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MRCOG Part 1 Practice MCQs

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MRCOG Part 1 Practice MCQs

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MRCOG Part 1 Practice MCQs

  1. 1. MRCOG PART 1 PRACTICE MCQs – SET B 1 1. The following statements are true A Interleukin-1 is produced by macrophages B Interleukin-2 is a polypeptide hormone C Interferons are a family of related aglycoproteins D Colony Stimulating Factors (CSF) regulate bone marrow production E Tumour Necrosis Factor (TNF) indirectly lyses tumour cells 2. Regarding the adrenal gland in pregnancy A Is closely related to the fetoplacental unit B Maternal adrenal gland usually increases in size by 30% C Plasma cortisol level increases from 20 weeks gestation D There is no change in unbound cortisol levels E Glucocorticoid receptors steadily increase till term 3. The umbilical cord A Contains two veins and one artery B Average length is between 55-60 cm C The cord continues to grow in length up to and beyond term D Umbilical cord artery has well formed internal elastic lamina E Wharton’s Jelly is rich in mucopolysaccharides 4. The following diseases have satisfactory vaccines A Tuberculosis B Tetanus C Syphilis D AIDS E Smallpox 5. Regarding the urinary system A The ureter receives blood supply from renal, gonadal and vesical artery B The vitamin D metabolism of kidney converts 1,25 to 25-cholecalciferol C It is responsible for the homeostasis of acid-base balance D The pudendal nerve plays no role in micturition E The ureter can be injured at the lateral vaginal fornix during surgery 6. The following are true combinations A Infarction – embolism causes vascular obstruction B Liver – easily infracted organ C Pulmonary hypertension – known outcome of pulmonary embolism D Wound healing by first intention – more intense inflammatory reaction E Wound healing by second intention – myofibroblasts cause wound contraction
  2. 2. MRCOG PART 1 PRACTICE MCQs – SET B 2 7. The following are true regarding gonadotrophins A Glycoproteins B Contain sialic acid C LH and FSH are synthesized in the same cell D Contain an alpha subunit which is similar to thyrotrophin E Its secretion shows a circadian rhythm 8. The following bacteria are in the bacilli group A Leptospira B Clostridium C Pseudomonas D Enterobactericiae E Bacteroides 9. The following associations regarding cancer are true A Vagina – stilboestrol B Liver – aflatoxin C Skin – paraffin D Melanoma – sunlight E Ovary – aniline dye 10. In septic shock A The causative organisms are invariably gram negative B A leucocytosis precedes death C Endotoxins are predominantly lipopolysaccharides D Antibiotic treatment may aggravate hypotension E There may be associated DIVC 11. Regarding Prothrombin A Is a Vitamin K dependant protein B Is synthesized in the liver C Converts fibrinogen to fibrin D Has a half life of 2-3 days E Has a molecular weight of 70 000 12. During pregnancy, thrombocytopenia may occur in association with A Bacterial infection B Viral infection C Alcoholism D Megaloblastic anaemia E Amniotic fluid embolism
  3. 3. MRCOG PART 1 PRACTICE MCQs – SET B 3 13. The following terminology regarding blood clotting factors are true A Factor I – fibrinogen B Factor II – prothrombin C Factor III – tissue factor D Factor IV – calcium ions E Factor V - proconvertin 14. Basal fetal heart rate in utero A Varies with gestational age B Is not subject to parasympathetic activity before the 20th week of pregnancy C Frequently accelerates with external head compression D Accelerates during orgasm E Accelerates in response to maternal ingestion of atropine sulphate 15. In the fetus A The umbilical arteries carry oxygenated blood B The ductus venosus short-circuits the capillaries of the liver C The right atrium contains a mixture of oxygenated and venous blood D The foramen ovale connects the ventricles of the heart E The ductus arteriosus joins the aorta proximal to the aortic arch 16. The sequelae of a vasectomy include A Varicocoele B Sperm granuloma C Torsion of the testis D Sperm antibodies E Loss of libido 17. Ureteral dilatation during pregnancy is caused by the following A Uterine pressure at the pelvic brim B Pressure from the dilated right ovarian vein C Progesterone effect D The increased glomerular filtration rate E Increased size of the kidneys 18. Human spermatozoa A Require the presence of FSH for normal development B Normally fertilise the ovum in the uterus C Are matured in the epididymis D Contain hyaluronidase E Production is less at 38◦ than 36◦ Celsius
