5. Cholinergic Agents
⢠Parasympathomimic
⢠Produce effects of acetylcholine
⢠Other can inhibit acetyl cholinesterase (metabolize ACH)--
indirect-acting cholinergic agent
⢠PNS can be directly stimulated by some agents
⢠Actions:
â Slow heartbeat
â Increase GI motility
â Increase GI secretions
â Increased contraction of urinary bladder w/relaxation of muscle
sphincter
â Increase contractility of bronchial smooth muscle
â Sweating
â Miosis of eye which decrease intaocular pressure
â Increased force of contraction of skeletal muscle
â Sometimes decrease blood pressure
6. Cholinergic Agents
⢠VS: HR & BP
⢠The higher the doses the greater the likelihood
for adverse effects
⢠CAE:
⢠N/V/D/AC
⢠Dizziness
⢠Hypotension (monitor orthostatic pressures)
⢠Bronchospasm & wheezing
⢠Bradycardia (withhold the next dose)
⢠Interactions: atropine, antihistamines