can move and innovate at the speed of
the experimentation system- Scott Cook (Founder of Intuit)

14. Measure how much and how fast you are
learning per unit of effort:
Title or Job Number | XX Month 201X See tutorial regarding
confidentiality disclosures.
14
The concept of innovation
Accounting:
The Three Learning Milestones
1. Establish the baseline (MVP)/
Customer behave now.
2. Tune the engine
• Experiment
3. Pivot or persevere
4. - when experiments reach
diminishing returns it’s time to
pivot

15. • More face time
• Care that
revolves
around them
• More active
role in care
decisions
• Home care
• Configurable
tools to match
their workflow
• Integration with
existing systems
• View of patient
across care
pathway … in
and outside the
hospital
Value assumptions
Engage patients and providers together in the care
continuum
Patients seek… Providers need…
JB21000XX | May
2014

16. Innovation models:
16
• Investment
• CECR Incubators
• Innovation villages

17. Innovation Model: Investment
GE Ventures - Healthcare snapshot
• GE Network: Access to the GE technology, product
development and commercialization experts
• GE Collaborations: Formal program to accelerate proof
of concept, product development, and commercialization
• GE Brand: Association with the GE Brand will bring
credibility and a heighted level of exposure for PR
GEV value proposition to startups
Investment themes and theses
Affordable
Medical
Procedures
Healthcare
IT / services
IT-based solutions that align stakeholders
to:
• Improve decision making
• Increase efficiency, decrease costs
• Enable remote and personalized care
Fund size ~25% of total fund
Investments
~6 investments p.a.
Geographies US, Israel, India
Ownership
Minority stake
Observer seat
Stage
~30% early
~70% mid/late
Team
Head: Rafael Torres
Leslie Bortorff
Noah Lewis
Jason Sibley
Alex de Winter
Remy Durand
Ruchita Sinha
Avg. check ~$10M total
<$5M initial
Precision
medicine
Life sciences: Invest in efficient
methods of clinical translation for
large, rapid growth markets
Mol Dx: Improve utility, care and
health economics of Dx
Reduce patient procedure time via
devices, processes and tools that
are:
• Less invasive
• More efficient
• Prevent infections
• Enable remote
monitoring

18. GE Ventures: Top 4 Investment areas
1. Digital Health – sensors, s/w analytics, s/w to enable chronic
care, SMAC – social, mobile, analytical, cloud
2. Medical Devices – minimally invasive procedures
3. Patient Monitoring – follow the patient from hospital to home
4. Precision Medicine – In vitro Dx
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19. Centres for Excellence in Research and
Commercialization
Access to early stage technology and research experience
• Centre for Probe Development and
Commercialization
• Centre for Imaging Technology
Commercialization
• Centre for Commercialization of Regenerative
Medicine
• TECHNA
• TRIUMF / AAPS
• MaRS Innovation
Gov’t funded Incubators focused on Commercialisation in
Canada established in 2008
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20. Centre For Probe Development and
Commercialization (CPDC)
What: Centre dedicated to validation, translation and
commercialization of innovative imaging probes
• GEHC investment: $1m in kind 2007, $1.5m in kind
2012. Research partner (in-kind, cash).
• GEHC involvement : BOD, scientific advisory board.
• Alignment: Medical Devices, Precision Medicine.
• Opportunity: world market $14B, de-risked
technology 20
Chemistry
Preclinical
assessment
Scale-up
GMP
Regulatory
affairs
Clinical
trials
In vitro
screening
New product
Research Development Commercialization
Figure 1
Chemistry
Preclinical
assessment
Scale-up
GMP
Regulatory
affairs
Clinical
trials
In vitro
screening
New product
Research Development Commercialization
Figure 1

21. Centre for Imaging Technology
Commercialization (CIMTEC)
• What: Commercialization centre for medical imaging
and digital pathology technology
• GEHC investment: $1m in kind 2011,
• GEHC involvement – Commercialization council,
BOD, research partner
• Alignment: Medical Devices
• Opportunity: Access to a number of SMEs at
various stages of commercialization. Partnered with
Isis Innovation at the University of Oxford.
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22. Centre for Commercialization of Regenerative
Medicine (CCRM)
• What: Development of technologies that accelerate
the commercialization of stem cell- and biomaterials-
based products and therapies.
• GEHC investment: in-kind contribution,
• GEHC involvement - BOD, TBA
• Opportunity: CCRM Spin-Out Companies
22

23. TRIUMF / AAPS
23
• What: Centre of Excellence for Commercialization
and Research, bridging the gap between innovation
and commercialization in the physical sciences.
commercializes technologies emerging from
worldwide subatomic research
• GEHC investment: 99Tc cyclotron project , GRC
partnership – oxidative stress,
• GEHC involvement: – Research Partnership
• Alignment: Medical Devices, Precision Medicine
• Opportunity: IKOMED Technologies (2010), x-ray
radiation reduction technology for fluoroscopic
medical imaging technologies

24. GE confidential
24
GE Title or job number
10/13/2015
Example: Outside the hospital
Wearable patient monitoring
• Faster “step down” approach
… critical to sub-acute
• Hospital to home monitoring of
chronic patient
• Reducing re-admission rates
• Sensors : miniaturization &
low power wireless
• Distributed computing,
analytics, mobility
Care pathway optimizationDisruptive
Smart & ubiquitous
• From bedside devices to body-
worn monitoring
• Seamless data
• Continuous patient monitoring
as care standard of care
Efficient care
• Decreased adverse patient
outcome … i.e. respiratory distress)
• Decreased ICU transfers, length of
stay
• Lower overall cost

25. Thinking
Differently