  4. 4. MRCOG PART 1 PRACTICE MCQs – SET B 4 19. Cholesterol can be synthesized from acetate by A Ovary B Adrenal gland C Testis D Placenta E Pancreas 20. In the fetus A The umbilical arteries carry oxygenated blood B The ductus venosus short-circuits the capillaries of the liver C The foramen ovale is formed from the septum secundum overlapping the lower part of the septum primum D The definite interventricular septum originates predominantly from the sinus venosus E The ductus venosus shunts blood from the umbilical artery to the inferior vena cava 21. In the newborn child A The mastoid antrum is full adult size B The mandible has a midline fibrous joint C The thorax is oval in cross section D The spinal cord extends to L3 E Paranasal sinuses are full adult size 22. In the fetal circulation A Blood in the superior vena cava is more oxygenated than in the inferior vena cava B Blood from the SVC is preferentially shunted through the foramen ovale to the left atrium C 70% of blood from the right ventricle goes through the pulmonary artery to perfuse the lungs D The ductus arteriosus is histologically different from the pulmonary artery E 50% of blood bypasses the liver to enter the IVC 23. The following regarding viruses are true A The mumps virus is a paramyxoviridae B The dengue and yellow fever are flaviridae C Both rubella and yellow fever are of the same family of virus D Rotavirus is single stranded DNA E Hapatitis B virus is partially double stranded enveloped
  5. 5. MRCOG PART 1 PRACTICE MCQs – SET B 5 24. Regarding the prostaglandins A There are 4 main groups of prostaglandin B Are very rapidly metabolized C Are highly concentrated in the liver and brain D Exert their effects by releasing calcium ion E Their concentration is higher at term compared to early pregnancy 25. Ketosis is a condition in which A Acetoacetic acid, beta-hydroxybutyric acid and acetone accumulate in the blood B Respiratory acidosis develops C There is failure of the liver to oxidize the ketone bodies D Ketone bodies are produced by the peripheral tissues E There is an excessive carbohydrate availability for metabolism 26. Mycobacterium tuberculosis A Is resistant to strong acids but not alkalis B Is an obligate aerobe C Divides every 6-8 hours D Cord formation on culture predicts a low virulence E Spread to female genital tract is usually haematogenous 27. Danazol A Is a synthetic steroid B Is bound by serum albumin in the plasma C Acts by pituitary gonadtrophin stimulation D Increases oestradiol E Has weak impeded androgenic activity 28. The vagina A Is a tube that is directed upwards and backwards with a little curvature posteriorly B Is lined by stratified squamous epithelium C Has two fornices, anterior and posterior, at the vault D Is attached to the cardinal ligament E Is formed from single sino-vaginal bulb on the posterior wall of the urogenital sinus 29. Regarding arcinoid tumour: A Is malignant B Rapidly growing C Ocurs in Kulchitsky cells D Secretes 5-hydroxytrptamine E Commonest site is the ovarian teratoma
  6. 6. MRCOG PART 1 PRACTICE MCQs – SET B 6 30. In the development of the immune system in the fetus A Lymphocytes (T-cells) develop in the yolk sac at about 8 weeks B B-lymphocytes develop in the liver and spleen at 20 weeks C Cord blood levels of IgG is higher than maternal levels D The ratio of T to B cells is the same as in the adult during the first week of life E There is a greater proportion of null cells 31. The infection and pathogen pairs are correct A AIDS – HIV 1 & 2 B Neoplasm – HIV C Arthritis – HSV D Cervicitis – HPV E Anogenital warts – HSV 32. Rubella A Commonly infects before age 2 years in the UK B Has a worldwide distribution C Has single stranded RNA D Has an incubation period of 14-21 days E Presents with rashes after 3 days of fever 33. Known complications of rubella include A Encephalitis B Persistent suboccipital lymph nodes C Persistent arthralgia D Haematuria E Fetal rubella syndrome 34. In pregnancy A The maximum plasma volume has been reached by 30 weeks B The plasma volume increases more in primigravidae than in multigravidae C The increases in red cell volume is of same order as the increase in plasma volume D The fall in plasma proteins is mainly brought about by reduction in the globulin fractions E The concentration of serum cholesterol falls 35. In the regulation of glucose metabolism A Insulin promotes the uptake of glucose by muscle cells B Glucose-6-phosphate occurs in muscle but not in the liver C Adrenaline promotes the breakdown of hepatic glycogen D Lactate is the end product of the aerobic metabolism of glucose E Insulin is secreted by the alpha cells of the islet of Langerhans
