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Colorectal cancer (CRC): Dr.Mohammad Shaikhani. MBChB/CABM/FRCP.
CRC:PRECURSORS ,[object Object],[object Object]
CRC:PRECURSORS ,[object Object],[object Object],[object Object],[object Object]
CRC:APC mutation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CRC:  MMR Mutations   ,[object Object],[object Object]
CRC:IBD-associated mutations ,[object Object]
Key points: ,[object Object],[object Object],[object Object]
Epidemiology/risk factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Epidemiology/RFs: Key points ,[object Object],[object Object]
Hereditary CRC Syndromes: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hereditary CRC Syndromes: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hereditary CRC Syndromes: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Stratification of Colorectal Cancer Risk 5%–6% >50  years of age Average  ( negative family history ) 10%–20% Familial :  First - degree relative with colorectal cancer 20% Presence of chronic colitis due to ulcerative colitis or Crohn's colitis Moderate 80% Presence of hereditary nonpolyposis colorectal cancer 100% Presence of familial adenomatous polyposis High Lifetime Risk Risk Level
IBD: ,[object Object],[object Object],[object Object],[object Object]
Factors Associated with the Development of CRC Cholecystectomy Excessive alcohol intake Smoking Obesity Lack of dietary calcium and folate Calcium and folate supplementation Physical inactivity Regular aerobic exercise Diet high in red meat, sucrose, fat Diet high in fruits and vegetables * Birth in North America or Northern Europe Birth in Asia or Africa Personal history of inflammatory bowel disease No family history of colorectal cancer or an inherited colorectal cancer syndrome Family history of colorectal cancer or an inherited colorectal cancer syndrome Protective Factors Risk Factors
Primary prevention& screening: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Algorithm for screening symptomatic persons for CRC
Patient selection for screening : ,[object Object],[object Object],[object Object],[object Object]
Patient selection for screening: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Manifestations / Diagnosis of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Manifestations / Diagnosis of CRC: ,[object Object],[object Object],[object Object],[object Object]
Clinical Manifestations / Diagnosis of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Manifestations / Diagnosis of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Manifestations / Diagnosis of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of CRC: ,[object Object],[object Object],[object Object],[object Object]
Treatment of CRC: key point ,[object Object],[object Object]
Prognosis of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Git Crc 2010 Lec

  • 1. Colorectal cancer (CRC): Dr.Mohammad Shaikhani. MBChB/CABM/FRCP.
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13. Stratification of Colorectal Cancer Risk 5%–6% >50 years of age Average ( negative family history ) 10%–20% Familial : First - degree relative with colorectal cancer 20% Presence of chronic colitis due to ulcerative colitis or Crohn's colitis Moderate 80% Presence of hereditary nonpolyposis colorectal cancer 100% Presence of familial adenomatous polyposis High Lifetime Risk Risk Level
  • 14.
  • 15. Factors Associated with the Development of CRC Cholecystectomy Excessive alcohol intake Smoking Obesity Lack of dietary calcium and folate Calcium and folate supplementation Physical inactivity Regular aerobic exercise Diet high in red meat, sucrose, fat Diet high in fruits and vegetables * Birth in North America or Northern Europe Birth in Asia or Africa Personal history of inflammatory bowel disease No family history of colorectal cancer or an inherited colorectal cancer syndrome Family history of colorectal cancer or an inherited colorectal cancer syndrome Protective Factors Risk Factors
  • 16.
  • 17. Algorithm for screening symptomatic persons for CRC
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.