Parkinsonism

1. Sarita Sharma
Assistant professor
Department of pharmacology
Mumbai

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Schematic presentation of Pathophysiology of PD:
Destruction of dopaminergic neuronal cells in the
sunstantia nigra in the basal ganglia
Depletion of dopamine store
Degeneration of dopaminergic nigrostriatal pathway
Imbalance of excitatory (Ach) and inhibiting
(Dopamine) neurotransmitter in the corpus striatum
Impairment of extra pyramidal tract controlling
complex body movement
Tremor Rigidity Bradykinesia
Genetic Drugs Toxins Free radicals
Schematic presentation of Pathophysiology of PD:
Destruction of dopaminergic neuronal cells in the
sunstantia nigra in the basal ganglia
Depletion of dopamine store
Degeneration of dopaminergic nigrostriatal pathway
Imbalance of excitatory (Ach) and inhibiting
(Dopamine) neurotransmitter in the corpus striatum
Impairment of extra pyramidal tract controlling
complex body movement
Tremor Rigidity Bradykinesia
Genetic Drugs Toxins Free radicals
Motor pathways
Responsible for body movements

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 No specific test
 Patient history
 CT scan of brain
Diagnosis

11.  No cure for PD
 Carbidopa-levodopa. ...
 Carbidopa-levodopa infusion. ...
 Dopamine agonists. ...bromocriptine
 MAO-B inhibitors. ...selegiline
 Catechol-O-methyltransferase (COMT) inhibitors. ...
 Anticholinergics. ...benztropine, procyclidine
 Amantadine.
 Emotional support & help by relatives, friends or some
organisations with drug therapy may improve quality of life.
Treatment
Dopaminergic drugs

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Thank you