  7. 7. MRCOG PART 1 PRACTICE MCQs – SET B 7 36. Exotoxins A Are derived from gram negative bacteria B Have specific actions C Are more toxic than endotoxins D Are neutralized by their homologous antitoxin E Can be made into toxoids 37. Polyuria occurs A In hypercalcaemia B In chronic renal failure C In potassium depletion D In the recovery phase of acute tubular necrosis E On exercise 38. Oestrogens A Are metabolized mainly to sulphate conjugates B Excretion in bile is greater than that in urine C Half-life in the circulation is 5-6 hours D After hydroxylation at the 2 and 4 positions the resulting catecholoestrogens will not bind to oestrogen receptors E Oestradiol is the oestrogen in pregnancy 39. Regarding acute infections of maternal origin A Rubella at 8 weeks POA – spontaneous abortion B Hydrops fetalis – HPV 19 C Varicella zoster virus – good prognosis D Coxsackie – myocarditis of the noewborn E CMV - teratogenic 40. Regarding chronic infection of maternal origin A CMV – most common agent of intrauterine infection B HSV infection is always symptomatic C Postnatal HSV presents at end of 2nd week of life D HSV causes intrauterine growth retardation E HBS Ag – high risk perinatal infection 41. Regarding HIV A Only infects intrauterine B Is acquired via the birth canal C Is an indication for caesarian section D Affected mothers can breastfeed their babies E Rate of transmission is 25%
  8. 8. MRCOG PART 1 PRACTICE MCQs – SET B 8 42. The following statements are correct A Large doses of thiopentone cause tocolysis B Halothane doesn’t enter fetal circulation C NO2 increases the incidence of abortion D Local anaesthesia is not transferable to the fetus E Morphine can cause fatal respiratory depression 43. Phaechromocytoma A Is usually benign B Is derived from chromaffin cells in the adrenal cortex C Secretes aldosterone and catecholamines D Metastasis is usually to the lung E Contain totipotent cells 44. The following statements relating to adrenal glands are correct A The average weight of a normal adrenal gland in adult is 1 gram B Each gland is drained by the three separate veins C The medulla is endodermal in origin D The zona reticularis of the cortex lies next to the medulla E Aldosterone is produced by cells of the zona glomerulosa of the cortex 45. Total cerebral blood low is most markedly increased by A Hypercapnoea B Hypoxia C Cerebral activity D Vasomotor reflexes E Increase in mean arterial pressure 46. Carbon dioxide is transported in the blood A In combination with haemoglobin B As hydrochloric acid C In combination with plasma proteins D Mainly as bicarbonate E In physical solution in plasma 47. During normal coitus A Lengthening of the upper vagina precedes lubrication in the sexually stimulated woman B Retraction of the clitoral body occurs during the plateau phase of the female sexual cycle C Female vaginal contractions occur at 0.8 second intervals during orgasm D Increase in penile length on erection is proportional to flaccid penile length E The prostate gland is relatively insensitive to sexual stimulation
  9. 9. MRCOG PART 1 PRACTICE MCQs – SET B 9 48. Prostaglandins A Are small molecular weight polypeptides B Are chemically related to thromboxanes C Have been clearly shown to be responsible for luteolysis in man D Inhibit the secretion of rennin E Are produced in the seminal vesicles of man 49. The anterior abdominal wall: A Transversalis fascia terminates at arcuate line B Interval oblique forms the anterior and posterior walls of the rectus sheath C The pyramidalis muscles is often absent D The superior epigastric artery lies superficial to the rectus abdominis E The external oblique muscle arises from the lower eight ribs 50. The following statements about vitamins are true: A Many vitamins can be synthesized in adequate amounts in the body B Vitamin K is water soluble C Deficiency of pyridoxine (vitamin B6) can cause convulsions D Naturally occurring folate contains a single glutamic acid residue E Excessive vitamin D intake causes renal failure 51. In hypothyroidism: A Myxoedema results from lipid infiltration of the dermis B Mental changes are entirely reversible with substitution therapy C Anaemia is present in most patients D Enlargement of the sella turcica is diagnostic of primary hypothyroidism E Barbiturates should be avoided 52. The following progestogens are derived from testosterone: A Ethynodiol B Megestrol C Norgestrel D Chlormadione E Norethisterone 53. Histopathology A Labia majora –keratinising squamous epithelial B Cervix – keratinizing squamous epithelial C Squamous metaplasia – premalignant condition D MGH (multiglandular hyperplasia) – pregnancy E High karyotyping index – Oestrogenic stimulant
  10. 10. MRCOG PART 1 PRACTICE MCQs – SET B 10 54. The respiratory centre A Is situated in the medulla oblongata B Is inhibited during vomiting C Send out regular impulses to the inspiratory muscles during quiet respiration D Is reflexly regulated by vagal impulses E Is sensitive to blood pH alterations 55. Which of the following are characteristics of damaged cells A Fatty infiltration B Plasma membrane blebbing C Mitochondrial swelling D Nuclear karyorrhesis E Increased cytosolic calcium 56. The anterior relation of the sacro-iliac joints are A Common iliac vein B Ilio-lumbar artery C Sciatic nerve D Gluteus maximus E Superior gluteal artery 57. The anterior pituitary produces the following hormones A Prolactin B Vasopressin C Human placental lactogen D Thyroxine E Growth hormone 58. Metabolic responses to hypovolaemic shock include A Respiratory alkalosis B Metabolic alkalosis C Increased glycogenolysis D Increased gluconeogenesis E Increased glycogenesis 59. During early placentation A The chorion frondosum lies adjacent to the decidua capsularis B The layer of Nitabuch cheeks invasion of the villi C The secondary villi have no mesodermal core D Chorio-decidual spaces form in the cytotrophoblastic layer E The body stalk develops into the umbilical cord
  11. 11. MRCOG PART 1 PRACTICE MCQs – SET B 11 60. In the anterior abdominal wall A The posterior wall of the rectus sheath below the Douglas fold is formed by the transversalis fascia only B The deep inguinal ring is 1 cm above the middle of the inguinal ligament C The conjoint tendon is formed from the internal and external oblique muscles D The internal spermatic fascia originates from the external oblique muscle E The dermatome at the umbilical level is T12 61. An abnormal karyotype is characteristic of A Phenylketonuria B Turner’s Syndrome C Aplasia of the vagina D Congenital adrenogenital hyperplasia E Down’s Syndrome 62. Blood coagulation may be delayed by A Deficiency of prothrombin B Deficiency of factor IX (Christmas factor) C Heparin D Calcium citrate E Potassium oxalate 63. Which of the following are true A TB can cause hypopituitary state B Galactorhoea is a result of 1◦ hypoparathyroidism C Craniopharyngioma causes high prolactin levels D Dopamine and serotonin are neurotransmitters E Action of stomatostatin on pancreas inhibits insulin secretion 64. Regarding acid base balance A The conversion of H+ ion is important for metabolism B Base donates protons C The neutral pH at 37◦C is 7.0 D The ICF pH 6.8-7.3 E The major protein buffer in blood is haemoglobin 65. Hyperoestrogenic effects are common in A Granulosa cell tumour B Thecoma C Leydig cell tumour D Disgerminomas E Mature cystic teratoma
  12. 12. MRCOG PART 1 PRACTICE MCQs – SET B 12 66. The healing of a wound is delayed by A Vitamin C deficiency B Starvation C The administration of glucocorticoids D Lack of blood supply E Infection 67. Regarding rubella : A It can occur in children under 2 years old B It is always teratogenic C Reinfection can result in positive rubella-specific IgM D Placental infection occurs from ascending genital infection E Rubella vaccine causes fetal damage if given to rubella-susceptible pregnant women during the first trimester 68. The inguinal lymph nodes receive lymph from A Perianal skin B Infraumbilical region C Prostate D Testis E Clefts between toes 69. The following structures leave the pelvis by passing through the greater sciatic foramen above the piriformis muscle A The sciatic nerve B The superior gluteal nerve C The internal pudendal vessels D The nerve to quadratus femoris muscle E The inferior gluteal nerve 70. Adrenocorticotropic hormone (ACTH) A Controls glucocorticoid production B Controls catecholamine production C Is increased by the secretion of a hypothalamic releasing factor D Is suppressed by a high level of circulating glucocorticoid E Shows diurnal physiological variations 71. The ductus venosus A Connects the left branch of the portal hepatic vein to the umbilical vein B Conveys blood to the inferior vena cava before birth C After birth becomes the ligamentum teres of the liver D Becomes the lateral umbilical ligament of the adult E Receives blood from the umbilical vein
  13. 13. MRCOG PART 1 PRACTICE MCQs – SET B 13 72. The ureter A On the right crosses the external iliac vessels to enter the pelvis B Lies portero-superior to the internal iliac artery on the side wall of the pelvis C Lies superior to the uterine artery as it passes through the base of the broad ligament D Th narrowest where it joins the bladder wall E On the side wall of the pelvis lies medial to the obturator nerve and vessels 73. With regards to carbohydrates A Digestion of carbohydrates begins in the mouth B 1g of carbohydrates yields the same amount of energy as 1g of protein C Fructose absorption requires energy D Gastrointestinal glucose absorption is facilitated by insulin E Absorption of glucose by the enterocytes take place mainly in the terminal ileum 74. Cervical ectropion A Is frequently asymptomatic B Consists of squamous epithelium C Is related to trauma during childbirth D Is exaggerated by bi-valve speculum examination E May be corrected by trachelorrhapy 75. Precocious puberty A Is constitutional in the majority of cases B May initially manifest as precocious telarche C Occurs with intra-cranial tumours D Occurs with ovarian tumours E Occurs in Albright Syndrome 76. Which of the following are characteristic of benign tumours A High degree of differentiation B More mitoses than normal tissues C Many abnormal mitotic features D Marked nuclear pleomorphism E Encapsulation 77. Which of the following antimicrobial drugs may adversely affect the fetus if given to the mother in late pregnancy A Oxytetracycline B Long acting sulphonamides C Ampicillin D Streptomycin E Erythromycin
  14. 14. MRCOG PART 1 PRACTICE MCQs – SET B 14 78. The fetal membrane comprises of A Amnion B Chorion C Yolk sac D All of the above E A and B only 79. In the human feto-placental unit A The intervillous space contains fetal blood B The invasion of maternal spiral arteries by throphoblast causes dilatation C Two-cell membranes separate the maternal and fetal circulations D The spiral arteries enter the placental cotyledons E Cytotrophoblast cells disappear towards term 80. During early placentation A The chorion frondosum lies adjacent to the decidua capsularis B The layer of “Nitabuch” checks invasion of villi C The secondary villi has no mesodermal core D Chorio-decidual spaces form in the cytotrophoblastic layer E The boy stalk develops into the umbilical cord 81. Throphoblasts A Enter the maternal circulation in normal pregnancy B Are lysed in the maternal lung C Are genetically maternal D Produce human chorionic gonadotrophin E Are immunologically inert 82. The functions of the placenta include A Production of erythrocytes B The formation of immunological barriers C Excretion of waste products D Production of insulin E Production of progesterone 83. The following statements about placental pathology are appropriate A Placenta extrachorialis predisposes to postpartum haemorrhage B A velamentous insertion of the cord is of no clinical importance C Placental succenturiata (succenturiate lobe) predisposes to antepartum haemorrhage D A haemangioma of the placenta causes oligohydramnios E Placenta percreta penetrates through the serosal surface of the uterus
  15. 15. MRCOG PART 1 PRACTICE MCQs – SET B 15 84. The following substances cross the placenta to the fetus against a concentration gradient A Calsium B Magnesium C Amino acids D Iron E Fat soluble vitamins 85. The following crosses the placenta to the fetus A Thyroxine B Triiodothyronine C Thiouracil D TSH E LATS 86. The following statements relate to syphilis A Treponema pallidum is a gram negative organism B The primary chancre usually appears within one week of exposure to infection C Spirochaetes are distributed through out the body at the time of appearance of the primary chancre D Serology is positive in all cases of tertiary syphilis E The Reiter protein complement fixation test is the most reliable verification test available 87. Cytomegalovirus A Has infected 80% of the adult population B Is demonstrable in 0.5 to 1.5% of neonates C Is an adenovirus D Cause neonatal jaundice E Is commonly present in the salivary glands 88. The following antibiotics act by inhibiting bacterial cell wall synthesis A Cephalosporins B Cephamycins C Aminoglycosides D Polymyxins E Rifamycins 89. In the human testis A Spermatogenesis takes place in the seminiferous tubules B Spermatozoa arise directly from germ cells C Sertoli cellsregulate spermatogenesis D FSH stimulates spermatogenesis by increasing the protein content of Sertoli cells E Spermatogenesis only occurs at normal deep body temperature
  16. 16. MRCOG PART 1 PRACTICE MCQs – SET B 16 90. In the adult female A The fallopian tubes convey ova from the ovaries to the uterus B The fallopian tube segment closest to the ovary is called the ampulla C The uterus and connective tissue capsules of the ovaries are connected by the broad ligament D The middle layer of the uterus is muscular E The structure of the inner layer of the uterus varies during the menstrual cycle 91. In the human ovary A Ovarian follicles are formed during fetal life B Each ovarian follicle contains several primordial ova C The zona granulosa is formed from proliferating follicle cells D FSH causes mature Graffian follicle to rupture E The ovum is released into the fallopian tube 92. Progesterone A Is produced by the developing ovarian follicle B Transforms the endometrium into a secretory endothelium C Enhances the contractile reponse of the myometrium to oxytocin D Is produced by the placenta throughout pregnancy E Is metabolized mainly in the liver 93. The following are sedative agents A Lorazepam B Promethazine C Maxolon D Lignocaine E Droperidol 94. The following are correct statements A Ovarian artery – supplies to the uterus B Vaginal artery – supplies the cervix C Lumbar plexus – psoas major, psoas minor D Sacral plexus – iliacus E Ventral root – brachial plexus 95. Innervation of the female genitalia A Ilio-inguinal nerve B Inferior rectal nerve C Superior rectal nerve D Inferior perineal nerve E Labial nerve
  17. 17. MRCOG PART 1 PRACTICE MCQs – SET B 17 96. Regarding lymphatic drainage of the genital organs A Superior inguinal lymph node – fallopian tubes B Internal iliac lymph node – nulva C Paraaortic lymph node – ovaries D Lower 1/3 vagina – sacral lymph node E Cervix – paracervical lymph node 97. Regarding uterine contraction A There are no contractions before 25 week POA B Highly sensitive to oxytocin due to raised prostaglandin level C Is caused by a fall in oestrogen level D Is associated with raised pregnanediol E Causes raised prostaglandin level 98. The following are effects of prostaglandin A PGI2 – vasodilator effects B TXA2 – stimulate platelet aggregation C PG1 is derived from linoleic acid D PG3 is derived from plants E Alkaloic acid is associated with PG1 99. During sexual intercourse A Increased activity in sacral parasympathetic nerves causes the penis B The vagina is engorged with blood C Vaginal stimulation causes the release of oxytocin D Ejaculation is produced by smooth muscle contranction at the root of the penis E Impairment of the parasympathetic innervation causes failure of ejaculation 100. The side effects of cytotoxic drugs may include A Immunosuppression B Gastrointestinal disturbances C Renal dysfunction D Loss of hair E Inhibition of wound healing 101. The antifungal drug griseofulvin A Is effective gainst ringworm caused by all known forms of fungi B Is used by topical administration and may not be given orally C Is normally used in combination with topical zinc undecenoate ot tolnaftate D Can inhibit mammalian cell division E Has a broader spectrum of action than clotrimazole
  18. 18. MRCOG PART 1 PRACTICE MCQs – SET B 18 102. Nystatin A Is used in the treatment of candidiasis B Binds selectively to biological membranes which do not contain sterols C Does not exert toxic effects mammalian cells D Acts on fungi in a manner which differs from that of ampothericin E Is the drug of choice for the treatment of pulmonary aspergillosis 103. The Wasserman reaction is a A Precipitin test B Complement fixation test C Haemagglutination inhibition test D Agglutination test E Treponemal immobilization test 104. Which of the following cell types may be found in germinal cetres? A LYmphoblasts B Plasma cells C Macrophages D Eosinophils E Mast cells 105. Ultrasound A Produces images of tissue structure B Enables both size and nature of structure to be ascertained C Is not applicable to study the eye D Is essentially similar to x-ray E Is a non-invasive technique 106. Regarding morphine A The major pathway for its detoxification is by oxidation to gentisic acid B It increases biliary tract pressure C It is eliminated mainly in the conjugated state via glomerular filtration D It is secreted in the bile E It alters the threshold or responsiveness of nerve endings to noxious stimulation 107. Patients with testicular feminizing syndrome A Have well-formed breasts B Complain of secondary amenorrhoea C Lack pubic hair D Have XY karyotype E Are liable to develop malignant change in the gonads
  19. 19. MRCOG PART 1 PRACTICE MCQs – SET B 19 108. The following are the primary branches of the celiac artery A Left gastric artery B Right gastro-epiploic artery C Gastroduodenal artery D Hepatic artery E Splenic artery 109. The following statements relating to the adrenal glands are correct A The average weight of a normal adrenal gland in the adult is 1 gram B Each gland is drained by the 3 separate veins C The medulla is endodermal in origin D The zona reticularis of the cortex lies next to the medulla E Aldosterone is produced by cells of the zona glomerulosa of the cortex 110. The cerebral blood flow is most markedly increased by A Hypercapnoea B Hypoxia C Cerebral activity D Vasomotor reflexes E Increase in mean arterial pressure 111. Carbon dioxide is transported in the blood A In combination with haemoglobin B As hydrochloric acid C In combination with plasma proteins D Mainly as bicarbonate E In physical solution in plasma 112. The respiratory centre A Is situated in the medulla oblongata B Is inhibited during vomiting C Sends out regular impulses to the inspiratory muscles during quiet respiration D Is reflexly regulated by vagal impulses E Is sensitive to blood pH alterations 113. Transexual patients characterictically A Have normal external genitalia B Have abnormal karyotype C Have abnormal hormone profiles D Are of subnormal intelligence E Are maladjusted socially
  20. 20. MRCOG PART 1 PRACTICE MCQs – SET B 20 114. Oestrogens A Are synthesized from cholesterol B Are secreted by the anterior pituitary gland C Are secreted by thr adrenal gland D Are secreted by the stromal cells of the ovary E Are principally excreted in the urine 115. Cervical erosions A Are often asymptomatic B Show ulcerative features on microscopic examination C Are associated with pregnancy D Are associated with oral contraceptive use E Are associated with later development of cervical carcinoma 116. Which of the following separate maternal and fetal blood in the human placenta? A Throphoblast B Maternal vascular endothelium C Fetal vascular endothelium D Maternal connective tissue E Fetal connective tissue 117. Progesteron is A Synthesized by the throphoblast B Mainly excreted as pregnanediol glucoronide C Synthesized from cholesterol D A smooth muscle stimulant E A glycoprotein 118. Lymphatic drainage from the uterine cervix is through the following lymph node A Superficial femoral B Superficial inguinal C External iliac D Obturator E Lumbosacral 119. Pudendal nerve carries the following nerves A Sensory from the anterior part of the labia majora B Sensory from the perineum C Sensory from the lower part of the uterus D Motor to the external anal sphincter E Sensory from the clitoris
  21. 21. MRCOG PART 1 PRACTICE MCQs – SET B 21 120. The following structures support the uterus in position A The broad ligament B The infundibulo-pelvic ligaments C The transverse cervical ligaments D The vagina E The transverse perineal muscles 121. Urogenital diaphragm is pierced by the A Ureters B Rectum C Vagina D Urethra E Obturator nerve 122. The following associations of types of epithetlium are correct A Ciliated and uterine body B Stratified squamous and vagina C Transitional and bladder D Columnar and cervix E Transitional and urethra 123. The ovarian ligaments A Contain the ureters B Contain the ovarian arteries C Are attached laterally to the pelvic wall D Lie anterior to the broad ligament E Are homologous to part of the gubernaculums testis in the male 124. The following are synovial joints A Symphysis pubis B Sacro-iliac C Sacro-coccygeal D Lumbo-sacral E Patello-femoral 125. The following statements relate to nerves of the pelvis A The genitofemoral nerve arises from L1 and L2 B The levator ani is in part supplied by the perineal nerve C The pudendal nerve lies just posterior to the sacro-tuberous ligament D The skin of the anal triangle is supplied by S1 and S2 fibres E The obturator nerve arises from the sacral plexus
  22. 22. MRCOG PART 1 PRACTICE MCQs – SET B 22 126. The following diseases are commonly made worse by pregnancy A Gout B Systemic lupus erythematosus C Migraine D Hyperthyroidism E Addison’s disease 127. The following structures lie in the posterior triangle of the neck A Supraclavicular lymph glands B Common carotid artery C Subclavian artery D Vagus nerve E Brachial plexus 128. The following are primary branches of the coeliac artery A Left gastric artery B Right gastro-epiploic artery C Gastro-duodenal artery D Hepatic artery E Splenic artery 129. Ectopic breast tissue may appear anywhere along A Toldt’s line B Semicircular line C Milk line D Subway line E Red line 130. The ovarian artery contributes to the blood supply of the A Fallopian tube B Round ligament C Uterus D All of the above E None of the above 131. The following pelvic structures are extensively covered by peritoneum A Uterine corpus B Uterine cervix C Ovary D All of the above E None of the above
  23. 23. MRCOG PART 1 PRACTICE MCQs – SET B 23 132. Which of the following diseases are shown to be commonly related to infection with streptococci A Scarlet fever B Glomerulonephritis C Cellulitis D Acute rheumatic fever E Thyroiditis 133. Dysplasia A Is an abnormal maturation epithelial cells B Is an irreversible process C Often arises from a background of squamous metaplasia D Invariably progresses to cancer E Shows increase mitoses 134. Cancer suppressor genes include A Retinoblastoma gene B Adenomatous polyposis coli gene C P53 gene D nM gene E Bcl 2 gene 135. The terminal ileum mainly absorbs A Iron B Cyanocobalamin C Fatty acids D Bile salts E Water-soluble vitamins 136. The fat embolism syndrome A Is associated with severe skeletal injuries B Usually manifests within 12 hours of injury C Is associated with thrombocythaemia D Is fatal in the majority of cases in postmortem E Can be diagnosed histologically by paraffin-embedded tissue injection 137. The human placenta A Produces pregnanediol B Is haemochorial C Has anastomoses between villous vessels D Has syncytiotrophoblast as the major component of the trophoblast near term E Is anchored to the myometrium by stem villi
  24. 24. MRCOG PART 1 PRACTICE MCQs – SET B 24 138. The kidneys secrete A 1,25-dehydrocholecalciferol B Rennin C Angiotensin D Vasopressin E Erythropoietin 139. The following statements about haemophilia are true A All sons of affected males will inherit the condition B Half of the sons of a carrier female will inherit the condition C The incidence of haemophilia in the daughters of an affected male (married to a normal female) will be one in four D If a carrier female marries anaffected male, all of the offspring will inherit the haemophilia gene E Normal daughters cannot be born to a carrier female 140. The following statements relate to the normal distribution A The mean and mode are equal B The median is one standard deviation below the mean C 99.7% of the population lies within two standard deviations of the mean D The standard error of the mean is the variance divided by the square root of the number of observations E No other symmetrical distribution is possible 141. The volume of amniotic fluid A Is closely related to the fetal crown-rump length in the 3rd trimester of pregnancy B May be predicted by ultrasound C Is excessive in severe rhesus disease D Increases following amniocentesis E Is reduced in severe pre-eclampsia 142. Spermatogenesis A Is a process requiring 110 + 5 days in the human male B Requires both FSH and LH to stimulate sperm maturation C Is associated with an increase in testosterone in the intertubular tissue of the testis D Is abnormal in a male with a karyotype 47XXY E Is depressed by mycoplasma infection of the male genital tract 143. The placental barrier between mother and fetus is composed of A Fetal capillary endothelium B Throphoblasts C Maternal capillary endothelium D All the above E A and B only
  25. 25. MRCOG PART 1 PRACTICE MCQs – SET B 25 144. The following statements relate to clostridia and clostridial infection A All clostridia are anaerobes B Clostridium tetani produces central spores C Clostridium perfringens (Welchii) is the only organism which causes gas gangrene D Clostridium perfringens (Welchii) must be actively treated when isolated from vaginal swabs E Patients with tetanus must be barrier nursed 145. The following obtains the following substances by simple diffusion A Water B Sodium C Oxygen D Calcium E Iron 146. An episiotomy during childbirth A Prevents uterine injury B Enlarges the pelvic outlet C Prevents tearing of the perineal muscles D Cause tearing of the central tendon of the perineum E Helps prevent uterine prolapse 147. Renin A Has a molecular weight of 40,000 B Is only produced in the kidney C Is released when there is a rise in blood pressure D Is released by decreased blood sodium concentration E Falls in amount with a rise in plasma potassium 148. Which of the following statements are true A Warfarin does not cross the placenta to enter the fetus B Plasma insulin is lower on the fetal side C Local anaesthetic crosses the placenta readily D Corticosteroid administration may lead to higher oestriol secretion in the maternal urine E Low urinary oestriol concentration may occur with acute urinary tract infection 149. Human chorionic gonadotrophin A Has all the properties of LH B Can transform a normal cyclic corpus luteum into a pseudopregnant corpus luteum C Is responsible for the onset of parturition D Is detectable before implantation of the ovum E Is significantly elevated in pre-eclampsia
  26. 26. MRCOG PART 1 PRACTICE MCQs – SET B 26 150. These methods of placental transfer are appropriate for the following substances A Oxygen – active B Fats – pinocytosis C Iron – active D Carbon dioxide – passive E Antibodies - pinocytosis

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